Overcoming TGFβ-mediated immune evasion in cancer

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148

The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments

Son, Y. M., & Kim, J. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2208.08002 · Cited by 23

Tumor Cell-derived Extracellular Vesicles in Modulating Phenotypes and Immune Functions of Macrophages: Mechanisms and Therapeutic Applications

Tian, J.-W., Zhang, H., Siyuan, L., Guo, Y.-L., Chen, G., & Yu, Z. (2023) · Journal of Cancer · doi:10.7150/jca.84632 · Cited by 25

Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its targeting

Hourani, T., Sharma, A., Luwor, R. B., & Achuthan, A. A. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2411998 · Cited by 24

Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue

Gabriel, M. T., Tekpli, X., Reine, T. M., Hegge, B., Nielsen, S. R., Chen, M., Moi, L. L. H., Normann, L. S., Busund, L., Călin, G. A., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.868868 · Cited by 22

Reprogramming of regulatory T cells in inflammatory tumor microenvironment: can it become immunotherapy turning point?

Liu, J., Zhang, B., Zhang, G., & Shang, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345838 · Cited by 21

CD8+ T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance

Lao, L., Zeng, W., Huang, P., Chen, H., Jia, Z., Wang, P., Huang, D., Chen, J.-N., Nie, Y., Yang, L., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0356 · Cited by 21

Targeting inflammatory microenvironments: overcoming therapy resistance and immunosuppression

Zhou, Y., Bai, M., Chen, L., Han, H., Hou, S., Wang, X., Fan, P., Han, S., Chen, F., Li, J., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02583-z · Cited by 24

Comprehensive characterization of TGFB1 across hematological malignancies

Wang, C., Zhang, Z., Zhang, Y., Zheng, L., Liu, Y., Yan, A., Zhang, Y.-C., Chang, Q.-H., Sha, S., & Xu, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-46552-8 · Cited by 21

TGF-β: an active participant in the immune and metabolic microenvironment of multiple myeloma

Xue, H.-Y., & Fang, W. (2024) · Annals of Hematology · doi:10.1007/s00277-024-05843-4 · Cited by 20

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Lyu, L., Yi, M., Chen, J., Zhang, J., Ma, X., Zhang, X., Zeng, L., Xue, Y., Wen, H., Deng, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202501819 · Cited by 19

Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy

Barcellos‐Hoff, M. H., & Gulley, J. L. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3750 · Cited by 21

Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes

Kartal, B., Garris, C., Kim, H. S., Köhler, R. H., Carrothers, J. E., Halabi, E. A., Iwamoto, Y., Goubet, A., Xie, Y., Wirapati, P., et al. (2024) · Advanced Science · doi:10.1002/advs.202410360 · Cited by 21

Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer

Iwane, K., Nakanishi, Y., Muta, Y., Chen, J., Yasumura, K., Omatsu, M., Aoyama, N., Ikeda, M., Masui, Y., Cai, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66485-2 · Cited by 20

Distinct cellular immune profiles in lung adenocarcinoma manifesting as pure ground glass opacity versus solid nodules

Qu, R., Ye, F., Hu, S., Wang, B., Qin, S., Xiong, J., Fu, X., Li, L., & Cai, Y. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04289-3 · Cited by 18

TGFβ in Pancreas and Colorectal Cancer: Opportunities to Overcome Therapeutic Resistance

Johansen, A. M., Forsythe, S. D., McGrath, C. T., Barker, G., Jimenez, H., Paluri, R. K., & Pasche, B. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0468 · Cited by 19

Comprehensive PTM profiling with SCASP-PTM uncovers mechanisms of p62 degradation and ALDOA-mediated tumor progression

Lin, Z.-P., Gan, G., Xu, X., Wen, C., Ding, X., Chen, X., Zhang, K., Guo, W., Lin, M., Wang, Y.-Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115500 · Cited by 19

Stalled CARs: Mechanisms of Resistance to CAR T Cell Therapies

Salas‐Benito, D., Berger, T. R., & Maus, M. V. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-012235 · Cited by 17

Transforming growth factor-β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis

