Cited by 3,456Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsUltrasound and Hyperthermia Applications

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Clinical development and potential of photothermal and photodynamic therapies for cancer

Li, Xingshu, Lovell, Jonathan F., Yoon, Juyoung, Chen, Xiaoyuan·2020·Nature Reviews Clinical Oncology

DOI 10.1038/s41571-020-0410-2

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Abstract

Light-activated, photosensitizer-based therapies have been established as safe modalities of tumour ablation for numerous cancer indications. Two main approaches are available: photodynamic therapy, which results in localized chemical damage in the target lesions, and photothermal therapy, which results in localized thermal damage. Whereas the administration of photosensitizers is a key component of photodynamic therapy, exogenous photothermal contrast agents are not required for photothermal therapy but can enhance the efficiency and efficacy of treatment. Over the past decades, great strides have been made in the development of phototherapeutic drugs and devices as cancer treatments, but key challenges have restricted their widespread clinical use outside of certain dermatological indications. Improvements in the tumour specificity of photosensitizers, achieved through targeting or localized activation, could provide better outcomes with fewer adverse effects, as could combinations with chemotherapies or immunotherapies. In this Review, we provide an overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments.

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Authors: Li, X., Lovell, J. F., Yoon, J., & Chen, X.
Affiliations: Fuzhou University (CN)
University at Buffalo, State University of New York (US)
Ewha Womans University (KR)
National Institutes of Health (US)
Corresponding author: Lovell, Jonathan F.
Yoon, Juyoung
Chen, Xiaoyuan
ORCID: Li, Xingshu
Lovell, Jonathan F.
Yoon, Juyoung
Chen, Xiaoyuan
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2020-07-22
Volume: 17
Issue: 11
Pages: 657-674
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/s41571-020-0410-2
OpenAlex: W3044858173
Cited by: 3,456
References: 222
Citations by year: 2026: 388 · 2025: 753 · 2024: 798 · 2023: 636 · 2022: 502 · 2021: 344 · 2020: 34
FWCI: 53.11
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (DP5OD017898)
National Institute of Biomedical Imaging and Bioengineering (R01EB017270)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords: photothermal therapy, photodynamic therapy, photosensitizers, cancer phototherapy, tumor targeting, combination chemotherapy, combination therapy with immunotherapy
MeSH terms: Photothermal Therapy, Clinical Trials as Topic, Humans, Neoplasms, Photochemotherapy, Research Design, Treatment Outcome, Photosensitizing Agents, Nanotechnology

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Clinical development and potential of photothermal and photodynamic therapies for cancer

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