The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.
Obesity: a neuroimmunometabolic perspective
Abstract
Neuroimmunology and immunometabolism are burgeoning topics of study, but the intersection of these two fields is scarcely considered. This interplay is particularly prevalent within adipose tissue, where immune cells and the sympathetic nervous system (SNS) have an important role in metabolic homeostasis and pathology, namely in obesity. In the present Review, we first outline the established reciprocal adipose-SNS relationship comprising the neuroendocrine loop facilitated primarily by adipose tissue-derived leptin and SNS-derived noradrenaline. Next, we review the extensive crosstalk between adipocytes and resident innate immune cells as well as the changes that occur in these secretory and signalling pathways in obesity. Finally, we discuss the effect of SNS adrenergic signalling in immune cells and conclude with exciting new research demonstrating an immutable role for SNS-resident macrophages in modulating SNS-adipose crosstalk. We posit that the latter point constitutes the existence of a new field - neuroimmunometabolism.
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In the citing paper
“induction of beige adipocytes by exercise or functional enhancement of existing BAT has shown to improve total energy expenditure and insulin sensitivity, contributing to fat and weight loss [16,17,18,19]”
In the citing paper
“It has been shown to directly increase GLP-1 in mice [73] and to stimulate SNS, increasing WAT lipolysis and “browning” and BAT thermogenesis [19].”
In the citing paper
“enhancing SNS output [19] (3b)”
Citations
Cites
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization
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Identification and Importance of Brown Adipose Tissue in Adult Humans
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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TLR4 links innate immunity and fatty acid-induced insulin resistance
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Targeted disruption of the melanocortin-4 receptor results in obesity in mice
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Reactive Oxygen Species in Macrophages: Sources and Targets
Canton, M., Sánchez‐Rodríguez, R., Spera, I., Venegas, F. C., Favia, M., Viola, A., & Castegna, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734229 · Cited by 490
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 424
Brestoff, J. R., Wilen, C. B., Moley, J. R., Li, Y., Zou, W., Malvin, N. P., Rowen, M. N., Saunders, B. T., Ma, H., Mack, M. R., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.008 · Cited by 399
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
“It has been shown to directly increase GLP-1 in mice [73] and to stimulate SNS, increasing WAT lipolysis and “browning” and BAT thermogenesis [19].”
BackgroundAdipose tissue at single-cell resolution
Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.002 · Cited by 218
Metadata
- Authors
- Larabee, C. M., Neely, O. C., & Domingos, A. I.
- Affiliations
- University of Oxford (GB)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Domingos, Ana I.
- Venue
- Nature Reviews Endocrinology
- Published
- 2019-11-27
- Volume
- 16
- Issue
- 1
- Pages
- 30-43
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2989580600
- Cited by
- 123
- References
- 233
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 21 · 2023: 24 · 2022: 22 · 2021: 21 · 2020: 17
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (208576/Z/17/Z)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, neuroimmunology, immunometabolism, adipose tissue, sympathetic nervous system, leptin, norepinephrine, innate immune cells, adrenergic signaling, adipose tissue macrophages, metabolic homeostasis
- MeSH terms
- Animals, Energy Metabolism, Humans, Macrophages, Obesity, Neuroimmunomodulation, Adipocytes
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