Ibi, H., Takahashi, K., Harada, H., Watabe, T., & Podyma‐Inoue, K. A. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149965 · Cited by 17

The role of NK cells in regulating tumorimmunity: current state, challenges and future strategies

Zhu, W., Fan, C., Zhao, Y., Li, W., Niu, J., Dong, S., Yang, Z., & Zhou, W. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03980-y · Cited by 17

Meaningful connections: Interrogating the role of physical fibroblast cell–cell communication in cancer

Gardiner, J. C., & Cukierman, E. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.004 · Cited by 16

The emerging era of personalized medicine in advanced colorectal cancer

Wu, C. W., Reid, M., Leedham, S. J., & Lui, R. N.-S. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15937 · Cited by 17

The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes

Rafia, C., Loizeau, C., Renoult, O., Harly, C., Pecqueur, C., Joalland, N., & Scotet, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1066336 · Cited by 16

From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer

Pereira, F., Fernández‐Barral, A., Larriba, M. J., Barbáchano, A., & González‐Sancho, J. M. (2023) · FEBS Journal · doi:10.1111/febs.16955 · Cited by 18

Advances in immunology of obstructive sleep apnea: mechanistic insights, clinical impact, and therapeutic perspectives

Dong, N., & Yue, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1654450 · Cited by 18

Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

Li, J., Liu, H., Guo, Q., Zhang, Y., Li, J., Diao, T., Zheng, L., Deng, Z., Yang, Y., Chen, X., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2025.12.018 · Cited by 16

A Bifunctional Antibody Targeting PD-1 and TGF-β Signaling Has Antitumor Activity in Combination with Radiotherapy and Attenuates Radiation-Induced Lung Injury

Wang, S., Xu, D., Wang, Y., Zhou, Y., Xiao, L., Li, F., Tu, J., Qin, W., Tian, S., Zheng, B., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0903 · Cited by 14

Inflammation-associated drug resistance and tumor growth in TNBC

Hassan, A. F., Kheraldine, H., Abujamous, L., Al-Thawadi, H., & Elhissi, A. M. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1623137 · Cited by 15

Cancer Stem Cells Decide the Fate of Cancer Immunotherapy by Remodeling Tumor Microenvironment

Chakraborty, S., Basak, U., Mukherjee, S., Mukherjee, S., & Das, T. (2025) · Cancer Control · doi:10.1177/10732748251381441 · Cited by 16

Effective Antitumor Immunity Can Be Triggered by Targeting VISTA in Combination with a TLR3-Specific Adjuvant

Wang, B., Ou, Z., Zhong, W., Huang, L., Liao, W., Sheng, Y., Guo, Z., Chen, J., Yang, W., Chen, K., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0117 · Cited by 14

Red Blood Cell Membrane-Camouflaged Nanoparticles for Synergistic Sonodynamic Therapy and TGF-β Inhibition to Reprogram Immunosuppressive Tumor Microenvironment

Liao, Z., Liao, H., Luo, Y., Chen, S., Chen, M., He, J., Xu, Y., Wang, L., & Niu, C. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c07008 · Cited by 14

The Potential of Antibody Technology and Silver Nanoparticles for Enhancing Photodynamic Therapy for Melanoma

Malindi, Z., Barth, S., & Abrahamse, H. (2022) · Biomedicines · doi:10.3390/biomedicines10092158 · Cited by 14

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

Dai, Y., Luo, X., Zhang, L., & Yan, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1742654 · Cited by 13

Mapping intratumor heterogeneity across layers for advancing immunotherapy

Marine, J., Bartok, O., Sagie, S., Vitiello, P. P., Bardelli, A., Weller, C., Chang, T., Tonelli, C., Spranger, S., Ruppin, E., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.025 · Cited by 16

Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition

Luong, T., & Cukierman, E. (2022) · BMC Cancer · doi:10.1186/s12885-022-10330-y · Cited by 14

Nanomedicines: intervention in inflammatory pathways of cancer

Anwar, F., Naqvi, S., Shams, S., Sheikh, R. A., Al-Abbasi, F. A., Asseri, A. H., Baig, M. R., & Kumar, V. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01217-w · Cited by 13

