Moving from probiotics to precision probiotics

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695

The pros, cons, and many unknowns of probiotics

Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398

Personalized medicine: Time for one-person trials

Schork, N. J. (2015) · Nature · doi:10.1038/520609a · Cited by 1,274

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.047 · Cited by 1,184

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971

Analysis of the Fecal Microflora of Human Subjects Consuming a Probiotic Product Containing Lactobacillus rhamnosus DR20

Tannock, G. W., Munro, K., Harmsen, H. J. M., Welling, G. W., Smart, J., & Gopal, P. K. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2578-2588.2000 · Cited by 671

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

Maldonado-Gómez, M. X., Martínez, I., Bottacini, F., O’Callaghan, A., Ventura, M., van Sinderen, D., Hillmann, B., Vangay, P., Knights, D., Hutkins, R. W., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.09.001 · Cited by 517

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

Swinney, D. C. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.236 · Cited by 417

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide

Sniffen, J. C., McFarland, L. V., Evans, C. T., & Goldstein, E. J. C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0209205 · Cited by 265

Life around Us

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0002

Life beneath Our Feet

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0003

Food and Eating

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0008

Laughing and Crying

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0012

Standing Up

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0009

The Heart of the Matter

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0010

Supermarket Systematics

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0004

Fellow Travelers

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.003.0005

The Biology of Us

Howard, G. C. (2024) · doi:10.1093/oso/9780197664797.001.0001 · Cited by 1

Copyright Page

Howard, G. C. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780197664797.002.0003

The human microbiome as drug targets

Lim, P. P., Joseph, C., Parmar, I., Amudha, N. M., Roy, M., Varanasi, G. V. S. A., & Patankar, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15435-5.00015-3

Probiotics Application in the Treatment of Autoimmune Diseases and Enhancement of Efficacy Through Genetic Engineering

Kebede, B., & Tilahun, A. (2024) · American Journal of Bioscience and Bioengineering · doi:10.11648/j.bio.20241206.12

Gut Microbiota-Based Strategies for Targeting Hepatic Encephalopathy

Romaní‐Pérez, M., Cénit, M. C., & Agustí, A. (2025) · Neuromethods · doi:10.1007/978-1-0716-4354-9_10

Commercially available human and animal postbiotics

Pandey, S., Chaudhari, A., & Dwivedi, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22188-0.00016-4

The Role of Microbiome in Metabolic Pattern Changes

Akool, E., Shatat, A.-A. S., & Balah, A. (2025) · Springer eBooks · doi:10.1007/978-981-96-1305-2_13

Gut reaction: How the gut microbiome may influence the severity of COVID-19

Moossavi, S., & Arrieta, M. (2020) · doi:10.64628/aam.uxc4m9rm4

Supremacy of marine-derived probiotics and carbohydrate-based prebiotics

Padhi, A., & Barve, K. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33122-0.00009-x

Additional file 1 of Bacteroides uniformis CECT 7771 requires adaptive immunity to improve glucose tolerance but not to prevent body weight gain in diet-induced obese mice

Romaní‐Pérez, M., López‐Almela, I., Bullich‐Vilarrubias, C., Evtoski, Z., Benítez‐Páez, A., & Sanz, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25989129

Custom Sustenance Through Gut Biotics

Manna, D., Laishram, R., Das, D., & Dahuja, A. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-4382-2.ch003

Du laboratoire à l’assiette comment les découvertes sur le microbiote intestinal ont changé notre alimentation

Veiga, P., & Hiol, A. N. (2024) · Histoire de la recherche contemporaine · doi:10.4000/15v9o

Analyse fonctionnelle de bactéries du microbiote intestinal humain et évaluation de leurs propriétés bénéfiques contre l’obésité et l’inflammation intestinale

Cuffaro, B. (2021) · theses.fr (ABES) · doi:10.70675/c303a161z5e08z4284za4baz590c01ce4043

Comprehensive study of the microbiome of fermented vegetables using integrative approaches

Junker, R. (2024) · theses.fr (ABES) · doi:10.70675/26164caeze8c2z4baaz9744z98cbc2b9a7c8

Fermented foods: lessons learned from metagenomics

Valentino, V., Filippis, F. D., & Ercolini, D. (2026) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2026.103545 · Cited by 1

How to Apply Microbiome Products for Precision Prevention?

