Cited by 517Gut microbiota and healthProbiotics and Fermented FoodsInfant Nutrition and Health

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

Open access
Maldonado-Gómez, María X., Martínez, Inés, Bottacini, Francesca, O’Callaghan, Amy, Ventura, Marco, van Sinderen, Douwe, Hillmann, Benjamin, Vangay, Pajau +3 more·2016·Cell Host & Microbe

Abstract

Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. Thus, phylogenetic limiting and resource availability are two factors that control the niche opportunity for AH1206 colonization. These findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precise and personalized microbiome reconstitution.

Integrity signals

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Crossref · 10.1016/j.chom.2016.09.001

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  • Maldonado-Gómez et al. demonstrated that personalised engraftment of a probiotic was dependent on the availability of an open ecological niche.

    “Maldonado-Gómez et al. demonstrated that personalised engraftment of a probiotic was dependent on the availability of an open ecological niche [50].”

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Authors
Maldonado-Gómez, M. X., Martínez, I., Bottacini, F., O’Callaghan, A., Ventura, M., van Sinderen, D., Hillmann, B., Vangay, P., Knights, D., Hutkins, R. W., & Walter, J.
Affiliations
  • University of Nebraska–Lincoln (US)
  • University College Cork (IE)
  • University of Parma (IT)
  • University of Minnesota (US)
Corresponding author
Walter, Jens
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2016-10
Volume
20
Issue
4
Pages
515-526
ISSN
1931-3128 (ISSN-L)
OpenAlex
W2527237309
Cited by
517
References
61
Citations by year
2026: 54 · 2025: 52 · 2024: 58 · 2023: 57 · 2022: 68 · 2021: 72 · 2020: 45 · 2019: 42 · 2018: 39 · 2017: 25 · 2016: 5
FWCI
19.24
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • Lincoln (University of Nebraska) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
probiotic colonization, gut microbiota, resource availability, oral administration
MeSH terms
Gastrointestinal Microbiome, Bifidobacterium longum, Administration, Oral, Carrier State, Humans, Time Factors, Probiotics, Microbiota

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