The gut microbiome as a modulator of healthy ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413

Evolution of mammals and their gut microbes

Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747

The Human Intestinal Microbiome in Health and Disease

Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357

The role of the gut microbiota in nutrition and health

Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,283

Human gut microbes impact host serum metabolome and insulin sensitivity

Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., et al. (2016) · Nature · doi:10.1038/nature18646 · Cited by 2,116

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050

The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963

Health equity in England: the Marmot review 10 years on

Marmot, M. (2020) · BMJ · doi:10.1136/bmj.m693 · Cited by 1,834

Gut microbiota and IBD: causation or correlation?

Ni, J., Wu, G. D., Albenberg, L., & Tomov, V. T. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.88 · Cited by 1,778

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., Abe, F., & Osawa, R. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0708-5 · Cited by 1,521

Gut microbial metabolites as multi-kingdom intermediates

Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

Lin, H. V., Frassetto, A., Kowalik Jr, E. J., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., Hubert, J. A., Szeto, D., Yao, X., Forrest, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035240 · Cited by 1,378

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0406-6 · Cited by 1,373

A new genomic blueprint of the human gut microbiota

Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D., & Finn, R. D. (2019) · Nature · doi:10.1038/s41586-019-0965-1 · Cited by 1,314

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., et al. (2020) · Nature · doi:10.1038/s41586-020-2080-8 · Cited by 1,208

Gut microbiota and aging

O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202

Cohabiting family members share microbiota with one another and with their dogs

Song, S. J., Lauber, C. L., Costello, E. K., Lozupone, C., Humphrey, G., Berg-Lyons, D., Caporaso, J. G., Knights, D., Clemente, J. C., Nakielny, S., et al. (2013) · eLife · doi:10.7554/elife.00458 · Cited by 1,120

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711235114 · Cited by 1,040

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Thomas, A. M., Manghi, P., Asnicar, F., Pasolli, E., Armanini, F., Zolfo, M., Beghini, F., Manara, S., Karcher, N., Pozzi, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0405-7 · Cited by 1,030

Gut Microbiota and Extreme Longevity

Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Asnicar, F., Berry, S. E., Valdes, A. M., Nguyen, L. H., Piccinno, G., Drew, D. A., Leeming, E., Gibson, R., Le Roy, C., Khatib, H. A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01183-8 · Cited by 995

Mediterranean Diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Ghosh, T. S., Rampelli, S., Jeffery, I. B., Santoro, A., Neto, M., Capri, M., Giampieri, E., Jennings, A., Candela, M., Turroni, S., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319654 · Cited by 991

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

(2017) · doi:10.1038/s41467-017-01973-8 · Cited by 986

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

Stein, M. M., Hrusch, C. L., Gozdz, J., Igartua, C., Pivniouk, V., Murray, S. E., Ledford, J. G., Marques dos Santos, M., Anderson, R. L., Metwali, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1508749 · Cited by 939

Human postprandial responses to food and potential for precision nutrition

Berry, S. E., Valdes, A. M., Drew, D. A., Asnicar, F., Mazidi, M., Wolf, J., Capdevila, J., Hadjigeorgiou, G., Davies, R., Al Khatib, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0934-0 · Cited by 932

Longitudinal analysis of microbial interaction between humans and the indoor environment

Lax, S. M., Smith, D. P., Hampton‐Marcell, J., Owens, S. M., Handley, K. M., Scott, N. M., Gibbons, S. M., Larsen, P. E., Shogan, B. D., Weiss, S. J., et al. (2014) · Science · doi:10.1126/science.1254529 · Cited by 924

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii , a commensal bacterium deficient in Crohn’s disease

Quévrain, E., Maubert, M.-A., Michon, C., Chain, F., Marquant, R., Tailhades, J., Miquel, S., Carlier, L., Bermúdez‐Humarán, L. G., Pigneur, B., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307649 · Cited by 901

Viral and host factors related to the clinical outcome of COVID-19

Zhang, X., Tan, Y., Ling, Y., Lü, G., Liu, F., Yi, Z., Jia, X., Wu, M., Shi, B., Xu, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2355-0 · Cited by 874

