Deiodinases and their intricate role in thyroid hormone homeostasis

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement

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Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases

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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

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Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism

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2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism

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Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

Visser, W. E., Friesema, E. C. H., & Visser, T. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0095 · Cited by 390 · see citing works

Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients

Panicker, V., Saravanan, P., Vaidya, B., Evans, J., Hattersley, A. T., Frayling, T. M., & Dayan, C. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1301 · Cited by 327 · see citing works

Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients

Gullo, D., Latina, A., Frasca, F., Le Moli, R., Pellegriti, G., & Vigneri, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022552 · Cited by 307 · see citing works

Thyroxine-Triiodothyronine Combination Therapy<i>Versus</i>Thyroxine Monotherapy for Clinical Hypothyroidism: Meta-Analysis of Randomized Controlled Trials

Grozinsky-Glasberg, S., Fraser, A., Nahshoni, E., Weizman, A., & Leibovici, L. (2006) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-0448 · Cited by 296 · see citing works

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

Escobar-Morreale, H. F., Obregón, M. J., Escobar del Rey, F., & Morreale de Escobar, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118353 · Cited by 287 · see citing works

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin Resistance

Mentuccia, D., Proietti-Pannunzi, L., Tanner, K., Bacci, V., Pollin, T. I., Poehlman, E. T., Shuldiner, A. R., & Celi, F. S. (2002) · Diabetes · doi:10.2337/diabetes.51.3.880 · Cited by 205 · see citing works

Combined Levothyroxine Plus Liothyronine Compared With Levothyroxine Alone in Primary Hypothyroidism: A Randomized Controlled Trial

Clyde, P. W., Harari, A. E., Getka, E. J., & Shakir, K. M. M. (2003) · JAMA · doi:10.1001/jama.290.22.2952 · Cited by 195 · see citing works

Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.

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The Contribution of Local Tissue Thyroxine Monodeiodination to the Nuclear 3,5,3′- Triiodothyronine in Pituitary, Liver, and Kidney of Euthyroid Rats*

SILVA, J. E., DICK, T. E., & LARSEN, P. R. (1978) · Endocrinology · doi:10.1210/endo-103-4-1196 · Cited by 189 · see citing works

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine

Werneck de Castro, J. P., Fonseca, T. L., Ueta, C. B., McAninch, E. A., Abdalla, S., Wittmann, G., Lechan, R. M., Gereben, B., & Bianco, A. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77588 · Cited by 184 · see citing works

Is a Normal TSH Synonymous With “Euthyroidism” in Levothyroxine Monotherapy?

Peterson, S. J., McAninch, E. A., & Bianco, A. C. (2016) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2016-2660 · Cited by 182 · see citing works

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

Galton, V. A., Schneider, M. J., Clark, A. S., & St. Germain, D. L. (2009) · Endocrinology · doi:10.1210/en.2008-1572 · Cited by 181 · see citing works

Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS

Abuid, J., & Larsen, P. R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107744 · Cited by 156 · see citing works

Coordination of hypothalamic and pituitary T3 production regulates TSH expression

Fonseca, T. L., Correa-Medina, M., Campos, M. P. O., Wittmann, G., Werneck-de-Castro, J. P., Arrojo e Drigo, R., Mora-Garzon, M., Ueta, C. B., Caicedo, A., Fekete, C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61231 · Cited by 155 · see citing works

Local impact of thyroid hormone inactivation

Dentice, M., & Salvatore, D. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0002 · Cited by 143 · see citing works

Reduction in extrathyroidal triiodothyronine production by propylthiouracil in man.