Mn-CaCO3-based nanosystem for augmented sonodynamic-chemodynamic immunotherapy via PI3K/Akt signaling pathway

Sha, M., Li, H., Liu, Y., Tang, C., Bai, X., Wang, Y., Yuan, B., Liu, K., Gao, X., Yan, J., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149450 · Cited by 13

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells

Guo, F., Zhang, L., Yu, Y., Gong, L., Tao, S., Werder, R. B., Mishra, S. V., Zhou, Y., Anamika, W. J., Lao, T., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105026 · Cited by 13

Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses

Tapia‐Galisteo, A., Sánchez-Rodríguez, I., Narbona, J., Iglesias-Hernández, P., Aragón-García, S., Jiménez-Reinoso, A., Compte, M., Khan, S. A., Tsuda, T., Chames, P., et al. (2024) · OncoImmunology · doi:10.1080/2162402x.2024.2338558 · Cited by 13

Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy

Huang, X., Han, L., Wang, R., Zhu, W., Zhang, N., Qu, W., Liu, W., Liu, F., Feng, F., & Xue, J. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2069877 · Cited by 13

Advances in the potential roles of Cullin-RING ligases in regulating autoimmune diseases

Zhang, X., Liu, Y., Zhang, T., Tan, Y., Dai, X., Yang, Y., & Zhang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125224 · Cited by 15

Clonal Hematopoiesis in Cancer and Cardiovascular Disease

Evans, M. A., & Walsh, K. X. (2025) · JACC CardioOncology · doi:10.1016/j.jaccao.2025.06.006 · Cited by 14

Programmed cyclodextrin-based core–shell nanoparticles for cooperative TGF-β blockade to reverse immunosuppression post photodynamic therapy

Han, L., Huang, X., Zhu, H., Wang, R., Zhao, B., Liu, S., Li, Q., Qian, W., Feng, F., Liu, F., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140830 · Cited by 12

Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer

Mouillet‐Richard, S., Gougèlet, A., Passet, B., Brochard, C., Corre, D. L., Pitasi, C. L., Joubel, C., Sroussi, M., Gallois, C., Lavergne, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05164-0 · Cited by 12

Angiogenesis and immune microenvironment in triple-negative breast cancer: Targeted therapy

Zhang, Y., Yang, H., Jiang, Y., Jiang, Y., & Mao, R. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167880 · Cited by 16

SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Murimwa, G. Z., Williams, N. E., Alzhanova, D. V., Mohammadi, A., Westcott, J. M., Beato, F., Dai, R., Nivelo, L. A., Rossi, F., Fleming, H. K., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-1970 · Cited by 13

Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer

Jiang, Y., Liu, Y., Huang, H., Zhao, T., Zhao, Z., & Gao, Y. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03926-9 · Cited by 11

Emerging trends and converging evidence in tumor evolution: A comprehensive review

Jin, C., Li, W., Liu, B., Cao, L.-Q., Stefan, S. M., Yuan, L., Yu, X., Shi, L., & Yu, H. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101380 · Cited by 12

Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction

Guo, J., Zhao, J., Sun, L., & Chen, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.955718 · Cited by 11

Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response

Qiu, Y., Wang, Y., Liu, J., Sun, K., Liu, B., & Hou, Q. (2025) · BMC Cancer · doi:10.1186/s12885-025-14212-x · Cited by 12

Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy

Liao, W., Zhou, X., Lin, H., Feng, Z., Chen, X., Chen, Y., Chen, M., Lin, M., YAO, G., Chen, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1557461 · Cited by 12

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer

Liu, Y., Zhou, M., Wu, J., Wen, Z., Fang, Y. V., Li, L., Luo, M., Sun, L., & Liao, W. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06919-4 · Cited by 11

Sequentially targeting and intervening mutual Polo-like Kinase 1 on CAFs and tumor cells by dual targeting nano-platform for cholangiocarcinoma treatment

