Overcoming TGFβ-mediated immune evasion in cancer

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148

Tumor-Associated Macrophages: From Mechanisms to Therapy

Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,470

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

The Transforming Growth Factor-Beta Family

Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Twyman-Saint Victor, C., Rech, A. J., Maity, A., Rengan, R., Pauken, K. E., Stelekati, E., Benci, J. L., Xu, B., Dada, H., Odorizzi, P. M., et al. (2015) · Nature · doi:10.1038/nature14292 · Cited by 2,434

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,269

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,210

Innate Lymphoid Cells: 10 Years On

Vivier, É., Artis, D., Colonna, M., Diefenbach, A., Santo, J. P. D., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.017 · Cited by 2,136

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,928

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851

Neutrophils in cancer: Neutral no more

Coffelt, S. B., Wellenstein, M. D., & de Visser, K. E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.52 · Cited by 1,830

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S. B., Álvarez‐Mon, M., Derynck, R., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.5.1037 · Cited by 1,581

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., & Tuveson, D. A. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0710 · Cited by 1,360

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

Long, E. O., Kim, H. S., Liu, D., Peterson, M., & Rajagopalan, S. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075005 · Cited by 1,258

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

Imai, K., Matsuyama, S., Miyaké, S., Suga, K., & Nakachi, K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03231-1 · Cited by 1,189

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., & Brenner, M. B. (1994) · Nature · doi:10.1038/372190a0 · Cited by 1,178

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,158

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C., Validire, P., Trautmann, A., Mami-Chouaib, F., & Donnadieu, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45817 · Cited by 1,138

Radiotherapy and immunotherapy: a beneficial liaison?

Weichselbaum, R. R., Liang, H. L., Deng, L., & Fu, Y. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.211 · Cited by 1,091

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Calon, A., Lonardo, E., Berenguer-Llergo, A., Espinet, E., Hernando-Momblona, X., Iglesias, M., Sevillano, M., Palomo-Ponce, S., Tauriello, D. V. F., Byrom, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3225 · Cited by 1,070

Tumour-associated neutrophils in patients with cancer

Shaul, M. E., & Fridlender, Z. G. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0222-4 · Cited by 1,067

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

Calon, A., Espinet, E., Palomo-Ponce, S., Tauriello, D. V. F., Iglesias, M., Céspedes, M. V., Sevillano, M., Nadal, C., Jung, P., Zhang, X. H.-F., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.013 · Cited by 1,060

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014

Latent TGF-β structure and activation

Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013

Tissue-resident memory T cells: local specialists in immune defence

Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taı̈eb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B. J., Vivier, É., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 1,004

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944

Dendritic Cells and Cancer Immunity

Gardner, A., & Ruffell, B. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.006 · Cited by 922

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866

Single-cell RNA sequencing reveals stromal evolution into LRRC15(+) myofibroblasts as a determinant of patient response to cancer immunotherapy

Dominguez, C. X., Müller, S., Keerthivasan, S., Koeppen, H., Hung, J., Gierke, S., Breart, B., Foreman, O., Bainbridge, T. W., Castiglioni, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0644 · Cited by 857

TGF-β Activation and Function in Immunity

Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856

Contextual determinants of TGFβ action in development, immunity and cancer

David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

Sagiv, J. Y., Michaeli, J., Assi, S., Mishalian, I., Kisos, H., Levy, L., Damti, P., Lumbroso, D., Polyansky, L., Sionov, R. V., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.039 · Cited by 842

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 830

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation

Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, É., Kroemer, G., Martin, F., Chauffert, B., & Zitvogel, L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050463 · Cited by 817

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 794

Specificity, versatility, and control of TGF-β family signaling

Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β1

Li, H., Han, Y., Guo, Q., Zhang, M., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.240 · Cited by 777

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine · doi:10.1038/nm1001-1118 · Cited by 770

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Kehrl, J. H., Roberts, A. B., Wakefield, L. M., Jakowlew, S. B., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.12.3855 · Cited by 759

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Castriconi, R., Cantoni, C., Chiesa, M. D., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 727

