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Cited by 3,456Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsUltrasound and Hyperthermia Applications

The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.

Clinical development and potential of photothermal and photodynamic therapies for cancer

Li, Xingshu, Lovell, Jonathan F., Yoon, Juyoung, Chen, Xiaoyuan·2020·Nature Reviews Clinical Oncology
DOI 10.1038/s41571-020-0410-2
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Abstract

Light-activated, photosensitizer-based therapies have been established as safe modalities of tumour ablation for numerous cancer indications. Two main approaches are available: photodynamic therapy, which results in localized chemical damage in the target lesions, and photothermal therapy, which results in localized thermal damage. Whereas the administration of photosensitizers is a key component of photodynamic therapy, exogenous photothermal contrast agents are not required for photothermal therapy but can enhance the efficiency and efficacy of treatment. Over the past decades, great strides have been made in the development of phototherapeutic drugs and devices as cancer treatments, but key challenges have restricted their widespread clinical use outside of certain dermatological indications. Improvements in the tumour specificity of photosensitizers, achieved through targeting or localized activation, could provide better outcomes with fewer adverse effects, as could combinations with chemotherapies or immunotherapies. In this Review, we provide an overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments.

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Crossref · 10.1038/s41571-020-0410-2

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Metadata

Authors
Li, X., Lovell, J. F., Yoon, J., & Chen, X.
Affiliations
  • Fuzhou University (CN)
  • University at Buffalo, State University of New York (US)
  • Ewha Womans University (KR)
  • National Institutes of Health (US)
Corresponding author
  • Lovell, Jonathan F.
  • Yoon, Juyoung
  • Chen, Xiaoyuan
ORCID
Venue
Nature Reviews Clinical Oncology
Publisher
Springer Science and Business Media LLC
Published
2020-07-22
Volume
17
Issue
11
Pages
657-674
ISSN
  • 1759-4774 (ISSN-L)
  • 1759-4782
DOI
10.1038/s41571-020-0410-2
OpenAlex
W3044858173
Cited by
3,456
References
222
Citations by year
2026: 388 · 2025: 753 · 2024: 798 · 2023: 636 · 2022: 502 · 2021: 344 · 2020: 34
FWCI
53.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (DP5OD017898)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB017270)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords
photothermal therapy, photodynamic therapy, photosensitizers, cancer phototherapy, tumor targeting, combination chemotherapy, combination therapy with immunotherapy
MeSH terms
Photothermal Therapy, Clinical Trials as Topic, Humans, Neoplasms, Photochemotherapy, Research Design, Treatment Outcome, Photosensitizing Agents, Nanotechnology

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