Cited by 140Regulation of Appetite and ObesityVagus Nerve Stimulation ResearchGastrointestinal motility and disorders

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The metabolic role of vagal afferent innervation

Waise, T. M. Zaved, Dranse, Helen J., Lam, Tony K. T.·2018·Nature Reviews Gastroenterology & Hepatology

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Abstract

The regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in gastrointestinal regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.

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Authors: Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T.
Affiliations: University Health Network (CA)
Corresponding author: Lam, Tony K. T.
ORCID: Waise, T. M. Zaved
Lam, Tony K. T.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2018-09-05
Volume: 15
Issue: 10
Pages: 625-636
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/s41575-018-0062-1
OpenAlex: W2890943375
Cited by: 140
References: 251
Citations by year: 2026: 21 · 2025: 25 · 2024: 22 · 2023: 16 · 2022: 16 · 2021: 24 · 2020: 10 · 2019: 6
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: vagus nerve, gut-brain signaling, glucose homeostasis, energy homeostasis, appetite regulation, obesity, diabetes mellitus
MeSH terms: Animals, Energy Metabolism, Glucose, Homeostasis, Humans, Vagus Nerve, Gastrointestinal Tract

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The metabolic role of vagal afferent innervation

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