Oxygen, a source of life and stress

Targeting HIF-1 for cancer therapy

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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Angiogenesis as a therapeutic target

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Hypoxia signalling in cancer and approaches to enforce tumour regression

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p53 Regulates Mitochondrial Respiration

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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Glycolysis inhibition for anticancer treatment

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Death by design: apoptosis, necrosis and autophagy

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

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Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

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Tumor microenvironmental physiology and its implications for radiation oncology

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The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

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The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

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HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

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The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1

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Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

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Glycolytic Enzymes Can Modulate Cellular Life Span

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The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Tissue oxygen tension and brain sensitivity to hypoxia

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

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JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

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Regulation of tumor pH and the role of carbonic anhydrase 9

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Proline hydroxylation and gene expression

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Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3

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Lactate: mirror and motor of tumor malignancy

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Akt-dependent transformation: there is more to growth than just surviving

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Targeting tumor-associated carbonic anhydrase IX in cancer therapy

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Hypoxia and Glucose Metabolism in Malignant Tumors

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Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

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The Expanding Family of Eucaryotic Na+/H+Exchangers

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Retinal degeneration and local oxygen metabolism

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Tumor pH controls the <i>in vivo</i> efficacy of weak acid and base chemotherapeutics

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Cell-Permeating <i>α</i> -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359 · see citing works

Signalling hypoxia by HIF hydroxylases

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Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes &amp; Development · doi:10.1101/gad.1363206 · Cited by 321 · see citing works

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells

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The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

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Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

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Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome

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Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

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Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

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HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes

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The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling

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Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer

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Cancer: looking outside the genome

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Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma

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Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1α, Causing Glycolysis Shutdown and Cell Death

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Altitude is a phenotypic modifier in hereditary paraganglioma type�1: evidence for an oxygen-sensing defect

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Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.

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Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway

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Induction of the Heat Shock Pathway during Hypoxia Requires Regulation of Heat Shock Factor by Hypoxia-inducible Factor-1

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RACK1 vs. HSP90: Competition for HIF-1α Degradation vs. Stabilization

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The NHERF1 PDZ2 Domain Regulates PKA–RhoA–p38-mediated NHE1 Activation and Invasion in Breast Tumor Cells

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Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment

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Transport Activity of MCT1 Expressed in Xenopus Oocytes Is Increased by Interaction with Carbonic Anhydrase

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Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Lau, K. W., Tian, Y.-M., Raval, R. R., Ratcliffe, P. J., & Pugh, C. W. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603675 · Cited by 104 · see citing works

BNip3 and signal-specific programmed death in the heart

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Hypoxia-inducible Factor 2α Regulates Expression of the Mitochondrial Aconitase Chaperone Protein Frataxin

Oktay, Y., Dioum, E. M., Matsuzaki, S., Ding, K., Yan, L., Haller, R. G., Szweda, L. I., & Garcia, J. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611133200 · Cited by 92 · see citing works

The Hypoxia-Inducible Factor and Tumor Progression Along the Angiogenic Pathway

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Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis

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Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer

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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

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Adipose tissue remodeling and obesity

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Redox regulation of cell survival

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Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

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The antioxidant properties of serum albumin

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pH-Responsive Nanoparticles for Drug Delivery

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Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

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Reduced Adipose Tissue Oxygenation in Human Obesity

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Hypoxia and cancer

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Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

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Wound healing essentials: Let there be oxygen

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Hypoxia and mitochondrial oxidative metabolism

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Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

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Hypoxia-Modified Cancer Cell Metabolism

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Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

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Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

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Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology

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pH control mechanisms of tumor survival and growth

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Nanopreparations to overcome multidrug resistance in cancer

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The role of low-grade inflammation in the polycystic ovary syndrome

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