Optimizing immunotherapy for colorectal cancer
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Approximately 90% of patients with pMMR/MSS CRC have a low tumour mutational burden, are immune-cold, and do not respond to ICB.
“In contrast, approximately 90% of patients with pMMR/MSS CRC have a low tumour mutational burden, are immune-cold and do not respond to ICB109 (figure 2).”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [109]
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- Authors
- Ganesh, K.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Ganesh, Karuna
- ORCID
- Ganesh, Karuna
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2021-12-14
- Volume
- 19
- Issue
- 2
- Pages
- 93-94
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC9487162
- OpenAlex
- W4200537999
- Cited by
- 120
- References
- 12
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 41 · 2023: 21 · 2022: 5
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (U2CCA233284, K08CA230213, P30CA008748, R37CA266185)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, immunotherapy, microsatellite instability-high, mismatch repair deficiency, metastatic colorectal cancer, first-line therapy, tumor immune microenvironment, single-cell analysis, spatial analysis, preclinical models
- MeSH terms
- Antineoplastic Agents, Immunological, Humans, Immunotherapy, Colorectal Neoplasms, Tumor Microenvironment, Antibodies, Monoclonal, Humanized
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