The DOI matches its Crossref record; 202 of the 203 references it cites were found in a registry or an index.
The obese adipose tissue microenvironment in cancer development and progression
Open accessAbstract
Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. In this Review, we describe how the adipose tissue microenvironment (ATME) evolves during body-weight gain, and how these changes might influence tumour initiation and progression. We focus on multiple facets of ATME physiology, including inflammation, vascularity and fibrosis, and discuss therapeutic interventions that have the potential to normalize the ATME, which might be translationally relevant for cancer prevention and therapy. Given that the prevalence of obesity is increasing on an international scale, translational research initiatives are urgently needed to provide mechanistic explanations for the obesity-cancer relationship, and how to best identify high-risk individuals without relying on crude measures, such as BMI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Variably increased risk has been reported for cancers of the breast (postmenopausal) endometrium ovary gall bladder, stomach and esophagus, kidney, thyroid (papillary, follicular, and anaplastic but not medullary), colon, bladder, and pancreas.1733,1734,1739–1752”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1744]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Items 201–202 of 202
Canter, R. J., Aguilar, E. G., Wang, Z., Le, C. T., Khuat, L. T., Dunai, C., Rebhun, R. B., Tarantal, A. F., Blazar, B. R., Monjazeb, A. M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.36.5_suppl.65 · Cited by 5
Fuchs, W. A., & Miller, G. (2009) · Gastroenterologia · doi:10.1159/000201583 · Cited by 1
Cited by
Sorted by citations
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Inflammation and cancer: triggers, mechanisms, and consequences
Greten, F. R., & Grivennikov, S. I. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.025 · Cited by 3,806
Tumor microenvironment as a therapeutic target in cancer
Xiao, Y. Q., & Yu, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107753 · Cited by 2,026
Macrophages as tools and targets in cancer therapy
Mantovani, A., Allavena, P., Marchesi, F., & Garlanda, C. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00520-5 · Cited by 1,807
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507
Metadata
- Authors
- Quail, D. F., & Dannenberg, A. J.
- Affiliations
- McGill University (CA)
- Weill Cornell Medicine (US)
- Corresponding author
- Quail, Daniela F.
- Dannenberg, Andrew J.
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-11-20
- Volume
- 15
- Issue
- 3
- Pages
- 139-154
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC6374176
- OpenAlex
- W2900496024
- Cited by
- 542
- References
- 203
- Citations by year
- 2026: 59 · 2025: 62 · 2024: 74 · 2023: 81 · 2022: 74 · 2021: 107 · 2020: 65 · 2019: 18 · 2018: 2
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA215797, U54CA210184)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue microenvironment, tumor progression, tumor initiation, adipose tissue inflammation, adipose tissue fibrosis, adipose tissue metabolism, weight gain, cancer prevention, obesity as cancer risk factor
- MeSH terms
- Adipose Tissue, Animals, Cell Transformation, Neoplastic, Female, Humans, Male, Neoplasms, Obesity, Sensitivity and Specificity, Comorbidity, Body Mass Index, Prevalence, Adipocytes, Risk Assessment, Mice, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
