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Cited by 3,648

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Update on Key Emerging Challenges in Cystic Fibrosis

Open access
Jennings, Mark T., Riekert, Kristin A., Boyle, Michael P.·2014·Medical Principles and Practice
DOI 10.1159/000357646
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Abstract

Cystic fibrosis (CF) is a multisystem disease causing severe chronic sinopulmonary disease and loss of pancreatic exocrine function, which affects approximately 70,000 individuals worldwide. New therapeutic developments over the last few decades have resulted in a significant increase in survival, with the median predicted survival now reaching the late thirties and more and more CF patients living well into adulthood. However, with this advent of new therapies and the associated increase in survival, new challenges in CF care have also emerged. Two of these challenges, i.e. chronic methicillin-resistant Staphylococcus aureus lung infection and patient adherence to very complicated and time-consuming therapeutic regimens, are reviewed in detail here. In addition, the ultimate challenge of treating the underlying cause of CF by correcting the dysfunction of the CF transmembrane conductance regulator chloride channel is reviewed, as agents to correct channel function will likely significantly alter CF clinical outcomes and treatment approaches in the next decade.

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Research works printed but not linked: 43

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Metadata

Authors
Jennings, M. T., Riekert, K. A., & Boyle, M. P.
Venue
Medical Principles and Practice
Publisher
S. Karger AG
Published
2014
Volume
23
Issue
5
Pages
393-402
ISSN
  • 1011-7571 (ISSN-L)
  • 1423-0151
DOI
10.1159/000357646
OpenAlex
W2078078890
Cited by
3,648
References
15
FWCI
259.52
Type
journal article
Language
en
Open access
diamond
Licence

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CoChat. (2026). Citation check: Update on Key Emerging Challenges in Cystic Fibrosis. https://app.cochat.ai/papers/10.1159/000357646
The paper
Jennings, M. T., Riekert, K. A., & Boyle, M. P. (2014). Update on Key Emerging Challenges in Cystic Fibrosis. Medical Principles and Practice. https://doi.org/10.1159/000357646

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.