Croteau, Deborah L.

Ageing as a risk factor for neurodegenerative disease

Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019) · Nature Reviews Neurology

Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

Cited by 3,310

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 1,740

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 711

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineDNA Repair Mechanisms

Cited by 575

NAD(+) in aging: molecular mechanisms and translational implications

Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 501

NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsSirtuins and Resveratrol in Medicine

Cited by 472

Nuclear DNA damage signalling to mitochondria in ageing

Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2016) · Nature Reviews Molecular Cell Biology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 387

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome

Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., et al. (2014) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 352

Prokaryotic Nucleotide Excision Repair: The UvrABC System

Truglio, J. J., Croteau, D. L., Van Houten, B., & Kisker, C. (2006) · Chemical Reviews

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 340

Cockayne syndrome: Clinical features, model systems and pathways

Karikkineth, A. C., Scheibye-Knudsen, M., Fivenson, E., Croteau, D. L., & Bohr, V. A. (2017) · Ageing Research Reviews

DNA Repair MechanismsGenomics and Rare Diseases

Cited by 262

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

Hou, Y., Chu, X., Park, J., Zhu, Q., Hussain, M., Li, Z., Madsen, H. B., Yang, B., Wei, Y., Wang, Y., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 145

Genome instability in Alzheimer disease

Hou, Y., Song, H., Croteau, D. L., Akbari, M., & Bohr, V. A. (2017) · Mechanisms of Ageing and Development

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 120

Toward understanding genomic instability, mitochondrial dysfunction and aging

Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2019) · The FEBS Journal

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 77

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L., & Bohr, V. A. (2014) · Autophagy

Autophagy in Disease and TherapyDNA Repair Mechanisms

Cited by 50

A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

Roberts, J. A., Varma, V. R., An, Y., Varma, S., Candia, J., Fantoni, G., Tiwari, V., Anerillas, C., Williamson, A., Saito, A., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 49

NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs

Zong, L., Tanaka-Yano, M., Park, B., Yanai, H., Turhan, F. T., Croteau, D. L., Tian, J., Fang, E. F., Bohr, V. A., & Beerman, I. (2021) · npj Aging and Mechanisms of Disease

Sirtuins and Resveratrol in MedicineHematopoietic Stem Cell Transplantation

Cited by 22