Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works

Hallmarks of Cancer: New Dimensions

Hanahan, D. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1059 · Cited by 9,887 · see citing works

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

The consensus molecular subtypes of colorectal cancer

Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3967 · Cited by 5,170 · see citing works

Tumour heterogeneity and resistance to cancer therapies

Dagogo-Jack, I., & Shaw, A. T. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.166 · Cited by 3,846 · see citing works

Influence of tumour micro-environment heterogeneity on therapeutic response

Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,159 · see citing works

Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice

Chassaing, B., Aitken, J. D., Malleshappa, M., & Vijay–Kumar, M. (2014) · Current Protocols in Immunology · doi:10.1002/0471142735.im1525s104 · Cited by 2,094 · see citing works

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851 · see citing works

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

Bardia, A., Hurvitz, S. A., Tolaney, S. M., Loirat, D., Punie, K., Oliveira, M., Brufsky, A., Sardesai, S. D., Kalinsky, K., Zelnak, A. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2028485 · Cited by 1,711 · see citing works

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L. K., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,194 · see citing works

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Yaeger, R., Chatila, W. K., Lipsyc, M. D., Hechtman, J. F., Cercek, A., Sanchez-Vega, F., Jayakumaran, G., Middha, S., Zehir, A., Donoghue, M. T. A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.004 · Cited by 858 · see citing works

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Melo, F. D. S. E., Kurtova, A. V., Harnoss, J. M., Kljavin, N. M., Hoeck, J. D., Hung, J., Anderson, J. E., Storm, E. E., Modrusan, Z. D., Koeppen, H., et al. (2017) · Nature · doi:10.1038/nature21713 · Cited by 782 · see citing works

The great escape: tumour cell plasticity in resistance to targeted therapy

Boumahdi, S., & de Sauvage, F. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0044-1 · Cited by 759 · see citing works

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742 · see citing works

Visualization and targeting of LGR5+ human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T., & Sato, T. (2017) · Nature · doi:10.1038/nature22081 · Cited by 728 · see citing works

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Yui, S., Azzolin, L., Maimets, M., Pedersen, M. T., Fordham, R. P., Hansen, S. L., Larsen, H. L., Guiu, J., Alves, M. R. P., Rundsten, C. F., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.001 · Cited by 678 · see citing works

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015) · Nature · doi:10.1038/nature15382 · Cited by 647 · see citing works

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Nguyen, B., Fong, C. J., Luthra, A., Smith, S. A., DiNatale, R. G., Nandakumar, S., Walch, H. S., Chatila, W. K., Madupuri, R., Kundra, R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.003 · Cited by 616 · see citing works

Lgr5 stem cells are indispensable for radiation-induced intestinal regeneration

Metcalfe, C., Kljavin, N. M., Ybarra, R., & de Sauvage, F. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.008 · Cited by 575 · see citing works

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

Ayyaz, A., Kumar, S., Sangiorgi, B., Ghoshal, B., Gosio, J., Ouladan, S., Fink, M., Barutcu, S., Trcka, D., Shen, J., et al. (2019) · Nature · doi:10.1038/s41586-019-1154-y · Cited by 569 · see citing works

TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With Metastatic Urothelial Carcinoma Progressing After Platinum-Based Chemotherapy and Checkpoint Inhibitors

Tagawa, S. T., Balar, A. V., Petrylak, D. P., Kalebasty, A. R., Loriot, Y., Fléchon, A., Jain, R. K., Agarwal, N., Bupathi, M., Barthelemy, P., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03489 · Cited by 543 · see citing works

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

Montgomery, R. K., Carlone, D. L., Richmond, C. A., Farilla, L., Kranendonk, M. E. G., Henderson, D. E., Baffour‐Awuah, N. Y., Ambruzs, D. M., Fogli, L. K., Algra, S. O., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013004108 · Cited by 537 · see citing works

Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)*

Goldenberg, D. M., Cardillo, T. M., Govindan, S. V., Rossi, E. A., & Sharkey, R. M. (2015) · Oncotarget · doi:10.18632/oncotarget.4318 · Cited by 500 · see citing works

Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial

Rugo, H. S., Bardia, A., Marmé, F., Cortés, J., Schmid, P., Loirat, D., Trédan, O., Ciruelos, E., Dalenc, F., Gómez Pardo, P., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01245-x · Cited by 496 · see citing works

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.018 · Cited by 495 · see citing works

Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study

Cardoso, R., Guo, F., Heisser, T., Hackl, M., Ihle, P., Schutter, H. D., Damme, N. V., Valerianova, Z., Atanasov, T., Májek, O., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00199-6 · Cited by 487 · see citing works

Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

Miyoshi, H., Ajima, R., Luo, C. T., Yamaguchi, T. P., & Stappenbeck, T. S. (2012) · Science · doi:10.1126/science.1223821 · Cited by 470 · see citing works

Therapeutic modulation of Notch signalling — are we there yet?

