The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
The gut microbiome as a modulator of healthy ageing
Open accessAbstract
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut microbiome of older individuals and general cohort studies across geographically distinct populations. We also address the promise of the targeted restoration of microorganisms associated with healthier ageing.
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“The microbiota and its metabolites are altered during ageing; for example, the abundance of the anti-inflammatory bacterium Faecalibacterium decreases, whereas that of proinflammatory Fusobacterium increases, leading to intestinal inflammation.234”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [234]
In the citing paper
“Finally, late life ushers in tertiary succession, which is marked by declining α- and β-diversity and loss of keystone commensals like Faecalibacterium and Bifidobacterium.39,40”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [40]
In the citing paper
“However, the composition and activity of this microbial ecosystem undergoes continuous changes during aging, which finally results in a substantial decrease in diversity.”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [88]
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Items 201–203 of 203
The Present Status of Fecal Microbiota Transplantation and Its Value in the Elderly
Cheng, Y., & Fischer, M. (2017) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-017-0143-1 · Cited by 21
Bamba, S., Nishida, A., Imaeda, H., Inatomi, O., Sasaki, M., Sugimoto, M., & Andoh, A. (2017) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2017.08.027 · Cited by 21
Qu, H., Zhang, Y., Chai, H., Gao, Z.-Y., & Shi, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211233 · Cited by 15
Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., et al. (2023) · Nutrients · doi:10.3390/nu15092211 · Cited by 1,397
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
What defines a healthy gut microbiome?
Hul, M. V., Cani, P. D., Petitfils, C., de Vos, W. M., Tilg, H., & El-Omar, E. M. (2024) · Gut · doi:10.1136/gutjnl-2024-333378 · Cited by 448
Metadata
- Authors
- Ghosh, T. S., Shanahan, F., & O’Toole, P. W.
- Affiliations
- National University of Ireland (IE)
- Corresponding author
- O’Toole, Paul W.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2022-04-25
- Volume
- 19
- Issue
- 9
- Pages
- 565-584
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC9035980
- OpenAlex
- W4224868124
- Cited by
- 817
- References
- 203
- Citations by year
- 2026: 217 · 2025: 230 · 2024: 223 · 2023: 120 · 2022: 26
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, healthy aging, non-communicable diseases, older adults, microbiota composition, microbiome function, microbiota restoration
- MeSH terms
- Gastrointestinal Microbiome, Healthy Aging, Humans
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