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 853

Colonocyte metabolism shapes the gut microbiota

Litvak, Y., Byndloss, M. X., & Bäumler, A. J. (2018) · Science · doi:10.1126/science.aat9076 · Cited by 789

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Scheithauer, T. P. M., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., van Raalte, D. H., & Herrema, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571731 · Cited by 715

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706

Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00348-0 · Cited by 675

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661

Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights

Pasolli, E., Truong, D. T., Malik, F., Waldron, L., & Segata, N. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004977 · Cited by 659

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.032 · Cited by 653

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Sato, Y., Atarashi, K., Plichta, D. R., Arai, Y., Sasajima, S., Kearney, S. M., Suda, W., Takeshita, K., Sasaki, T., Okamoto, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03832-5 · Cited by 632

Differences in gut microbiota in patients with vs without inflammatory bowel diseases: A systematic review

Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., & Moayyedi, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.294 · Cited by 623

Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits

PICARD, C., FIORAMONTI, J., FRANCOIS, A., ROBINSON, T., NEANT, F., & MATUCHANSKY, C. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02615.x · Cited by 618

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

Shao, Y., Gao, Z., Marks, P. A., & Jiang, X. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408345102 · Cited by 611

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., Auwerx, J., Singh, A., & Rinsch, C. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0073-4 · Cited by 590

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

Meslier, V., Laiola, M., Roager, H. M., De Filippis, F., Roume, H., Quinquis, B., Giacco, R., Mennella, I., Ferracane, R., Pons, N., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320438 · Cited by 583

Anxiety, depression, and the microbiome: A role for gut peptides

Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573

Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Kim, C.-S., Cha, J., Sim, M., Jung, S., Chun, W. Y., Baik, H. W., & Shin, D.-M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa090 · Cited by 572

Microbial regulation of organismal energy homeostasis

Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0017-4 · Cited by 569

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

Ansaldo, E., Slayden, L. C., Ching, K. L., Koch, M. A., Wolf, N. K., Plichta, D. R., Brown, E. M., Graham, D. B., Xavier, R. J., Moon, J. J., et al. (2019) · Science · doi:10.1126/science.aaw7479 · Cited by 566

Host–microbiota maladaptation in colorectal cancer

Janney, A., Powrie, F., & Mann, E. H. (2020) · Nature · doi:10.1038/s41586-020-2729-3 · Cited by 445

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

Brown, J. M., & Hazen, S. L. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-060513-093205 · Cited by 438

Signatures of early frailty in the gut microbiota

Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine · doi:10.1186/s13073-016-0262-7 · Cited by 436

Composition and temporal stability of the gut microbiota in older persons

Jeffery, I. B., Lynch, D. B., & O’Toole, P. W. (2016) · The ISME Journal · doi:10.1038/ismej.2015.88 · Cited by 421

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

Tomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V., & Espín, J. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5024615 · Cited by 419

Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults

de la Cuesta‐Zuluaga, J., Kelley, S. T., Chen, Y., Escobar, J. S., Mueller, N. T., Ley, R. E., McDonald, D. T., Huang, S. W., Swafford, A. D.-E., Knight, R. D., et al. (2019) · mSystems · doi:10.1128/msystems.00261-19 · Cited by 413

Alzheimer’s disease microbiome is associated with dysregulation of the anti-inflammatory p-glycoprotein pathway

Haran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin

He, Z., Gharaibeh, R. Z., Newsome, R. C., Pope, J. L., Dougherty, M. W., Tomkovich, S., Pons, B., Mirey, G., Vignard, J., Hendrixson, D. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317200 · Cited by 409

Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

Govindarajan, N., Agis-Balboa, R. C., Walter, J., Sananbenesi, F., & Fischer, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110080 · Cited by 405

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Fransen, F., van Beek, A. A., Borghuis, T., Aidy, S. E., Hugenholtz, F., van der Gaast – de Jongh, C., Savelkoul, H. F. J., De Jonge, M. I., Boekschoten, M. V., Smidt, H., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01385 · Cited by 403

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

Wang, D. D., Nguyen, L. H., Li, Y., Yan, Y., Ma, W., Rinott, E., Ivey, K. L., Shai, I., Willett, W. C., Hu, F. B., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01223-3 · Cited by 386

The Healthy Microbiome—What Is the Definition of a Healthy Gut Microbiome?

