The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
Towards the sustainable discovery and development of new antibiotics
Open accessAbstract
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations. Antimicrobial resistance is an increasing threat to public health and encouraging the development of new antimicrobials is one of the most important ways to address the problem. This Roadmap article aims to bring together industrial, academic and political partners, and proposes both short-term and long-term solutions to this challenge.
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Cites
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Cited by
Ikuta, K. S., Swetschinski, L. R., Robles Aguilar, G., Sharara, F., Mestrovic, T., Gray, A. P., Davis Weaver, N., Wool, E. E., Han, C., Gershberg Hayoon, A., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)02185-7 · Cited by 2,235
The IUPHAR/BPS Guide to PHARMACOLOGY in 2024
Harding, S. D., Armstrong, J. F., Faccenda, E., Southan, C., Alexander, S. P. H., Davenport, A. P., Spedding, M., & Davies, J. A. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkad944 · Cited by 226
Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens
Saxena, D., Maitra, R., Bormon, R., Czekanska, M., Meiers, J., Titz, A., Verma, S., & Chopra, S. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00016-1 · Cited by 217
Self-citationPandi, A., Adam, D., Zare, A., Trinh, V. T., Schaefer, S. L., Burt, M., Klabunde, B., Bobkova, E., Kushwaha, M., Foroughijabbari, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42434-9 · Cited by 173
Self-citationGhosh, S., Basu, S., Anbarasu, A., & Ramaiah, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.8365 · Cited by 33
Metadata
- Authors
- Miethke, M., Pieroni, M., Weber, T., Brönstrup, M., Hammann, P., Halby, L., Arimondo, P. B., Glaser, P., Aigle, B., Bode, H. B., Moreira, R., Li, Y., Luzhetskyy, A., Medema, M. H., Pernodet, J.-L., Stadler, M., Tormo, J. R., Genilloud, O., Truman, A. W., Weissman, K. J., Takano, E., Sabatini, S., Stegmann, E., Brötz-Oesterhelt, H., Wohlleben, W., Seemann, M., Empting, M., Hirsch, A. K. H., Loretz, B., Lehr, C.-M., Titz, A., Herrmann, J., Jaeger, T., Alt, S., Hesterkamp, T., Winterhalter, M., Schiefer, A., Pfarr, K., Hoerauf, A., Graz, H., Graz, M., Lindvall, M., Ramurthy, S., Karlén, A., van Dongen, M., Petkovic, H., Keller, A., Peyrane, F., Donadio, S., Fraisse, L., Piddock, L. J. V., Gilbert, I. H., Moser, H. E., & Müller, R.
- Venue
- Nature Reviews Chemistry
- Published
- 2021-08-19
- Volume
- 5
- Issue
- 10
- Pages
- 726-749
- ISSN
- 2397-3358 (ISSN-L)
- OpenAlex
- W3194188670
- Cited by
- 1,151
- References
- 280
- FWCI
- 31.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Miethke, M., Pieroni, M., Weber, T., Brönstrup, M., Hammann, P., Halby, L., Arimondo, P. B., Glaser, P., Aigle, B., Bode, H. B., Moreira, R., Li, Y., Luzhetskyy, A., Medema, M. H., Pernodet, J.-L., Stadler, M., Tormo, J. R., Genilloud, O., Truman, A. W., . . . Müller, R. (2021). Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry. https://doi.org/10.1038/s41570-021-00313-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
