Cited by 308Lanthanide and Transition Metal ComplexesMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials

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A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

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Wang, Ting, Wang, Shangfeng, Liu, Zhiyong, He, Zuyang, Yu, Peng, Zhao, Mengyao, Zhang, Hongxin, Lu, Lingfei, Wang, Zhengxin, Wang, Ziyu, Zhang, Weian, Fan, Yong, Sun, Caixia, Zhao, Dongyuan, Liu, Weimin, Bünzli, Jean-Claude G., Zhang, Fan·2021·Nature Materials

DOI 10.1038/s41563-021-01063-7

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Abstract

Spectrally distinct fluorophores are desired for multiplexed bioimaging. In particular, monitoring biological processes in living mammals needs fluorophores that operate in the 'tissue-transparent' near-infrared (NIR) window, that is, between 700 and 1,700 nm. Here we report a fluorophore system based on molecular erbium(III)-bacteriochlorin complexes with large Stokes shift (>750 nm) and narrowband NIR-to-NIR downconversion spectra (full-width at half-maximum ≤ 32 nm). We have found that the fast (2 × 10 9 s-¹) and near-unity energy transfer from bacteriochlorin triplets to the erbium(III) 4 I 13/2 level overcomes the notorious vibrational overtones quenching, resulting in bright and long-lived (1.73 μs) 1,530 nm luminescence in water. We demonstrate the excitation/emission-multiplexed capability of the complexes in the visualization of dynamic circulatory and metabolic processes in living mice, and through skull tracking of cancer cell metastases in mouse brain. This hybrid probe system facilitates robust multiplexed NIR imaging with high contrast and spatial resolution for applications ranging from fluorescence-guided surgery, diagnostics and intravital microscopy.

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Authors: Wang, T., Wang, S., Liu, Z., He, Z., Yu, P., Zhao, M., Zhang, H., Lu, L., Wang, Z., Wang, Z., Zhang, W., Fan, Y., Sun, C., Zhao, D., Liu, W., Bünzli, J.-C. G., & Zhang, F.
Affiliations: Fudan University (CN)
East China University of Science and Technology (CN)
ShanghaiTech University (CN)
École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Wang, Shangfeng
Zhang, Weian
Zhang, Fan
ORCID: Wang, Ting
Wang, Shangfeng
Yu, Peng
Zhao, Mengyao
Zhang, Hongxin
Lu, Lingfei
Wang, Zhengxin
Wang, Ziyu
Zhang, Weian
Fan, Yong
Zhao, Dongyuan
Liu, Weimin
Bünzli, Jean-Claude G.
Zhang, Fan
Venue: Nature Materials
Publisher: Springer Science and Business Media LLC
Published: 2021-07-29
Volume: 20
Issue: 11
Pages: 1571-1578
ISSN: 1476-1122 (ISSN-L)
1476-4660
DOI: 10.1038/s41563-021-01063-7
OpenAlex: W3186280068
Cited by: 308
References: 46
Citations by year: 2026: 41 · 2025: 71 · 2024: 64 · 2023: 59 · 2022: 58 · 2021: 15
FWCI: 14.87
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: cc-by-nc-nd
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Materials (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: China Postdoctoral Science Foundation (KLH1615200, KLH1615215)
National Natural Science Foundation of China (22088101, 21725502, 51961145403, 21904023)
Ministry of Science and Technology of the People’s Republic of China (2017YFA0207303)
Science and Technology Commission of Shanghai Municipality (20JC1411700, 19490713100, 20490710600, 20S31903700)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords: erbium(III) complexes, bacteriochlorins, near-infrared fluorescence, Stokes shift, energy transfer, deep tissue imaging, fluorescence-guided surgery, brain metastasis imaging, intravital microscopy
MeSH terms: Animals, Erbium, Fluorescent Dyes, Porphyrins, Spectroscopy, Near-Infrared

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A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

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