The metabolic role of vagal afferent innervation

Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet.

Gil, K., Bugajski, A. J., & Thor, P. (2011) · PubMed · Cited by 57

Regulation of ACTH secretory pathways in cultured pituitary cells

Schwartz, J., Gibson, S., & White, A. E. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.261.5.c793 · Cited by 57

Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells

Poreba, M., Dong, C. X., Li, S. K., Stahl, A., Miner, J. H., & Brubaker, P. L. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00116.2012 · Cited by 56

Dichotomizing Axons in Spinal and Vagal Afferents of the Mouse Stomach

Zhong, F., Christianson, J. A., Davis, B. M., & Bielefeldt, K. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9843-z · Cited by 55

Effect of brain stem NMDA-receptor blockade by MK-801 on behavioral and Fos responses to vagal satiety signals

Zheng, H., Kelly, L., Patterson, L. M., & Berthoud, H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1104 · Cited by 54

Heterogeneous functional expression of calcium channels at sensory and synaptic regions in nodose neurons

Mendelowitz, D., Reynolds, P. J., & Andresen, M. C. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.872 · Cited by 54

Synapse formation among developing sensory neurones from rat nodose ganglia grown in tissue culture.

Cooper, E. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015244 · Cited by 53

Colesevelam Improves Oral but Not Intravenous Glucose Tolerance by a Mechanism Independent of Insulin Sensitivity and β-Cell Function

Marina, A., Utzschneider, K., Wright, L., Montgomery, B., Marcovina, S., & Kahn, S. (2012) · Diabetes Care · doi:10.2337/dc11-2050 · Cited by 52

Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry

Yang, M., Wang, J., Wu, S., Yuan, L., Zhao, X., Liu, C., Xie, J., Jia, Y., Lai, Y., Zhao, A. Z., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.28 · Cited by 52

Abrogation of peripheral cholecystokinin-satiety in the capsaicin treated rat

MacLean, D. B. (1985) · Regulatory Peptides · doi:10.1016/0167-0115(85)90204-6 · Cited by 51

Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats

Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2006) · Diabetes · doi:10.2337/db06-0730 · Cited by 50

Altered gastric vagal mechanosensitivity in diet-induced obesity persists on return to normal chow and is accompanied by increased food intake

Kentish, S. J., O’Donnell, T. A., Frisby, C. L., Li, H., Wittert, G., & Page, A. J. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.138 · Cited by 49

Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

Rasmussen, B. A., Breen, D. M., Luo, P., Cheung, G. W. C., Yang, C. S., Sun, B., Kokorovic, A., Rong, W., & Lam, T. K. T. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.053 · Cited by 49

Luminal CCK-releasing factors in the isolated vascularly perfused rat duodenojejunum

Cuber, J.-C., Bernard, G., Fushiki, T., et al. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.259.2.g191 · Cited by 49

Changes in microglial activation within the hindbrain, nodose ganglia, and the spinal cord following subdiaphragmatic vagotomy

Gallaher, Z. R., Ryu, V., Herzog, T., Ritter, R. C., & Czaja, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.079 · Cited by 47

A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism

Burcelin, R., Sérino, M., & Cabou, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.003 · Cited by 47

Critical Role of Axonal A-Type K+Channels and Axonal Geometry in the Gating of Action Potential Propagation along CA3 Pyramidal Cell Axons: A Simulation Study

Kopysova, I. L., & Debanne, D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07436.1998 · Cited by 46

Synergistic Interaction between Leptin and Cholecystokinin in the Rat Nodose Ganglia Is Mediated by PI3K and STAT3 Signaling Pathways

Heldsinger, A. A., Grabauskas, G., Song, I., & Owyang, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198945 · Cited by 44

Peripheral neural targets in obesity

Page, A. J., Symonds, E. L., Peiris, M., Blackshaw, L. A., & Young, R. L. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01951.x · Cited by 43

Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent

Yang, H., Wang, L., Wu, S. V., Tay, J., Goulet, M., Boismenu, R., Czimmer, J., Wang, Y., Wu, S. V., Ao, Y., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.027 · Cited by 43

Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons

Ghilardi, J. R., Allen, C. J., Vigna, S. R., McVey, D. C., & Mantyh, P. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)91519-9 · Cited by 42

Glucagon-like peptide-1 inhibits voltage-gated potassium currents in mouse nodose ganglion neurons

Gaisano, G., park, S. J., Daly, D., & Beyak, M. J. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01430.x · Cited by 40

Plasticity of gastrointestinal vagal afferent satiety signals

Page, A. J., & Kentish, S. J. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12973 · Cited by 39

Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Ayush, E., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., Nakata, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067198 · Cited by 38

Plasticity of vagal afferent signaling in the gut

Grabauskas, G., & Owyang, C. (2017) · Medicina · doi:10.1016/j.medici.2017.03.002 · Cited by 38

Plasticity of gastro-intestinal vagal afferent endings

Kentish, S. J., & Page, A. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.012 · Cited by 37

Both CCK-A and CCK-B/gastrin receptors are present on rabbit vagus nerve

Lin, C., & Miller, T. R. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r591 · Cited by 36

Duodenal Mucosal Protein Kinase C-δ Regulates Glucose Production in Rats

Kokorovic, A., Cheung, G. W. C., Breen, D. M., Chari, M., Lam, C., & Lam, T. K. T. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.042 · Cited by 34

Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat

Wolfe, M. M., Zhao, K.-B., Glazier, K. D., Jarboe, L. A., & Tseng, C. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.3.g561 · Cited by 34

N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat

Czaja, K., Ritter, R. C., & Burns, G. A. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20955 · Cited by 33

Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons

Iwasaki, Y., Goswami, C., & Yada, T. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.05.003 · Cited by 31

Spike conduction properties of T-shaped C neurons in the rabbit nodose ganglion

Ducreux, C., Reynaud, J., & Puizillout, J. J. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00384348 · Cited by 30

Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production

Breen, D. M., Yue, J. T. Y., Rasmussen, B. A., Kokorovic, A., Cheung, G. W. C., & Lam, T. K. T. (2011) · Diabetes · doi:10.2337/db11-0852 · Cited by 30

Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses

Fenwick, A. J., Wu, S.-W., & Peters, J. H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00006 · Cited by 26

Comment on Kazda et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care 2016;39:1241–1249

Agrawal, S., & Gupta, Y. (2016) · Diabetes Care · doi:10.2337/dc16-1340 · Cited by 26

Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W

Li, H., Kentish, S. J., Kritas, S., Young, R. L., Isaacs, N. J., O’Donnell, T. A., Blackshaw, L. A., Wittert, G., & Page, A. J. (2013) · Acta Physiologica · doi:10.1111/apha.12154 · Cited by 24

Organization of vagal afferents in pylorus: Mechanoreceptors arrayed for high sensitivity and fine spatial resolution?

Powley, T. L., Hudson, C. N., McAdams, J. L., Baronowsky, E. A., Martin, F. N., Mason, J. K., & Phillips, R. J. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.02.008 · Cited by 24

Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation

Heldsinger, A., Grabauskas, G., Wu, X., Zhou, S., Lu, Y., Song, I., & Owyang, C. (2014) · Endocrinology · doi:10.1210/en.2013-2095 · Cited by 22

How the Gut Feels, Smells, and Talks

Beumer, J., & Clevers, H. C. (2017) · Cell · doi:10.1016/j.cell.2017.06.023 · Cited by 22

Channeling satiation: A primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons

Wu, S.-W., Fenwick, A. J., & Peters, J. H. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.09.003 · Cited by 19

Cranial Nerves

Monkhouse, S. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543524 · Cited by 19

Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans

Cvijanovic, N., Isaacs, N. J., Rayner, C. K., Feinle‐Bisset, C., Young, R. L., & Little, T. J. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.02.005 · Cited by 18

Long-chain fatty acid sensing in the gastrointestinal tract

McLaughlin, J. T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351199 · Cited by 17

Abdominal vagal afferent pathways and their distributions of intraganglionic laminar endings in the rat duodenum

Wang, F., Young, Y. K., & Kao, C. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22812 · Cited by 16

Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor–restored GHSR-null mice

Okada, T., Waise, T. M. Z., Toshinai, K., Mita, Y., Sakoda, H., & Nakazato, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.035 · Cited by 15

Physiological and morphological effects of long-term vagal stimulation in diet induced obesity in rats.

Gil, K., Bugajski, A. J., Kurnik‐Łucka, M., Zaraska, W., & Thor, P. (2009) · PubMed · Cited by 14

Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: Impact of age and sex

Li, H., Frisby, C. L., O’Donnell, T. A., et al. (2015) · Peptides · doi:10.1016/j.peptides.2015.07.011 · Cited by 8

Distribution of the internal branch of the human accessory nerve

Liu, H.-F., Won, H., Chung, I., et al. (2014) · Anatomical Science International · doi:10.1007/s12565-014-0244-z · Cited by 8

The Effect of Aging on the Differentiation of Rat Osteoblast-like Cells in vitro

Haraguchi, T., Yamane, G., Shimono, M., et al. (2003) · Biomedical Research · doi:10.2220/biomedres.24.1 · Cited by 7

Satellite glial cells in the nodose ganglion of the rat vagus nerve: Morphologicalalterations of microglial cells.

Yakura, T., Miki, T., Warita, K., et al. (2013) · Biomedical Research-tokyo · Cited by 4

Untitled work

Phillips (2000) · doi:10.1002/(sici)1096-9861(20000605)421:3

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686

Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health

Stogios, N., Gdanski, A., Gerretsen, P., Chintoh, A. F., Graff-Guerrero, A., Rajji, T. K., Remington, G., Hahn, M. K., & Agarwal, S. M. (2021) · npj Schizophrenia · doi:10.1038/s41537-021-00151-6 · Cited by 98

Hypothalamic PDE3B deficiency alters body weight and glucose homeostasis in mouse

Sahu, M., Anamthathmakula, P., & Sahu, A. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0304 · Cited by 6

Primer

Flier, J. S., & Maratos–Flier, E. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00393-6 · Cited by 32

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

Alsina, R., Trotta, M., & Bumaschny, V. F. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00554 · Cited by 9

The Role of AMPK in the Regulation of Appetite and Energy Homeostasis: Role of AMPK in Appetite

Belli, İ., & Yaman, M. (2020) · DergiPark (Istanbul University) · Cited by 3

Central Nervous System Nutrient-sensing and the Regulation of Energy and Glucose Homeostasis

Lam, K. L. C. (2010) · TSpace (University of Toronto)