The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
The metabolic role of vagal afferent innervation
Abstract
The regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in gastrointestinal regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.
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“In turn, sensory afferent neurons of the vagus nerve detect a diverse range of chemical and mechanical stimuli within the intestines and GMB, and transmit messages to the nucleus tractus solitarius in the brainstem to initiate autonomic, endocrine and behavioural responses104.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [104]
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2 retracted
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RetractedRetracted: KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin
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RetractedRole of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Research works printed but not linked: 1
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The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686
Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
Stogios, N., Gdanski, A., Gerretsen, P., Chintoh, A. F., Graff-Guerrero, A., Rajji, T. K., Remington, G., Hahn, M. K., & Agarwal, S. M. (2021) · npj Schizophrenia · doi:10.1038/s41537-021-00151-6 · Cited by 98
Metadata
- Authors
- Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Lam, Tony K. T.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2018-09-05
- Volume
- 15
- Issue
- 10
- Pages
- 625-636
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2890943375
- Cited by
- 140
- References
- 251
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 22 · 2023: 16 · 2022: 16 · 2021: 24 · 2020: 10 · 2019: 6
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- vagus nerve, gut-brain signaling, glucose homeostasis, energy homeostasis, appetite regulation, obesity, diabetes mellitus
- MeSH terms
- Animals, Energy Metabolism, Glucose, Homeostasis, Humans, Vagus Nerve, Gastrointestinal Tract
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