Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects
Open accessAbstract
Background Preclinical studies have identified certain probiotics as psychobiotics - live microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has been shown to reduce stress-related behaviour, corticosterone release and alter central expression of GABA receptors in an anxious mouse strain. However, it is unclear if this single putative psychobiotic strain has psychotropic activity in humans. Consequently, we aimed to examine if these promising preclinical findings could be translated to healthy human volunteers.Objectives To determine the impact of L. rhamnosus on stress-related behaviours, physiology, inflammatory response, cognitive performance and brain activity patterns in healthy male participants.Methods An 8week, randomized, placebo-controlled, cross-over design was employed. Twenty-nine healthy male volunteers participated. Participants completed self-report stress measures, cognitive assessments and resting electroencephalography (EEG). Plasma IL10, IL1β, IL6, IL8 and TNFα levels and whole blood Toll-like 4 (TLR-4) agonist-induced cytokine release were determined by multiplex ELISA. Salivary cortisol was determined by ELISA and subjective stress measures were assessed before, during and after a socially evaluated cold pressor test (SECPT).Results There was no overall effect of probiotic treatment on measures of mood, anxiety, stress or sleep quality and no significant effect of probiotic over placebo on subjective stress measures, or the HPA response to the SECPT. Visuospatial memory performance, attention switching, rapid visual information processing, emotion recognition and associated EEG measures did not show improvement over placebo. No significant anti-inflammatory effects were seen as assessed by basal and stimulated cytokine levels.Conclusions L. rhamnosus was not superior to placebo in modifying stress-related measures, HPA response, inflammation or cognitive performance in healthy male participants. These findings highlight the challenges associated with moving promising preclinical studies, conducted in an anxious mouse strain, to healthy human participants. Future interventional studies investigating the effect of this psychobiotic in populations with stress-related disorders are required.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In an RDBPCOT of 29 healthy male participants, Lactobacillus rhamnosus JB-1 had no significant effects on mood, anxiety, sleep quality, or cognitive performance compared to placebo.
“Despite promising preclinical findings in animal models, the study found no significant effects of JB-1 on mood, anxiety, sleep quality, or cognitive performance compared to placebo.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Kelly et al., 2017
In that trial, there were no notable changes in inflammatory markers or the HPA stress response with JB-1.
“Additionally, there were no notable changes in inflammatory markers or the HPA stress response.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Kelly et al., 2017
In an eight-week crossover design, 29 healthy male volunteers supplemented with L. rhamnosus exhibited little difference in stress-related measures, HPA axis response, inflammation, or cognitive performance compared to placebo.
“However, in an eight-week crossover design, 29 healthy male volunteers who supplemented with L. rhamnosus exhibited little difference in stress-related measures, HPA axis response, inflammation, or cognitive performance in comparison to placebo [296].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [296]
Psychobiotic treatment has met with mixed results in healthy human subjects, with strain-specific positive results and a failure to translate.
“has met with somewhat mixed results in healthy human subjects with strain-specific positive results (Allen et al., 2016;Papalini et al., 2018) and a failure to translate (Kelly et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Kelly et al., 2017
Probiotic Lactobacillus rhamnosus failed to alter mood, anxiety, and stress-related measures when subjects faced socially evaluated cold pressor test.
“However, the probiotic Lactobacillus rhamnosus failed to alter mood, anxiety, and stress-related measures when subjects faced a socially evaluated cold pressor test [392]”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [392]
L. rhamnosus was not found to be superior to placebo in modifying stress, HPA response, inflammation, or cognitive performance.
“For instance, L. rhamnosus was not found to be superior to placebo in modifying stress, HPA response, inflammation, or cognitive performance, and the authors highlighted the challenges associated with advancing promising preclinical studies in animals to the clinic (487).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [487]
In that trial, the participants were healthy adult males and not patients with stress-related disorders.
