p120-catenin-dependent collective brain infiltration by glioma cell networks
Open accessAbstract
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and mediate directional persistence. Downregulation of p120-catenin compromises cell-cell interaction and communication, disrupts collective networks, and both the cadherin and RhoA binding domains of p120-catenin are required for network formation and migration. Deregulating p120-catenin further prevents diffuse glioma cell infiltration of the mouse brain with marginalized microlesions as the outcome. Transcriptomics analysis has identified p120-catenin as an upstream regulator of neurogenesis and cell cycle pathways and a predictor of poor clinical outcome in glioma patients. Collective glioma networks infiltrating the brain thus depend on adherens junctions dynamics, the targeting of which may offer an unanticipated strategy to halt glioma progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness.
“Interstitial compartments are organized into various 3D architectures, including fibrillar porous networks or aligned bundles, heterogeneous in density, topology, and stiffness [11,12].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735 · see citing works
Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., TAPHOORN, M. J. B., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Bélanger, K., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70025-7 · Cited by 7,667 · see citing works
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575 · see citing works
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063 · see citing works
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
Grauer, O. M., Wesseling, P., & Adema, G. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00315.x · Cited by 4,023 · see citing works
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148 · see citing works
GMAP: A genomic mapping and alignment program for mRNA and EST sequences
Wu, T. D., & Watanabe, C. K. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti310 · Cited by 2,354 · see citing works
Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L. M., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.003 · Cited by 1,975 · see citing works
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940 · see citing works
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Venkataramani, V., Tanev, D. I., Strahle, C., Studier-Fischer, A., Fankhauser, L., Kessler, T., Körber, C., Kardorff, M., Ratliff, M., Xie, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1564-x · Cited by 1,197 · see citing works
Brain tumour cells interconnect to a functional and resistant network
Osswald, M., Jung, E., Sahm, F., Solecki, G. M., Venkataramani, V., Blaes, J., Heuer, S., Horstmann, H., Wiestler, B., Syed, M., et al. (2015) · Nature · doi:10.1038/nature16071 · Cited by 1,140 · see citing works
Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
Gilbert, M. R., Wang, M., Aldape, K. D., Stupp, R., Hegi, M. E., Jaeckle, K. A., Armstrong, T. S., Wefel, J. S., Won, M., Blumenthal, D. T., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.6968 · Cited by 1,063 · see citing works
Adherens junctions: from molecules to morphogenesis
Harris, T., & Tepass, U. (2010) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2927 · Cited by 983 · see citing works
Classifying collective cancer cell invasion
Friedl, P., Locker, J. D., Sahai, E. A., & Segall, J. E. (2012) · Nature Cell Biology · doi:10.1038/ncb2548 · Cited by 966 · see citing works
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
Cheung, K. J., Gabrielson, E. W., Werb, Z., & Ewald, A. J. (2013) · Cell · doi:10.1016/j.cell.2013.11.029 · Cited by 838 · see citing works
E-cadherin is required for metastasis in multiple models of breast cancer
Padmanaban, V., Krol, I., Suhail, Y., Szczerba, B. M., Aceto, N., Bader, J. S., & Ewald, A. J. (2019) · Nature · doi:10.1038/s41586-019-1526-3 · Cited by 828 · see citing works
A neurocentric perspective on glioma invasion
Cuddapah, V. A., Robel, S., Watkins, S., & Sontheimer, H. W. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3765 · Cited by 826 · see citing works
WHO 2016 Classification of gliomas
Wesseling, P., & Capper, D. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12432 · Cited by 799 · see citing works
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Gravendeel, L. A. M., Kouwenhoven, M. C. M., Gevaert, O., de Rooi, J. J., Stubbs, A., Duijm, J. E., Daemen, A., Bleeker, F. E., Bralten, L. B. C., Kloosterhof, N. K., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2307 · Cited by 668 · see citing works
Building the Neuronal Microtubule Cytoskeleton
Kapitein, L. C., & Hoogenraad, C. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.046 · Cited by 654 · see citing works
Collective cell durotaxis emerges from long-range intercellular force transmission