Andersson, E. R., & Lendahl, U. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4252 · Cited by 452 · see citing works

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Jackstadt, R., van Hooff, S. R., Leach, J. D. G., Cortés-Lavaud, X., Lohuis, J. O., Ridgway, R. A., Wouters, V. M., Roper, J., Kendall, T. J., Roxburgh, C. S. D., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.003 · Cited by 427 · see citing works

A model for RAS mutation patterns in cancers: finding the sweet spot

Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0076-6 · Cited by 384 · see citing works

Cancer cell plasticity during tumor progression, metastasis and response to therapy

Pérez-González, A., Bévant, K., & Blanpain, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00595-y · Cited by 353 · see citing works

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

Touil, Y. S., Igoudjil, W., Corvaisier, M., Dessein, A., Vandomme, J., Monté, D., Stechly, L., Skrypek, N., Langlois, C., Grard, G., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1854 · Cited by 333 · see citing works

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

Nusse, Y. M., Savage, A. K., Marangoni, P., Huber, A. R., Landman, T. A., de Sauvage, F. J., Locksley, R. M., & Klein, O. D. (2018) · Nature · doi:10.1038/s41586-018-0257-1 · Cited by 333 · see citing works

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Chen, B., Scurrah, C. R., McKinley, E. T., Simmons, A. J., Ramirez-Solano, M. A., Zhu, X., Markham, N. O., Heiser, C. N., Vega, P. N., Rolong, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.031 · Cited by 328 · see citing works

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli, A., Oost, K. C., Kester, L. A., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.02.008 · Cited by 321 · see citing works

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Peltonen, K., Colis, L. C., Liu, H., Trivedi, R. K., Moubarek, M. S., Moore, H. M., Bai, B., Rudek, M. A., Bieberich, C. J., & Laiho, M. (2014) · Cancer Cell · doi:10.1016/j.ccr.2013.12.009 · Cited by 317 · see citing works

Human trophoblast cell-surface antigens defined by monoclonal antibodies.

Lipinski, M., Parks, D. R., Rouse, R. V., & Herzenberg, L. A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.5147 · Cited by 306 · see citing works

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

Roulis, M., Kaklamanos, A., Schernthanner, M., Bielecki, P., Zhao, J., Kaffe, E., Frommelt, L.-S., Qu, R., Knapp, M. S., Henriques, A. R., et al. (2020) · Nature · doi:10.1038/s41586-020-2166-3 · Cited by 298 · see citing works

Identification of Lgr5-Independent Spheroid-Generating Progenitors of the Mouse Fetal Intestinal Epithelium

Mustata, R. C., Vasile, G., Vallone, V. B. F., Strollo, S., Lefort, A., Libert, F., Monteyne, D., Pérez-Morga, D. L., Vassart, G., & Garcia, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.005 · Cited by 291 · see citing works

CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers

Smith, L. M., Nesterova, A., Ryan, M. C., Duniho, S. M., Jonas, M., Anderson, M. E., Zabinski, R. F., Sutherland, M. K., Gerber, H.-P., Orden, K. L. V., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604437 · Cited by 287 · see citing works

Efficient colonic mucosal wound repair requires Trem2 signaling

Seno, H., Miyoshi, H., Brown, S. L., Geske, M. J., Colonna, M., & Stappenbeck, T. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803343106 · Cited by 286 · see citing works

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Cañellas-Socias, A., Cortina, C., Hernando-Momblona, X., Palomo-Ponce, S., Mulholland, E. J., Turon, G., Mateo, L., Conti, S., Roman, O., Sevillano, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05402-9 · Cited by 256 · see citing works

L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer

Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A. M., He, L., Sharma, R., O’Rourke, K. P., Reuter, V. P., Huang, Y.-H., Turkekul, M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-019-0006-x · Cited by 245 · see citing works

Progressive plasticity during colorectal cancer metastasis

Moorman, A., Benitez, E. K., Cambuli, F., Jiang, Q., Mahmoud, A., Lumish, M., Hartner, S., Balkaran, S., Bermeo, J., Asawa, S., et al. (2025) · Nature · doi:10.1038/s41586-024-08150-0 · Cited by 229 · see citing works