“Notably, the participants were healthy adult males and not patients with stress-related disorders.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [487]
Cites
1 retracted
Mohammadi, A. A., Jazayeri, S., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000023 · Cited by 239 · see citing works
Retracted(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Self-citationBravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Self-citationPruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00108-7 · Cited by 3,638 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Self-citationEEG analysis based on time domain properties
Hjorth, B. (1970) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(70)90143-4 · Cited by 1,504 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Self-citationConsumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
Self-citationCorrelation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Self-citationMicrobiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866 · see citing works
Self-citationWhorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works
Akkasheh, G., Kashani-Poor, Z., Tajabadi-Ebrahimi, M., Jafari, P., Akbari, H., Taghizadeh, M., Memarzadeh, M. R., Asemi, Z., & Esmaillzadeh, A. (2016) · Nutrition · doi:10.1016/j.nut.2015.09.003 · Cited by 767 · see citing works
HPA axis activation by a socially evaluated cold-pressor test
Schwabe, L., Haddad, L., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.001 · Cited by 698 · see citing works
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works
Self-citationCoull, J. T., Frith, C. D., Frackowiak, R. S. J., & Grasby, P. M. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00029-2 · Cited by 566 · see citing works
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · see citing works
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554 · see citing works
Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522 · see citing works
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513 · see citing works
Self-citationInterleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG
Pessi, T., Sütas, Y., Hurme, M., & Isolauri, E. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00948.x · Cited by 432 · see citing works
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works
Self-citationTaylor, M. J., Freemantle, N., Geddes, J. R., & Bhagwagar, Z. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1217 · Cited by 406 · see citing works
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works
Self-citationKarimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361 · see citing works
Self-citationDidari, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i10.3072 · Cited by 356 · see citing works
Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function
Patel, R. M., Myers, L. S., Kurundkar, A. R., Maheshwari, A., Nusrat, A., & Lin, P. W. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.025 · Cited by 341 · see citing works
Khanna, S., Pardi, D. S., Kelly, C. R., Kraft, C. S., Dhere, T., Henn, M. R., Lombardo, M.-J., Vulić, M., Ohsumi, T. K., Winkler, J. A., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv766 · Cited by 317 · see citing works
Ma, D., Forsythe, P., & Bienenstock, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5308-5314.2004 · Cited by 289 · see citing works
Self-citationJanik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.018 · Cited by 283 · see citing works
Self-citationKamiya, T., Wang, L., Forsythe, P., Goettsche, G., Mao, Y., Wang, Y., Tougas, G., & Bienenstock, J. (2006) · Gut · doi:10.1136/gut.2005.070987 · Cited by 242 · see citing works
Self-citationHuman Microbiota-Associated Mice: A Model with Challenges
Arrieta, M., Walter, J., & Finlay, B. B. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.014 · Cited by 236 · see citing works
Wang, Y., Liu, Y., Sidhu, A., Ma, Z., McClain, C. J., & Feng, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2012 · Cited by 235 · see citing works
Stress and the Aging Hippocampus
McEwen, B. S. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0173 · Cited by 231 · see citing works
Collins, S. M., Kassam, Z., & Berčík, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.004 · Cited by 206 · see citing works
Brain-gut-microbiota axis: challenges for translation in psychiatry
Kelly, J. R., Clarke, G. A., Cryan, J. F., & Dinan, T. G. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.008 · Cited by 200 · see citing works