Sunyer, R., Conte, V., Escribano, J. M. G., Elósegui-Artola, A., Labernadie, A., Valon, L., Navajas, D., García‐Aznar, J. M., Muñoz, J. J., Roca‐Cusachs, P., et al. (2016) · Science · doi:10.1126/science.aaf7119 · Cited by 632 · see citing works
Mechanisms and Molecules of Neuronal Wiring: A PrimerPreprint
Kolodkin, A. L., & Tessier‐Lavigne, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001727 · Cited by 626 · see citing works
Weissman, T. A., Riquelme, P. A., Ivic, L., Flint, A. C., & Kriegstein, A. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.015 · Cited by 579 · see citing works
Korff, T., & Augustin, H. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1341 · Cited by 561 · see citing works
The integrated landscape of driver genomic alterations in glioblastoma
Frattini, V., Trifonov, V., Chan, J. M., Castano, A. M., Lia, M., Abate, F., Keir, S. T., Ji, A. X., Zoppoli, P., Niola, F., et al. (2013) · Nature Genetics · doi:10.1038/ng.2734 · Cited by 543 · see citing works
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
Sawamiphak, S., Seidel, S., Essmann, C. L., Wilkinson, G. A., Pitulescu, M. E., Acker, T., & Acker‐Palmer, A. (2010) · Nature · doi:10.1038/nature08995 · Cited by 532 · see citing works
Inhibition of RhoA by p120 catenin
Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y., & Reynolds, A. B. (2000) · Nature Cell Biology · doi:10.1038/35023588 · Cited by 472 · see citing works
Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L. M., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.012 · Cited by 390 · see citing works
Ishiyama, N., Lee, S.-H., Liu, S., Li, G., Smith, M. J., Reichardt, L. F., & Ikura, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.017 · Cited by 358 · see citing works
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells
Reffay, M., Parrini, M. C., Cochet‐Escartin, O., Ladoux, B., Buguin, A., Coscoy, S., Amblard, F., Camonis, J., & Silberzan, P. (2014) · Nature Cell Biology · doi:10.1038/ncb2917 · Cited by 355 · see citing works
Interstitial guidance of cancer invasion
Gritsenko, P. G., Ilina, O., & Friedl, P. (2011) · The Journal of Pathology · doi:10.1002/path.3031 · Cited by 347 · see citing works
Cadherins in Brain Morphogenesis and Wiring
Hirano, S., & Takeichi, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00014.2011 · Cited by 317 · see citing works
Mir, S. E., Hamer, P. C. D. W., Krawczyk, P. M., Balaj, L., Claes, A., Niers, J. M., van Tilborg, A. A. G., Zwinderman, A. H., Geerts, D., Kaspers, G. J. L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.011 · Cited by 294 · see citing works
A secreted luciferase for ex vivo monitoring of in vivo processes
Wurdinger, T. D., Badr, C. E., Pike, L. S., de Kleine, R. H. J., Weissleder, R., Breakefield, X. O., & Tannous, B. A. (2008) · Nature Methods · doi:10.1038/nmeth.1177 · Cited by 284 · see citing works
Axon growth inhibition by RhoA/ROCK in the central nervous system
Fujita, Y., & Yamashita, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00338 · Cited by 271 · see citing works
Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders
Sloan, S. A., & Barres, B. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.005 · Cited by 248 · see citing works
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
Chan, C.-H., Lee, S.-W., Li, C.-F., Wang, J., Yang, W.-L., Wu, C.-Y., Wu, J., Nakayama, K. I., Kang, H.-Y., Huang, H.-Y., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2047 · Cited by 209 · see citing works
Elia, L. P., Yamamoto, M. P., Zang, K., & Reichardt, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.018 · Cited by 206 · see citing works
Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors
Montana, V., & Sontheimer, H. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3825-10.2011 · Cited by 201 · see citing works
Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic FunctionPreprint
Salinas, P. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008003 · Cited by 189 · see citing works
Cadherins in collective cell migration of mesenchymal cells
Théveneau, E., & Mayor, R. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.002 · Cited by 186 · see citing works
Rho GTPases in collective cell migration
Zegers, M. M., & Friedl, P. (2014) · Small GTPases · doi:10.4161/sgtp.28997 · Cited by 178 · see citing works
Wu, Y., Siadaty, M. S., Berens, M. E., Hampton, G. M., & Theodorescu, D. (2008) · Oncogene · doi:10.1038/onc.2008.264 · Cited by 175 · see citing works
Adherens junction treadmilling during collective migration
Péglion, F., Llense, F., & Etienne‐Manneville, S. (2014) · Nature Cell Biology · doi:10.1038/ncb2985 · Cited by 164 · see citing works
Serres, É., Debarbieux, F. C., Stanchi, F., Maggiorella, L., Grall, D., Turchi, L., Burel‐Vandenbos, F., Figarella-Branger, D. F., Virolle, T., Rougon, G. N., et al. (2013) · Oncogene · doi:10.1038/onc.2013.305 · Cited by 159 · see citing works
Camand, E., Péglion, F., Osmani, N., Sanson, M., & Etienne‐Manneville, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.087668 · Cited by 145 · see citing works
