Cited by 123Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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Obesity: a neuroimmunometabolic perspective

Larabee, Chelsea M., Neely, Oliver C., Domingos, Ana I.·2020·Nature Reviews Endocrinology

DOI 10.1038/s41574-019-0283-6

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Abstract

Neuroimmunology and immunometabolism are burgeoning topics of study, but the intersection of these two fields is scarcely considered. This interplay is particularly prevalent within adipose tissue, where immune cells and the sympathetic nervous system (SNS) have an important role in metabolic homeostasis and pathology, namely in obesity. In the present Review, we first outline the established reciprocal adipose-SNS relationship comprising the neuroendocrine loop facilitated primarily by adipose tissue-derived leptin and SNS-derived noradrenaline. Next, we review the extensive crosstalk between adipocytes and resident innate immune cells as well as the changes that occur in these secretory and signalling pathways in obesity. Finally, we discuss the effect of SNS adrenergic signalling in immune cells and conclude with exciting new research demonstrating an immutable role for SNS-resident macrophages in modulating SNS-adipose crosstalk. We posit that the latter point constitutes the existence of a new field - neuroimmunometabolism.

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Authors: Larabee, C. M., Neely, O. C., & Domingos, A. I.
Affiliations: University of Oxford (GB)
Howard Hughes Medical Institute (US)
Corresponding author: Domingos, Ana I.
ORCID: Larabee, Chelsea M.
Domingos, Ana I.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2019-11-27
Volume: 16
Issue: 1
Pages: 30-43
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-019-0283-6
OpenAlex: W2989580600
Cited by: 123
References: 233
Citations by year: 2026: 4 · 2025: 14 · 2024: 21 · 2023: 24 · 2022: 22 · 2021: 21 · 2020: 17
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (208576/Z/17/Z)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: obesity, neuroimmunology, immunometabolism, adipose tissue, sympathetic nervous system, leptin, norepinephrine, innate immune cells, adrenergic signaling, adipose tissue macrophages, metabolic homeostasis
MeSH terms: Animals, Energy Metabolism, Humans, Macrophages, Obesity, Neuroimmunomodulation, Adipocytes

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