Cited by 235Electrochemical sensors and biosensorsDiabetes Management and ResearchPancreatic function and diabetes

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Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

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Xie, Xi, Doloff, Joshua C., Yesilyurt, Volkan, Sadraei, Atieh, McGarrigle, James J., Omami, Mustafa, Veiseh, Omid, Farah, Shady, Isa, Douglas, Ghani, Sofia, Joshi, Ira, Vegas, Arturo, Li, Jie, Wang, Weiheng, Bader, Andrew, Tam, Hok Hei, Tao, Jun, Chen, Hui-jiuan, Yang, Boru, Williamson, Katrina Ann, Oberholzer, Jose, Langer, Robert, Anderson, Daniel G.·2018·Nature Biomedical Engineering

DOI 10.1038/s41551-018-0273-3PMC PMC6436621

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Abstract

Continuous glucose monitors (CGMs), used by patients with diabetes mellitus, can autonomously track fluctuations in blood glucose over time. However, the signal produced by CGMs during the initial recording period following sensor implantation contains substantial noise, requiring frequent recalibration via fingerprick tests. Here, we show that coating the sensor with a zwitterionic polymer, found via a combinatorial-chemistry approach, significantly reduces signal noise and improves CGM performance. We evaluated the polymer-coated sensors in mice as well as in healthy and diabetic non-human primates, and show that the sensors accurately record glucose levels without the need for recalibration. We also show that the polymer-coated sensors significantly abrogated immune responses to the sensor, as indicated by histology, fluorescent whole-body imaging of inflammation-associated protease activity, and gene expression of inflammation markers. The polymer coating may allow CGMs to become standalone measuring devices.

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Authors: Xie, X., Doloff, J. C., Yesilyurt, V., Sadraei, A., McGarrigle, J. J., Omami, M., Veiseh, O., Farah, S., Isa, D., Ghani, S., Joshi, I., Vegas, A., Li, J., Wang, W., Bader, A., Tam, H. H., Tao, J., Chen, H.-J., Yang, B., Williamson, K. A., Oberholzer, J., Langer, R., & Anderson, D. G.
Affiliations: Sun Yat-sen University (CN)
Boston Children's Hospital (US)
Koch Institute for Integrative Cancer Research At MIT (US)
University of Illinois Chicago (US)
Harvard University (US)
Corresponding author: Anderson, Daniel G.
ORCID: Xie, Xi
Doloff, Joshua C.
Sadraei, Atieh
McGarrigle, James J.
Veiseh, Omid
Farah, Shady
Joshi, Ira
Vegas, Arturo
Tam, Hok Hei
Tao, Jun
Williamson, Katrina Ann
Anderson, Daniel G.
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2018-07-30
Volume: 2
Issue: 12
Pages: 894-906
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-018-0273-3
PMC: PMC6436621
OpenAlex: W2884370030
Cited by: 235
References: 60
Citations by year: 2026: 27 · 2025: 41 · 2024: 24 · 2023: 35 · 2022: 31 · 2021: 30 · 2020: 29 · 2019: 17 · 2018: 1
FWCI: 7.36
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders: National Institutes of Health (4r37eb000244-34)
University of Illinois at Chicago
National Cancer Institute (U54CA151884)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091526)
National Institute of Biomedical Imaging and Bioengineering (R01EB000244, R37-EB000244, R01EB000351)
National Institute of Dental and Craniofacial Research (R01DE013023)
Topics: Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: continuous glucose monitoring, diabetes mellitus, inflammation, combinatorial chemistry, implantable glucose sensor, non-human primates
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Experimental, Electrodes, Female, Humans, Male, Mice, Inbred C57BL, Polymers, Skin, Biosensing Techniques, Reactive Oxygen Species, Coated Materials, Biocompatible, Mice, Electrochemical Techniques, Transcriptome, Signal-To-Noise Ratio

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Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

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