Schackmann, R. C. J., van Amersfoort, M., Haarhuis, J. H. I., Vlug, E. J., Halim, V. A., Roodhart, J. M. L., Vermaat, J. S. P., Voest, E. E., van der Groep, P., van Diest, P. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41695 · Cited by 143 · see citing works
Faber‐Elman, A., Solomon, A., Abraham, J. A., Marikovsky, M., & Schwartz, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118385 · Cited by 142 · see citing works
Hydrodynamic Cellular Volume Changes Enable Glioma Cell Invasion
Watkins, S., & Sontheimer, H. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3938-11.2011 · Cited by 138 · see citing works
Cheng, W., Kandel, J. J., Yamashiro, D. J., Canoll, P., & Anastassiou, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034705 · Cited by 132 · see citing works
Fujii, Y., Maékawa, S., & Morita, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13243-0 · Cited by 129 · see citing works
Beyond β-catenin: prospects for a larger catenin network in the nucleus
McCrea, P. D., & Gottardi, C. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.3 · Cited by 125 · see citing works
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H. N., Frankum, J. R., Song, F., Rafiq, R., Konde, A., Krastev, D. B., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0603 · Cited by 125 · see citing works
Chu, Y., Hughes, S., & Chan‐Ling, T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0868fje · Cited by 112 · see citing works
p120-catenin in cancer – mechanisms, models and opportunities for intervention
Schackmann, R. C. J., Tenhagen, M., van de Ven, R. A. H., & Derksen, P. W. B. (2013) · Journal of Cell Science · doi:10.1242/jcs.134411 · Cited by 100 · see citing works
Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina
Gnanaguru, G., Bachay, G., Biswas, S., Pinzón‐Duarte, G., Hunter, D. D., & Brunken, W. J. (2013) · Development · doi:10.1242/dev.087817 · Cited by 98 · see citing works
Molecules and mechanisms that regulate multipolar migration in the intermediate zone
Cooper, J. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00386 · Cited by 97 · see citing works
Plasticity of Cancer Cell Invasion—Mechanisms and Implications for Therapy
Boekhorst, V. T., & Friedl, P. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.07.005 · Cited by 86 · see citing works
An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth
Dohn, M. R., Brown, M. V., & Reynolds, A. B. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807096 · Cited by 82 · see citing works
Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion
Deborah, H., Lewis‐Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodríguez, F. J., Giannini, C., Galanis, E., Sarkaria, J. N., & Anastasiadis, P. Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056505 · Cited by 81 · see citing works
Gritsenko, P. G., Leenders, W. P. J., & Friedl, P. (2017) · Histochemistry and Cell Biology · doi:10.1007/s00418-017-1604-2 · Cited by 77 · see citing works
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
Depner, C., Buttel, H. Z., Böğürcü, N., Cuesta, Á. M., Aburto, M. R., Seidel, S., Finkelmeier, F., Foss, F., Hofmann, J., Kaulich, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms12329 · Cited by 75 · see citing works
Claes, A., Schuuring, J., Boots‐Sprenger, S., Hendriks-Cornelissen, S. J. B., Dekkers, M. M. G., van der Kogel, A. J., Leenders, W. P. J., Wesseling, P., & Jeuken, J. W. M. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00141.x · Cited by 72 · see citing works
Hensel, N., Rademacher, S., & Claus, P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00198 · Cited by 69 · see citing works
Wesseling, P. (2012) · Springer eBooks · doi:10.1007/978-0-85729-458-6_1 · Cited by 57 · see citing works
Nestin expression in astrocytic tumors delineates tumor infiltration
Kitai, R., Horita, R., Sato, K., Yoshida, K., Arishima, H., Higashino, Y., Hashimoto, N., Takeuchi, H., Kubota, T., & Kikuta, K. (2010) · Brain Tumor Pathology · doi:10.1007/s10014-009-0261-0 · Cited by 55 · see citing works
Skalli, O., Wilhelmsson, U., Örndahl, C., Fekete, B., Malmgren, K., Rydenhag, B., & Pekny, M. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.03.013 · Cited by 54 · see citing works
Intercellular protein–protein interactions at synapses
Yang, X., Hou, D., Jiang, W., & Zhang, C. (2014) · Protein & Cell · doi:10.1007/s13238-014-0054-z · Cited by 49 · see citing works
Muramatsu, T., Kozaki, K., Imoto, S., Yamaguchi, R., Tsuda, H., Kawano, T., Fujiwara, N., Morishita, M., Miyano, S., & Inazawa, J. (2016) · Oncogene · doi:10.1038/onc.2016.71 · Cited by 44 · see citing works
Neuronal polarization in the developing cerebral cortex
Sakakibara, A., & Hatanaka, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00116 · Cited by 41 · see citing works
van de Ven, R. V. D., Tenhagen, M., Meuleman, W., van Riel, J. J. G., Schackmann, R., & Derksen, P. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018648 · Cited by 38 · see citing works