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

Mamessier, É., Sylvain, A., Thibult, M., Houvenaeghel, G. F., Jacquemier, J. D., Castellano, R., Gonçalvès, A., André, P., Romagné, F., Thibault, G., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45816 · Cited by 722

Signaling Receptors for TGF-β Family Members

Heldin, C.-H., & Moustakas, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022053 · Cited by 711

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

Reizis, B. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.027 · Cited by 702

Cancer-related inflammation: Common themes and therapeutic opportunities

Balkwill, F. R., & Mantovani, A. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.005 · Cited by 701

NK cells and cancer immunosurveillance

Waldhauer, I., & Steinle, A. (2008) · Oncogene · doi:10.1038/onc.2008.267 · Cited by 682

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Gao, Y., Souza-Fonseca-Guimarães, F., Bald, T., Ng, S. S., Young, A., Ngiow, S. F., Rautela, J., Straube, J., Waddell, N., Blake, S. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3800 · Cited by 681

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionPreprint

Sanjabi, S., Oh, S. A., & Li, M. O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022236 · Cited by 664

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Hong, M., Clubb, J. D., & Chen, Y. Y. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.005 · Cited by 659

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Chakravarthy, A., Khan, L., Bensler, N. P., Bose, P., & De Carvalho, D. D. (2018) · Nature Communications · doi:10.1038/s41467-018-06654-8 · Cited by 656

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

Yoram Vodovotz, B., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.605 · Cited by 649

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Kloss, C. C., Lee, J., Zhang, A., Chen, F., Melenhorst, J. J., Lacey, S. F., Maus, M. V., Fraietta, J. A., Zhao, Y., & June, C. H. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.003 · Cited by 648

Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis

Lichtman, M. K., Otero-Viñas, M., & Falanga, V. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12398 · Cited by 635

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 625

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Ohnmacht, C., Pullner, A., King, S. B. S., Drexler, I., Meier, S., Brocker, T., & Voehringer, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082394 · Cited by 597

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

Clayton, A., Mitchell, J. P., Court, J., Linnane, S. J., Mason, M. D., & Tabi, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7249 · Cited by 574

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Lahn, M. M. F., Herbertz, S., Sawyer, J. S., Stauber, A. J., Gueorguieva, I., Driscoll, K. E., Estrem, S. T., Cleverly, A., Desaiah, D., Guba, S. C., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s86621 · Cited by 571

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

Rook, A. H., Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Sporn, M. B., Burlington, D. B., Lane, H. C., & Fauci, A. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.10.3916 · Cited by 570

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

Gorelik, L., Constant, S. L., & Flavell, R. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012076 · Cited by 544

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15234 · Cited by 522

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz‐Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y., & Rao, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081242 · Cited by 518

TGFβ is a master regulator of radiation therapy-induced antitumor immunity

Vanpouille-Box, C., Diamond, J. M., Pilones, K. A., Zavadil, J., Babb, J. S., Formenti, S. C., Barcellos-Hoff, M. H., & Demaria, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3511 · Cited by 514

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature · doi:10.1038/nature06110 · Cited by 503

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

Bragado, P., Estrada, Y., Parikh, F., Krause, S., Capobianco, C., Farina, H. G., Schewe, D. M., & Aguirre-Ghiso, J. A. (2013) · Nature Cell Biology · doi:10.1038/ncb2861 · Cited by 503

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Lan, Y., Zhang, D., Xu, C., Hance, K. W., Marelli, B., Qi, J., Yu, H., Qin, G., Sircar, A., Hernández, V. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5488 · Cited by 502

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312172 · Cited by 500

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

Lindsay, M. E., Schepers, D., Bolar, N. A., Doyle, J. J., Gallo, E. M., Fert‐Bober, J., Kempers, M. J. E., Fishman, E. K., Chen, Y., Myers, L. A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2349 · Cited by 495

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients1

Lee, J.-C., Lee, K.-M., Kim, D.-W., & Heo, D. (2004) · Journal of Immunology · doi:10.4049/jimmunol.172.12.7335 · Cited by 488

Phase I study of GC1008 (fresolimumab): a human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma

Morris, J. C., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Reiss, M., Hsu, F. J., Berzofsky, J. A., & Lawrence, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090353 · Cited by 487