Zhou, Y., Xu, L., Wang, Z., Liu, H., Zhang, X., Shu, C., Zhang, M., Wang, T., Xu, X., Pu, X., et al. (2022) · Theranostics · doi:10.7150/thno.70557 · Cited by 11

Immunogenic cell death triggered by impaired deubiquitination in multiple myeloma relies on dysregulated type I interferon signaling

Sadiq, Z. W., Brioli, A., Al‐Abdulla, R., Çetin, G., Schütt, J., Escobar, H. M., Krüger, E., & Ebstein, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.982720 · Cited by 11

Computational modeling of multiple myeloma interactions with resident bone marrow cells

Urdeitx, P., Mousavi, S. J., Avril, S., & Doweidar, M. H. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106458 · Cited by 10

Machine learning identifies the role of SMAD6 in the prognosis and drug susceptibility in bladder cancer

Chen, Z., Ou, Y., Ye, F., Li, W., Jiang, H., & Liu, S. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05798-z · Cited by 10

Mechanisms of tumor-associated macrophages promoting tumor immune escape

Li, S., Zhang, M., Gao, Y., Zhao, C., Liao, S., Zhao, X., Ning, Q., & Tang, S. (2025) · Carcinogenesis · doi:10.1093/carcin/bgaf023 · Cited by 11

Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy

Zhang, M., Chen, Y., Li, Y., Zhao, Y., Lv, B., Cao, J., Yu, B., & Cong, H. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111588 · Cited by 10

Activation of transforming growth factor beta 1 through integrin alpha V beta 6 and its molecular insights into cancer progression, and future directions

Deb, V. K., & Jain, U. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147121 · Cited by 11

Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF ‐β/Smad pathway

Wu, Y., Hong, L., Ling, Z., Hu, X., Liu, Z., Li, P., & Ling, Z. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24617 · Cited by 9

Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinomaPreprint

Peng, Y., Yang, J., Ao, J., Li, Y., Shen, J., He, X., Tang, D., Chu, C., Liu, C., & Weng, L. (2024) · eLife · doi:10.7554/elife.97335 · Cited by 10

Context-Dependent Regulation of Peripheral Nerve Abundance by the PI3K Pathway in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma

Khorani, K., Burkart, S., Weusthof, C., Han, R., Liang, S., Stögbauer, F., & Heß, J. (2024) · Cells · doi:10.3390/cells13121033 · Cited by 9

Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC

Piqué‐Gili, M., Andreu-Oller, C., Mesropian, A., Esteban-Fabró, R., Bárcena‐Varela, M., de Galarreta, M. R., Montironi, C., Martinez-Quetglas, I., Cappuyns, S., Peix, J., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101212 · Cited by 9

TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

White, S. E., Schwartze, T. A., Mukundan, A., Schoenherr, C., Singh, S. P., van Dinther, M., Cunningham, K. T., White, M. P. J., Campion, T., Pritchard, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56954-z · Cited by 9

Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer

Jiang, H., Kuang, L., Zhang, T., & Zhao, X. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10042-6 · Cited by 11

Co-targeting TGF-β and PD-L1 sensitizes triple-negative breast cancer to experimental immunogenic cisplatin-eribulin chemotherapy doublet

Kalfeist, L., Ledys, F., Petit, S., Poirrier, C., Mohammed, S. K., Galland, L., Dérangère, V., Ilie, A., Rageot, D., Aucagne, R., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184422 · Cited by 9

Inflammatory burden index predicts long term mortality in a nationally representative population from NHANES

Li, W., Zhao, D., & Li, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-09574-y · Cited by 9

TGF-β-mediated suppression of NK cell function and targeting strategies in tumor immunotherapy

Wang, B., & Bi, J. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105141 · Cited by 10

Membrane-derived biomimetic nanovesicles in anti-tumor immunotherapy: Advances and outlook

Zhang, X., Jing, H., Wang, Y., Mu, S., Wang, X., Zheng, H., Chen, Y., Wang, K., Sun, J., Bi, J., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.01.019 · Cited by 11

