The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
Evolution of macromolecular complexity in drug delivery systems
Open accessAbstract
Designing therapeutics is a process with many challenges. Even if the first hurdle — designing a drug that modulates the action of a particular biological target in vitro — is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects can, in many cases, result from the need to use higher doses without targeted delivery. However, the established use of macromolecules to encapsulate or conjugate drugs can provide improved delivery, and stands to enable better therapeutic outcomes. In this Review, we discuss how drug delivery approaches have evolved alongside our ability to prepare increasingly complex macromolecular architectures. We examine how this increased complexity has overcome the challenges of drug delivery and discuss its potential for fulfilling unmet needs in nanomedicine.
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Cited by
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
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Self-citationPrecise nanomedicine for intelligent therapy of cancer
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Drug delivery systems for programmed and on-demand release
Davoodi, P., Lee, L. Y., Xu, Q., Sunil, V., Sun, Y., Soh, S., & Wang, C.-H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.002 · Cited by 353
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Metadata
- Authors
- Kakkar, A., Traverso, G., Farokhzad, O. C., Weissleder, R., & Langer, R.
- Venue
- Nature Reviews Chemistry
- Published
- 2017-08-09
- Volume
- 1
- Issue
- 8
- ISSN
- 2397-3358 (ISSN-L)
- OpenAlex
- W2744506252
- Cited by
- 320
- References
- 187
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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