Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome
Open accessAbstract
Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. Thus, phylogenetic limiting and resource availability are two factors that control the niche opportunity for AH1206 colonization. These findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precise and personalized microbiome reconstitution.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maldonado-Gómez et al. demonstrated that personalised engraftment of a probiotic was dependent on the availability of an open ecological niche.
“Maldonado-Gómez et al. demonstrated that personalised engraftment of a probiotic was dependent on the availability of an open ecological niche [50].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [50]
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Self-citationHill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
The Ecology of Invasions by Animals and Plants.
Richards, P. W., & Elton, C. (1959) · Journal of Ecology · doi:10.2307/2257385 · Cited by 3,907 · see citing works
The Competitive Exclusion Principle
Hardin, G. (1960) · Science · doi:10.1126/science.131.3409.1292 · Cited by 3,456 · see citing works
Impacts of biological invasions: what's what and the way forward
Simberloff, D., Martin, J.-L., Genovesi, P., Maris, V., Wardle, D. A., Aronson, J., Courchamp, F., Galil, B., García-Berthou, E., Pascal, M., et al. (2013) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.07.013 · Cited by 3,344 · see citing works
Vive la différence: plant functional diversity matters to ecosystem processes
Dı́az, S., & Cabido, M. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02283-2 · Cited by 3,306 · see citing works
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works
Community ecology theory as a framework for biological invasions
Shea, K. (2002) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(02)02495-3 · Cited by 2,235 · see citing works
Anvi’o: an advanced analysis and visualization platform for ‘omics data
Eren, A. M., Esen, Ö. C., Quince, C., Vineis, J. H., Morrison, H. G., Sogin, M. L., & Delmont, T. O. (2015) · PeerJ · doi:10.7717/peerj.1319 · Cited by 1,823 · see citing works
Opposing effects of competitive exclusion on the phylogenetic structure of communities
Mayfield, M. M., & Levine, J. M. (2010) · Ecology Letters · doi:10.1111/j.1461-0248.2010.01509.x · Cited by 1,669 · see citing works
Tilman, D. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403458101 · Cited by 1,540 · see citing works
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437 · see citing works
Biodiversity as a barrier to ecological invasion
Kennedy, T. A., Naeem, S., Howe, K. M., Knops, J. M. H., Tilman, D. G., & Reich, P. B. (2002) · Nature · doi:10.1038/nature00776 · Cited by 1,180 · see citing works
Initial community evenness favours functionality under selective stress
Wittebolle, L., Marzorati, M., Clement, L., Balloi, A., Daffonchio, D. G., Heylen, K., Vos, P. D., Verstraete, W., & Boon, N. (2009) · Nature · doi:10.1038/nature07840 · Cited by 979 · see citing works
Genomic variation landscape of the human gut microbiome
Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., et al. (2013) · Nature · doi:10.1038/nature11711 · Cited by 907 · see citing works
Walter, J. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00753-08 · Cited by 756 · see citing works
Self-citationThe human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720 · see citing works
Self-citationBacterial colonization factors control specificity and stability of the gut microbiota
Lee, S. M., Donaldson, G. P., Mikulski, Z., Boyajian, S., Ley, K. F., & Mazmanian, S. K. (2013) · Nature · doi:10.1038/nature12447 · Cited by 629 · see citing works
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · cited 1× · see citing works
“In most studies, the introduction of a live microbe did not result in significant alterations of the fecal microbiota (Kristensen et al., 2016).”