Self-citationSchwabe, L., & Wolf, O. T. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.12.010 · Cited by 186 · see citing works
Chung, Y.-C., Jin, H.-M., Cui, Y., Kim, D. S., Jung, J. M., Park, J.-I., Jung, E.-S., Choi, E.-K., & Chae, S.-W. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.007 · Cited by 173 · see citing works
de Rover, M., Pironti, V. A., McCabe, J. A., Acosta‐Cabronero, J., Arana, F. S., Morein‐Zamir, S., Hodges, J. R., Robbins, T. W., Fletcher, P. C., Nestor, P. J., et al. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.03.037 · Cited by 163 · see citing works
Altered peripheral toll-like receptor responses in the irritable bowel syndrome
McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04624.x · Cited by 160 · see citing works
Self-citationKozáková, H., Schwarzer, M., Tučková, L., Šrůtková, D., Czarnowska, E., Rosiak, I., Hudcovic, T., Schabussová, I., Hermanová, P. P., Zakostelska, Z. J., et al. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.09 · Cited by 159 · see citing works
Eichenbaum, H., & Bunsey, M. D. (1995) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10770954 · Cited by 139 · see citing works
Harrington, J. M., Perry, I. J., Lutomski, J. E., Fitzgerald, T., Shiely, F., McGee, H. M., Barry, M. M., Lente, E. V., Morgan, K., & Shelley, E. (2009) · European Journal of Public Health · doi:10.1093/eurpub/ckp102 · Cited by 135 · see citing works
Microbiota and neuroimmune signalling—Metchnikoff to microglia
Cryan, J. F., & Dinan, T. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.127 · Cited by 122 · see citing works
Self-citationKennedy, P. J., Cryan, J. F., Quigley, E. M. M., Dinan, T. G., & Clarke, G. (2014) · Psychological Medicine · doi:10.1017/s003329171400052x · Cited by 120 · see citing works
Self-citationKennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2014) · Psychological Medicine · doi:10.1017/s0033291713002171 · Cited by 106 · see citing works
Self-citationMortaz, E., Adcock, I. M., Ricciardolo, F. L. M., Varahram, M., Jamaati, H., Velayati, A. A., Folkerts, G., & Garssen, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136455 · Cited by 105 · see citing works
Mood by microbe: towards clinical translation
Dinan, T. G., & Cryan, J. F. (2016) · Genome Medicine · doi:10.1186/s13073-016-0292-1 · Cited by 99 · see citing works
Self-citationWang, B., Mao, Y., Diorio, C. J., Pasyk, M., Wu, R., Bienenstock, J., & Kunze, W. (2010) · The FASEB Journal · doi:10.1096/fj.09-153841 · Cited by 98 · see citing works
Self-citationMa, X., Mao, Y., Wang, B., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90511.2008 · Cited by 93 · see citing works
Self-citationO’Mahony, C. M., Sweeney, F. F., Daly, E., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.038 · Cited by 80 · see citing works
Self-citationAntidepressants in healthy subjects: What are the psychotropic/psychological effects?
Serretti, A., Calati, R., Goracci, A., Simplicio, M. C. D., Castrogiovanni, P., & Ronchi, D. D. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.009 · Cited by 76 · see citing works
Savignac, H. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.049 · Cited by 73 · see citing works
Self-citationProbiotics and microbiota composition
Sanders, M. E. (2016) · BMC Medicine · doi:10.1186/s12916-016-0629-z · Cited by 72 · see citing works
Jazayeri, S., Mohammadi, A., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.164146 · Cited by 69 · see citing works
Minkley, N., Schröder, T. P., Wolf, O. T., & Kirchner, W. H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.022 · Cited by 59 · see citing works
Julio‐Pieper, M., O’Mahony, C. M., Clarke, G. A., Bravo, J. A., Dinan, T. G., & Cryan, J. F. (2011) · Stress · doi:10.3109/10253890.2011.607524 · Cited by 50 · see citing works
Self-citationForsythe, P., Wang, B., Khambati, I., & Kunze, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041234 · Cited by 48 · see citing works
Browne, C. A., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.020 · Cited by 48 · see citing works
Self-citationKennedy, P. J., Allen, A. P., O’Neill, A., Quigley, E. M. M., Cryan, J. F., Dinan, T. G., & Clarke, G. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3767-z · Cited by 39 · see citing works
Self-citationHales, J. B., Israel, S. L., Swann, N. C., & Brewer, J. B. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21096 · Cited by 31 · see citing works
Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