Shin, N., Park, S., Son, W., & Yang, M. (2026) · Food Supplements and Biomaterials for Health · doi:10.52361/fsbh.2026.6.e12

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment

Fousekis, F., Lianos, G. D., Stavropoulou, E., Patrikiou, E., Vradelis, S., Cassimos, D. C., & Tsigalou, C. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104127 · Cited by 1

Yeast-derived post-biotics: production technologies, characterization, applications, and future prospects

Ali, A., Nawaz, I., Butt, M. U., Khalid, A., Dita, H. A., Sadikan, M. Z., Zhang, F., Javed, N., Fatima, N. E., Islam, F., et al. (2026) · European Food Research and Technology · doi:10.1007/s00217-026-05203-8

Oral colonization of probiotics: one size fits all?

Holm, W. V., Marynissen, J., Campenhout, L. V., Minnebo, Y., Mermans, F., Lauwens, K., Teughels, K., Saghi, M., Zayed, N., Boon, N., et al. (2026) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2026.100642

Probiotics in Autoimmune Disease: Strain-specific Mechanisms and Therapeutic Perspectives

Zhou, J., Cao, J., Dong, S., Li, H., Yang, S., Yan, Z., Wang, C., Pei, Y., Su, Y., Wen, B., et al. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09190-2

Multidimensional interactions of living materials with biological entities

Shuqing, D., Liu, Y., Liu, Y., Tan, Y., Man, Y., Zhang, Z., Lv, Z., Lee, L. P., Chen, Q., & Liu, Z. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124565

Co-culture-driven metabolic reprogramming increases hypoxanthine levels to enhance the freeze-drying tolerance of Bifidobacterium bifidum: insights from metabolomics and exogenous validation

Guo, S., Mao, B., Tang, X., Zhang, H., Zhang, Q., Zhai, Q., Chen, W., Zhao, J., & Cui, S. (2026) · LWT · doi:10.1016/j.lwt.2026.119906

Rewiring lactobacilli: challenges, opportunities, and the translational path to therapeutics

Tadimarri, V. S., Blanch‐Asensio, M., & Sankaran, S. (2026) · Current Opinion in Microbiology · doi:10.1016/j.mib.2026.102826

Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation

Kim, S.-H., Hong, S., Lee, E. Y., Kim, S.-A., Han, N. S., Kim, S. Y., & Lee, C. H. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2728833

The economy of probiotics in drugs, supplements, and foods, and the future trend

Golowczyc, M. A., & Gómez‐Zavaglia, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29835-6.00013-7

Screening of constipation-alleviating probiotics targeting key bile acids and the mechanism of the selected strain Bifidobacterium longum BL2

Wang, L., Yang, Y., Xue, Y., Liang, M., Guo, Y., Yang, Y., Cheng, W., Lu, W., Wang, G., Zhai, Q., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.110283

Postbiotics in livestock and poultry production: A review of mechanisms focusing on intestinal barrier enhancement, immune regulation, and pathogen exclusion

Li, X., & Yang, B. (2026) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2026.117097

Precision medicine approaches to personalized probiotic therapy

Dinda, A., Banik, S., Kirtania, P., & Bhowmik, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27594-4.00015-2

Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition

Jiang, Y., Jiang, S., Wang, Z., Zhu, P., Zhang, J., Teng, F., & Huang, S. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2623359 · Cited by 41

From One-Size-Fits-All to Precision Medicine: The Promise of Personalized Probiotics

Montazeri‐Najafabady, N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10815-9 · Cited by 16

Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics

Idrees, M., Imran, M., Atiq, N., Zahra, R., Abid, R., Alreshidi, M. M., Roberts, T. K., Abdelgadir, A., Tipu, M. K., Farid, A., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.959941 · Cited by 56

Beyond Generic Probiotics: The Role of Strain Precision, Genetic Optimization, and Microbiome Integration in Probiotic Efficacy

gallant, M., Deumić, S., Kovačić, D., & Avdić, M. (2026) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-032-06531-5_71