Intestinal Regeneration: Regulation by the Microenvironment

Hageman, J. H., Heinz, M. C., Kretzschmar, K., van der Vaart, J., Clevers, H. C., & Snippert, H. J. G. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.07.009 · Cited by 215 · see citing works

Cell–matrix interface regulates dormancy in human colon cancer stem cells

Ohta, Y., Fujii, M., Takahashi, S., Takano, A., Nanki, K., Matano, M., Hanyu, H., Saito, M. K., Shimokawa, M., Nishikori, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05043-y · Cited by 211 · see citing works

CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer

Swaminathan, S. K., Roger, E., Toti, U. S., Niu, L., Ohlfest, J. R., & Panyam, J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.014 · Cited by 196 · see citing works

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

Zhang, H., Ramakrishnan, S. K., Triner, D., Centofanti, B., Maitra, D., Győrffy, B., Sebolt-Leopold, J. S., Dame, M. K., Varani, J., Brenner, D. E., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aac5418 · Cited by 196 · see citing works

Trop2: A possible therapeutic target for late stage epithelial carcinomas

Cubas, R., Li, M., Chen, C., & Yao, Q. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.001 · Cited by 192 · see citing works

The challenge of targeting cancer stem cells to halt metastasis.

Agliano, A., Calvo, A., & Box, C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.003 · Cited by 188 · see citing works

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Cheung, P., Xiol, J., Dill, M. T., Yuan, W.-C., Panero, R., Roper, J., Osorio, F. G., Maglic, D., Li, Q., Gurung, B., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.003 · Cited by 185 · see citing works

A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer

Berlin, J. D., Bendell, J. C., Hart, L. L., Firdaus, I., Gore, I., Hermann, R. C., Mulcahy, M. F., Zalupski, M. M., Mackey, H. M., Yauch, R. L., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1800 · Cited by 182 · see citing works

Targeting LGR5 ⁺ cells with an antibody-drug conjugate for the treatment of colon cancer

Junttila, M. R., Mao, W., Wang, X., Wang, B.-E., Pham, T., Flygare, J., Yu, S.-F., Yee, S., Goldenberg, D., Fields, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7433 · Cited by 182 · see citing works

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Herpers, B., Eppink, B., James, M. I., Cortina, C., Cañellas-Socias, A., Boj, S. F., Hernando-Momblona, X., Glodzik, D., Roovers, R. C., van de Wetering, M., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00359-0 · Cited by 178 · see citing works

Incidence of Recurrence and Time to Recurrence in Stage I to III Colorectal Cancer

Nors, J., Iversen, L. H., Erichsen, R., Gotschalck, K. A., & Andersen, C. L. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.5098 · Cited by 167 · see citing works

Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis

Zeng, P., Chen, M., Zhou, L.-N., Tang, M., Liu, C., & Lu, P. (2016) · Scientific Reports · doi:10.1038/srep33658 · Cited by 164 · see citing works

Recent Advances in Lgr5 + Stem Cell Research

Leung, C., Tan, S. H., & Barker, N. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.01.010 · Cited by 157 · see citing works

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Sharma, N., Nanta, R., Sharma, J. P., Gunewardena, S., Singh, K. P., Shankar, S., & Srivastava, R. K. (2015) · Oncotarget · doi:10.18632/oncotarget.5055 · Cited by 151 · see citing works

The Trop-2 signalling network in cancer growth

Guerra, E., Trerotola, M., Aloisi, A. L., Tripaldi, R., Vacca, G., Sorda, R. L., Lattanzio, R., Piantelli, M., & Alberti, S. (2012) · Oncogene · doi:10.1038/onc.2012.151 · Cited by 149 · see citing works

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Álvarez-Varela, A., Novellasdemunt, L., Barriga, F. M., Hernando‐Momblona, X., Cañellas-Socias, A., Cano-Crespo, S., Sevillano, M., Cortina, C., Stork, D., Morral, C., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00402-0 · Cited by 146 · see citing works

Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance

McCaw, T. R., Inga, E. E., Chen, H., Jaskula‐Sztul, R., Dudeja, V., Bibb, J. A., Ren, B., & Rose, J. B. (2020) · The Oncologist · doi:10.1002/onco.13627 · Cited by 126 · see citing works

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Vázquez, E. G., Nasreddin, N., Valbuena, G. N., Mulholland, E. J., Belnoue-Davis, H. L., Eggington, H. R., Schenck, R. O., Wouters, V. M., Wirapati, P., Gilroy, K. L., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.008 · Cited by 122 · see citing works

Optimizing immunotherapy for colorectal cancer

Ganesh, K. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00569-4 · Cited by 120 · see citing works