Fukami, G., Hashimoto, T., Shirayama, Y., Hasegawa, T., Watanabe, H., Fujisaki, M., Hashimoto, K., & Iyo, M. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-37 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 75 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Self-citationThe role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works
Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0173-3 · Cited by 2,059 · see citing works
The neuroactive potential of the human gut microbiota in quality of life and depression
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963 · see citing works
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398 · see citing works
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Stress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150 · see citing works
Self-citationTomiyama, A. J. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102936 · Cited by 695 · see citing works
Liu, R. T., Walsh, R. F. L., & Sheehan, A. E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.023 · Cited by 564 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Self-citationThe Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.002 · Cited by 555 · see citing works
Gut microbiota and the neuroendocrine system
Farzi, A., Fröhlich, E. E., & Holzer, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0600-5 · Cited by 478 · see citing works
Microbiota and the social brain
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works
Self-citationSlykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., Rowden, J., Stone, P., Crane, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.013 · Cited by 422 · see citing works
Microbiota-Gut-Brain Axis: New Therapeutic Opportunities
Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023628 · Cited by 419 · see citing works
Self-citationSignalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Probiotics and the microbiota-gut-brain axis: Focus on psychiatry
Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00313-5 · Cited by 337 · see citing works
Self-citationGlutamatergic Signaling Along The Microbiota-Gut-Brain Axis
Baj, A., Moro, E., Bistoletti, M., Orlandi, V. T., Crema, F., & Giaroni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061482 · Cited by 330 · see citing works
Brain-Gut-Microbiota Axis and Mental Health
Dinan, T. G., & Cryan, J. F. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000519 · Cited by 325 · see citing works
Self-citationGut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Self-citationRecent developments in understanding the role of the gut microbiota in brain health and disease
Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works
Self-citationInternational Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
Cross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works
Self-citationRevisit gut microbiota and its impact on human health and disease
Ding, R., Goh, W.-R., Wu, R., Yue, X., Luo, X. G., Khine, W. W. T., Wu, J., & Lee, Y. K. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.012 · Cited by 269 · see citing works
Chunchai, T., Thunapong, W., Yasom, S., Wanchai, K., Eaimworawuthikul, S., Metzler, G., Lungkaphin, A., Pongchaidecha, A., Sirilun, S., Chaiyasut, C., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1055-2 · Cited by 273 · see citing works
Hao, Z., Wang, W., Guo, R., & Liu, H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.025 · Cited by 242 · see citing works
Mitrea, L., Nemeș, S. A., Szabo, K., Teleky, B., & Vodnar, D. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.813204 · Cited by 242 · see citing works
Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236 · see citing works
Self-citationMoving from probiotics to precision probiotics
Veiga, P., Suez, J., Derrien, M., & Elinav, E. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0721-1 · Cited by 235 · see citing works
The Microbiome in Psychology and Cognitive Neuroscience
Sarkar, A., Harty, S., Lehto, S. M., Moeller, A. H., Dinan, T. G., Dunbar, R., Cryan, J. F., & Burnet, P. W. J. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.04.006 · Cited by 231 · see citing works
Self-citationThe role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works
Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works
Making Sense of … the Microbiome in Psychiatry
Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 223 · see citing works