Adaptive adhesion systems mediate glioma cell invasion in complex environments
Gritsenko, P. G., & Friedl, P. (2018) · Journal of Cell Science · doi:10.1242/jcs.216382 · Cited by 38 · see citing works
van de Ven, R. A. H., de Groot, J. S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O. M., Ali, H. R., Caldas, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13874 · Cited by 35 · see citing works
Barriga, E. H., & Mayor, R. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.023 · Cited by 33 · see citing works
Phosphorylation and isoform use in p120-catenin during development and tumorigenesis
Hong, J. Y., Oh, I., & McCrea, P. D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.008 · Cited by 33 · see citing works
Ozaki, C., Yoshioka, M., Tominaga, S., Osaka, Y., Obata, S., & Suzuki, S. (2010) · Cell Structure and Function · doi:10.1247/csf.10009 · Cited by 16 · see citing works
The function of p120 catenin in filopodial growth and synaptic vesicle clustering in neurons
Cheng Ann, C. H. E. N., Li, P. P., Madhavan, R., & Peng, H. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-01-0004 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 82 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [78]Weissman TA, Riquelme PA, Ivic L, Flint AC & Kriegstein AR Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex. Neuron 43, 647– 661 (2004). 15339647
Cited by
Sorted by citations
Glioblastoma hijacks neuronal mechanisms for brain invasion
Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.054 · Cited by 644 · see citing works
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 578 · see citing works
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
Weiß, F., Lauffenburger, D. A., & Friedl, P. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00427-0 · Cited by 294 · see citing works
Autonomous rhythmic activity in glioma networks drives brain tumour growth
Hausmann, D., Hoffmann, D. C., Venkataramani, V., Jung, E., Horschitz, S., Tetzlaff, S. K., Jabali, A., Hai, L., Keßler, T., Azorín, D. D., et al. (2022) · Nature · doi:10.1038/s41586-022-05520-4 · Cited by 260 · see citing works
Jiang, D., Christ, S., Correa‐Gallegos, D., Ramesh, P., Gopal, S. K., Wannemacher, J., Mayr, C. H., Lupperger, V., Yu, Q., Ye, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19425-1 · Cited by 132 · see citing works
Disconnecting multicellular networks in brain tumours
Venkataramani, V., Schneider, M. B., Giordano, F. A., Kuner, T., Wick, W., Herrlinger, U., & Winkler, F. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00475-0 · Cited by 122 · see citing works
Comba, A., Faisal, S. M., Dunn, P., Argento, A. E., Hollon, T. C., Al‐Holou, W. N., Varela, M. L., Zamler, D. B., Quass, G. L., Apostolides, P. F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31340-1 · Cited by 112 · see citing works
Wen, P. Y., Weller, M., Lee, E. Q., Touat, M., Khasraw, M., Rahman, R. M., Platten, M., Lim, M. K., Winkler, F., Horbinski, C., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf177 · Cited by 95 · see citing works
Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration
Ozawa, M., Hiver, S., Yamamoto, T., Shibata, T., Upadhyayula, S., Mimori‐Kiyosue, Y., & Takeichi, M. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202006196 · Cited by 84 · see citing works
Cadherin Expression and EMT: A Focus on Gliomas
Noronha, C., Ribeiro, A. S., Taipa, R. J. F., Castro, D. S., Reis, J., Faria, C. C., & Paredes, J. (2021) · Biomedicines · doi:10.3390/biomedicines9101328 · Cited by 79 · see citing works
Nerve input to tumours: Pathophysiological consequences of a dynamic relationship
Hutchings, C., Phillips, J. A., & Djamgoz, M. B. A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188411 · Cited by 79 · see citing works
Regulation of Collective Metastasis by Nanolumenal Signaling
Wrenn, E. D., Yamamoto, A., Moore, B. M., Huang, Y. C., McBirney, M., Thomas, A. J., Greenwood, E., Rabena, Y., Rahbar, H., Partridge, S. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.045 · Cited by 78 · see citing works
Recording physiological history of cells with chemical labeling
Huppertz, M.-C., Wilhelm, J., Grenier, V., Schneider, M., Falt, T., Porzberg, N., Hausmann, D., Hoffmann, D. C., Hai, L., Tarnawski, M., et al. (2024) · Science · doi:10.1126/science.adg0812 · Cited by 70 · see citing works
Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
Coban, B., Bergonzini, C., Zweemer, A. J. M., & Danen, E. H. J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01150-7 · Cited by 62 · see citing works
Cancer-on-chip models for metastasis: importance of the tumor microenvironment
Jouybar, M., de Winde, C. M., Wolf, K., Friedl, P., Mebius, R. E., & den Toonder, J. M. J. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.10.001 · Cited by 66 · see citing works
Jung, E., Alfonso, J., Monyer, H., Wick, W., & Winkler, F. (2020) · International Journal of Cancer · doi:10.1002/ijc.33138 · Cited by 66 · see citing works
