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Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora

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Effects of food on pharmacokinetics and safety of metformin hydrochloride tablets: A meta-analysis of pharmacokinetic, bioavailability, or bioequivalence studies

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Lower bile acids as an independent risk factor for renal outcomes in patients with type 2 diabetes mellitus and biopsy-proven diabetic kidney disease

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The Association Between Metformin Treatment and Outcomes in Type 2 Diabetes Mellitus Patients With Heart Failure With Preserved Ejection Fraction: A Retrospective Study

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The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved

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Are Fish Populations at Risk? Metformin Disrupts Zebrafish Development and Reproductive Processes at Chronic Environmentally Relevant Concentrations

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Stimulatory effect of imeglimin on incretin secretion

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Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

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Associations of Innate and Adaptive Immune Cell Subsets With Incident Type 2 Diabetes Risk: The MESA Study

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PDIA4 , a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue

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Metformin's anticancer odyssey: Revealing multifaceted mechanisms across diverse neoplastic terrains- a critical review

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Exploring the protective effect of metformin against sarcopenia: insights from cohort studies and genetics

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Metabolic Homeostasis of Immune Cells Modulates Cardiovascular Diseases

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The Future of Metformin in the Prevention of Diabetes-Related Osteoporosis

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Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review

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Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk

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Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double‐blind, sham‐controlled trial

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Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling

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Co-occurrence, toxicity, and biotransformation pathways of metformin and its intermediate product guanylurea: Current state and future prospects for enhanced biodegradation strategy

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Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes

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Editorial: Metformin: Beyond Diabetes

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Vinegar-processed Schisandra chinensis polysaccharide ameliorates type 2 diabetes via modulation serum metabolic profiles, gut microbiota, and fecal SCFAs

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Metformin prevents diabetes development in type 1 diabetes models via suppression of mTOR and STAT3 signaling in immune cells

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Partial Replacement of High-Fat Diet with Beef Tallow Attenuates Dyslipidemia and Endoplasmic Reticulum Stress in db / db Mice

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Polystyrene microplastics mitigate the embryotoxic damage of metformin and guanylurea in Danio rerio

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Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS ‐mediated pathways

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Impact of metformin on immunological markers: Implication in its anti-tumor mechanism

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Type 2 Diabetes Mellitus as a Multisystem Disease: From Insulin Resistance to Organ Crosstalk—A Narrative Review

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Genetic and Phenotypic Factors Affecting Glycemic Response to Metformin Therapy in Patients with Type 2 Diabetes Mellitus

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The anti-diabetic effects of metformin are mediated by regulating long non-coding RNA

Chang, W., Li, W., & Li, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1256705 · Cited by 19

Paclitaxel-Loaded Niosomes in Combination with Metformin: Development, Characterization and Anticancer Potentials

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Bioinformatics analysis of gene and microRNA targets for fibromyalgia

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Role of Metformin in Various Pathologies: state-of-the-art Microcapsules for Improving Its Pharmacokinetics

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Metformin induced M2 polarization to improve peripheral nerve regeneration by regulating AMPK/PGC-1α/PPAR-γ pathwayPreprint

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Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review

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Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs

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A new direction in Chinese herbal medicine ameliorates for type 2 diabetes mellitus: Focus on the potential of mitochondrial respiratory chain complexes

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Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization

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Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway

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Metformin in gestational diabetes: physiological actions and clinical applications

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A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in Cryptococcus neoformans

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New Horizons in Microbiota and Metabolic Health Research

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Metformin Use Is Associated with Decreased Mortality in COVID-19 Patients with Diabetes: Evidence from Retrospective Studies and Biological Mechanism

Poly, T. N., Islam, M. M., Li, Y., Lin, M., Hsu, M., & Wang, Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163507 · Cited by 18

Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?

Marini, C., Cossu, V., Bauckneht, M., Lanfranchi, F., Raffa, S., Orengo, A. M., Ravera, S., Bruno, S., & Sambuceti, G. (2021) · Biomolecules · doi:10.3390/biom11081231 · Cited by 18

Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes

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High Mobility Group Proteins in Sepsis

Liang, G.-B., & He, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911152 · Cited by 18

From bench to bedside: the research status and application opportunity of extracellular vesicles and their engineering strategies in the treatment of skin defects

Cui, L., Song, Y., Hou, Z., Yang, L., Guo, S., & Wang, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03461-4 · Cited by 18

Metformin and Adipose Tissue: A Multifaceted Regulator in Metabolism, Inflammation, and Regeneration

Wei, X.-L., Tao, M., Li, R.-H., Ge, S.-H., & Xiao, W. (2025) · Endocrinology and Metabolism · doi:10.3803/enm.2025.2371 · Cited by 17

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Morrison, K. R., Wang, T., Chan, K. Y., Trotter, E. W., Gillespie, A., Michael, M., Oakhill, J. S., Hagan, I., & Petersen, J. (2023) · Open Biology · doi:10.1098/rsob.230021 · Cited by 17

Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum

Wang, Y., Yu, F., Zheng, X., Li, J., Zhang, Z., Zhang, Q., Chen, J., He, Y., Yang, H., & Zhou, P. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01880-6 · Cited by 17