Self-citationYou’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works
Self-citationAntidepressive Mechanisms of Probiotics and Their Therapeutic Potential
Yong, S. J., Tong, T., Chew, J., & Lim, W. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01361 · Cited by 217 · see citing works
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Crosstalk between the microbiota-gut-brain axis and depression
Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191 · see citing works
Harnessing Gut Microbes for Mental Health: Getting From Here to There
Bruce‐Keller, A. J., Salbaum, J. M., & Berthoud, H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.014 · Cited by 188 · see citing works
A review of dietary and microbial connections to depression, anxiety, and stress
Taylor, A. M., & Holscher, H. D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1493808 · Cited by 187 · see citing works
A psychology of the human brain-gut-microbiome axis
Allen, A. P., Dinan, T. G., Clarke, G., & Cryan, J. F. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12309 · Cited by 174 · see citing works
Self-citationDo bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis
de Weerth, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.016 · Cited by 181 · see citing works
Stress and the gut microbiota-brain axis
Molina‐Torres, G., Rodríguez-Arrastia, M. J., Román, P., Sánchez‐Labraca, N., & Cardona, D. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000478 · Cited by 186 · see citing works
Snigdha, S., Ha, K., Tsai, P., Dinan, T. G., Bartos, J. D., & Shahid, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107978 · Cited by 171 · see citing works
Self-citationThe gut microbiome and mental health: implications for anxiety- and trauma-related disorders
Malan-Muller, S., Valles-Colomer, M., Raes, J., Lowry, C. A., Seedat, S., & Hemmings, S. M. J. (2018) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2017.0077 · Cited by 161 · see citing works
Wang, H., Braun, C., Murphy, E. F., & Enck, P. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000203 · Cited by 159 · see citing works
Self-citationGutted! Unraveling the Role of the Microbiome in Major Depressive Disorder
Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000243 · Cited by 159 · see citing works
Self-citationWiley, N., Dinan, T. G., Ross, R. P., Stanton, C., Clarke, G. A., & Cryan, J. F. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1256 · Cited by 180 · see citing works
Self-citationPsychobiotics: The Next-Generation Probiotics for the Brain
Sharma, R., Gupta, D., Mehrotra, R., & Mago, P. (2021) · Current Microbiology · doi:10.1007/s00284-020-02289-5 · Cited by 159 · see citing works
Ma, T., Jin, H., Kwok, L., Sun, Z., Liong, M., & Zhang, H. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100294 · Cited by 153 · see citing works
Short-chain fatty acids-producing probiotics: A novel source of psychobiotics
Cheng, Y., Liu, J., & Ling, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1920884 · Cited by 155 · see citing works
Yunes, R. А., Poluektova, E. U., Васильева, Е. В., Odorskaya, M. V., Марсова, М. В., Kovalev, G. I., & Даниленко, В. Н. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09601-1 · Cited by 150 · see citing works
Gut Microbiota: A Perspective for Psychiatrists
Rea, K., Dinan, T. G., & Cryan, J. F. (2019) · Neuropsychobiology · doi:10.1159/000504495 · Cited by 142 · see citing works
Self-citationThe role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Aljumaah, M. R., Bhatia, U., Roach, J., Gunstad, J., & Peril, M. A. A. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.09.012 · Cited by 138 · see citing works
Chao, L., Liu, C., Sutthawongwadee, S., Li, Y., Lv, W., Chen, W., Yu, L., Zhou, J., Guo, A., Li, Z., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00421 · Cited by 125 · see citing works
The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 132 · see citing works
Virk, M. S., Virk, M. A., He, Y., Tufail, T., Gul, M., Qayum, A., Rehman, A., Rashid, A., Ekumah, J., Han, X., et al. (2024) · Nutrients · doi:10.3390/nu16040546 · Cited by 137 · see citing works
Reis, D. J., Ilardi, S. S., & Punt, S. E. W. (2018) · PLOS ONE · doi:10.1371/journal.pone.0199041 · Cited by 123 · see citing works
Stress matters: randomized controlled trial on the effect of probiotics on neurocognition
Papalini, S., Michels, F., Kohn, N., Wegman, J., van Hemert, S., Roelofs, K., Arias-Vasquez, A., & Aarts, E. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100141 · Cited by 123 · see citing works