A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment

Jones, C. E., Sharick, J. T., Sizemore, S. T., Cukierman, E., Strohecker, A. M., & Leight, J. L. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0157 · Cited by 9

Mitochondrial-targeted photodynamic therapy combined with TGF-β inhibition potentiates anti-PD-1 therapy in pancreatic ductal adenocarcinoma

Xu, S., Yang, N., Du, F., Zhang, Z., Zhang, Y., Zhang, Y., Liang, J., Zhao, Y., Zhang, J., Zhang, Z., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03795-z · Cited by 8

Regulatory T cells in cancer and inflammation

Yang, H., Zhang, H., Xia, N., & Cheng, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02584-w · Cited by 8

Killers on the loose: Immunotherapeutic strategies to improve NK cell-based therapy for cancer treatment

Dunai, C., Ames, E., Ochoa, M. C., Fernández-Sendin, M., Melero, I., Simonetta, F., Baker, J. B., & Álvarez, M. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.001 · Cited by 8

TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy

Han, L., Huang, X., Zhao, B., Zhu, H., Wang, R., Liu, S., Lin, H., Feng, F., Ma, X., Liu, F., et al. (2023) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03479-3 · Cited by 8

hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC

Trono, P., Tocci, A., Palermo, B., Carlo, A. D., D’Ambrosio, L., D’Andrea, D., Modugno, F. D., Nicola, F. D., Goeman, F., Corleone, G., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006913 · Cited by 9

Targeting CAFs to Improve Anti-PD-1 Checkpoint Immunotherapy

Tauriello, D. V. F. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3677 · Cited by 8

Blocking TGFβR synergistically enhances anti-tumor effects of anti-PD-1 antibody in a mouse model of incomplete thermal ablation

Ju, S., Duan, X., Wang, Y., Zhang, M., Bai, Y., He, X., Wang, C., Liu, J., Yao, W. Q., Zhou, C., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112585 · Cited by 7

Coagulation-Targeted TGF-β Signaling Pathway Inhibitor Nanomedicine for Inhibiting the Growth and Lung Metastasis of Breast Cancer

Xu, Y., Lv, J., Liu, Y., Du, J., Luo, C., Wang, Y., Liu, L., Sakurai, K., Tang, Z., & Chen, X. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c05355 · Cited by 7

Tumor infiltration of inactive CD8 + T cells was associated with poor prognosis in Gastric Cancer

Katayama, N., Ohuchida, K., Son, K., Tsutsumi, C., Mochida, Y., Noguchi, S., Iwamoto, C., Torata, N., Horioka, K., Shindo, K., et al. (2024) · Gastric Cancer · doi:10.1007/s10120-024-01577-4 · Cited by 7

Targeted protein degradation with small molecules for cancer immunotherapy

Yang, Z., Xu, J., Yang, X., & Chen, J. (2025) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2025.101058 · Cited by 7

CD47-mediated tumor microenvironment remodeling: a central mechanism in immune evasion

Yuan, H., Zhu, L., Yang, L., Yi, Y., & Lv, T. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025071 · Cited by 8

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

Wen, J., Li, B., Wang, S., Yao, Y., Huang, Z., & Yu, D. (2026) · MedComm · doi:10.1002/mco2.70604 · Cited by 11

Copper-coordinated self-assembly nanogels for efficient cancer immunotherapy by synergistic suppression of tumor-infiltrating regulatory T cells

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A TGF-β–dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children

Xiao, X., Hao, Y., Cheng, C., Hu, H., Chen, H., Tan, J., Wang, Y., Liu, X., Peng, B., Liao, J., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000534 · Cited by 7

Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference

Talebi, F., Gregucci, F., Ahmed, J. U., Ben‐Chetrit, N., Brown, B. D., Chan, T. A.-T., Chand, D. S., Constanzo, J., Demaria, S., Gabrilovich, D. I., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2507856 · Cited by 6

Targeting the tumor immune microenvironment in chordoma: From mechanistic insights to therapeutic breakthroughs

Zhang, H. F., Xing, J., Yuan, Z., Zhao, C., & Yang, C. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189520 · Cited by 6

