Obesity: a neuroimmunometabolic perspective

Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Identification and Importance of Brown Adipose Tissue in Adult Humans

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Macrophages, inflammation, and insulin resistance

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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The role of neuropeptide Y in the antiobesity action of the obese gene product

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,425

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,411

The role of estrogens in control of energy balance and glucose homeostasis

Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

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Metabolic Instruction of Immunity

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Monocyte chemoattractant protein 1 in obesity and insulin resistance

Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,229

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

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Type 2 innate lymphoid cells control eosinophil homeostasis

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Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035

Receptor-mediated regional sympathetic nerve activation by leptin.

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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

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Fibrosis and adipose tissue dysfunction.

Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 956

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

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Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

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Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

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Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

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Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

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TNF‐α and adipocyte biology

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Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

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Reduced Adipose Tissue Oxygenation in Human Obesity

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βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

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A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

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Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

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Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

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Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

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Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

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Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

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Selective deletion of leptin receptor in neurons leads to obesity

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UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

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The role of peripheral immune cells in the CNS in steady state and disease

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Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

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Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

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Human Leptin Stimulates Proliferation and Activation of Human Circulating Monocytes

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Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

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GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK

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Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

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Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

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Selective deletion of leptin receptor in neurons leads to obesity

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Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes

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Proinflammatory Phenotype of Perivascular Adipocytes

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Melanocortin receptors in leptin effects

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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

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Adipocyte lipolysis and insulin resistance

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Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

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Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

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Leptin targets in the mouse brain

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Adiponectin differentially regulates cytokines in porcine macrophages

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Role of innate and adaptive immunity in obesity-associated metabolic disease

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Sympathetic and sensory innervation of brown adipose tissue

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Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

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Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

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Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

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CNS origins of the sympathetic nervous system outflow to brown adipose tissue

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Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

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Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

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Adrenergic activation of triiodothyronine production in brown adipose tissue

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Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

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Production of Chemokines by Perivascular Adipose Tissue

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