Trop2: From development to disease

McDougall, A. R. A., Tolcos, M., Hooper, S. B., Cole, T. J., & Wallace, M. J. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24242 · Cited by 118 · see citing works

TGFB1 induces fetal reprogramming and enhances intestinal regeneration

Chen, L., Qiu, X., Dupre, A., Pellón-Cárdenas, O., Fan, X., Xu, X., Rout, P., Walton, K. D., Burclaff, J., Zhang, R., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.015 · Cited by 116 · see citing works

SOX17 enables immune evasion of early colorectal adenomas and cancers

Goto, N., Westcott, P. M. K., Goto, S., Imada, S., Taylor, M. S., Eng, G. M., Braverman, J., Deshpande, V., Jacks, T., Agudo, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07135-3 · Cited by 116 · see citing works

An oncogenic phenoscape of colonic stem cell polarization

Qin, X., Rodriguez, F. C., Sufi, J., Vlckova, P., Claus, J., & Tape, C. J. (2023) · Cell · doi:10.1016/j.cell.2023.11.004 · Cited by 115 · see citing works

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

Insua‐Rodríguez, J., Pein, M., Hongu, T., Meier, J., Descot, A., Lowy, C., Braekeleer, E. D., Sinn, H., Spaich, S., Sütterlin, M., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809003 · Cited by 111 · see citing works

Pharmacological disruption of the Notch transcription factor complex

Lehal, R., Zarić, J., Vigolo, M., Urech, C., Frismantas, V., Zangger, N., Cao, L., Berger, A., Chicote, I., Loubéry, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922606117 · Cited by 108 · see citing works

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Morral, C., Stanisavljević, J., Hernando‐Momblona, X., Mereu, E., Álvarez-Varela, A., Cortina, C., Stork, D., Slebe, F., Turón, G., Whissell, G., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.04.012 · Cited by 99 · see citing works

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Heinz, M. C., Peters, N. A., Oost, K. C., Lindeboom, R. G. H., van Voorthuijsen, L., Fumagalli, A., van der Net, M. C., de Medeiros, G., Hageman, J. H., Verlaan-Klink, I., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-0933 · Cited by 91 · see citing works

The epithelial/carcinoma antigen EGP‐1, recognized by monoclonal antibody RS7–3G11, is phosphorylated on serine 303

Basu, A., Goldenberg, D. M., & Stein, R. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910620419 · Cited by 88 · see citing works

Trop2 is a potential biomarker for the promotion of EMT in human breast cancer

Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X., Tian, Z., Wang, X., Lv, Q., Wang, B., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6496 · Cited by 88 · see citing works

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Leach, J. D. G., Vlahov, N., Tsantoulis, P. K., Ridgway, R. A., Flanagan, D. J., Gilroy, K. L., Sphyris, N., Vázquez, E. G., Vincent, D. F., Faller, W. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23717-5 · Cited by 83 · see citing works

New insights into the ambivalent role of YAP/TAZ in human cancers

Luo, J., Deng, L., Zou, H., Guo, Y., Tong, T., Huang, M., Ling, G., & Li, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02704-2 · Cited by 83 · see citing works

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

Mzoughi, S., Schwarz, M. C., Wang, X., Demircioğlu, D., Ulukaya, G. B., Mohammed, K., Zorgati, H., Torre, D., Tomalin, L. E., Tullio, F. D., et al. (2025) · Nature Genetics · doi:10.1038/s41588-024-02058-1 · Cited by 83 · see citing works

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

Miyazaki, Y., Matsubara, S., Ding, Q., Tsukasa, K., Yoshimitsu, M., Kosai, K.-I., & Takao, S. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0534-2 · Cited by 82 · see citing works

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9275 · Cited by 80 · see citing works

Lineage Reversion Drives WNT Independence in Intestinal Cancer

Han, T., Goswami, S., Hu, Y., Tang, F., Zafra, M. P., Murphy, C. J., Cao, Z., Poirier, J. T., Khurana, E., Elemento, O., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1536 · Cited by 79 · see citing works

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.009 · Cited by 76 · see citing works

Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti–PD-1 therapy

Kim, Y. J., Sheu, K. M., Tsoi, J., Abril-Rodríguez, G., Medina, E., Grasso, C. S., Torrejon, D. Y., Champhekar, A. S., Litchfield, K., Swanton, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145859 · Cited by 75 · see citing works

TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2– breast cancer

Bardia, A., Jhaveri, K. L., Kalinsky, K. M., Pernas, S., Tsurutani, J., Xu, B., Hamilton, E. P., Im, S., Nowecki, Z. I., Sohn, J., et al. (2023) · Future Oncology · doi:10.2217/fon-2023-0188 · Cited by 74 · see citing works

Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses

Ramos Zapatero, M., Tong, A., Opzoomer, J. W., O’Sullivan, R., Cardoso Rodriguez, F., Sufi, J., Vlckova, P., Nattress, C., Qin, X., Claus, J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.005 · Cited by 72 · see citing works

Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

Sun, M., Zhang, N., Wang, X., Li, Y., Qi, W., Zhang, H., Li, Z., & Yang, Q. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0104-8 · Cited by 68 · see citing works

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation

Bala, P., Rennhack, J. P., Aitymbayev, D., Morris, C. X., Moyer, S. M., Duronio, G. N., Doan, K. T., Li, Z., Liang, X., Hornick, J. L., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf0927 · Cited by 67 · see citing works

Inhibition of sonic hedgehog and PI3K/Akt/mTOR pathways cooperate in suppressing survival, self-renewal and tumorigenic potential of glioblastoma-initiating cells

Nanta, R., Shrivastava, A., Sharma, J. P., Shankar, S., & Srivastava, R. K. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3448-z · Cited by 64 · see citing works

p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

Solé, L., Lobo‐Jarne, T., Villanueva, D. A., Alonso‐Marañón, J., Guillén, Y., Guix, M., Sangrador, I., Rozalén, C., Vert, A., Barbáchano, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30382-9 · Cited by 61 · see citing works

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice

Funk, M. C., Gleixner, J., Heigwer, F., Vonficht, D., Valentini, E., Aydin, Z., Tonin, E., Prete, S., Mahara, S., Throm, Y., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.11.013 · Cited by 60 · see citing works

Identification of Quiescent LGR5+ Stem Cells in the Human Colon

Ishikawa, K., Sugimoto, S., Oda, M., Fujii, M., Takahashi, S., Ohta, Y., Takano, A., Ishimaru, K., Matano, M., Yoshida, K., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.07.081 · Cited by 59 · see citing works

Plastic persisters: revival stem cells in colorectal cancer

Tape, C. J. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.11.003 · Cited by 58 · see citing works

An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

Hansen, S. L., Larsen, H. L., Pikkupeura, L. M., Maciag, G., Guiu, J., Müller, I., Clement, D. L., Mueller, C., Johansen, J. V., Helin, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg4055 · Cited by 55 · see citing works

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration

Koppens, M. A. J., Belnoue-Davis, H. L., Valbuena, G. N., Mulholland, E. J., Nasreddin, N., Colombé, M., Antanaviciute, A., Biswas, S., Friedrich, M., Lee, L., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.03.052 · Cited by 53 · see citing works

Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage

Vallone, V. B. F., Leprovots, M., Strollo, S., Vasile, G., Lefort, A., Libert, F., Vassart, G., & Garcia, M. (2016) · Development · doi:10.1242/dev.131490 · Cited by 51 · see citing works

Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell

Sphyris, N., Hodder, M. C., & Sansom, O. J. (2021) · Cancers · doi:10.3390/cancers13051000 · Cited by 45 · see citing works

A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors

Hanna, G. J., Stathis, A., López-Miranda, E., Racca, F., Quon, D. V. K., Leyvraz, S., Hess, D., Keam, B., Rodon, J. A., Ahn, M., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0333 · Cited by 44 · see citing works

Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage

Fazilaty, H., Brügger, M. D., Valenta, T., Szczerba, B. M., Berková, L., Doumpas, N., Hausmann, G., Scharl, M. M., & Basler, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109484 · Cited by 43 · see citing works

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Pikkupeura, L. M., Bressan, R. B., Guiu, J., Chen, Y., Maimets, M., Mayer, D., Schweiger, P. J., Hansen, S. L., Maciag, G. J., Larsen, H. L., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf9460 · Cited by 43 · see citing works

Serrated colorectal cancer: preclinical models and molecular pathways

Aiderus, A., Barker, N., & Tergaonkar, V. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.09.011 · Cited by 42 · see citing works

Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells

Wu, B., Yu, C.-L., Zhou, B., Huang, T., Gao, L., Liu, T., & Yang, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4788 · Cited by 39 · see citing works

Active elimination of intestinal cells drives oncogenic growth in organoids

García, A. K., Fumagalli, A., Le, H. Q., Jackstadt, R., Lannagan, T. R. M., Sansom, O. J., van Rheenen, J., & Suijkerbuijk, S. J. E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109307 · Cited by 39 · see citing works