Saberi, M., Sterling, F. H., & Utiger, R. D. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107924 · Cited by 138 · see citing works

Partial Substitution of Thyroxine (T₄) with Tri-Iodothyronine in Patients on T₄Replacement Therapy: Results of a Large Community-Based Randomized Controlled Trial

Saravanan, P., Simmons, D. J., Greenwood, R., Peters, T. J., & Dayan, C. M. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1672 · Cited by 136 · see citing works

Atypical Expression of Type 2 Iodothyronine Deiodinase in Thyrotrophs Explains the Thyroxine-Mediated Pituitary Thyrotropin Feedback Mechanism

Christoffolete, M. A., Ribeiro, R., Singru, P., Fekete, C., da Silva, W. S., Gordon, D. F., Huang, S. A., Crescenzi, A., Harney, J. W., Ridgway, E. C., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1300 · Cited by 118 · see citing works

Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Jo, S., Fonseca, T. L., Bocco, B. M. L. C., Fernandes, G. W., McAninch, E. A., Bolin, A. P., Da Conceição, R. R., Werneck-de-Castro, J. P., Ignacio, D. L., Egri, P., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci123176 · Cited by 107 · see citing works

No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study

Wouters, H. J. C. M., van Loon, H. C. M., van der Klauw, M. M., Elderson, M. F., Slagter, S. N., Kobold, A. M., Kema, I. P., Links, T. P., van Vliet-Ostaptchouk, J. V., & Wolffenbuttel, B. H. R. (2017) · Thyroid® · doi:10.1089/thy.2016.0199 · Cited by 97 · see citing works

Hypothyroid Patients Encoding Combined MCT10 and DIO2 Gene Polymorphisms May Prefer L-T3 + L-T4 Combination Treatment – Data Using a Blind, Randomized, Clinical Study

Carlé, A., Faber, J., Steffensen, R., Laurberg, P., & Nygaard, B. (2017) · European Thyroid Journal · doi:10.1159/000469709 · Cited by 93 · see citing works

Alterations in 3,3'5'-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man.

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Efficacy of Combined Levothyroxine and Liothyronine as Compared with Levothyroxine Monotherapy in Primary Hypothyroidism: A Randomized Controlled Trial

Valizadeh, M., Seyyed-Majidi, M. R., Hajibeigloo, H., Momtazi, S., Musavinasab, N., & Hayatbakhsh, M. R. (2009) · Endocrine Research · doi:10.1080/07435800903156340 · Cited by 65 · see citing works

The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross‐over study in thyroidectomized patients

Celi, F. S., Zemskova, M., Linderman, J. D., Babar, N. I., Skarulis, M. C., Csako, G., Wesley, R., Costello, R., Penzak, S. R., & Pucino, F. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03700.x · Cited by 65 · see citing works

Metal coordinated poly-zinc-liothyronine provides stable circulating triiodothyronine levels in hypothyroid rats

Da Conceição, R. R., Fernandes, G. W., Fonseca, T. L., Bocco, B. M. L. C., & Bianco, A. C. (2018) · Thyroid · doi:10.1089/thy.2018.0205 · Cited by 23 · see citing works

Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion

Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works

Liraglutide Activates Type 2 Deiodinase and Enhances β3-Adrenergic-Induced Thermogenesis in Mouse Adipose Tissue

Oliveira, F. C. B., Bauer, E. J., Ribeiro, C. M., Pereira, S. A., Beserra, B. T. S., Wajner, S. M., Maia, A. L., Neves, F. A. R., Coelho, M. S., & Amato, A. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.803363 · Cited by 30 · see citing works

Clinical and laboratory aspects of 3,3′,5′-triiodothyronine (reverse T3)

Halsall, D. J., & Oddy, S. (2021) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563220969150 · Cited by 28 · see citing works

Thyroid hormone resistance: mechanisms and therapeutic development

Yao, B., Yang, C., Pan, C., & Li, Y. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111679 · Cited by 26 · see citing works

Serum thyrotropin and triiodothyronine levels in levothyroxine-treated patients

Ettleson, M. D., Prieto, W. H., Russo, P. S. T., de Sa, J., Wan, W., Laiteerapong, N., Maciel, R. M. B., & Bianco, A. C. (2023) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgac725 · Cited by 25 · see citing works

Triiodothyronine alongside levothyroxine in the management of hypothyroidism?

Gottwald-Hostalek, U., & Kahaly, G. J. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.1984219 · Cited by 9 · see citing works