The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome
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Abstract
Imbalances of the microbiome, also referred to as microbial dysbiosis, could lead to a series of different diseases. One factor that has been shown to lead to dysbiosis of the microbiome is exposure to psychological stressors. Throughout evolution microorganisms of the human microbiome have developed systems for sensing host-associated signals such as hormones associated with those stressors, enabling them to recognize essential changes in their environment, thus changing their expression gene profile to fit the needs of the new environment. The most widely accepted theory explaining the ability of hormones to affect the outcome of an infection involves the suppression of the immune system. Commensal microbiota is involved in stressor-induced immunomodulation, but other biological effects are not yet known. Here we present the impact that cortisol had on the community-wide transcriptome of the oral community. We used a metatranscriptomic approach to obtain first insights into the metabolic changes induced by this stress hormone as well as which members of the oral microbiome respond to the presence of cortisol in the environment. Our findings show that the stress hormone cortisol directly induces shifts in the gene expression profiles of the oral microbiome that reproduce results found in the profiles of expression of periodontal disease and its progression.
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Application of transcriptomic approaches has proved extremely significant for delineating both microbial and host gene expression in the context of oral health and pathology.
“Application of transcriptomic approaches has proved extremely significant for delineating both microbial and host gene expression in the context of oral health and pathology.14, 68, 94”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [94]
The stress hormone cortisol has been shown to directly induce shifts in the composition of the oral microbial community and in its gene expression profiles in vitro, which reproduces results found for the gene expression profiles of the oral microbial community in periodontal disease and during its progression.
“Moreover, the stress hormone, cortisol, has been shown to directly induce shifts in the composition of the oral microbial community and in its gene expression profiles in vitro, which reproduces results found for the gene expression profiles of the oral microbial community in periodontal disease and during its progression.94”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [94]
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
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- Authors
- Duran-Pinedo, A. E., Solbiati, J., & Frias-Lopez, J.
- Affiliations
- University of Florida (US)
- Venue
- npj Biofilms and Microbiomes
- Published
- 2018-10-18
- Volume
- 4
- Issue
- 1
- Pages
- 25-25
- ISSN
- 2055-5008 (ISSN-L)
- PMC
- PMC6194028
- OpenAlex
- W2897333988
- Cited by
- 96
- References
- 27
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 13 · 2019: 2 · 2018: 1
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Biofilms and Microbiomes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (DE021553)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- cortisol, oral microbiota, dysbiosis, psychological stress, metatranscriptomics, gene expression, periodontal disease, host-microbe signaling, immunomodulation, commensal microbiota
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