Reactivation of embryonic genetic programs in tissue regeneration and disease

Fazilaty, H., & Basler, K. (2023) · Nature Genetics · doi:10.1038/s41588-023-01526-4 · Cited by 35 · see citing works

Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity

Karo‐Atar, D., Ouladan, S., Javkar, T., Joumier, L., Matheson, M. K., Merritt, S., Westfall, S., Rochette, A., Gentile, M. E., Fontès, G., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212311 · Cited by 33 · see citing works

Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

Silva, J., Alkan, F., Ramalho, S., Snieckute, G., Preković, S., García, A. K., Hernández-Pérez, S., van der Kammen, R., Barnum, D., Hoekman, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32220-4 · Cited by 30 · see citing works

Hedgehog antagonist GDC‐0449 is effective in the treatment of advanced basal cell carcinoma

Amin, S. H., Tibes, R., Kim, J., & Hybarger, C. P. (2010) · The Laryngoscope · doi:10.1002/lary.21145 · Cited by 29 · see citing works

Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma

Sawanyawisuth, K., Tantapotinan, N., Kraiklang, R., Puapairoj, A., Wongkham, C., Riggins, G. J., & Wongkham, S. (2015) · Annals of Hepatology · doi:10.5604/16652681.1184223 · Cited by 29 · see citing works

Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

Lemmetyinen, T. T., Viitala, E. W., Wartiovaara, L., Kaprio, T., Hagström, J., Haglund, C. H., Katajisto, P., Wang, T. C., Domènech‐Moreno, E., & Ollila, S. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049692 · Cited by 29 · see citing works

Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines

Schmidtova, S., Kaľavská, K., Lišková, V., Plavá, J., Miklikova, S., Kučerová, L., Matúšková, M., Rojikova, L., Čierna, Z., Rogozea, A. L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084263 · Cited by 28 · see citing works

Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas

Xu, P., Zhao, Y., Liu, K., Lin, S., Liu, X., Wang, M., Yang, P., Tian, T., Zhu, Y., & Dai, Z. (2017) · Cancer Management and Research · doi:10.2147/cmar.s147033 · Cited by 27 · see citing works

Clinical investigation of TROP-2 as an independent biomarker and potential therapeutic target in colon cancer

ZHAO, P., YU, H.-Z., & CAI, J.-H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3900 · Cited by 24 · see citing works

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Avolio, M., & Trusolino, L. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1531 · Cited by 24 · see citing works

Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development

Shimomura, K., Hattori, N., Iida, N., Muranaka, Y., Sato, K., Shiraishi, Y., Arai, Y., Hama, N., Shibata, T., Narushima, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42228-z · Cited by 21 · see citing works

FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells

Xu, C., Zhang, W., & Liu, C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284871 · Cited by 18 · see citing works

Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer

Li, L., Li, R., & Wang, Y. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105707 · Cited by 16 · see citing works

Mapping the adult human esophagus in vivo and in vitro

Ferrer-Torres, D., Wu, J. H., Zhang, C. J., Hammer, M. A., Dame, M. K., Wu, A., Holloway, E. M., Karpoff, K., McCarthy, C. L., Bohm, M. S., et al. (2022) · Development · doi:10.1242/dev.200614 · Cited by 9 · see citing works

Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

Nusse, Y. M., Savage, A. K., Marangoni, P., Huber, A. R., Landman, T. A., de Sauvage, F. J., Locksley, R. M., & Klein, O. D. (2018) · Nature · doi:10.1038/s41586-018-0370-1 · Cited by 4 · see citing works

Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formationPreprint

van der Net, M. C., Vliem, M. J., Kemp, L. J. S., Gonzalez, C. P., Strating, E., García, A. K., Houtekamer, R. M., van den Anker, K. B., Monster, J. L., Snippert, H. J. G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.17.557771 · Cited by 4 · see citing works

A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancerPreprint

Mzoughi, S., Schwarz, M. C., Wang, X., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.10.570854 · Cited by 4 · see citing works

The immune microenvironment of colorectal cancer

Kennel, K. B., & Greten, F. R. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00872-1 · Cited by 100 · see citing works

MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

White, M., Mills, M. L., Millett, L. M., Gilroy, K. L., Hong, Y., Zeiger, L. B., Simpson, R. J., Corry, S. M., Ligeza, A., Lannagan, T. R. M., et al. (2025) · Nature · doi:10.1038/s41586-025-09916-w · Cited by 43 · see citing works

Current and emerging concepts for systemic treatment of metastatic colorectal cancer