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 + regulatory T cells

Tran, D. Q., Andersson, J., Wang, R., Ramsey, H. E., Unutmaz, D., & Shevach, E. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901944106 · Cited by 473

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

Lodyga, M., & Hinz, B. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.010 · Cited by 467

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., Wymant, J. M., Jones, A. T., Kynaston, H., Mason, M. D., et al. (2014) · Oncogene · doi:10.1038/onc.2013.560 · Cited by 461

Novel therapies emerging in oncology to target the TGF‐β pathway

Kim, B.-G., Malek, E., Choi, S. H., Ignatz-Hoover, J. J., & Driscoll, J. J. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01053-x · Cited by 453

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

Laouar, Y., Sutterwala, F. S., Gorelik, L., & Flavell, R. A. (2005) · Nature Immunology · doi:10.1038/ni1197 · Cited by 452

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 451

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

Zhang, N., & Bevan, M. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.019 · Cited by 450

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases

Wolf, K., Müller, R., Borgmann, S., Bröcker, E., & Friedl, P. (2003) · Blood · doi:10.1182/blood-2002-12-3791 · Cited by 442

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

Sporn, M. B., Roberts, A. B., Shull, J. H., Smith, J. M., Ward, J. M., & Sodek, J. (1983) · Science · doi:10.1126/science.6572416 · Cited by 439

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Jackstadt, R., van Hooff, S. R., Leach, J. D. G., Cortés-Lavaud, X., Lohuis, J. O., Ridgway, R. A., Wouters, V. M., Roper, J., Kendall, T. J., Roxburgh, C. S. D., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.003 · Cited by 438

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Kaur, A., Ecker, B. L., Douglass, S. M., Kugel, C. H., Webster, M. R., Almeida, F. V., Somasundaram, R., Hayden, J. E., Ban, E., Ahmadzadeh, H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0193 · Cited by 437

TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors

Tang, N., Cheng, C. Y., Zhang, X., Qiao, M., Li, N., Mu, W., Wei, X., Han, W., & Wang, H. (2020) · JCI Insight · doi:10.1172/jci.insight.133977 · Cited by 424

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

Szczepański, M. J., Szajnik, M. E., Welsh, A., Whiteside, T. L., & Boyiadzis, M. M. (2011) · Haematologica · doi:10.3324/haematol.2010.039743 · Cited by 421

Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

Strauss, J., Heery, C. R., Schlom, J., Madan, R. A., Cao, L., Kang, Z., Lamping, E., Marté, J. L., Donahue, R. N., Grenga, I., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2653 · Cited by 406

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

Robertson, I. B., & Rifkin, D. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021907 · Cited by 403

The Optimal Efficiency and the Economic Degrees of Coupling of Oxidative Phosphorylation

Stucki, J. W. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04792.x · Cited by 394

Differences in tumor microenvironment dictate T helper lineage polarization and response to immune checkpoint therapy

Jiao, S., Subudhi, S. K., Aparicio, A., Ge, Z., Guan, B., Miura, Y., & Sharma, P. (2019) · Cell · doi:10.1016/j.cell.2019.10.029 · Cited by 386

Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma

Bates, R. C., Bellovin, D. I., Brown, C. L., Maynard, E., Wu, B., Kawakatsu, H., Sheppard, D., Oettgen, P., & Mercurio, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23183 · Cited by 380

Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non–Small-Cell Lung Cancer

Nemunaitis, J. J., Dillman, R. O., Schwarzenberger, P. O., Senzer, N. N., Cunningham, C. C., Cutler, J., Tong, A., Kumar, P., Pappen, B. O., Hamilton, C., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.5335 · Cited by 365

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

Mishalian, I., Bayuh, R., Levy, L., Zolotarov, L., Michaeli, J., & Fridlender, Z. G. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1476-9 · Cited by 364

Immunoregulation by members of the TGFβ superfamily

Chen, W., & ten Dijke, P. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.112 · Cited by 360

