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Cited by 80Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsThyroid Cancer Diagnosis and Treatment

Alterations in 3,3'5'-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man.

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LoPresti, J S, Eigen, A, Kaptein, E, Anderson, K P, Spencer, C A, Nicoloff, J T·1989·Journal of Clinical Investigation
DOI 10.1172/jci114343PMC PMC304032
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Abstract

To elucidate the mechanisms involved in altering serum 3,3',5'-triiodothyronine (rT3) levels with absolute or relative low 3,5,3'-triiodothyronine (T3) states in man, agents capable of lowering circulating T3 levels were sequentially administered to six euthyroid subjects. These agents included propylthiouracil (PTU) (300 mg/6 h X 5 d), dexamethasone (DEX) (2 mg/6 h X 5 d), and thyroxine (T4) (3.0 mg load and 0.3 mg/d X 5 d). [125I] rT3 clearance rates and rT3 production rates were then determined. Increased serum rT3 levels and rT3/T4 values occurred with both PTU and DEX as compared with control, while T4 increased serum rT3 but did so without changing rT3/T4 values. The rT3 clearance rate was significantly decreased by PTU without altering production rate, while DEX increased the rT3 production rate without altering the rT3 clearance rate. T4 administration did not change rT3 clearance but proportionately increased rT3 production. These responses indicate that circulating rT3 predominantly originates from a non-PTU inhibitable deiodinase enzyme system located in extrahepatic tissues. This enzyme system appears to have a high capacity and low affinity for T4 and can be stimulated by DEX administration.

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  • The role of D2 is to convert T4 to T3; approximately 60% of circulating T3 is estimated to originate from the D2 pathway in healthy individuals (18-20).

    “The role of D2 is to convert T4 to T3; approximately 60% of circulating T 3 is estimated to originate from the D2 pathway in healthy individuals (18-20).”

    From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [20]

    The Introduction describes conversion of T4 to T3, and the Discussion identifies type II deiodinase as a pathway generating circulating T3. But the Discussion gives estimates of up to 40% or about 50% in rats; it does not support the claimed 60% estimate for healthy humans. (LLM, conf=0.86)

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Research works printed but not linked: 1

  1. Croxson, M. S., D. S. Duick, and J. T. Nicoloff. 1976. Effect of glucocorticoids on serum triiodothyronine (T3) concentrations in man. In Thyroid Research. J. Robbins and L. E. Braverman, editors. Excerpta Medica/American Elsevier, New York. 266-269.

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Related

Authors
LoPresti, J. S., Eigen, A., Kaptein, E., Anderson, K. P., Spencer, C. A., & Nicoloff, J. T.
Affiliations
University of Southern California (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1989-11-01
Volume
84
Issue
5
Pages
1650-1656
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci114343
PMC
PMC304032
OpenAlex
W1998437047
Cited by
80
References
47
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
2.03
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK11727)
  • National Center for Research Resources (RR-43)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
reverse T3, propylthiouracil, dexamethasone, thyroxine, deiodinases, thyroid hormone regulation, euthyroid subjects
MeSH terms
Adult, Chromatography, High Pressure Liquid, Dexamethasone, Humans, Kinetics, Male, Metabolic Clearance Rate, Middle Aged, Propylthiouracil, Thyrotropin, Thyroxine, Triiodothyronine, Reverse

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