Steup, C., Kennel, K. B., Neurath, M. F., Fichtner-Feigl, S., & Greten, F. R. (2025) · Gut · doi:10.1136/gutjnl-2025-335412 · Cited by 39 · see citing works

Petosemtamab, a Bispecific Antibody Targeting Epidermal Growth Factor Receptor (EGFR) and Leucine-Rich G Repeat-Containing Protein-Coupled Receptor (LGR5) Designed for Broad Clinical Applications

Lundberg, A. S., Geuijen, C. A. W., Hill, S., van Bueren, J. J. L., Fumagalli, A., de Kruif, J., Silverman, P. B., & Tabernero, J. M. (2025) · Cancers · doi:10.3390/cancers17101665 · Cited by 24 · see citing works

A patient-derived organoid model captures fetal-like plasticity in colorectal cancer

Xiong, L., Xu, Y., Gao, Z.-Y., Shi, J., Wang, Y.-F., Wang, X.-D., Huang, W.-S., Li, M., Wang, L.-T., Xu, J., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01139-y · Cited by 18 · see citing works

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Su, Z., Li, Y., Zhou, Z., Feng, B. C., Chen, H., & Zheng, G. (2025) · Cell Proliferation · doi:10.1111/cpr.70065 · Cited by 16 · see citing works

Establishment of a novel mouse model of colorectal cancer by orthotopic transplantation

Chen, C., Fu, Q., Wang, L., Tanaka, S., & Imajo, M. (2025) · BMC Cancer · doi:10.1186/s12885-025-13834-5 · Cited by 12 · see citing works

Gene context drift identifies drug targets to mitigate cancer treatment resistance

Jassim, A., Nimmervoll, B. V., Terranova, S., Nathan, E., Hu, L., Taylor, J., Masih, K. E., Ruff, L., Duarte, M., Cooper, E. A., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.005 · Cited by 11 · see citing works

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

van der Net, M. C., Vliem, M. J., Kemp, L. J. S., Gonzalez, C. P., Haddad, T. S., Strating, E., García, A. K., Houtekamer, R. M., Pannekoek, W., van den Anker, K. B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116308 · Cited by 14 · see citing works

Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis

Shi, G., Yang, L., Shen, H., He, Q., & Zhu, P. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae042 · Cited by 9 · see citing works

Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines

Luk, I. Y., Mooi, J. K., Mouradov, D., Tan, T., Scott, C. M., Chionh, F. J. M., Jenkins, L. J., Reehorst, C. M., Nightingale, R., Savas, P. S., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08251-0 · Cited by 6 · see citing works

Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcomePreprint

Bertillot, F., Hervé, S., Drobjazko, N., Kedei, N., Gendi, M. A. E., Hernandez, M. O., Kruse, K., Erkan, E. P., Binner, M., Punovuori, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.11.669722 · Cited by 5 · see citing works

TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer

Vaquero‐Siguero, N., Georgakopoulos, N., Heinz, M. C., Chiotakakos, I., Meier, J., Fey, S. K., Diamante, G., Mastel, M., Martinez, A. G., Belthier, G., et al. (2026) · Nature · doi:10.1038/s41586-026-10705-2 · Cited by 4 · see citing works

Epithelial states in colorectal cancer are co-determined by YAP associated fetal programming and WNT signalingPreprint

Hong, Y., Susanti, S., Mills, M. L., Gilroy, K. L., Hu, Z., Velez-Bravo, F. D., Ostapiuk, A., Lannagan, T. R. M., White, M., Ridgway, R. A., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6812365/v1 · Cited by 3 · see citing works

Network-Based Bioinformatics Highlights Broad Importance of Human Milk Hyaluronan

Burge, K. Y., Zhong, H., Wilson, A. P., & Chaaban, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312679 · Cited by 2 · see citing works

Targeting colorectal cancer stem-like cells: Overcoming therapeutic resistance and reprogramming the immunosuppressive niche.

Hamid, M., Siddig, A., Suliman, R., Saeed, A., Mussa, A., & Al-Hatamleh, M. A. I. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218665 · Cited by 2 · see citing works

Cancer Stem Cells in Colorectal Cancer: From Molecular Mechanisms to Diagnosis, Prognosis and Therapy Implications

Aiyejuto, D., Luthria, A., Hui, T., & Shenoy, A. K. (2026) · Cancers · doi:10.3390/cancers18162569 · Cited by 2 · see citing works

The E. coli CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoidsPreprint

Letourneur, D., Bergsten, E., Raynaud, N., Mondy, J., Nigro, G., Tsoumtsa, L. L., Vaysse, A., Descorps‐Declère, S., Yoshida, A. E., Stefani, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.02.680056 · Cited by 2 · see citing works

