The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs
Open accessAbstract
NAD + supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD + to physiological levels has been shown to improve the function of some adult stem cells, with implications that these changes will lead to sustained improvement of the tissue or system. Here, we examined the effect of elevating NAD + levels in models with reduced hematopoietic stem cell (HSC) potential, ATM-deficient and aged WT mice, and showed that supplementation of nicotinamide riboside (NR), a NAD + precursor, improved lymphoid lineage potential during supplementation. In aged mice, this improved lymphoid potential was maintained in competitive transplants and was associated with transcriptional repression of myeloid gene signatures in stem and lineage-committed progenitor cells after NR treatment. However, the altered transcriptional priming of the stem cells toward lymphoid lineages was not sustained in the aged mice after NR removal. These data characterize significant alterations to the lineage potential of functionally compromised HSCs after short-term exposure to NR treatment.
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“Likewise, nicotinamide riboside improves HSC function in young mice221 and ameliorates the lymphoid potential of HSCs in old mice222.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [222]
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Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
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Self-citationHematopoietic Stem Cells and the Immune System in Development and Aging
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Mitochondrial Contributions to Hematopoietic Stem Cell Aging
Morganti, C., & Ito, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011117 · Cited by 50
Biţă, A., Scorei, I. R., Ciocîlteu, M. V., Nicolaescu, O. E., Pîrvu, A. S., Bejenaru, L. E., Rău, G., Bejenaru, C., Radu, A., Neamţu, J., et al. (2023) · Molecules · doi:10.3390/molecules28166078 · Cited by 36
Metadata
- Authors
- Zong, L., Tanaka-Yano, M., Park, B., Yanai, H., Turhan, F. T., Croteau, D. L., Tian, J., Fang, E. F., Bohr, V. A., & Beerman, I.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Beerman, Isabel
- ORCID
- Venue
- npj Aging and Mechanisms of Disease
- Published
- 2021-09-21
- Volume
- 7
- Issue
- 1
- Pages
- 25-25
- ISSN
- 2056-3973 (ISSN-L)
- PMC
- PMC8455618
- OpenAlex
- W3199551479
- Cited by
- 22
- References
- 48
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Aging and Mechanisms of Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- U.S. Department of Health and Human Services (AG000992)
- National Natural Science Foundation of China (#81971327)
- Norges Forskningsråd (#262175)
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Institute on Aging (ZIAAG000992)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- NAD+ supplementation, nicotinamide riboside, hematopoietic stem cells, ATM deficiency, aging, competitive transplantation, DNA repair, mitochondrial function
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