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116871 · Cited by 359

Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development

Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904100 · Cited by 357

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Holmgaard, R. B., Schaer, D. A., Li, Y., Castaneda, S. P., Murphy, M. Y., Xu, X., Inigo, I., Dobkin, J., Manro, J. R., Iversen, P. W., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0356-4 · Cited by 356

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Cortez, V. S., Ulland, T. K., Cervantes‐Barragán, L., Bando, J. K., Robinette, M. L., Wang, Q., White, A. J., Gilfillan, S., Cella, M., & Colonna, M. (2017) · Nature Immunology · doi:10.1038/ni.3809 · Cited by 350

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Rachidi, S., Metelli, A., Riesenberg, B., Wu, B. X., Nelson, M. H., Wallace, C., Paulos, C. M., Rubinstein, M. P., Garrett-Mayer, E. S., Hennig, M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aai7911 · Cited by 347

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

Kim, B., Li, C., Qiao, W., Mamura, M., Kasperczak, B., Anver, M. R., Wolfraim, L. A., Hong, S., Mushinski, E. B., Potter, M., et al. (2006) · Nature · doi:10.1038/nature04846 · Cited by 325

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K. A., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., V. Artemov, A., Wysocki, P. T., Mehra, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02696-6 · Cited by 325

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., et al. (2017) · Nature Communications · doi:10.1038/ncomms15221 · Cited by 321

Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity

Bollard, C. M., Rössig, C., Calonge, M. J., Huls, M. H., Wagner, H.-J., Massagué, J., Brenner, M. K., Heslop, H. E., & Rooney, C. M. (2002) · Blood · doi:10.1182/blood.v99.9.3179 · Cited by 316

Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma

Sun, H., Huang, Q., Huang, M., Wen, H., Lin, R., Zheng, M., Qu, K., Li, K., Wei, H., Xiao, W., et al. (2018) · Hepatology · doi:10.1002/hep.30347 · Cited by 302

Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells

Yu, J., Wei, M., Becknell, B., Trotta, R., Liu, S., Boyd, Z. S., Jaung, M., Blaser, B. W., Sun, J. P., Benson, D. M., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.016 · Cited by 288

TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

Trotta, R., Col, J. D., Yu, J., Ciarlariello, D., Thomas, B., Zhang, X., Allard, J., Wei, M., Mao, H. C., Byrd, J. C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3784 · Cited by 286

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

Li, W., Li, Q., Jiao, Y., Qin, L., Ali, R., Zhou, J., Ferruzzi, J., Kim, R. W., Geirsson, A., Dietz, H. C., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69942 · Cited by 284

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Anderton, M. J., Mellor, H. R., Bell, A., Sadler, C., Pass, M., Powell, S., Steele, S. J., Roberts, R. R. A., & Heier, A. (2011) · Toxicologic Pathology · doi:10.1177/0192623311416259 · Cited by 284

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

Tsushima, H., Kawata, S., Tamura, S., Ito, N., Shirai, Y., Kiso, S., Imai, Y., Shimomukai, H., Nomura, Y., Matsuda, Y., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566583 · Cited by 282

Resident memory T cells in the skin mediate durable immunity to melanoma

Malik, B. T., Byrne, K. T., Vella, J. L., Zhang, P., Shabaneh, T. B., Steinberg, S. M., Molodtsov, A. K., Bowers, J. S., Angeles, C. V., Paulos, C. M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6346 · Cited by 282

A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer

Giaccone, G., Bazhenova, L. A., Nemunaitis, J., Tan, M., Juhász, E., Ramlau, R., van den Heuvel, M. M., Lal, R., Kloecker, G. H., Eaton, K. D., et al. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.07.035 · Cited by 279

Clinical development of therapies targeting TGFβ: current knowledge and future perspectives

Ciardiello, D., Élez, E., Tabernero, J. M., & Seoane, J. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.07.009 · Cited by 279

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

Sad, S., & Mosmann, T. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.8.3514 · Cited by 278

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

Liu, Y., Lai, L., Chen, Q., Song, Y., Xu, S., Ma, F., Wang, X., Wang, J., Yu, H. C., Cao, X., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103505 · Cited by 278

TGF-β contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice

Maeda, H., & Shiraishi, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.73 · Cited by 273

TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease

El-Asady, R. S., Yuan, R., Liu, K., Wang, D., Gress, R. E., Lucas, P. J., Drachenberg, C. B., & Hadley, G. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041044 · Cited by 271

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation

Arwert, E. N., Harney, A. S., Entenberg, D. R., Wang, Y., Sahai, E. A., Pollard, J. W., & Condeelis, J. S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.007 · Cited by 264

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Pascual-García, M., Bonfill-Teixidor, E., Planas-Rigol, E., Rubio-Perez, C., Iurlaro, R., Arias, A., Cuartas, I., Sala-Hojman, A., Escudero, L., Martínez-Ricarte, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10369-9 · Cited by 262

Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer

Formenti, S. C., Lee, P. P., Adams, S., Goldberg, J. D., Li, X., Xie, M. W., Ratikan, J. A., Felix, C., Hwang, L. H., Faull, K. F., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3322 · Cited by 260

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

Chang, Z. L., Lorenzini, M. H., Chen, X., Tran, U., Bangayan, N. J., & Chen, Y. Y. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2565 · Cited by 259

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

Bonavita, E., Bromley, C. P., Jonsson, G., Pelly, V. S., Sahoo, S., Walwyn-Brown, K., Mensurado, S., Moeini, A., Flanagan, E., Bell, C. R., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.020 · Cited by 257

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

Gutcher, I., Donkor, M. K., Ma, Q., Rudensky, A. Y., Flavell, R. A., & Li, M. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.005 · Cited by 254

Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines.

Kobie, J. J., Wu, R. S., Kurt, R. A., Lou, S., Adelman, M. K., Whitesell, L. J., Ramanathapuram, L. V., Arteaga, C. L., & Akporiaye, E. T. (2003) · PubMed · Cited by 247

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

Lind, H., Gameiro, S. R., Jochems, C., Donahue, R. N., Strauss, J., Gulley, J. L., Palena, C., & Schlom, J. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000433 · Cited by 247

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

Li, S., Liu, M., Do, M. H., Chou, C., Stamatiades, E. G., Nixon, B. G., Shi, W., Zhang, X., Li, P., Gao, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2850-3 · Cited by 247

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 + regulatory T cells

Wei, J., Duramad, O., Perng, O. A., Reiner, S. L., Liu, Y., & Qin, F. X.-F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703642104 · Cited by 241

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

Rodon, J. A., Carducci, M. A., Sepúlveda-Sánchez, J. M., Azaro, A., Calvo, E., Seoane, J., Braña, I., Sicart, E., Gueorguieva, I., Cleverly, A., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1380 · Cited by 239

TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T Cells

Ahmadzadeh, M., & Rosenberg, S. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5215 · Cited by 231

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

Gunderson, A. J., Yamazaki, T., McCarty, K., Fox, N., Phillips, M., Alice, A. F., Blair, T. C., Whiteford, M. H., O’Brien, D. P., Ahmad, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15404-8 · Cited by 230

TGF- and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

Eisele, G. (2006) · Brain · doi:10.1093/brain/awl205 · Cited by 228

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

Albrengues, J., Bourget, I., Pons, C., Butet, V., Hofman, P. M., Tartare‐Deckert, S., Féral, C. C., Meneguzzi, G., & Gaggioli, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.036 · Cited by 225

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8456 · Cited by 224

Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer

Melisi, D., Oh, D., Hollebecque, A., Calvo, E., Varghese, A. M., Borazanci, E. H., Macarulla, T. M., Merz, V., Zecchetto, C., Zhao, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002068 · Cited by 216

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

Worthington, J. J., Kelly, A., Smedley, C., Bauché, D., Campbell, S. S., Marie, J. C., & Travis, M. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.012 · Cited by 215

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Grauel, A. L., Nguyen, B., Ruddy, D., Laszewski, T., Schwartz, S., Chang, J., Chen, J., Piquet, M., Pelletier, M., Yan, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19920-5 · Cited by 211

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Desbois, M., Udyavar, A. R., Ryner, L. C., Kozlowski, C., Guan, Y., Dürrbaum, M., Lu, S., Fortin, J., Koeppen, H., Ziai, J. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19408-2 · Cited by 209

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial

Paz-Ares, L. G., Kim, T. M., Vicente, D., Felip, E., Lee, D. H., Lee, K. H., Lin, C., Flor, M. J., Nicola, M. D., Alvarez, R. M., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.03.003 · Cited by 208

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.