FOXP2 inhibits the aggressiveness of lung cancer cells by blocking TGFβ signaling

Su, W., Hu, S., Zhou, L., Bi, H. C., & Li, Z. (2024) · Oncology Letters · doi:10.3892/ol.2024.14361 · Cited by 6

Integrated analysis reveals an aspartate metabolism-related gene signature for predicting the overall survival in patients with hepatocellular carcinoma

Shi, J., Wen, K., Mui, S., Li, H., Liao, H., He, C., Yan, Y., Zhou, Z., & Xiao, Z. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03431-6 · Cited by 6

Revealing Cellular Heterogeneity and Key Regulatory Factors of Triple-Negative Breast Cancer through Single-Cell RNA Sequencing

Zhang, H., Sun, Y., & Du, X. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2908290 · Cited by 7

ATP6V1C1, associated with the tumor microenvironment and mTORC1 signaling pathway, is a potential diagnostic, prognostic, and therapeutic biomarker for hepatocellular carcinoma

Pan, Y., Chen, H., Lv, C., He, W., Xu, Y., & Xuan, Q. (2024) · Discover Oncology · doi:10.1007/s12672-024-01578-w · Cited by 6

Multiphasic Heterogeneity of Fibroblasts in the Microenvironment of Pancreatic Ductal Adenocarcinoma: Dissection and the Sum of the Dynamics

Ijichi, H. (2022) · Cancers · doi:10.3390/cancers14194880 · Cited by 6

An immune and epithelial–mesenchymal transition-related risk model and immunotherapy strategy for grade II and III gliomas

Luo, W., Quan, Q., Jiang, J., & Peng, R. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1070630 · Cited by 6

Integrated multiomics analyses unveil the implication of a costimulatory molecule score on tumor aggressiveness and immune evasion in breast cancer: A large-scale study through over 8,000 patients

Zhang, D., Wang, Y., Zhao, F., & Yang, Q. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106866 · Cited by 5

Primary tumor-induced immunity suppresses bone metastases of breast cancer in syngeneic immunocompetent mouse models

Hiraga, T., Nishida, D., & Horibe, K. (2023) · Bone · doi:10.1016/j.bone.2023.116944 · Cited by 6

miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39

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Insights into inflammation and implications for the pathogenesis and long-term outcomes of endometrial cancer: genome-wide surveys and a clinical cohort study

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Comprehensive bioinformatics analysis of a RBM family-based prognostic signature with experiment validation in hepatocellular carcinoma

Wu, Z., Guo, L., Wan, L., Xu, K., Luo, L., & Wen, Z. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05084-4 · Cited by 6

Inhibition of recurrence and metastasis in triple-negative breast cancer through nanoparticle-mediated silencing of LPCAT1 to remodel ATP energy metabolism

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MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

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Neutrophil-Mediated Delivery Platforms for Synergistic Chemo-Immunotherapy of Non-Small-Cell Lung Cancer Therapy

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Feasibility IB trial of paclitaxel/carboplatin + Galunisertib. (a small molecule inhibitor of the kinase domain of type 1 TGF-B receptor) in patients with newly diagnosed, persistent or recurrent carcinosarcoma of the uterus or ovary

Washington, C., Dwivedi, S. K. D., Gunderson-Jackson, C., Walker, J. L., Mannel, R. S., Holman, L. L., Richardson, D. L., Neelakantan, D., Cohoon, A. J., Ding, K., et al. (2025) · Gynecologic Oncology · doi:10.1016/j.ygyno.2025.10.021 · Cited by 5

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 1

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366

TGF-β Signaling in Cancer Immunity: Immune Suppression, Stromal Remodeling, and Therapeutic Targeting

Jiang, M., Zhang, K., Zheng, X., Bo, Z., & Wei, R. (2026) · Cancer Biome and Targeted Therapy · doi:10.66505/cbtt.v1i2.17

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

van den Bulk, J., de Miranda, N. F. C. C., & ten Dijke, P. (2021) · Clinical Science · doi:10.1042/cs20201236 · Cited by 78