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Li, S. S., Zhu, A., Beneš, V., Costea, P. I., Hercog, R., Hildebrand, F., Huerta‐Cepas, J., Nieuwdorp, M., Salojärvi, J., Voigt, A. Y., et al. (2016) · Science · doi:10.1126/science.aad8852 · Cited by 544 · see citing works
Phylogenetic limiting similarity and competitive exclusion
Violle, C., Nemergut, D. R., Pu, Z., & Jiang, L. (2011) · Ecology Letters · doi:10.1111/j.1461-0248.2011.01644.x · Cited by 516 · see citing works
An update on the use and investigation of probiotics in health and disease
Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A. (2013) · Gut · doi:10.1136/gutjnl-2012-302504 · Cited by 503 · see citing works
Microbial Invasions: The Process, Patterns, and Mechanisms
Mallon, C. A., van Elsas, J. D., & Salles, J. F. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.07.013 · Cited by 488 · see citing works
Supervised classification of human microbiota
Knights, D., Costello, E. K., & Knight, R. D. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00251.x · Cited by 482 · see citing works
Self-citationStecher, B., Chaffron, S., Käppeli, R., Hapfelmeier, S., Freedrich, S., Weber, T. C., Kirundi, J., Suar, M., McCoy, K. D., von Mering, C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000711 · Cited by 421 · see citing works
Horizontal gene transfer in evolution: facts and challenges
Boto, L. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.1679 · Cited by 379 · cited 1× · see citing works
“Horizontal gene transfer can further lead to similar genetic information being shared among bacterial taxa that are not closely related, resulting in phylogenetically distant taxa with similar traits (Boto, 2010).”
Davis, L. M. G., Martínez, I., Walter, J., Goin, C., & Hutkins, R. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025200 · Cited by 321 · see citing works
Self-citationExploring the Diversity of the Bifidobacterial Population in the Human Intestinal Tract
Turroni, F., Foroni, E., Pizzetti, P., Giubellini, V., Ribbera, A., Merusi, P., Cagnasso, P., Bizzarri, B., de'Angelis, G. L., Shanahan, F., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02216-08 · Cited by 311 · see citing works
Self-citationSynbiotics in Health and Disease
Kolida, S., & Gibson, G. R. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133739 · Cited by 309 · see citing works
Resolving Darwin’s naturalization conundrum: a quest for evidence
Thuiller, W., Gallien, L., Boulangeat, I., de Bello, F., Münkemüller, T., Roquet, C., & Lavergne, S. (2010) · Diversity and Distributions · doi:10.1111/j.1472-4642.2010.00645.x · Cited by 281 · see citing works
Zhang, C., Derrien, M., Levenez, F., Brazeilles, R., Ballal, S. A., Kim, J., Degivry, M.-C., Quéré, G., Garault, P., van Hylckama Vlieg, J. E. T., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.13 · Cited by 264 · see citing works
Functional and phylogenetic assembly of microbial communities in the human microbiome
Shafquat, A., Cordy, R. J., Simmons, S. L., & Huttenhower, C. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.01.011 · Cited by 212 · see citing works
Therapeutic modulation of intestinal dysbiosis
Walker, A. W., & Lawley, T. D. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.008 · Cited by 197 · see citing works
Inter-individual differences in the gene content of human gut bacterial species
Zhu, A., Sunagawa, S., Mende, D. R., & Bork, P. (2015) · Genome biology · doi:10.1186/s13059-015-0646-9 · Cited by 196 · see citing works
Martínez, I., Muller, C. E., & Walter, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069621 · Cited by 181 · see citing works
Self-citationSearching for phylogenetic pattern in biological invasions
Procheş, Ş., Wilson, J. R., Richardson, D. M., et al. (2007) · Global Ecology and Biogeography · doi:10.1111/j.1466-8238.2007.00333.x · Cited by 180 · see citing works
Alander, M., Mättö, J., Kneifel, W., Johansson, M., Kögler, B., Crittenden, R. G., Mattila, T., & Saarela, M. (2001) · International Dairy Journal · doi:10.1016/s0958-6946(01)00100-5 · Cited by 175 · see citing works
Environmental conditions and community evenness determine the outcome of biological invasion
Roy, K. D., Marzorati, M., Negroni, A., Thas, O., Balloi, A., Fava, F., Verstraete, W., Daffonchio, D. G., & Boon, N. (2013) · Nature Communications · doi:10.1038/ncomms2392 · Cited by 158 · see citing works
Olle, B. (2013) · Nature Biotechnology · doi:10.1038/nbt.2548 · Cited by 140 · see citing works
Li, S., Cadotte, M. W., Meiners, S. J., et al. (2015) · Ecology Letters · doi:10.1111/ele.12522 · Cited by 132 · see citing works
O’Callaghan, A. A., Bottacini, F., Motherway, M. O., & van Sinderen, D. (2015) · BMC Genomics · doi:10.1186/s12864-015-1968-4 · Cited by 108 · see citing works
Self-citationCharbonneau, D., Gibb, R. D., & Quigley, E. M. M. (2013) · Gut Microbes · doi:10.4161/gmic.24196 · Cited by 99 · see citing works
Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health
Ceapa, C., Wopereis, H., Rezaïki, L., Kleerebezem, M., Knol, J., & Oozeer, R. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.04.004 · Cited by 98 · see citing works
Metabolism of a plant derived galactose‐containing polysaccharide by Bifidobacterium breve UCC2003
Motherway, M. O., Fitzgerald, G. F., & van Sinderen, D. (2010) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2010.00218.x · Cited by 96 · see citing works
A unified approach for quantifying invasibility and degree of invasion.