Wahl, S. M., Allen, J. B., Weeks, B. S., Wong, H. L., & Klotman, P. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4577 · Cited by 206

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Bernink, J. H., Ohne, Y., Teunissen, M. B. M., Wang, J., Wu, J., Krabbendam, L., Guntermann, C., Volckmann, R., Köster, J., van Tol, S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0423-0 · Cited by 202

Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

Senzer, N. N., Barve, M. A., Kuhn, J. A., Melnyk, A., Beitsch, P. D., Lazar, M. L., Lifshitz, S. G., Magee, M. J., Oh, J., Mill, S. W., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.269 · Cited by 201

The Discovery and Early Days of TGF-β: A Historical PerspectivePreprint

Moses, H. L., Roberts, A. B., & Derynck, R. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021865 · Cited by 198

TGF-β suppresses type 2 immunity to cancer

Liu, M., Kuo, F., Capistrano, K. J., Kang, D., Nixon, B. G., Shi, W., Chou, C., Do, M. H., Stamatiades, E. G., Gao, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2836-1 · Cited by 193

CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions

Franciszkiewicz, K., Floc’h, A. L., Boutet, M., Vergnon, I., Schmitt, A., & Mami‐Chouaib, F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2569 · Cited by 189

GARP regulates the bioavailability and activation of TGFβ

Wang, R., Zhu, J., Dong, X., Shi, M., Lu, C., & Springer, T. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1018 · Cited by 188

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Katsuno, Y., & Derynck, R. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.028 · Cited by 187

Transforming growth factor-β stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity

Boutard, V., Havouis, R., Fouqueray, B. L., Philippe, C., Moulinoux, J.-P., & Baud, L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.2077 · Cited by 186

Dendritic Cells As Inducers of Peripheral Tolerance

Iberg, C. A., Jones, A., & Hawiger, D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.007 · Cited by 186

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

Roth, T. L., Li, P. J., Blaeschke, F., Nies, J. F., Apathy, R., Mowery, C., Yu, R., Nguyen, M. L. T., Lee, Y., Truong, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.039 · Cited by 186

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D. J., Iwamura, C., et al. (2012) · Nature Immunology · doi:10.1038/ni.2362 · Cited by 184

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

Campbell, M. G., Cormier, A., Ito, S., Seed, R., Bondesson, A. J., Lou, J., Marks, J. D., Baron, J. L., Cheng, Y., & Nishimura, S. L. (2020) · Cell · doi:10.1016/j.cell.2019.12.030 · Cited by 183

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma

Bollard, C. M., Tripic, T., Cruz, C. R., Dotti, G., Gottschalk, S., Torrano, V., Dakhova, O., Carrum, G., Ramos, C. A., Liu, H., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.3179 · Cited by 181

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

Qin, Y., Garrison, B. S., Ma, W., Wang, R., Jiang, A., Li, J., Mistry, M., Bronson, R. T., Santoro, D., Franco, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.027 · Cited by 180

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

Worthington, J. J., Czajkowska, B. I., Melton, A. C., & Travis, M. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.057 · Cited by 179

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

Genestier, L., Kasibhatla, S., Brunner, T., & Green, D. R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.231 · Cited by 177

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

Zaiatz-Bittencourt, V., Finlay, D. K., & Gardiner, C. M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701461 · Cited by 177

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Dodagatta-Marri, E., Meyer, D. S., Reeves, M. Q., Paniagua, R., To, M. D., Binnewies, M., Broz, M. L., Mori, H., Wu, D., Adoumie, M., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0493-9 · Cited by 177

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

Yu, C. I., Becker, C., Wang, Y., Marches, F., Helft, J., Leboeuf, M., Anguiano, E., Pourpe, S., Göller, K., Pascual, V., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.004 · Cited by 176

