Obesity: a neuroimmunometabolic perspective

EFFECTS OF ADRENERGIC BLOCKING AGENTS ON LIPID MOBILIZATION FROM CANINE SUBCUTANEOUS ADIPOSE TISSUE AFTER SYMPATHETIC NERVE STIMULATION

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Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

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Leptin Has a Priming Effect on Eotaxin-Induced Human Eosinophil Chemotaxis

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Thyroid hormones and browning of adipose tissue

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Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments

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High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion

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Effects of central or peripheral leptin administration on norepinephrine turnover in defined fat depots

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Bone Marrow Leptin Signaling Mediates Obesity-Associated Adipose Tissue Inflammation in Male Mice

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Microvascular Endothelial Dysfunction in Obesity Is Driven by Macrophage-Dependent Hydrogen Sulfide Depletion

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Studies on Lipolysis in Human Adipose Cells *

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Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells

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β2-adrenoceptor signaling reduction in dendritic cells is involved in the inflammatory response in adjuvant-induced arthritic rats

Wu, H., Chen, J., Song, S., Yuan, P., Liu, L., Zhang, Y., Zhou, A., Chang, Y., Zhang, L., & Wei, W. (2016) · Scientific Reports · doi:10.1038/srep24548 · Cited by 53

TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone

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Regulatory aspects of the human hypothalamus-pituitary-thyroid axis

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Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis

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A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

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Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K + Channels

Noblet, J. N., Owen, M. K., Goodwill, A. G., Sassoon, D., & Tune, J. D. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305500 · Cited by 41

Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin

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Reduced adipose tissue oxygenation in human obesity evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

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Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery.

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An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice

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Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress (1160.5)

Sidossis, L. S., Porter, C. C., Saraf, M. K., Chao, T., Finnerty, C. C., Chondronikola, M., Børsheim, E., Hawkins, H. K., & Herndon, D. N. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1160.5 · Cited by 33

Studies of Substrate Regulation in Fasting: I. Evidence for Central Regulation of Lipolysis by Plasma Glucose Mediated by the Sympathetic Nervous System

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How Does Fat Transition from White to Beige?

Reitman, M. L. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.011 · Cited by 33

Adrenergic receptors regulate macrophage secretion

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Sympathetic neural-immune interactions regulate hematopoiesis, thermoregulation and inflammation in mammals

Madden, K. S. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.04.015 · Cited by 31

β2-agonist-induced inhibition of neutrophil chemotaxis is not associated with modification of LFA-1 and Mac-1 expression or with impairment of polymorphonuclear leukocyte antibacterial activity

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Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue

Pino, M. F., Divoux, A., Simmonds, A. V., Smith, S. R., & Sparks, L. M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.155 · Cited by 26

Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and restoration of normal anticontractile activity despite persistent obesity

Aghamohammadzadeh, R., Greenstein, A. S., Yadav, R., Jeziorska, M., Hama, S., Pemberton, P. W., Soran, H., Ammori, B. J., & Heagerty, A. M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60458-4 · Cited by 24

Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation

Noguchi, T., Nakagome, K., Kobayashi, T., Ueda, Y., Soma, T., Nakamoto, H., & Nagata, M. (2015) · Allergology International · doi:10.1016/j.alit.2015.05.009 · Cited by 20

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity

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Generation of Leptin Receptor Bone Marrow Chimeras: Recovery From Irradiation, Immune Cellularity, Cytokine Expression, and Metabolic Parameters

Gove, M. E., Sherry, C. L., Pini, M., & Fantuzzi, G. (2010) · Obesity · doi:10.1038/oby.2010.84 · Cited by 17

Effect of α2-adrenergic agonists and antagonists on cytokine release from human lung macrophages cultured in vitro

Piazza, O., Staiano, R. I., ROBERTIS, E. D., Conti, G., Crescenzo, V. G. D., Loffredo, S., Marone, G., Marinosci, G. Z., & Cataldi, M. (2016) · PubMed Central · doi:10.14273/unisa-2673 · Cited by 11

Reactive Oxygen Species in Macrophages: Sources and Targets

Canton, M., Sánchez‐Rodríguez, R., Spera, I., Venegas, F. C., Favia, M., Viola, A., & Castegna, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734229 · Cited by 490

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 424

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

Brestoff, J. R., Wilen, C. B., Moley, J. R., Li, Y., Zou, W., Malvin, N. P., Rowen, M. N., Saunders, B. T., Ma, H., Mack, M. R., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.008 · Cited by 399

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278

Adipose tissue at single-cell resolution

Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.002 · Cited by 218

Neuroimmunometabolism in Health and Disease

Sweeney, C. A. P., Liu, H., Dean, M., & Domingos, A. I. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090122-050509

Cross-regulation between adipose tissue innervation and metaflammation: a potential therapeutic target for obesity

Shi, W. (2025) · American Journal of Translational Research · doi:10.62347/aiws5429 · Cited by 7

Neuro-immune interactions in obesity

Pirzgalska, R. M. (2018) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity

O’Brien, C. J. O., Haberman, E. R., & Domingos, A. I. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120319-114106 · Cited by 23

The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

Martínez‐Sánchez, N., Sweeney, O., Sidarta-Oliveira, D., Caron, A., Stanley, S. A., & Domingos, A. I. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.017 · Cited by 127