Shanahan, F., Ghosh, T. S., & O’Toole, P. W. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.057 · Cited by 383

Gut microbiota signatures of longevity

Kong, F., Hua, Y., Zeng, B., Ning, R., Li, Y., & Zhao, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.015 · Cited by 371

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

DeJong, E. N., Surette, M. G., & Bowdish, D. M. E. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.013 · Cited by 370

Microbial Genetic Composition Tunes Host Longevity

Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 355

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

Marizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200306 · Cited by 351

Identification of Metabolic Signatures Linked to Anti-Inflammatory Effects of Faecalibacterium prausnitzii

Miquel, S., Leclerc, M., Martín, R., Chain, F., Lenoir, M., Raguideau, S., Hudault, S., Bridonneau, C., Northen, T. R., Bowen, B. P., et al. (2015) · mBio · doi:10.1128/mbio.00300-15 · Cited by 339

Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial

Nilsson, A. G., Sundh, D., Bäckhed, F., & Lorentzon, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12805 · Cited by 323

Microbiota from young mice counteracts selective age-associated behavioral deficits

Boehme, M., Guzzetta, K. E., Bastiaanssen, T. F. S., van de Wouw, M., Moloney, G. M., Gual-Grau, A., Spichak, S., Olavarría-Ramírez, L., Fitzgerald, P., Morillas, E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00093-9 · Cited by 313

Trimethylamine‐N‐oxide promotes brain aging and cognitive impairment in mice

Li, D., Ke, Y., Zhan, R., Liu, C., Zhao, M., Zeng, A., Shi, X., Ji, L., Cheng, S., Pan, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12768 · Cited by 304

Identification of probiotic effector molecules: present state and future perspectives

Lebeer, S., Bron, P. A., Marco, M. L., van Pijkeren, J., Motherway, M. O., Hill, C., Pot, B., Roos, S., & Klaenhammer, T. R. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.10.007 · Cited by 303

Microbiota regulation of the mammalian gut-brain axis

Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300

Irritable bowel syndrome: a gut microbiota-related disorder?

Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 294

Human gut microbiome aging clock based on taxonomic profiling and deep learning

Galkin, F., Mamoshina, P., Aliper, A., Lane, E., Moskalev, V., Gladyshev, V. N., & Zhavoronkov, A. (2020) · iScience · doi:10.1016/j.isci.2020.101199 · Cited by 292

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.007 · Cited by 285

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Collino, S., Montoliu, I., Martin, F.-P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056564 · Cited by 270

Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018) · Current Alzheimer Research · doi:10.2174/1389200219666180813144834 · Cited by 269

Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity

Wu, J., Li, Q., & Fu, X. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.003 · Cited by 259

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

Sahuri-Arisoylu, M., Brody, L., Parkinson, J. R. C., Parkes, H. G., Navaratnam, N., Miller, A. D., Thomas, E. L., Frost, G. S., & Bell, J. D. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.23 · Cited by 258

Aging progression of human gut microbiota

Xu, C., Zhu, H., & Qiu, P. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1616-2 · Cited by 258

Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters

Fukuda, S., Toh, H., Taylor, T. D., Ohno, H., & Hattori, M. (2012) · Gut Microbes · doi:10.4161/gmic.21214 · Cited by 257

Gut microbiome composition and diversity are related to human personality traits

Johnson, K. V. ‐. (2019) · Human Microbiome Journal · doi:10.1016/j.humic.2019.100069 · Cited by 257

Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis

Sung, J., Kim, S., Cabatbat, J. J. T., Jang, S., Jin, Y., Jung, G. Y., Chia, N., & Kim, P. (2017) · Nature Communications · doi:10.1038/ncomms15393 · Cited by 253

Adherence to Mediterranean Diet Reduces Incident Frailty Risk: Systematic Review and Meta‐Analysis

Kojima, G., Avgerinou, C., Iliffe, S., & Walters, K. R. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15251 · Cited by 252

Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities

Zhang, X., Zhong, H., Li, Y., Shi, Z., Ren, H., Zhang, Z., Zhou, X., Tang, S., Han, X., Lin, Y., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00014-2 · Cited by 250