Aabedi, A. A., Young, J. S., Zhang, Y., Ammanuel, S., Morshed, R. A., Ore, C. D., Brown, D., Phillips, J. J., Bush, N. A. O., Taylor, J. W., et al. (2021) · Neurosurgery · doi:10.1227/neu.0000000000001753 · Cited by 64 · see citing works
Ratliff, M., Jazi, K. K., Hoffmann, D. C., Rauschenbach, L., Simon, M., Hai, L., Mandelbaum, H., Schubert, M. C., Keßler, T., Uhlig, S., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad109 · Cited by 55 · see citing works
Brain Tumor Networks in Diffuse Glioma
Yang, Y., Schubert, M. C., Kuner, T., Wick, W., Winkler, F., & Venkataramani, V. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01320-w · Cited by 49 · see citing works
Tumor cell network integration in glioma represents a stemness feature
Xie, R., Keßler, T., Grosch, J. K., Hai, L., Venkataramani, V., Huang, L., Hoffmann, D. C., Solecki, G. M., Ratliff, M., Schlesner, M., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa275 · Cited by 48 · see citing works
Hai, L., Hoffmann, D. C., Wagener, R. J., Azorín, D. D., Hausmann, D., Xie, R., Huppertz, M.-C., Hiblot, J., Sievers, P., Heuer, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45067-8 · Cited by 47 · see citing works
Li, W., Chen, R., Feng, L., Dang, X., Liu, J., Chen, T., Yang, J., Su, X., Lv, L., Li, T., et al. (2023) · Nature Human Behaviour · doi:10.1038/s41562-023-01746-y · Cited by 47 · see citing works
Aabedi, A. A., Young, J. S., Zhang, Y., Ammanuel, S. G., Morshed, R. A., Ore, C. L. D., Brown, D. A., Phillips, J. J., Bush, N. A. O., Taylor, J. W., et al. (2022) · eScholarship (California Digital Library) · Cited by 43 · see citing works
Ratliff, M., Kim, H., Qi, H., Kim, M., Ku, B., Azorín, D. D., Hausmann, D., Khajuria, R. K., Patel, A., Maier, E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126572 · Cited by 41 · see citing works
Collective metastasis: coordinating the multicellular voyage
Wrenn, E. D., Huang, Y. C., & Cheung, K. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10111-0 · Cited by 43 · see citing works
Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence
Putavet, D. A., & de Keizer, P. L. J. (2021) · Cancers · doi:10.3390/cancers13071560 · Cited by 39 · see citing works
Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature
Palmisciano, P., Ferini, G., Watanabe, G., Ogasawara, C. T., Lesha, E., Bin-Alamer, O., Umana, G. E., Yu, K. K. H., Cohen‐Gadol, A., Ahmadieh, T. Y. E., et al. (2022) · Cancers · doi:10.3390/cancers14102507 · Cited by 37 · see citing works
Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future
Zhu, Z., Fang, C., Xu, H., Yuan, L., Du, Y., Ni, Y., Xu, Y., Shao, A., Zhang, A., & Lou, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.976557 · Cited by 36 · see citing works
Monzo, P., Crestani, M., Chong, Y. K., Ghisleni, A., Hennig, K., Li, Q., Kakogiannos, N., Giannotta, M., Richichi, C., Dini, T., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.09.007 · Cited by 34 · see citing works
Collective cell migration modes in development, tissue repair and cancer
Cheung, K. J., & Horne‐Badovinac, S. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00858-9 · Cited by 34 · see citing works
Wang, X., Liang, J., & Sun, H.-T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.921975 · Cited by 31 · see citing works
Novel facets of glioma invasion
Fabian, C., Han, M., Bjerkvig, R., & Niclou, S. P. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.08.001 · Cited by 31 · see citing works
Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion
Fazio, E. D., Pittarello, M., Gans, A., Ghosh, B., Slika, H., Alimonti, P., & Tyler, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052563 · Cited by 31 · see citing works
Advanced Spheroid, Tumouroid and 3D Bioprinted In-Vitro Models of Adult and Paediatric Glioblastoma
Orcheston-Findlay, L., Bax, S., Utama, R. H., Engel, M., Govender, D., & O’Neill, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062962 · Cited by 30 · see citing works
Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists
Blaschuk, O. W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.866200 · Cited by 30 · see citing works
Glioblastoma revisited: from neuronal-like invasion to pacemaking
Heuer, S., & Winkler, F. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.009 · Cited by 28 · see citing works
Venkataramani, V., Yang, Y., Ille, S., Suchorska, B., Loges, S., Tost, H., Sahm, F., Pfister, S. M., Trumpp, A., Krieg, S. M., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0194 · Cited by 29 · see citing works
Neurotoxicity study of lead-based perovskite nanoparticles
Mei, L., Xie, R., Zhu, S., Deng, S., Xu, H., Fan, X., Yin, W., & Gu, Z. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101830 · Cited by 28 · see citing works
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer
Zhang, S., Yuan, L., Lin, P., Yang, G., Zhou, X., Jinfu, X., Wu, M., & Huang, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02364-y · Cited by 26 · see citing works
