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The obese adipose tissue microenvironment in cancer development and progression
Open accessAbstract
Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. In this Review, we describe how the adipose tissue microenvironment (ATME) evolves during body-weight gain, and how these changes might influence tumour initiation and progression. We focus on multiple facets of ATME physiology, including inflammation, vascularity and fibrosis, and discuss therapeutic interventions that have the potential to normalize the ATME, which might be translationally relevant for cancer prevention and therapy. Given that the prevalence of obesity is increasing on an international scale, translational research initiatives are urgently needed to provide mechanistic explanations for the obesity-cancer relationship, and how to best identify high-risk individuals without relying on crude measures, such as BMI.
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“Variably increased risk has been reported for cancers of the breast (postmenopausal) endometrium ovary gall bladder, stomach and esophagus, kidney, thyroid (papillary, follicular, and anaplastic but not medullary), colon, bladder, and pancreas.1733,1734,1739–1752”
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3 retracted
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
RetractedShah, D., Romero, F., Duong, M., Wang, N., Paudyal, B., Suratt, B. T., Kallen, C. B., Sun, J., Zhu, Y., Walsh, K. X., et al. (2015) · Scientific Reports · doi:10.1038/srep11362 · Cited by 73
RetractedCaloric Restriction Reverses Obesity-Induced Mammary Gland Inflammation in Mice
Bhardwaj, P., Du, B., Zhou, X. K., Sue, E., Harbus, M. D., Falcone, D. J., Giri, D. D., Hudis, C. A., Kopelovich, L., Subbaramaiah, K., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0467 · Cited by 51
Self-citationRetracted(2004) · The Lancet · doi:10.1016/s0140-6736(03)15268-3 · Cited by 12,717
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994
Self-citationOverweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
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Wishart, A. L., Conner, S. J., Guarin, J. R., Fatherree, J. P., Peng, Y., McGinn, R. A., Crews, R., Naber, S. P., Hunter, M., Greenberg, A. S., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc3175 · Cited by 185
Sánchez, A., Furberg, H. F., Kuo, F., Vuong, L. H., Ged, Y. M. A., Patil, S., Ostrovnaya, I., Petruzella, S., Reising, A., Patel, P., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30797-1 · Cited by 182
Self-citationThe hallmarks of cancer are also the hallmarks of wound healing
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Nisar, A., Jagtap, S., Vyavahare, S., Deshpande, M., Harsulkar, A., Ranjekar, P. K., & Prakash, O. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1177050 · Cited by 183
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García‐Estévez, L., Cortés, J., Pérez, S., Calvo, I., Gallegos, I., & Moreno‐Bueno, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.705911 · Cited by 154
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Panaroni, C., Fulzele, K. S., Mori, T., Siu, K. T., Onyewadume, C., Maebius, A., & Raje, N. S. (2021) · Blood · doi:10.1182/blood.2021013832 · Cited by 118
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Li, J., Zhang, G., Liu, C., Xiang, X., Le, M. T. N., Sethi, G., Wang, L., Goh, B.-C., & Ma, Z. (2021) · Theranostics · doi:10.7150/thno.64096 · Cited by 115
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Ruze, R., Song, J., Yin, X., Chen, Y., Xu, R., Wang, C., & Zhao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01376-w · Cited by 111
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Assumpção, J. A. F., Pasquarelli-do-Nascimento, G., Viegas, M. S., Bonamino, M., & Magalhães, K. G. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00796-0 · Cited by 97
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Obesity, sleep apnea, and cancer
Almendros, I., Martínez‐García, M. Á., Farré, R., & Gozal, D. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0549-z · Cited by 93
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
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Unveiling the link between chronic inflammation and cancer
Tripathi, S., Sharma, Y., & Kumar, D. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100347 · Cited by 103
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Kort-Mascort, J., Flores-Torres, S., Peza-Chavez, O., Jang, J. H., Pardo, L. A., Tran, S. D., & Kinsella, J. M. (2022) · Biomaterials Science · doi:10.1039/d2bm01273a · Cited by 78
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Sipe, L. M., Chaib, M., Pingili, A. K., Pierre, J. F., & Makowski, L. (2020) · Immunological Reviews · doi:10.1111/imr.12856 · Cited by 75
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Koelwyn, G. J., Aboumsallem, J. P., Moore, K. J., & de Boer, R. A. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.09.008 · Cited by 71
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Li, C., & Xu, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03215-0 · Cited by 70
Macrophages and T cells in metabolic disorder-associated cancers
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Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 70
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Reddy, T. P., Glynn, S. A., Billiar, T. R., Wink, D. A., & Chang, J. C. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2791 · Cited by 74
Geng, J., Zhang, X., Prabhu, S., Shahoei, S. H., Nelson, E. R., Swanson, K. S., Anastasio, M. A., & Smith, A. M. (2021) · Science Advances · doi:10.1126/sciadv.abe2480 · Cited by 66
Ritter, A., Kreis, N., Hoock, S. C., Solbach, C., Louwen, F., & Yuan, J. (2022) · Cancers · doi:10.3390/cancers14163908 · Cited by 69
Obesity-associated changes in molecular biology of primary breast cancer
Nguyen, H.-L., Geukens, T., Maetens, M., Aparicio, S. A. J. R., Bassez, A., Borg, Å., Brock, J. E., Broeks, A., Caldas, C., Cardoso, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39996-z · Cited by 71
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Jiménez‐Cortegana, C., López-Saavedra, A., Sánchez-Jiménez, F., Pérez‐Pérez, A., Castiñeiras, J., Virizuela-Echaburu, J. A., de la Cruz‐Merino, L., & Sánchez‐Margalet, V. (2021) · Biomolecules · doi:10.3390/biom11060913 · Cited by 69
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Faria, S. S., Corrêa, L. H., Cardoso, G. S. H. R., de Sant’Ana, L. P., Almeida, R. D. N., & Magalhães, K. G. (2020) · Journal of Breast Cancer · doi:10.4048/jbc.2020.23.e35 · Cited by 72
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Dai, L., Song, K., & Di, W. J. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00718-4 · Cited by 63
Lee‐Rueckert, M., Canyelles, M., Tondo, M., Rotllán, N., Kovanen, P. T., Llorente‐Cortés, V., & Escolá‐Gil, J. C. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.05.002 · Cited by 68
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Yin, X., Chen, Y., Ruze, R., Xu, R., Song, J., Wang, C., & Xu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01178-6 · Cited by 72
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Metadata
- Authors
- Quail, D. F., & Dannenberg, A. J.
- Affiliations
- McGill University (CA)
- Weill Cornell Medicine (US)
- Corresponding author
- Quail, Daniela F.
- Dannenberg, Andrew J.
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-11-20
- Volume
- 15
- Issue
- 3
- Pages
- 139-154
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC6374176
- OpenAlex
- W2900496024
- Cited by
- 542
- References
- 203
- Citations by year
- 2026: 59 · 2025: 62 · 2024: 74 · 2023: 81 · 2022: 74 · 2021: 107 · 2020: 65 · 2019: 18 · 2018: 2
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA215797, U54CA210184)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue microenvironment, tumor progression, tumor initiation, adipose tissue inflammation, adipose tissue fibrosis, adipose tissue metabolism, weight gain, cancer prevention, obesity as cancer risk factor
- MeSH terms
- Adipose Tissue, Animals, Cell Transformation, Neoplastic, Female, Humans, Male, Neoplasms, Obesity, Sensitivity and Specificity, Comorbidity, Body Mass Index, Prevalence, Adipocytes, Risk Assessment, Mice, Tumor Microenvironment
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