Transmission of human-associated microbiota along family and social networks

Brito, I., Gurry, T., Zhao, S., Huang, K. H., Young, S., Shea, T. P., Naisilisili, W., Jenkins, A., Jupiter, S. D., Gevers, D., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0409-6 · Cited by 248

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M. E., van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., de Vos, P., Dekker, J. P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-35228-3 · Cited by 242

Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial

Birkeland, E., Gharagozlian, S., Birkeland, K. I., Valeur, J., Måge, I., Rud, I., & Aas, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02282-5 · Cited by 241

Microbial transmission in animal social networks and the social microbiome

Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Archie, E. A., Schell, L. D., Carmody, R. N., Clutton-Brock, T. H., Dunbar, R., & Burnet, P. W. J. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1220-8 · Cited by 236

Adjusting for age improves identification of gut microbiome alterations in multiple diseases

Ghosh, T. S., Das, M., Jeffery, I. B., & O'Toole, P. W. (2020) · eLife · doi:10.7554/elife.50240 · Cited by 233 · cited 1×

Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial

Buigues, C., Fernández-Garrido, J., Pruimboom, L., Hoogland, A., Navarro-Martínez, R., Martínez-Martínez, M., Verdejo, Y., Mascarós, M., Peris, C., & Cauli, O. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060932 · Cited by 222

Biological aging and the human gut microbiota

Maffei, V. J., Kim, S., Blanchard, E., Luo, M., Jazwinski, S. M., Taylor, C. M., & Welsh, D. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx042 · Cited by 219

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

Selma, M. V., Beltrán, D., Luna, M. C., Romo‐Vaquero, M., Garcı́a-Villalba, R., Mira, Á., Espı́n, J. C., & Tomás-Barberán, F. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01521 · Cited by 212

Age-dependent changes in GI physiology and microbiota: time to reconsider?

An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D. (2018) · Gut · doi:10.1136/gutjnl-2017-315542 · Cited by 209

Differences in Fecal Microbiomes and Metabolomes of People With vs Without Irritable Bowel Syndrome and Bile Acid Malabsorption

Jeffery, I. B., Das, A., O’Herlihy, E. A., Coughlan, S., Cisek, K. K., Moore, M., Bradley, F., Carty, T., Pradhan, M., Dwibedi, C. K., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.11.301 · Cited by 208

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

Cortés‐Martín, A., Garcı́a-Villalba, R., González‐Sarrías, A., Romo‐Vaquero, M., Loria‐Kohen, V., de Molina, A. R., Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2018) · Food & Function · doi:10.1039/c8fo00956b · Cited by 205

A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians

Wu, L. H., Zeng, T., Zinellu, A., Rubino, S., Kelvin, D. J., & Carru, C. (2019) · mSystems · doi:10.1128/msystems.00325-19 · Cited by 201

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

Brunt, V. E., LaRocca, T. J., Bazzoni, A. E., Sapinsley, Z. J., Miyamoto-Ditmon, J., Gioscia-Ryan, R. A., Neilson, A. P., Link, C. D., & Seals, D. R. (2021) · GeroScience · doi:10.1007/s11357-020-00257-2 · Cited by 197

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

Rastelli, M., Knauf, C., & Cani, P. D. (2018) · Obesity · doi:10.1002/oby.22175 · Cited by 191

The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young

Bian, G., Gloor, G. B., Gong, A., Jia, C., Zhang, W., Hu, J., Zhang, H., Zhang, Y., Zhou, Z., Zhang, J., et al. (2017) · mSphere · doi:10.1128/msphere.00327-17 · Cited by 188

The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals

Agrawal, M., Aroniadis, O. C., Brandt, L. J., Kelly, C., Freeman, S., Surawicz, C., Broussard, E., Stollman, N., Giovanelli, A., Smith, B., et al. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000410 · Cited by 186

Gut microbiota composition and bone mineral loss—epidemiologic evidence from individuals in Wuhan, China

Li, C., Huang, Q., Yang, R., Dai, Y., Zeng, Y., Tao, L., Li, X., Zeng, J., & Wang, Q. (2019) · Osteoporosis International · doi:10.1007/s00198-019-04855-5 · Cited by 186

Gut microbiota alterations associated with reduced bone mineral density in older adults