Nair-Menon, J. U., Daulagala, A. C., Connor, D. M., Rutledge, L., Penix, T. S., Bridges, C., Wellslager, B., Spyropoulos, D. D., Timmers, C. D., Broome, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072559 · Cited by 25 · see citing works
Tutorial: methods for three-dimensional visualization of archival tissue material
Haddad, T. S., Friedl, P., Farahani, N., Treanor, D. E., Zlobec, I., & Nagtegaal, I. D. (2021) · Nature Protocols · doi:10.1038/s41596-021-00611-4 · Cited by 25 · see citing works
Sialic acid metabolism orchestrates transcellular connectivity and signaling in glioblastoma
Kuliešiūtė, U., Joseph, K., Straehle, J., Ravi, V. M., Kueckelhaus, J., Benotmane, J. K., Zhang, J., Vlachos, A., Beck, J., Schnell, O., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad101 · Cited by 25 · see citing works
Kundu, S., Nandhu, M. S., Longo, S. L., Longo, J. A., Rai, S., Chin, L. S., Richardson, T. E., & Viapiano, M. S. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac001 · Cited by 24 · see citing works
Mechanisms of invasion in glioblastoma
Chouleur, T., Tremblay, M. L., & Bikfalvi, A. (2020) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000679 · Cited by 24 · see citing works
Advancing glioblastoma therapy: Learning from the past and innovations for the future
Rana, M., Liou, K.-C., Thakur, A., Nepali, K., & Liou, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217601 · Cited by 24 · see citing works
Neuroblastoma Invasion Strategies Are Regulated by the Extracellular Matrix
Gavin, C., Geerts, N., Cavanagh, B., Haynes, M., Reynolds, C. P., Loessner, D., Ewald, A. J., & Piskareva, O. (2021) · Cancers · doi:10.3390/cancers13040736 · Cited by 23 · see citing works
Liu, Q., Peng, S., Tang, Q., Li, C., Chen, J., Pang, P., Liu, W., Zhou, X., Cai, X., Lin, H., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202404563 · Cited by 23 · see citing works
Okafo, G., Valdebenito, S., Donoso, M., Luu, R., Ajasin, D., Prideaux, B., Gorantla, S., & Eugenin, E. (2020) · Journal of Immunology · doi:10.4049/jimmunol.2000803 · Cited by 17 · see citing works
Glioma tumor microenvironment and immunotherapy: past, present, and future
Cvitković, J., Tan, W.-L., Jiang, T., & Zhao, Z. (2025) · Biomarker Research · doi:10.1186/s40364-025-00863-2 · Cited by 21 · see citing works
Lei, M., Wang, W., Zhang, H., Gong, J., Wang, Z., Cai, H., Yang, X., Wang, S., & Ma, C. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113522 · Cited by 20 · see citing works
Picart, T., & Hervey‐Jumper, S. L. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04719-x · Cited by 19 · see citing works
Becker, K. N., Pettee, K. M., Sugrue, A., Reinard, K. A., Schroeder, J. L., & Eisenmann, K. M. (2022) · Cells · doi:10.3390/cells11091559 · Cited by 16 · see citing works
Neural Influences on Tumor Progression Within the Central Nervous System
Lv, W., & Wang, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70097 · Cited by 15 · see citing works
Therapeutic Silencing of p120 in Fascia Fibroblasts Ameliorates Tissue Repair
Rajendran, V., Ramesh, P., Dai, R., Gopal, S. K., Ye, H., Machens, H., Adler, H., Jiang, D., & Rinkevich, Y. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.10.018 · Cited by 15 · see citing works
Liu, G., Zhang, P., Chen, S., Chen, Z., Qiu, Y., Peng, P., Huang, W., Cheng, F., Zhang, Y., Li, H., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad079 · Cited by 15 · see citing works
Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models
Schlieper-Scherf, S., Hebach, N. R., Hausmann, D., Azorín, D. D., Hoffmann, D. C., Horschitz, S., Maier, E., Koch, P., Karreman, M. A., Etminan, N., et al. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04786-0 · Cited by 13 · see citing works
SYK Is Associated With Malignant Phenotype and Immune Checkpoints in Diffuse Glioma
Zhou, Q., Wei, M., Shen, W., Huang, S., Fan, J., & Huang, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.899883 · Cited by 12 · see citing works
Heterogeneous Glioma Cell Invasion Under Interstitial Flow Depending on Their Differentiation Status
Namba, N., Chonan, Y., Nunokawa, T., Sampetrean, O., Saya, H., & Sudo, R. (2021) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0280 · Cited by 13 · see citing works
Artificial intelligence-based locoregional markers of brain peritumoral microenvironment
Samani, Z. R., Parker, D., Akbari, H., Wolf, R. L., Brem, S. S., Bakas, S., & Verma, R. (2023) · Scientific Reports · doi:10.1038/s41598-022-26448-9 · Cited by 12 · see citing works
The Alcatraz‐Strategy: a roadmap to break the connectivity barrier in malignant brain tumours
Schneider, M. B., Potthoff, A., Karpel‐Massler, G., Schuss, P., Siegelin, M. D., Debatin, K., Duffau, H., Vatter, H., Herrlinger, U., & Westhoff, M. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13642 · Cited by 12 · see citing works