Guo, Q.-F., Fei, S., Dukes, J., Oswalt, C., Iannone, B., & Potter, K. (2015) · Ecology · doi:10.1890/14-2172.1 · Cited by 80 · see citing works
Krumbeck, J. A., Maldonado-Gómez, M. X., Martínez, I., Frese, S. A., Burkey, T. E., Rasineni, K., Ramer‐Tait, A. E., Harris, E. N., Hutkins, R. W., & Walter, J. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03903-14 · Cited by 68 · see citing works
Self-citationFrese, S. A., Hutkins, R. W., & Walter, J. (2012) · Advances in Microbiology · doi:10.4236/aim.2012.23051 · Cited by 67 · see citing works
Self-citationEcological Factors Affecting Community Invasibility
Olyarnik, S. V., Bracken, M. E. S., Byrnes, J. E. K., et al. (2008) · Ecological studies · doi:10.1007/978-3-540-79236-9_12 · Cited by 64 · see citing works
Metabolism of Four α-Glycosidic Linkage-Containing Oligosaccharides by Bifidobacterium breve UCC2003
O’Connell, K. J., Motherway, M. O., O’Callaghan, J., Fitzgerald, G. F., Ross, R. P., Ventura, M., Stanton, C., & van Sinderen, D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01775-13 · Cited by 63 · see citing works
Self-citationFujiwara, S., Seto, Y., Kimura, A., & Hashiba, H. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01205.x · Cited by 61 · see citing works
Malinen, E., Mättö, J., Salmitie, M., et al. (2002) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00117 · Cited by 49 · see citing works
Encyclopedia & Dictionary of Medicine, Nursing & Allied Health
Miller, B. F. (2003) · Medical Entomology and Zoology · Cited by 45 · see citing works
Rattanaprasert, M., Roos, S., Hutkins, R. W., & Walter, J. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.05.017 · Cited by 44 · see citing works
Self-citationIntraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum
Chaplin, A. V., Efimov, B. A., Smeianov, V. V., Кафарская, Л. И., Pikina, A. P., & Shkoporov, A. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135658 · Cited by 43 · see citing works
Firmesse, O., Mogenet, A., Bresson, J., Corthier, G., & Furet, J. (2007) · Microbial Physiology · doi:10.1159/000106087 · Cited by 43 · see citing works
Disturbance-induced changes in community composition increase species invasion success
Kneitel, J. M., & Perrault, D. (2006) · Community Ecology · doi:10.1556/comec.7.2006.2.11 · Cited by 42 · see citing works
O’Connell, K. J., Motherway, M. O., Liedtke, A., Fitzgerald, G. F., Ross, R. P., Stanton, C., Zomer, A., & van Sinderen, D. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00130-14 · Cited by 37 · see citing works
Mächler, E., & Altermatt, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045400 · Cited by 32 · see citing works
Malinen, E., Mättö, J., Salmitie, M., et al. (2002) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(04)70109-5 · Cited by 29 · see citing works
Rochet, V., Rigottier‐Gois, L., Levenez, F., Cadiou, J., Marteau, P. R., Bresson, J., Goupil-Feuillerat, N., & Dore, J. M. (2008) · Canadian Journal of Microbiology · doi:10.1139/w08-050 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375 · see citing works
Self-citationSwanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196 · see citing works
Self-citationProbiotics and prebiotics in intestinal health and disease: from biology to the clinic
Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0173-3 · Cited by 2,059 · see citing works
Dysbiosis and the immune system
Levy, M., Kolodziejczyk, A. A., Thaiss, C. A., & Elinav, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.7 · Cited by 1,769 · see citing works
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699 · see citing works
Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695 · see citing works
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398 · see citing works
Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.047 · Cited by 1,184 · see citing works
Diet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879 · see citing works
Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration
Leeming, E. R., Johnson, A. J., Spector, T. D., & Le Roy, C. I. (2019) · Nutrients · doi:10.3390/nu11122862 · Cited by 817 · see citing works
Daily sampling reveals personalized diet-microbiome associations in humans
Johnson, A. J., Vangay, P., Al-Ghalith, G. A., Hillmann, B. M., Ward, T. L., Shields-Cutler, R. R., Kim, A. D., Shmagel, A. K., Syed, A. N., Walter, J., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.005 · Cited by 742 · see citing works
Self-citationShaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Self-citationAnxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Emerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works
An exclusive metabolic niche enables strain engraftment in the gut microbiota
Shepherd, E. S., DeLoache, W. C., Pruss, K. M., Whitaker, W. R., & Sonnenburg, J. L. (2018) · Nature · doi:10.1038/s41586-018-0092-4 · Cited by 367 · see citing works
Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Diet and the human gut microbiome: An international review
Wilson, A. S., Koller, K. R., Ramaboli, M. C., Nesengani, L. T., Ocvirk, S., Chen, C., Flanagan, C. A., Sapp, F. R., Merritt, Z. T., Bhatti, F., et al. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06112-w · Cited by 369 · see citing works
Krumbeck, J. A., Rasmussen, H. E., Hutkins, R. W., Clarke, J., Shawron, K., Keshavarzian, A., & Walter, J. (2018) · Microbiome · doi:10.1186/s40168-018-0494-4 · Cited by 342 · see citing works
Self-citationMining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Montassier, E., Valdés-Mas, R., Batard, E., Zmora, N., Dori-Bachash, M., Suez, J., & Elinav, E. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00920-0 · Cited by 256 · see citing works
Glycan Utilization and Cross-Feeding Activities by Bifidobacteria
Turroni, F., Milani, C., Duranti, S., Mahony, J., van Sinderen, D., & Ventura, M. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2017.10.001 · Cited by 263 · see citing works
Self-citationRethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252 · see citing works
Self-citationMoving from probiotics to precision probiotics
Veiga, P., Suez, J., Derrien, M., & Elinav, E. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0721-1 · Cited by 235 · see citing works
Frese, S. A., Hutton, A. A., Contreras, L. N., Shaw, C. A., Palumbo, M. C., Casaburi, G., Xu, G., Davis, J. C. C., Lebrilla, C. B., Henrick, B. M., et al. (2017) · mSphere · doi:10.1128/msphere.00501-17 · Cited by 231 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Martínez, I., Maldonado-Gomez, M. X., Gomes-Neto, J. C., Kittana, H., Ding, H., Schmaltz, R., Joglekar, P., Cardona, R. J., Marsteller, N. L., Kembel, S. W., et al. (2018) · eLife · doi:10.7554/elife.36521 · Cited by 199 · see citing works
Self-citationSharpton, S. R., Schnabl, B., Knight, R., & Loomba, R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.010 · Cited by 194 · see citing works
Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019) · Experimental Dermatology · doi:10.1111/exd.14016 · Cited by 189 · see citing works
Feeding the microbiota: Transducer of nutrient signals for the host
Shanahan, F., van Sinderen, D., O’Toole, P. W., & Stanton, C. (2017) · Gut · doi:10.1136/gutjnl-2017-313872 · Cited by 157 · see citing works
Self-citationGood microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome
Crits-Christoph, A., Hallowell, H. A., Koutouvalis, K., & Suez, J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2055944 · Cited by 156 · see citing works
Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?