Das, M., Cronin, O., Keohane, D. M., Cormac, E. M., Nugent, H., Nugent, M., Molloy, C., O’Toole, P. W., Shanahan, F., Molloy, M. G., et al. (2019) · Rheumatology · doi:10.1093/rheumatology/kez302 · Cited by 185

Gut microbiome, endocrine control of gut barrier function and metabolic diseases

Régnier, M., Hul, M. V., Knauf, C., & Cani, P. D. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0473 · Cited by 183

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

Bodogai, M., O’Connell, J., Kim, K., Kim, Y., Moritoh, K., Chen, C., Gusev, F., Vaughan, K., Shulzhenko, N., Mattison, J. A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4271 · Cited by 182

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Picca, A., Ponziani, F. R., Calvani, R., Marini, F., Biancolillo, A., Coelho‐Júnior, H. J., Gervasoni, J., Primiano, A., Putignani, L., CHIERICO, F. D., et al. (2019) · Nutrients · doi:10.3390/nu12010065 · Cited by 181

Signaling in Host-Associated Microbial Communities

Fischbach, M. A., & Segre, J. A. (2016) · Cell · doi:10.1016/j.cell.2016.02.037 · Cited by 180

The Surface-Associated Exopolysaccharide of Bifidobacterium longum 35624 Plays an Essential Role in Dampening Host Proinflammatory Responses and Repressing Local T H 17 Responses

Schiavi, E., Gleinser, M., Molloy, E. M., Groeger, D., Frei, R., Ferstl, R., Rodríguez‐Pérez, N., Ziegler, M., Grant, R., Moriarty, T. F., et al. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02238-16 · Cited by 179

A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults

Anderson, J. R., Carroll, I. M., Azcárate-Peril, M. A., Rochette, A. D., Heinberg, L. J., Peat, C. M., Steffen, K. J., Manderino, L. M., Mitchell, J. E., & Gunstad, J. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.07.018 · Cited by 175

Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults

Fielding, R. A., Reeves, A. R., Jasuja, R., Liu, C. K., Barrett, B. B., & Lustgarten, M. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110722 · Cited by 171

Human Skin, Oral, and Gut Microbiomes Predict Chronological Age

Huang, S., Haiminen, N., Carrieri, A.-P., Hu, R., Jiang, L., Parida, L., Russell, B., Allaband, C., Zarrinpar, A., Vázquez-Baeza, Y., et al. (2020) · mSystems · doi:10.1128/msystems.00630-19 · Cited by 167

Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation

Rampelli, S., Soverini, M., D’Amico, F., Barone, M., Tavella, T., Monti, D., Capri, M., Astolfi, A., Brigidi, P., Biagi, E., et al. (2020) · mSystems · doi:10.1128/msystems.00124-20 · Cited by 166

Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption

Eloe-Fadrosh, E. A., Brady, A., Crabtree, J., Drabek, E. F., Ma, B., Mahurkar, A., Ravel, J., Haverkamp, M., Fiorino, A.-M., Botelho, C., et al. (2015) · mBio · doi:10.1128/mbio.00231-15 · Cited by 160

Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress

Wang, H., Braun, C., Murphy, E. F., & Enck, P. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000203 · Cited by 159

Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging

Singh, H., Torralba, M. G., Moncera, K. J., DiLello, L., Petrini, J., Nelson, K. E., & Pieper, R. (2019) · GeroScience · doi:10.1007/s11357-019-00098-8 · Cited by 158

Feeding the microbiota: Transducer of nutrient signals for the host

Shanahan, F., van Sinderen, D., O’Toole, P. W., & Stanton, C. (2017) · Gut · doi:10.1136/gutjnl-2017-313872 · Cited by 157

Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups

Kim, B. S., Choi, C. W., Shin, H., Jin, S., Bae, J.-S., Han, M., Seo, E. Y., Chun, J., & Chung, J. H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1811.11023 · Cited by 157

Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease

Couto, M. R., Gonçalves, P., Magro, F., & Martel, F. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104947 · Cited by 153

A randomized trial to determine the impact of a digestion resistant starch composition on the gut microbiome in older and mid-age adults

Alfa, M. J., Strang, D., Tappia, P. S., Graham, M., Van Domselaar, G., Forbes, J. D., Laminman, V., Olson, N., DeGagne, P., Bray, D., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.03.025 · Cited by 149

Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study

Macfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., & Macfarlane, G. T. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12453 · Cited by 148

Effects of short‐term endurance exercise on gut microbiota in elderly men

Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., Hoshino, Y., Hosokawa, M., Takeyama, H., & Higuchi, M. (2018) · Physiological Reports · doi:10.14814/phy2.13935 · Cited by 143

Genomics and metagenomics of trimethylamine-utilizing Archaea in the human gut microbiome

Borrel, G., McCann, A., Deane, J., Neto, M. C., Lynch, D. B., Brugère, J., & O’Toole, P. W. (2017) · The ISME Journal · doi:10.1038/ismej.2017.72 · Cited by 137

A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Siddharth, J., Chakrabarti, A., Pannérec, A., Karaz, S., Morin-Rivron, D., Masoodi, M., Feige, J. N., & Parkinson, S. J. (2017) · Aging · doi:10.18632/aging.101262 · Cited by 127

Preliminary evidence for an association between the composition of the gut microbiome and cognitive function in neurologically healthy older adults

Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125

Comparative analysis of gut microbiota in elderly people of urbanized towns and longevity villages

Park, S., Kim, K., Ahn, Y., Jeong, J.-J., Huh, C., & Kim, D. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0386-8 · Cited by 112

Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity

Tran, T. T. T., Cousin, F., Lynch, D. B., Menon, R., Brulc, J. M., Brown, J. R.-M., O’Herlihy, E. A., Buttó, L. F., Power, K., Jeffery, I. B., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0654-1 · Cited by 112

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Conley, M. N., Wong, C. P., Duyck, K. M., Hord, N. G., Ho, E., & Sharpton, T. J. (2016) · PeerJ · doi:10.7717/peerj.1854 · Cited by 111

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations

Tuikhar, N., Keisam, S., Labala, R. K., Imrat, Ramakrishnan, P., Arunkumar, M. C., Ahmed, G., Biagi, E., & Jeyaram, K. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.001 · Cited by 103 · cited 1×

Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial

Kotani, Y., Shinkai, S., OKAMATSU, H., Toba, M., Ogawa, K., Yoshida, H., Fukaya, T., Fujiwara, Y., Chaves, P. H. M., Kakumoto, K., et al. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-11 · Cited by 102

P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse

Pascucci, T., Colamartino, M., Fiori, E., Sacco, R., Coviello, A., Ventura, R., Puglisi‐Allegra, S., Turriziani, L., & Persico, A. M. (2020) · Brain Sciences · doi:10.3390/brainsci10040233 · Cited by 96

Relative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharides

Chung, W. S. F., Walker, A. W., Bosscher, D., Garcia‐Campayo, V., Wagner, J., Parkhill, J., Duncan, S. H., & Flint, H. J. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01968-4 · Cited by 96

Relationship between oral and gut microbiota in elderly people

Iwauchi, M., Horigome, A., Ishikawa, K., Mikuni, A., Nakano, M., Xiao, J., Odamaki, T., & Hironaka, S. (2019) · Immunity Inflammation and Disease · doi:10.1002/iid3.266 · Cited by 96

The role of gut microbiota metabolite trimethylamine N-oxide in functional impairment of bone marrow mesenchymal stem cells in osteoporosis disease

Lin, H., Liu, T., Li, X., Gao, X., Wu, T., & Peng, L. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-5307 · Cited by 95

Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)

Costabile, A., Bergillos-Meca, T., Rasinkangas, P., Korpela, K., de Vos, W. M., & Gibson, G. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01443 · Cited by 94

Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?