Bloemendaal, M., Szopinska-Tokov, J., Belzer, C., Boverhoff, D., Papalini, S., Michels, F., van Hemert, S., Arias Vasquez, A., & Aarts, E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01404-9 · Cited by 118 · see citing works
Gut microbiome patterns depending on children’s psychosocial stress: Reports versus biomarkers
Michels, N., de Wiele, T. V., Fouhy, F., O’Mahony, S. M., Clarke, G. A., & Keane, J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.024 · Cited by 115 · see citing works
Self-citationThe role of the gut microbiome in the development of schizophrenia
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. A., & Dinan, T. G. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.02.010 · Cited by 119 · see citing works
Self-citationTooley, K. L. (2020) · Nutrients · doi:10.3390/nu12103009 · Cited by 111 · see citing works
Tette, F.-M., Kwofie, S. K., & Wilson, M. D. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44040096 · Cited by 114 · see citing works
Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review
Yang, B., Wei, J., Ju, P., & Chen, J. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100056 · Cited by 111 · see citing works
Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling
Cowan, C. S. M., Hoban, A. E., Ventura‐Silva, A. P., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2017) · BioEssays · doi:10.1002/bies.201700172 · Cited by 107 · see citing works
Self-citationZhang, Y., Cao, M., Li, Y., Dai, G.-C., Lu, P., Zhang, M., Bai, L., Chen, X.-X., Zhang, C., Shi, L., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2047005 · Cited by 110 · see citing works
Finding the needle in the haystack: systematic identification of psychobiotics
Bambury, A., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14127 · Cited by 107 · see citing works
Self-citationNishida, K., Sawada, D., Kuwano, Y., Tanaka, H., Sugawara, T., Aoki, Y., Fujiwara, S., & Rokutan, K. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.031 · Cited by 104 · see citing works
Gut Microbiota Interaction with the Central Nervous System throughout Life
Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 107 · see citing works
Higarza, S. G., Arboleya, S., Arias, J. L., Gueimonde, M., & Arias, N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1880240 · Cited by 104 · see citing works
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101 · see citing works
Psychobiotics: the Influence of Gut Microbiota on the Gut-Brain Axis in Neurological Disorders
Oroojzadeh, P., Bostanabad, S. Y., & Lotfi, H. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02053-3 · Cited by 105 · see citing works
Schneider, E., Doll, J. P. K., Schweinfurth, N., Kettelhack, C., Schaub, A.-C., Yamanbaeva, G., Varghese, N., Mählmann, L., Brand, S., Eckert, A., et al. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220117 · Cited by 107 · see citing works
Microbiota-gut-brain research: A critical analysis
Hooks, K. B., Konsman, J. P., & O’Malley, M. A. (2018) · Behavioral and Brain Sciences · doi:10.1017/s0140525x18002133 · Cited by 101 · see citing works
Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 101 · see citing works
Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
Radford‐Smith, D. E., & Anthony, D. C. (2023) · Nutrients · doi:10.3390/nu15081880 · Cited by 108 · see citing works
The Microbiome and Eating Disorders
Seitz, J., Trinh, S., & Herpertz‐Dahlmann, B. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.10.004 · Cited by 93 · see citing works
Fecal Microbial Transplantation and Its Potential Application in Cardiometabolic Syndrome
Leshem, A., Horesh, N., & Elinav, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01341 · Cited by 95 · see citing works
Man and the Microbiome: A New Theory of Everything?
Butler, M., Cryan, J. F., & Dinan, T. G. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095432 · Cited by 91 · see citing works
Self-citationVaghef‐Mehrabany, E., Maleki, V., Behrooz, M., Ranjbar, F., & Ebrahimi‐Mameghani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.004 · Cited by 95 · see citing works
Busnelli, M., Manzini, S., & Chiesa, G. (2019) · Nutrients · doi:10.3390/nu12010079 · Cited by 91 · see citing works
Navarro‐Tapia, E., Almeida-Toledano, L., Sebastiani, G., Serra-Delgado, M., García‐Algar, Ó., & Andreu-Férnández, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052351 · Cited by 91 · see citing works