Pflug, K. M., Lee, D. W., McFadden, K., Herrera, L., & Sitcheran, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-38996-9 · Cited by 11 · see citing works
Therapeutic Targeting of Glioblastoma and the Interactions with Its Microenvironment
Genoud, V., Kinnersley, B., Brown, N. F., Ottaviani, D., & Mulholland, P. J. (2023) · Cancers · doi:10.3390/cancers15245790 · Cited by 10 · see citing works
Two routes of direct intercellular communication in brain cancer
Azorín, D. D., & Winkler, F. (2021) · Biochemical Journal · doi:10.1042/bcj20200990 · Cited by 11 · see citing works
Maas, R. R., Soukup, K., Klemm, F., Kornete, M., Bowman, R. L., Bedel, R., Marie, D. N., Álvarez-Prado, Á. F., Labes, D., Wilson, A., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00594-2 · Cited by 11 · see citing works
A connectivity signature for glioblastomaPreprint
Hai, L., Hoffmann, D. C., Mandelbaum, H., Xie, R., Ito, J., Jung, E., Heuer, S., Sievers, P., Venkataramani, V., Azorín, D. D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.07.465791 · Cited by 11 · see citing works
Wood, K. B., Comba, A., Motsch, S., Grigera, T. S., & Lowenstein, P. R. (2023) · Science Advances · doi:10.1126/sciadv.adf7170 · Cited by 10 · see citing works
Huang, S., Cao, S., Cui, L., Qin, Y., & Yang, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11546 · Cited by 9 · see citing works
N-cadherin dynamically regulates pediatric glioma cell migration in complex environments
Kim, D., Olson, J. M., & Cooper, J. A. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202401057 · Cited by 8 · see citing works
Regulation of cell migration by extracellular matrix mechanics at a glance
Allan, C., & Chaudhuri, O. (2025) · Journal of Cell Science · doi:10.1242/jcs.263574 · Cited by 8 · see citing works
Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity
Wu, T., Zhao, P., Chen, Z., Ying, T., Nie, Z., Hua, W., Li, H., Mao, Y., & Bu, W. (2025) · Advanced Science · doi:10.1002/advs.202506694 · Cited by 8 · see citing works
Donati, V., Pietro, C. D., Persano, L., Rampazzo, E., Panarelli, M., Cambria, C., Selimi, A., Manfreda, L., do Rêgo, A. G. D. O., Sala, G. L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02370-1 · Cited by 8 · see citing works
Glioblastoma cells imitate neuronal excitability in humansPreprint
Tong, T., Hendriksen, J. D., Elbaek, K. J., Ozsvár, A., Eschen, J. T., Rodriguez-Gonzalez, F. G., Pusat, I. D., Christensen, E. L., Rahbaek, M., Frederiksen, K. P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.08.574637 · Cited by 8 · see citing works
Tumor microtubes: A new potential therapeutic target for high-grade gliomas
Guo, Y., Li, Y., Su, P., Yan, M., Wang, M., Li, S., Xiang, W., Chen, L., Dong, W., Zhou, Z., et al. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae119 · Cited by 7 · see citing works
Advances in neuroscientific mechanisms and therapies for glioblastoma
Li, K., Duan, M., Lu, Q., Liu, J., He, M., & Zhang, Y. (2025) · iScience · doi:10.1016/j.isci.2025.113347 · Cited by 7 · see citing works
Azorín, D. D., Hoffmann, D. C., Hebach, N. R., Jung, E., Hausmann, D., Ratliff, M., Hai, L., Horschitz, S., Jabali, A., Osswald, M., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0414 · Cited by 7 · see citing works
A Requirement for p120-catenin in the metastasis of invasive ductal breast cancer
Kurley, S. J., Tischler, V., Bierie, B., Novitskiy, S. V., Noske, A., Varga, Z., Zürrer‐Härdi, U., Brandt, S., Carnahan, R. H., Cook, R. S., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.250639 · Cited by 7 · see citing works
ECM Substrates Impact RNAi Localization at Adherens Junctions of Colon Epithelial Cells
Daulagala, A. C., & Kourtidis, A. (2022) · Cells · doi:10.3390/cells11233740 · Cited by 7 · see citing works
TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis
Wu, J., Liu, Y., Zong, J., Qiu, M., Zhou, Y., Li, Y., Aili, T., Zhao, X., & Hu, B. (2024) · Advanced Science · doi:10.1002/advs.202409250 · Cited by 6 · see citing works
Jamming Transitions in Astrocytes and Glioblastoma Are Induced by Cell Density and Tension
Hohmann, U., von Widdern, J. C., Ghadban, C., Giudice, C. L., Lemahieu, G., Cavalcanti‐Adam, E. A., Dehghani, F., & Hohmann, T. (2022) · Cells · doi:10.3390/cells12010029 · Cited by 6 · see citing works
Yuan, J., Liu, J., Fan, R., & Liu, Z. (2023) · Radiation Research · doi:10.1667/rade-22-00198 · Cited by 6 · see citing works
NPS ‐2143 inhibit glioma progression by suppressing autophagy through mediating AKT–mTOR pathway
Nie, J., Li, Q., Yin, H., Yang, J., Li, M., Li, Q., Fan, X., Zhao, Q., & Wen, Z. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18221 · Cited by 5 · see citing works
Etienne‐Manneville, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2828066/v1 · Cited by 6 · see citing works
Rosińska, S., André‐Grégoire, G., Kerhervé, M., Trillet, K., Fugio, L. B., Merlet, L., Roux, Q., Gall, M. L., Salnot, V., Faurobert, E., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116194 · Cited by 5 · see citing works