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

Zhang, N., & Bevan, M. J. (2012) · Nature Immunology · doi:10.1038/ni.2319 · Cited by 175

Epilysin (MMP-28) induces TGF-β mediated epithelial to mesenchymal transition in lung carcinoma cells

Illman, S. A., Lehti, K., Keski‐Oja, J., & Lohi, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03157 · Cited by 175

The integrin αVβ6 binds and activates latent TGFβ3

Annes, J. P., Rifkin, D. B., & Munger, J. S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03280-x · Cited by 173

Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells

Dumitriu, I. E., Dunbar, D. R., Howie, S., Sethi, T., & Gregory, C. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0712671 · Cited by 171

Tumor-derived TGF-β Mediates Conversion of CD4+Foxp3+ Regulatory T Cells in a Murine Model of Pancreas Cancer

Moo‐Young, T. A., Larson, J. W., Belt, B. A., Tan, M. C. B., Hawkins, W. G., Eberlein, T. J., Goedegebuure, P. S., & Linehan, D. C. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318189f13c · Cited by 170

TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet

Lin, J. T., Martin, S. L., Xia, L., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5950 · Cited by 170

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

Chen, C.-H., Seguin‐Devaux, C., Burke, N. A., Oriss, T. B., Watkins, S. C., Clipstone, N. A., & Ray, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021170 · Cited by 166

Association of Pre- and Postoperative Plasma Levels of Transforming Growth Factor β1 and Interleukin 6 and Its Soluble Receptor with Prostate Cancer Progression

Shariat, S. F., Kattan, M. W., Traxel, E. J., Andrews, B., Zhu, K., Wheeler, T. M., & Slawin, K. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0768-03 · Cited by 166

Reduced expression of tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer

Zhang, Q., Zhang, Y., Wang, S. Z., Wang, N., Jiang, W. G., Ji, Y. H., & Zhang, S. L. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-1 · Cited by 164

TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis

Pang, Y., Gara, S. K., Achyut, B. R., Li, Z., Yan, H. H., Day, C., Weiss, J. M., Trinchieri, G., Morris, J. C., & Li, Y. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0527 · Cited by 160

Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery

Verstraeten, A., Alaerts, M., Laer, L. V., & Loeys, B. (2016) · Human Mutation · doi:10.1002/humu.22977 · Cited by 160

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Liénart, S., Merceron, R., Vanderaa, C., Lambert, F., Colau, D., Stockis, J., van der Woning, B., de Haard, H., Saunders, M. J., Coulie, P. G., et al. (2018) · Science · doi:10.1126/science.aau2909 · Cited by 160

Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinoma

Feun, L. G., Li, Y., Wu, C., Wangpaichitr, M., Jones, P. D., Richman, S. P., Madrazo, B. L., Kwon, D., Garcia-Buitrago, M. T., Martin, P. B., et al. (2019) · Cancer · doi:10.1002/cncr.32339 · Cited by 159

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Cuende, J., Liénart, S., Dedobbeleer, O., van der Woning, B., De Boeck, G., Stockis, J., Huygens, C., Colau, D., Somja, J., Delvenne, P., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1983 · Cited by 155

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Chen, W., Zhao, H., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01547-9 · Cited by 1,306

The cancer-immunity cycle: Indication, genotype, and immunotype

Mellman, I., Chen, D. S., Powles, T. B., & Turley, S. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.011 · Cited by 1,018

TGF-β signaling in health and disease

Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890

The hallmarks of cancer immune evasion

Galassi, C., Chan, T. A.-T., Vitale, I., & Galluzzi, L. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.09.010 · Cited by 630

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Tufail, M., Jiang, C., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 454

Overcoming TGF beta-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 1

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366

TGF-β Signaling in Cancer Immunity: Immune Suppression, Stromal Remodeling, and Therapeutic Targeting

Jiang, M., Zhang, K., Zheng, X., Bo, Z., & Wei, R. (2026) · Cancer Biome and Targeted Therapy · doi:10.66505/cbtt.v1i2.17

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

van den Bulk, J., de Miranda, N. F. C. C., & ten Dijke, P. (2021) · Clinical Science · doi:10.1042/cs20201236 · Cited by 78