Metformin Eliminates Lymphedema in Mice by Alleviating Inflammation and Fibrosis: Implications for Human Therapy

Wei, M., Wang, L., Liu, X., Deng, Y., Yang, S., Pan, W., Zhang, X., Xu, G., Xiao, S., & Deng, C. (2024) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000011363 · Cited by 17

Metabolomic analysis of the Puerarin hypoglycemic activity via AMPK-mTOR and PPARγ-NF-κB signaling pathways

Gong, P., Wang, J., Wang, S., Yang, W., Yao, W., Li, N., Wang, J., Zhao, Y., Chen, F., Xie, J., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155546 · Cited by 17

Lipotoxicity: The missing link between diabetes and periodontitis?

Sun, Y. L., Yin, Y., Yang, S., Ai, D., Qin, H., Xia, X., Xu, X., & Song, J. (2024) · Journal of Periodontal Research · doi:10.1111/jre.13242 · Cited by 17

Effects of lifestyle interventions on the prevention of type 2 diabetes and reversion to normoglycemia by prediabetes phenotype: A systematic review and meta-analysis of randomized controlled trials

Chai, X., Wang, Y., Yin, X., Gong, Q., Zhang, J., Shao, R., & Li, G. (2025) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2025.103184 · Cited by 17

The Role of Tyrosine Kinases as a Critical Prognostic Parameter and Its Targeted Therapies in Ewing Sarcoma

Jin, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00613 · Cited by 17

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice

Ren, Y.-R., Ye, Y., Feng, Y., Xu, T., Shen, Y., Liu, J., Huang, S., Shen, J., & Leng, Y. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00609-w · Cited by 17

Metformin: Expanding the Scope of Application—Starting Earlier than Yesterday, Canceling Later

Kononova, Y. A., Likhonosov, N. P., & Babenko, A. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042363 · Cited by 17

Factors That Contribute to hIAPP Amyloidosis in Type 2 Diabetes Mellitus

Sevcuka, A., White, K., & Terry, C. (2022) · Life · doi:10.3390/life12040583 · Cited by 17

Global research trends on the links between the gut microbiota and diabetes between 2001 and 2021: A bibliometrics and visualized study

Zhang, B., Jin, Z., Zhai, T., Ding, Q., Yang, H., Wang, J., Zhang, L., & Zhao, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1011050 · Cited by 17

Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes

Cravalho, C. K. L., Meyers, A. G., Mabundo, L. S., Courville, A. B., Yang, S. B., Cai, H., Dai, Y., Walter, M. F., Walter, P. J., Sharma, S., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05236-y · Cited by 17

A new insight into cell biological and biochemical changes through aging

Sahabi, S., Jafari-Gharabaghlou, D., & Zarghami, N. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2021.151841 · Cited by 16

Hemato-biochemical indices alteration, oxidative stress, and immune suppression in the African catfish (Clarias gariepinus) exposed to metformin

Taher, H., Sabra, M. S., Salah-Eldin, A.-E., & Sayed, A. E. H. (2022) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-022-00150-9 · Cited by 16

Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets

AlZaim, I., Eid, A. H., Abd‐Elrahman, K. S., & EL‐Yazbi, A. F. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115337 · Cited by 16

Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition

Xie, Y., Zhou, Q., He, Q., Wang, X., & Wang, J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.008 · Cited by 16

The Link between Diabetes, Pancreatic Tumors, and miRNAs—New Players for Diagnosis and Therapy?

Kozłowska, M., & Śliwińska, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210252 · Cited by 16

N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism

Zhang, H., Gu, Y., Gang, Q., Huang, J., Xiao, Q., & Ha, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1166756 · Cited by 16

The effect of metformin on urate metabolism: Findings from observational and Mendelian randomization analyses

Dai, H., Hou, T., Wang, Q., Zhu, Z., Zhu, Y., Zhao, Z., Li, M., Xu, Y., Lu, J., Wang, T., et al. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15310 · Cited by 16

An apprise on novel drug delivery systems for management of diabetes mellitus

Pardhi, E. R., Bhor, Y., Singh, P. K., & Mehra, N. K. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105473 · Cited by 16

Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?

Papini, N., Giussani, P., & Tringali, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168884 · Cited by 16

Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation

Khodaei, F., Hosseini, S. M., Omidi, M., Hosseini, S. F., & Rezaei, M. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22662 · Cited by 16

Three genes expressed in relation to lipid metabolism considered as potential biomarkers for the diagnosis and treatment of diabetic peripheral neuropathy

Yang, Y., & Wang, Q. (2023) · Scientific Reports · doi:10.1038/s41598-023-35908-9 · Cited by 16

A multifunctional self-assembled hydrogel with bactericidal activity and macrophage metabolic reprogramming for diabetic bone defect repair

Wang, L., Wu, Z., Chen, X., Bai, J., Li, W., Ge, G., Zhang, W., Li, W., Qin, Y., Zhao, G., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102162 · Cited by 15

From Diabetes to Degenerative Diseases: The Multifaceted Action of Metformin

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