Self-organization of tumor heterogeneity and plasticityPreprint

Pérez-González, C., Brückner, D., Di-Luoffo, M., Richon, S., Goswami, R., Baghdadi, M. B., Piastra-Facon, F., Felsenthal, N., Bouras, R., Fumagalli, A., et al. (2025) · bioRxiv · doi:10.1101/2025.10.09.681487 · Cited by 2 · see citing works

Cradles for maturation: Turning progenitor cells into functional intestinal epithelium

Bera, K., & Anseth, K. S. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.01.016 · Cited by 1 · see citing works

APC loss promotes intestinal transformation through induction of bistable stem cell statesPreprint

Li, N., Myers, R., Zhu, Q., Tian, Y., Durning, K., Wang, X., Leu, N., Rhoades, J., Bankler-Jukes, D., Monaghan, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641686 · Cited by 1 · see citing works

Oncomimetic β-catenin activity onset, duration and region defines aberrant intestinal developmentPreprint

Soetje, B., Ma, H., Imtiaz, S., Corbat, A. A., Grecco, H. E., Schroeder, L., Brüggemann, Y., Seidler, S., Reichl, M., & Bastiaens, P. I. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.07.723518 · Cited by 1 · see citing works

Re‐evaluating Stem Cell Roles in Homeostasis and Cancer of the Esophagus

Kostic, L., & Barker, N. (2025) · BioEssays · doi:10.1002/bies.70044

Genotype-phenotype mapping identifies fetal-like CD55 + immunoregulatory cancer cells as mediators of immune escape in colorectal cancerPreprint

Mastel, M., Martinez, A. G., Diamante, G., Meier, J., Schuchmann, L., Georgakopoulos, N., Chiotakakos, I., Steffens, L. K., Artmann, C., Benítez-Riquelme, D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.09.697991

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Cramer, Z., Monaghan, K., Petroni, R., Wang, X., Adams-Tzivelekidis, S., Durning, K., Kim, M., Tian, Y., Johnson, N. M., Rodríguez, M. F. C., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117045

Mechanisms of Cell Plasticity during Injury-Induced Epithelial Reprogramming

Mazzarelli, E., & Lovisa, S. (2026) · Cells Tissues Organs · doi:10.1159/000552260

Multidimensional dissection of shared genetic susceptibility in ulcerative colitis and colorectal cancer: novel insights from integrative single-cell and multi-omics analysis

Zhu, F., Yao, X., Liu, D., Wang, S., Huang, X., Zhou, J., Wang, S., Tang, S., Lai, D., Yang, S., et al. (2026) · Inflammation Research · doi:10.1007/s00011-026-02268-9

Sacituzumab govitecan in colorectal cancer: clinical evidence and future directions

Nader, L., Hoffmeister‐Wittmann, P., Haag, G. M., Jackstadt, R., & Köhler, B. C. (2026) · Future Oncology · doi:10.1080/14796694.2026.2673807

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancerPreprint

Mulholland, T., Aybey, B., Li, Z., Schwarzmüller, L. E., Rindtorff, N., Tondo, L., Sui, P., Karabati, E., Albrecht, P., Riedesser, J. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.03.735750

Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation

Wang, H., Liu, S., Zhang, M., Deng, C., & Han, Z. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1912866

Villous Architecture in Colorectal Adenomas: Molecular Pathogenesis, Epithelial Plasticity, and Malignant Risk

Hu, Z., Vanoverbeke, T., Yin, K., Jans, A., Arpaia, C. C., Bisschops, R., Baldin, P., Tejpar, S., & Piessevaux, H. H. (2026) · Cells · doi:10.3390/cells15181685

Stemness in Colon Cancer

Cohen-Almagor, R., Sagadevan, S., & Ordóñez‐Morán, P. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5412-5_19

Intestinal stem cells and the colorectal cancer microenvironment

Bryan, B., Ong, Kenneth, K., Vega, Courtney, C., & Houchen (2014) · World Journal of Gastroenterology

Stemness in Colon Cancer

Cohen-Almagor, R., Sagadevan, S., & Ordóñez‐Morán, P. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5412-5_19

Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation

Wang, H., Liu, S., Zhang, M., Deng, C., & Han, Z. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1912866

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

Zeuner, A., Todaro, M., Stassi, G., & Maria, R. D. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.11.012 · Cited by 370 · see citing works

Advances in intestinal stem cells and cancer stem cells of colorectal cancer

Fan, L., & Dong, W. (2008) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v16.i36.4075