Foretz, Marc

Cellular and molecular mechanisms of metformin: an overview

Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012) · Clinical Science

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,720

Metformin: from mechanisms of action to therapies

Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,501

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 1,181

Anti-inflammatory effects of metformin irrespective of diabetes status

Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., et al. (2016) · Circulation Research

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 704

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 686

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 647

Mitochondrial fission and remodelling contributes to muscle atrophy

Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M., et al. (2010) · The EMBO Journal

Muscle Physiology and DisordersMitochondrial Function and Pathology

Cited by 596

AMPK inhibition in health and disease

Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 383

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 295

Metformin Activates AMP-Activated Protein Kinase in Primary Human Hepatocytes by Decreasing Cellular Energy Status

Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011) · Diabetologia

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 287

AMPK α1: A glucose sensor that controls CD 8 T ‐cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B., & Cantrell, D. A. (2013) · European Journal of Immunology

T-cell and B-cell ImmunologyMetabolism, Diabetes, and Cancer

Cited by 245

Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iɛ (CKIɛ)-dependent Degradation of Clock Protein mPer2

Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry

Circadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Cited by 244

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

Yang, Q., Liang, X., Sun, X., Zhang, L., Fu, X., Rogers, C. J., Berim, A., Zhang, S., Wang, S., Wang, B., et al. (2016) · Cell Metabolism

Adipose Tissue and MetabolismEpigenetics and DNA Methylation

Cited by 237

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

Lantier, L., Fentz, J., Mounier, R., Leclerc, J., Treebak, J. T., Pehmøller, C., Sanz, N., Sakakibara, I., Saint‐Amand, E., Rimbaud, S., et al. (2014) · The FASEB Journal

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 228

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 199

Enhanced muscle insulin sensitivity after contraction/exercise is mediated by AMPK

Kjøbsted, R., Munk-Hansen, N., Birk, J. B., Foretz, M., Viollet, B., Björnholm, M., Zierath, J. R., Treebak, J. T., & Wojtaszewski, J. F. P. (2017) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 178

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

Wu, Y., Song, P., Zhang, W., Liu, J., Dai, X., Liu, Z., Lu, Q., Ouyang, C., Xie, Z., Zhao, Z., et al. (2015) · Nature Medicine

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 169

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., et al. (2015) · Cellular Signalling

Metabolism, Diabetes, and CancerAdvanced Proteomics Techniques and Applications

Cited by 167

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK

Fu, X., Zhu, M., Zhang, S., Foretz, M., Viollet, B., & Du, M. (2016) · Diabetes

Muscle Physiology and DisordersMetabolism, Diabetes, and Cancer

Cited by 155

Important role for AMPKαl in limiting skeletal muscle cell hypertrophy

Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, K., Foretz, M., & Viollet, B. (2009) · The FASEB Journal

Muscle Physiology and DisordersMetabolism, Diabetes, and Cancer

Cited by 133

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., et al. (2012) · Biochemical Journal

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 131

LKB1 and AMPK regulate synaptic remodeling in old age

Samuel, M. A., Voinescu, P. E., Lilley, B. N., de Cabo, R., Foretz, M., Viollet, B., Pawlyk, B., Sandberg, M. A., Vavvas, D. G., & Sanes, J. R. (2014) · Nature Neuroscience

Retinal Development and DisordersNeuroscience and Neuropharmacology Research

Cited by 114

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

Obba, S., Hizir, Z., Boyer, L., Selimoglu-Buet, D., Pfeifer, A., Michel, G., Hamouda, M.-A., Gonçalvès, D., Cerezo, M., Marchetti, S., et al. (2015) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 100

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction

Kjøbsted, R., Roll, J. L. W., Jørgensen, N. O., Birk, J. B., Foretz, M., Viollet, B., Chadt, A., Al-Hasani, H., & Wojtaszewski, J. F. P. (2019) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 97