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Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans

Ye, Chao-Jie, Kong, Li-Jie, Wang, Yi-Ying, Dou, Chun, Zheng, Jie, Xu, Min, Xu, Yu, Li, Mian, Zhao, Zhi-Yun, Lu, Jie-Li, Chen, Yu-Hong, Ning, Guang, Wang, Wei-Qing, Bi, Yu-Fang, Wang, Tian-Ge·2023·Nature Human Behaviour
DOI 10.1038/s41562-023-01646-1
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Abstract

Human longevity correlates with socio-economic status, and there is evidence that educational attainment increases human lifespan. However, to inform meaningful health policies, we need fine-grained causal evidence on which dimensions of socio-economic status affect longevity and the mediating roles of modifiable factors such as lifestyle and disease. Here we performed two-sample Mendelian randomization analyses applying genetic instruments of education, income and occupation (n = 248,847 to 1,131,881) to estimate their causal effects and consequences on parental lifespan and self-longevity (n = 28,967 to 1,012,240) from the largest available genome-wide association studies in populations of European ancestry. Each 4.20 years of additional educational attainment were causally associated with a 3.23-year-longer parental lifespan independently of income and occupation and were causally associated with 30-59% higher odds of self-longevity, suggesting that education was the primary determinant. By contrast, each one-standard-deviation-higher income and one-point-higher occupation was causally associated with 3.06-year-longer and 1.29-year-longer parental lifespans, respectively, but not independently of the other socio-economic indicators. We found no evidence for causal effects of income or occupation on self-longevity. Mediation analyses conducted in predominantly European-descent individuals through two-step Mendelian randomization suggested that among 59 candidates, cigarette…

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Metadata

Authors
Ye, C.-J., Kong, L.-J., Wang, Y.-Y., Dou, C., Zheng, J., Xu, M., Xu, Y., Li, M., Zhao, Z.-Y., Lu, J.-L., Chen, Y.-H., Ning, G., Wang, W.-Q., Bi, Y.-F., & Wang, T.-G.
ORCID
Venue
Nature Human Behaviour
Publisher
Springer Science and Business Media LLC
Published
2023-06-29
Volume
7
Issue
8
Pages
1357-1370
ISSN
2397-3374
DOI
10.1038/s41562-023-01646-1
Cited by
58
References
21
Language
en
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