Gene Expression of CSF3R/CD114 Is Associated with Poorer Patient Survival in Glioma
Bark, S. A., Dalmolin, M., Malafaia, O., Roesler, R., Fernandes, M. A. C., & Isolan, G. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053020 · Cited by 5 · see citing works
Guo, Y., Wang, Y., Li, Q., Liu, Q., Zhang, X., Ren, J., & Wang, C. (2024) · Toxicology · doi:10.1016/j.tox.2024.153994 · Cited by 5 · see citing works
Mellor, N. G., Chung, S. A., Graham, E. S., Day, B. W., & Unsworth, C. P. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad0e7d · Cited by 5 · see citing works
Ma, L., Shen, T., Peng, H., Wu, J., Wang, W., & Gao, X. (2022) · Journal of Oncology · doi:10.1155/2022/2352360 · Cited by 5 · see citing works
Silencing glioblastoma networks to make temozolomide more effective
Winkler, F. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab186 · Cited by 5 · see citing works
Linazi, G., Maimaiti, A., Abulaiti, Z., Shi, H., Zhou, Z., Aisa, M. Y., Kang, Y., Abulimiti, A., Dilimulati, X., Zhang, T., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36989 · Cited by 4 · see citing works
Cancer memory as a mechanism to establish malignancy
Lissek, T. (2024) · Biosystems · doi:10.1016/j.biosystems.2024.105381 · Cited by 4 · see citing works
Brenner, S., Hartzendorf, S., Vogt, P. J., Maier, E., Etminan, N., Jung, E., Wick, W., Sahm, F., Winkler, F., & Ratliff, M. (2022) · Pathology & Oncology Research · doi:10.3389/pore.2022.1610268 · Cited by 4 · see citing works
Zhou, S., Fang, X., Luo, Y., Yang, Y., Wei, W., Huang, G., Zhang, X., & Wu, C. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00555 · Cited by 4 · see citing works
Zhou, M., Wu, W., Wang, Y., Zhang, B., Zhao, X., Zhou, H., Cao, Y., Wu, P., Wang, M., & Wang, J. (2025) · Journal of Neuro-Oncology · doi:10.1007/s11060-025-05036-7 · Cited by 3 · see citing works
A proteomic approach supports the clinical relevance of TAT-Cx43266-283 in glioblastoma
Pelaz, S. G., Flores-Hernández, R., Vujić, T., Schvartz, D., Álvarez-Vázquez, A., Ding, Y., García-Vicente, L., Belloso, A., Talaverón, R., Sánchez, J.-C., et al. (2024) · Translational research · doi:10.1016/j.trsl.2024.06.001 · Cited by 3 · see citing works
Lin, G.-S., Wang, W., Lin, H. D., & Lin, R. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/9367919 · Cited by 3 · see citing works
RetractedmiR-302e Suppresses Glioma Progression by Targeting VEGFA
Xie, Y., Liu, X., Hu, T., & Wang, W. (2020) · Cancer Management and Research · doi:10.2147/cmar.s268222 · Cited by 3 · see citing works
RetractedZhang, S., Fu, F., Zhen, L., Li, R., & Liao, C. (2021) · Bioengineered · doi:10.1080/21655979.2021.1974811 · Cited by 3 · see citing works
miR-512-3p as a Potential Biomarker of Poor Outcome in Pediatric Medulloblastoma
Corrêa, C. A. P., Chagas, P. S., Baroni, M., Andrade, A. F., Queiróz, R. G. D. P., Suazo, V. K., Cruzeiro, G. A. V., Fedatto, P. F., Antônio, D. S. M., Brandalise, S. R., et al. (2025) · The Cerebellum · doi:10.1007/s12311-025-01812-3 · Cited by 3 · see citing works
Targeting network circuitry in glioma
Robbins, S. M., & Senger, D. L. (2023) · Nature Cancer · doi:10.1038/s43018-023-00640-w · Cited by 2 · see citing works
Comba, A., Faisal, S. M., Dunn, P. J., Argento, A. E., Hollon, T. C., Al‐Holou, W. N., Varela, M. L., Zamler, D. B., Quass, G. L., Apostolides, P. F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.01.404970 · Cited by 2 · see citing works
- Authors
- Gritsenko, P. G., Atlasy, N., Dieteren, C. E. J., Navis, A. C., Venhuizen, J.-H., Veelken, C., Schubert, D., Acker-Palmer, A., Westerman, B. A., Wurdinger, T., Leenders, W., Wesseling, P., Stunnenberg, H. G., & Friedl, P.
- Affiliations
- Radboud University Medical Center (NL)
- Radboud University Nijmegen (NL)
- Karolinska Institutet (SE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Princess Máxima Center (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Friedl, Peter
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2020-01
- Volume
- 22
- Issue
- 1
- Pages
- 97-107
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC6952556
- OpenAlex
- W2997878069
- Cited by
- 112
- References
- 82
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 15 · 2020: 16
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Brain Tumour Charity (GN-000429)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (918.11.626, 863.13.019)
- National Cancer Institute (U54CA210184, P30CA016672)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- p120 catenin, glioma, brain infiltration, collective cell migration, multicellular networks, N-cadherin, β-catenin, adherens junctions, intercellular calcium signaling, RhoA, directional persistence, intercellular communication, neurogenesis, cell cycle, clinical outcome prediction
- MeSH terms
- Delta Catenin, Animals, Brain, Cell Adhesion, Glioma, Phosphoproteins, Phosphorylation, Down-Regulation, Cadherins, Adherens Junctions, Cell Line, Tumor, Catenins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
