Moving from probiotics to precision probiotics

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695

The pros, cons, and many unknowns of probiotics

Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398

Personalized medicine: Time for one-person trials

Schork, N. J. (2015) · Nature · doi:10.1038/520609a · Cited by 1,274

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.047 · Cited by 1,184

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971

Analysis of the Fecal Microflora of Human Subjects Consuming a Probiotic Product Containing Lactobacillus rhamnosus DR20

Tannock, G. W., Munro, K., Harmsen, H. J. M., Welling, G. W., Smart, J., & Gopal, P. K. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2578-2588.2000 · Cited by 671

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

Maldonado-Gómez, M. X., Martínez, I., Bottacini, F., O’Callaghan, A., Ventura, M., van Sinderen, D., Hillmann, B., Vangay, P., Knights, D., Hutkins, R. W., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.09.001 · Cited by 517

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

Swinney, D. C. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.236 · Cited by 417

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide

Sniffen, J. C., McFarland, L. V., Evans, C. T., & Goldstein, E. J. C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0209205 · Cited by 265

Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes

Zhang, C., Derrien, M., Levenez, F., Brazeilles, R., Ballal, S. A., Kim, J., Degivry, M.-C., Quéré, G., Garault, P., van Hylckama Vlieg, J. E. T., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.13 · Cited by 264

Fermented milk containing Bifidobacterium lactis DN-173 010 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: a randomised, double-blind, parallel, controlled study

Guyonnet, D., Schlumberger, A., Mhamdi, L., Jakob, S., & Chassany, O. (2009) · British Journal of Nutrition · doi:10.1017/s0007114509990882 · Cited by 95

Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity

Lucas, N., Legrand, R., Deroissart, C., Dominique, M., Azhar, S., Solliec, M.-A. L., Léon, F., do-Rego, J.-C., Déchelotte, P., Fetissov, S. O., et al. (2019) · Microorganisms · doi:10.3390/microorganisms8010035 · Cited by 49

Genetic counseling, 2030: An on‐demand service tailored to the needs of a price conscious, genetically literate, and busy world

Rashkin, M. D., Bowes, J., Dunaway, K. W., Dhaliwal, J. K., Loomis, E. W., Riffle, S., Washington, N. L., Ziegler, C., Lu, J. T., & Levin, E. (2019) · Journal of Genetic Counseling · doi:10.1002/jgc4.1123 · Cited by 23

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Zhou, J., Li, M., Chen, Q., Li, X., Chen, L., Dong, Z., Zhu, W., Yang, Y., Liu, Z., & Chen, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31171-0 · Cited by 725

Shaping the Future of Probiotics and Prebiotics

Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637

Microbiome and cancer

Cullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K., & Elinav, E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.08.006 · Cited by 578

Emerging issues in probiotic safety: 2023 perspectives

Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481

Probiotics, prebiotics, and postbiotics in health and disease

Ji, J., Jin, W., Liu, S., Jiao, Z., & Li, X. (2023) · MedComm · doi:10.1002/mco2.420 · Cited by 449

Precision medicine approaches to personalized probiotic therapy

Dinda, A., Banik, S., Kirtania, P., & Bhowmik, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27594-4.00015-2

Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition

Jiang, Y., Jiang, S., Wang, Z., Zhu, P., Zhang, J., Teng, F., & Huang, S. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2623359 · Cited by 41

From One-Size-Fits-All to Precision Medicine: The Promise of Personalized Probiotics

Montazeri‐Najafabady, N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10815-9 · Cited by 16

Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics

Idrees, M., Imran, M., Atiq, N., Zahra, R., Abid, R., Alreshidi, M. M., Roberts, T. K., Abdelgadir, A., Tipu, M. K., Farid, A., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.959941 · Cited by 56

Beyond Generic Probiotics: The Role of Strain Precision, Genetic Optimization, and Microbiome Integration in Probiotic Efficacy

gallant, M., Deumić, S., Kovačić, D., & Avdić, M. (2026) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-032-06531-5_71