Lerner, A., Shoenfeld, Y., & Matthias, T. (2019) · Microorganisms · doi:10.3390/microorganisms7040104 · Cited by 117 · see citing works
Podlesny, D., Durdevic, M., Paramsothy, S., Kaakoush, N. O., Högenauer, C., Gorkiewicz, G., Walter, J., & Fricke, W. F. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100711 · Cited by 111 · see citing works
Experimental Evaluation of Host Adaptation of Lactobacillus reuteri to Different Vertebrate Species
Duar, R. M., Frese, S. A., Lin, X. B., Fernando, S. C., Burkey, T. E., Tasseva, G., Peterson, D. A., Blom, J., Wenzel, C. Q., Szymanski, C. M., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00132-17 · Cited by 104 · see citing works
Self-citationEarly-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria
Casaburi, G., Duar, R. M., Vance, D. P., Mitchell, R., Contreras, L., Frese, S. A., Smilowitz, J. T., & Underwood, M. A. (2019) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-019-0583-6 · Cited by 101 · see citing works
Horrocks, V., King, O. G., Yip, A. Y. G., Marques, I. M., & McDonald, J. A. K. (2023) · Microbiology · doi:10.1099/mic.0.001377 · Cited by 104 · see citing works
Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84 · see citing works
Self-citationKong, L., Lloyd-Price, J., Vatanen, T., Seksik, P., Beaugerie, L., Simon, T., Vlamakis, H., Sokol, H., & Xavier, R. J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.045 · Cited by 69 · see citing works
Huang, S., Jiang, S., Huo, D., Allaband, C., Estaki, M., Cantu, V., Belda-Ferre, P., Vázquez-Baeza, Y., Zhu, Q., Ma, C., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01102-0 · Cited by 61 · see citing works
Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58 · see citing works
Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics
Ojima, M. N., Yoshida, K., Sakanaka, M., Jiang, L., Odamaki, T., & Katayama, T. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.06.023 · Cited by 46 · see citing works
Ostrem Loss, E., Thompson, J., Cheung, P. L. K., Qian, Y., & Venturelli, O. S. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01930-9 · Cited by 38 · see citing works
Alvarez, A.-S., Tap, J., Chambaud, I., Cools-Portier, S., Quinquis, L., Bourlioux, P., Marteau, P., Guillemard, E., Schrezenmeir, J., & Derrien, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-72161-w · Cited by 36 · see citing works
Phan, J., Nair, D., Jain, S., Montagne, T., Flores, D. V., Nguyen, A., Dietsche, S., Gombar, S., & Cotter, P. (2021) · mSystems · doi:10.1128/msystems.01215-21 · Cited by 33 · see citing works
Robinson, J. M., & Breed, M. F. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137626 · Cited by 30 · see citing works
Ladeira, R., Tap, J., & Derrien, M. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.01 · Cited by 19 · see citing works
Rana, A., & Smriti (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70275 · Cited by 7 · see citing works
- Authors
- Maldonado-Gómez, M. X., Martínez, I., Bottacini, F., O’Callaghan, A., Ventura, M., van Sinderen, D., Hillmann, B., Vangay, P., Knights, D., Hutkins, R. W., & Walter, J.
- Affiliations
- University of Nebraska–Lincoln (US)
- University College Cork (IE)
- University of Parma (IT)
- University of Minnesota (US)
- Corresponding author
- Walter, Jens
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 20
- Issue
- 4
- Pages
- 515-526
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2527237309
- Cited by
- 517
- References
- 61
- Citations by year
- 2026: 54 · 2025: 52 · 2024: 58 · 2023: 57 · 2022: 68 · 2021: 72 · 2020: 45 · 2019: 42 · 2018: 39 · 2017: 25 · 2016: 5
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotic colonization, gut microbiota, resource availability, oral administration
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium longum, Administration, Oral, Carrier State, Humans, Time Factors, Probiotics, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review