Marx, W., Scholey, A., Firth, J., D’Cunha, N. M., Lane, M., Hockey, M., Ashton, M. M., Cryan, J. F., O’Neil, A., Naumovski, N., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.036 · Cited by 87 · see citing works
Self-citationButler, M., Mörkl, S., Sandhu, K. V., Cryan, J. F., & Dinan, T. G. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719874168 · Cited by 89 · see citing works
Self-citationSanborn, V. E., Azcárate-Peril, M. A., Updegraff, J. A., Manderino, L. M., & Gunstad, J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s270035 · Cited by 86 · see citing works
Psychobiotics, gut microbiota and fermented foods can help preserving mental health
Casertano, M., Fogliano, V., & Ercolini, D. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110892 · Cited by 89 · see citing works
McVey Neufeld, K.-A., Kay, S., & Bienenstock, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00294 · Cited by 79 · see citing works
Self-citationLe Morvan de Sequeira, C., Hengstberger, C., Enck, P., & Mack, I. (2022) · Nutrients · doi:10.3390/nu14030621 · Cited by 82 · see citing works
Baldi, S., Mundula, T., Nannini, G., & Amedei, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i39.6715 · Cited by 85 · see citing works
The intestinal microbiome and its relevance for functionality in older persons
Ticinesi, A., Tana, C., & Nouvenne, A. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000521 · Cited by 80 · see citing works
Irritable Bowel Syndrome and Stress-Related Psychiatric Co-morbidities: Focus on Early Life Stress
O’Mahony, S. M., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_128 · Cited by 75 · see citing works
Self-citationA preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants
Rosin, S., Xia, K., Azcarate-Peril, M. A., Carlson, A. L., Propper, C. B., Thompson, A. L., Grewen, K., & Knickmeyer, R. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105046 · Cited by 74 · see citing works
Novel Pharmacological Approaches to the Treatment of Depression
Elias, E., Zhang, A. Y., & Manners, M. T. (2022) · Life · doi:10.3390/life12020196 · Cited by 74 · see citing works
Kuijer, E. J., & Steenbergen, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105296 · Cited by 71 · see citing works
Billeci, L., Callara, A. L., Guiducci, L., Prosperi, M., Morales, M. A., Calderoni, S., Muratori, F., & Santocchi, E. (2023) · Autism · doi:10.1177/13623613221082710 · Cited by 69 · see citing works
Xiao, J., Wang, T., Xu, Y., Gu, X., Li, D., Niu, K., Wang, T., Zhao, J., Zhou, R., & Wang, H.-L. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0719-8 · Cited by 70 · see citing works
Animal inflammation-based models of depression and their application to drug discovery
Ma, L., Demin, K. A., Kolesnikova, T. O., Kharsko, S. L., Zhu, X., Yuan, X., Song, C., Мешалкина, Д. А., Leonard, B. E., Tian, L., et al. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1362385 · Cited by 68 · see citing works
Slykerman, R. F., Kang, J., van Zyl, N., Barthow, C. A., Wickens, K. L., Stanley, T., Coomarasamy, C., Purdie, G., Murphy, R. J., Crane, J., et al. (2018) · Acta Paediatrica · doi:10.1111/apa.14590 · Cited by 67 · see citing works
- Authors
- Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., Clarke, G., & Dinan, T. G.
- Affiliations
- University College Cork (IE)
- Alimentary Health (Ireland) (IE)
- McMaster University (CA)
- Corresponding author
- Dinan, Timothy G.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 61
- Pages
- 50-59
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2554850339
- Cited by
- 355
- References
- 75
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 28 · 2023: 47 · 2022: 42 · 2021: 46 · 2020: 36 · 2019: 44 · 2018: 32 · 2017: 26
- FWCI
- 42.85
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
- Funders
- SFI (SFI/12/RC/2273)
- HRB (HRA_POR/2011/23, HRA_POR/2012/32, HRA-POR-2-14-647, MYNEWGUT FP7-KBBE-2013-7)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- psychobiotics, probiotics, stress, cognitive performance, hypothalamic-pituitary-adrenal axis, salivary cortisol, inflammation, cytokines, TLR4, visuospatial memory, emotion recognition, healthy men
- MeSH terms
- Adult, Attention, Brain, Cognition, Double-Blind Method, Electroencephalography, Humans, Hydrocortisone, Male, Neuropsychological Tests, Saliva, Stress, Psychological, Cytokines, Cross-Over Studies, Probiotics, Lacticaseibacillus rhamnosus, Young Adult, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
