The gut microbiome as a modulator of healthy ageing

The Hallmarks of Aging

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The Microbiota-Gut-Brain Axis

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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

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Evolution of mammals and their gut microbes

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The Human Intestinal Microbiome in Health and Disease

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Gut microbiota composition correlates with diet and health in the elderly

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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

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The role of the gut microbiota in nutrition and health

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Human gut microbes impact host serum metabolome and insulin sensitivity

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Hallmarks of aging: An expanding universe

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Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

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Meta-hallmarks of aging and cancer

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Chronic inflammation and the hallmarks of aging

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What defines a healthy gut microbiome?

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Biomarkers of aging

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

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Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases

Ikeda, T., Nishida, A., Yamano, M., & Kimura, I. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108273 · Cited by 287

Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis

Grabrucker, S., Marizzoni, M., Silajdžić, E., Lopizzo, N., Mombelli, E., Nicolas, S., Dohm-Hansen, S., Scassellati, C., Moretti, D. V., Rosa, M., et al. (2023) · Brain · doi:10.1093/brain/awad303 · Cited by 236

The changing metabolic landscape of bile acids – keys to metabolism and immune regulation

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The human gut microbiome and aging

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Aging and InflammationPreprint

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Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial

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Bioactive compounds for human and planetary health

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Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures

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Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

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Host control of the microbiome: Mechanisms, evolution, and disease

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Stress, epigenetics, and aging: Unraveling the intricate crosstalk

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Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid

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Toward an improved definition of a healthy microbiome for healthy aging

Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Aging · doi:10.1038/s43587-022-00306-9 · Cited by 133

Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

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Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure

Snelson, M., Muralitharan, R. R., Liu, C., Markó, L., Forslund, S. K., Marques, F. Z., & Tang, W. H. W. (2025) · Circulation Research · doi:10.1161/circresaha.125.325516 · Cited by 118

Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Shi, S., Zhang, Q., Sang, Y., Ge, S., Wang, Q., Wang, R., & He, J. (2022) · Nutrients · doi:10.3390/nu15010051 · Cited by 111

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer’s disease

Conn, K. A., Borsom, E. M., & Cope, E. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2371950 · Cited by 106

Gut microbiota development across the lifespan: Disease links and health‐promoting interventions

Schoultz, I., Claesson, M. J., Domínguez-Bello, M. G., Hållenius, F. F., Konturek, P. C., Korpela, K., Laursen, M. F., Penders, J., Roager, H. M., Vatanen, T., et al. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20089 · Cited by 108

Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors

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Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

Yaqub, M. O., Jain, A., Joseph, C. E., & Edison, L. K. (2025) · Gastrointestinal Disorders · doi:10.3390/gidisord7010007 · Cited by 100

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

Constantino-Jonapa, L. A., Espinoza-Palacios, Y., Escalona‐Montaño, A. R., Hernández-Ruiz, P., Amezcua-Guerra, L. M., Amedei, A., & Aguirre‐García, M. M. (2023) · Biomedicines · doi:10.3390/biomedicines11020431 · Cited by 99

Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

Molinero, N., Antón‐Fernández, A., Hernández, F., Ávila, J., Bartolomé, B., & Moreno-Arribas, M. V. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.014 · Cited by 101

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel, M. S., Aleya, S., Alsubih, M., & Aleya, L. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14020217 · Cited by 99

Enterotypes of the human gut mycobiome

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Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing

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Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota

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Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

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Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Campagnoli, L. I. M., Varesi, A., Barbieri, A., Marchesi, N., & Pascale, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713338 · Cited by 91

The fate of dietary polysaccharides in the digestive tract

Yang, Q., Chang, S., Zhang, X., Luo, F., Li, W., & Ren, J. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104606 · Cited by 89

Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan

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The leaky gut and the gut microbiome in sepsis – targets in research and treatment

Chancharoenthana, W., Kamolratanakul, S., Schultz, M. J., & Leelahavanichkul, A. (2023) · Clinical Science · doi:10.1042/cs20220777 · Cited by 86

Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

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The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

Jang, D., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84

The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease

Song, X., Dou, X., Chang, J., Zeng, X., Xu, Q., & Xu, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2414805 · Cited by 84

The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases

Münte, E., & Hartmann, P. (2025) · Biomolecules · doi:10.3390/biom15040469 · Cited by 85

Microbiota-immune-brain interactions: A lifespan perspective

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The Role of the Gut Microbiota in Female Reproductive and Gynecological Health: Insights into Endometrial Signaling Pathways

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Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk

Wang, T., Shi, Z., Ren, H., Xu, M., Lu, J., Yang, F., Ye, C., Wu, K., Chen, M., Xu, X., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03038-y · Cited by 81

Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Xiao, Y., Feng, Y., Zhao, J., Chen, W., & Lu, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.005 · Cited by 78

Pathological and Inflammatory Consequences of Aging

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Antibiotic-perturbed microbiota and the role of probiotics

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Smart capsules for sensing and sampling the gut: status, challenges and prospects

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Exercise, the Gut Microbiome and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms

Hawley, J. A., Forster, S. C., & Giles, E. M. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.01.224 · Cited by 76

Emerging epigenetic insights into aging mechanisms and interventions

Wu, Z., Zhang, W., Qu, J. T., & Liu, G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.002 · Cited by 77

Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Cacciatore, S., Calvani, R., Esposito, I., Massaro, C., Gava, G., Picca, A., Tosato, M., Marzetti, E., & Landi, F. (2024) · Nutrients · doi:10.3390/nu16193271 · Cited by 75

Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis

Guzzetta, K. E., Cryan, J. F., & O’Leary, O. F. (2022) · Brain Plasticity · doi:10.3233/bpl-220141 · Cited by 74

Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection

Deng, L., & Wang, S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2424914 · Cited by 76

Skin health and biological aging

Furman, D., Auwerx, J. H., Bulteau, A., Church, G. M., Couturaud, V., Crabbé, L., Davies, K. J. A., Decottignies, A., Gladyshev, V. N., Kennedy, B. K., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00901-6 · Cited by 73

Exploring the role of gut microbiota in antibiotic resistance and prevention

Dongre, D. S., Saha, U. B., & Saroj, S. D. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2478317 · Cited by 72

Gut Microbiota Markers and Dietary Habits Associated with Extreme Longevity in Healthy Sardinian Centenarians

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Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer

Qin, Y., Tong, X., Mei, W.-J., Cheng, Y., Zou, Y., Han, K., Yu, J., Jie, Z., Zhang, T., Zhu, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47523-x · Cited by 72

Gut microbiota and anti-aging: Focusing on spermidine

Yu, L., Pan, J., Guo, M., Duan, H., Zhang, H., Narbad, A., Zhai, Q., Tian, F., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2224867 · Cited by 63

Anemia and Its Connections to Inflammation in Older Adults: A Review

Wacka, E., Nicikowski, J., Jarmużek, P., & Zembroń-Łacny, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072049 · Cited by 64

Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases

Losol, P., Sokołowska, M., Hwang, Y.-K., Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Radzikowska, U., Ardıçlı, S., Yoon, J.-E., et al. (2023) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2023.15.6.705 · Cited by 63

Gut microbial features and circulating metabolomic signatures of frailty in older adults

Pu, Y., Sun, Z., Zhang, H., Huang, Q., Wang, Z., Mei, Z., Wang, P., Kong, M., Yang, W., Lin, C., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00678-0 · Cited by 62

Older adults with cancer and common comorbidities—challenges and opportunities in improving their cancer treatment outcomes

Chen, W., Altshuler, R. D., Daschner, P., Salvador-Morales, C., Germain, D. S., Guida, J., Prasanna, P. G. S., & Buchsbaum, J. C. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae163 · Cited by 63

Emerging strategies, applications and challenges of targeting NAD+ in the clinic

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Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation

Caetano‐Silva, M. E., Shrestha, A., Duff, A. F., Kontic, D., Brewster, P. C., Kasperek, M. C., Lin, C., Wainwright, D. A., Hernández‐Saavedra, D., Woods, J. A., et al. (2024) · Aging Cell · doi:10.1111/acel.14190 · Cited by 58

Novelties on Neuroinflammation in Alzheimer’s Disease–Focus on Gut and Oral Microbiota Involvement

Popescu, C., Munteanu, C., Anghelescu, A., Ciobanu, V., Spînu, A., Andone, I., Mandu, M., Bistriceanu, R., Băilă, M., Postoiu, R.-L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011272 · Cited by 61

Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids

Ibrahim, I., Soumyakrishnan, S., Ayariga, J. A., Xu, J., Robertson, B. K., SREEPRIYA, M., & Ajayi, O. S. (2022) · Metabolites · doi:10.3390/metabo12121247 · Cited by 57

The gut microbiota is an emerging target for improving brain health during ageing

Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. (2022) · Gut Microbiome · doi:10.1017/gmb.2022.11 · Cited by 57

Circadian clock communication during homeostasis and ageing

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Dysbiotic Gut Microbiota-Derived Metabolites and Their Role in Non-Communicable Diseases

Tan, J., Taitz, J., Nanan, R. K. H., Grau, G. E., & Macia, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015256 · Cited by 58

Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

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Recent advances in therapeutic probiotics: insights from human trials

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Theaflavins in Black Tea Mitigate Aging-Associated Cognitive Dysfunction via the Microbiota–Gut–Brain Axis

Li, M., Zhang, C., Xiao, X., Zhu, M., Quan, W., Liu, X., Zhang, S., & Liu, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06679 · Cited by 52

The impact of aging-induced gut microbiome dysbiosis on dendritic cells and lung diseases

Malik, J. A., Zafar, M. A., Lamba, T., Nanda, S., Khan, M. A., & Agrewala, J. N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290643 · Cited by 52

Microbiome One Health model for a healthy ecosystem

Tomasulo, A., Simionati, B., & Facchin, S. (2024) · Science in One Health · doi:10.1016/j.soh.2024.100065 · Cited by 52

Consistent signatures in the human gut microbiome of longevous populations

Chen, S., Zhang, Z., Liu, S., Chen, T., Lu, Z., Zhao, W., Mou, X., & Liu, S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2393756 · Cited by 55

Gut microbial metabolism in Alzheimer's disease and related dementias

Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 53

Anti-aging activities of Rehmannia glutinosa Libosch. crude polysaccharide in Caenorhabditis elegans based on gut microbiota and metabonomic analysis

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Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease

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