Vitale, M., Giacco, R., Laiola, M., Pepa, G. D., Luongo, D., Mangione, A., Salamone, D., Vitaglione, P., Ercolini, D., & Rivellese, A. A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.025 · Cited by 94

Immunoprotective effects of oral intake of heat-killed Lactobacillus pentosus strain b240 in elderly adults: a randomised, double-blind, placebo-controlled trial

Shinkai, S., Toba, M., Saito, T., Sato, I., Tsubouchi, M., Taira, K., Kakumoto, K., Inamatsu, T., Yoshida, H., Fujiwara, Y., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003753 · Cited by 92

Structural and functional characterization of the gut microbiota in elderly women with migraine

Chen, J., Wang, Q., Wang, A., & Lin, Z. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00470 · Cited by 89

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

Pathak, P., Helsley, R. N., Brown, A. L., Buffa, J. A., Choucair, I., Nemet, I., Baleanu‐Gogonea, C., Gogonea, V., Wang, Z., Garcı́a-Garcı́a, J. C., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00584.2019 · Cited by 89

Microbiome and health implications for ethnic minorities after enforced lifestyle changes

Keohane, D. M., Ghosh, T. S., Jeffery, I. B., Molloy, M. G., O’Toole, P. W., & Shanahan, F. (2020) · Nature Medicine · doi:10.1038/s41591-020-0963-8 · Cited by 89

Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women

Nyangale, E. P., Farmer, S., Cash, H. A., Keller, D., Chernoff, D., & Gibson, G. R. (2015) · Journal of Nutrition · doi:10.3945/jn.114.199802 · Cited by 89

Fecal microbiota transplantation in an elderly patient with mental depression

Cai, T., Shi, X., Yuan, L., Tang, D., & Wang, F. W. (2019) · International Psychogeriatrics · doi:10.1017/s1041610219000115 · Cited by 89

Functional microbiome deficits associated with ageing: Chronological age threshold

Ruiz‐Ruiz, S., Sánchez-Carrillo, S., Ciordia, S., Mena, M. C., Méndez–García, C., Rojo, D., Bargiela, R., Zubeldia‐Varela, E., Martínez‐Martínez, M., Barbas, C., et al. (2019) · Aging Cell · doi:10.1111/acel.13063 · Cited by 89

Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults

Sanborn, V. E., Azcárate-Peril, M. A., Updegraff, J. A., Manderino, L. M., & Gunstad, J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s270035 · Cited by 89

Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086

Nyangale, E. P., Farmer, S., Keller, D., Chernoff, D., & Gibson, G. R. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.09.002 · Cited by 87

Microbiome changes: an indicator of Parkinson’s disease?

Haikal, C., Chen, Q., & Li, J. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0175-7 · Cited by 83

An investigation into physical frailty as a link between the gut microbiome and cognitive health

Verdi, S., Jackson, M. A., Beaumont, M., Bowyer, R. C. E., Bell, J. T., Spector, T. D., & Steves, C. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00398 · Cited by 82

Effect of Short-Term Dietary Intervention and Probiotic Mix Supplementation on the Gut Microbiota of Elderly Obese Women

Cancello, R., Turroni, S., Rampelli, S., Cattaldo, S., Candela, M., Cattani, L., Mai, S., Vietti, R., Scacchi, M., Brigidi, P., et al. (2019) · Nutrients · doi:10.3390/nu11123011 · Cited by 82

Gut Microbiota Associations with Metabolic Health and Obesity Status in Older Adults

Zhong, X., Harrington, J. M., Millar, S., Perry, I. J., O’Toole, P. W., & Phillips, C. M. (2020) · Nutrients · doi:10.3390/nu12082364 · Cited by 76

Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation‐associated β3‐adrenergic receptor activation in high‐fat diet‐induced obese mice

Jia, Y., Hong, J., Li, H., Hu, Y., Jia, L., Cai, D., & Zhao, R. (2016) · Experimental Physiology · doi:10.1113/ep086114 · Cited by 75

The effects of non-viableLactobacilluson immune function in the elderly: a randomised, double-blind, placebo-controlled study

Maruyama, M., Abe, R., Shimono, T., Iwabuchi, N., Abe, F., & Xiao, J. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1126564 · Cited by 75

Metagenomics Study Reveals Changes in Gut Microbiota in Centenarians: A Cohort Study of Hainan Centenarians

Luan, Z., Sun, G., Huang, Y., Yang, Y., Yang, R., Li, C., Wang, T., Tan, D., Qi, S., Chen, J., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01474 · Cited by 74

Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers

Ntemiri, A., Ghosh, T. S., Gheller, M. E., Tran, T. T. T., Blum, J., Pellanda, P., Vlčková, K., Neto, M. C., Howell, A. B., Thalacker‐Mercer, A. E., et al. (2020) · Nutrients · doi:10.3390/nu12092800 · Cited by 74

Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells

Kumar, A., Alrefai, W. A., Borthakur, A., & Dudeja, P. K. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00186.2015 · Cited by 73

Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease

Margiotta, E., Miragoli, F., Callegari, M. L., Vettoretti, S., Caldiroli, L., Meneghini, M., Zanoni, F., & Messa, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228530 · Cited by 72

Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction

Wang, W., Wang, J., Li, J., Yan, P., Jin, Y., Zhang, R., Yue, W., Guo, Q., & Geng, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01402 · Cited by 70

Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol

Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J. (2012) · AGE · doi:10.1007/s11357-011-9294-5 · Cited by 67

Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature

Xie, W.-R., Yang, X.-Y., Xia, H. H.-X., Wu, L.-H., & He, X.-X. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i19.3074 · Cited by 67

Lactobacillus gasseri KS-13,Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2 Ingestion Induces a Less Inflammatory Cytokine Profile and a Potentially Beneficial Shift in Gut Microbiota in Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Spaiser, S. J., Culpepper, T., Nieves, C., Ukhanova, M., Mai, V., Percival, S. S., Christman, M. C., & Langkamp-Henken, B. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.983249 · Cited by 66

Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly

An, R., Wilms, E., Smolinska, A., Hermes, G. D. A., Masclee, A., de Vos, P., Schols, H. A., van Schooten, F., Smidt, H., Jonkers, D. M. A. E., et al. (2019) · Nutrients · doi:10.3390/nu11092193 · Cited by 66

Association Between Gut Microbiome and Frailty in the Older Adult Population in Korea

Lim, M. Y., Hong, S. P., Kim, J., & Nam, Y. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa319 · Cited by 66

Lactic Acid Bacteria as Promoters of Human Health

Sanders, M. E. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2073-3_14 · Cited by 63

Can a Prebiotic Formulation Reduce Frailty Levels in Older People?

Theou, O., Jayanama, K., Garrido, J. F., Buigues, C., Pruimboom, L., Hoogland, A. J., Navarro-Martínez, R., Rockwood, K. J., & Cauli, O. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.39 · Cited by 63

Mitochondrial gene polymorphism is associated with gut microbial communities in mice

Hirose, M., Künstner, A., Schilf, P., Sünderhauf, A., Rupp, J., Jöhren, O., Schwaninger, M., Sina, C., Baines, J. F., & Ibrahim, S. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-15377-7 · Cited by 63

Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota

Landman, C., Grill, J.-P., Mallet, J., Marteau, P. R., Humbert, L., Balc’h, E. L., Maubert, M.-A., Pérez, K., Chaara, W., Brot, L., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202587 · Cited by 62

Changes in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota

Watson, A. W., Houghton, D., Avery, P. J., Stewart, C. J., Vaughan, E. E., Meyer, P., Kuil, M. J. J. D. B., Weijs, P. J. M., & Brandt, K. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.06.006 · Cited by 62

Dissecting the role of the gut microbiota and diet on visceral fat mass accumulation

Roy, C. I. L., Bowyer, R. C. E., Fernandez, J. C., Pallister, T., Menni, C., Steves, C. J., Berry, S. E., Spector, T. D., & Bell, J. T. (2019) · Scientific Reports · doi:10.1038/s41598-019-46193-w · Cited by 62

Age-related changes in the gut microbiota and the core gut microbiome of healthy Thai humans

La-ongkham, O., Nakphaichit, M., Nakayama, J., Keawsompong, S., & Nitisinprasert, S. (2020) · 3 Biotech · doi:10.1007/s13205-020-02265-7 · Cited by 61

Associations between dietary fiber, the fecal microbiota and estrogen metabolism in postmenopausal women with breast cancer

Zengul, A. G., Demark-Wahnefried, W., Barnes, S., Morrow, C. D., Bertrand, B., Berryhill, T. F., & Frugé, A. D. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2020.1784444 · Cited by 60

Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions

Pellanda, P., Ghosh, T. S., & O’Toole, P. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.11.001 · Cited by 60

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

Igwe, E. O., Charlton, K. E., Roodenrys, S. J., Kent, K., Fanning, K., & Netzel, M. E. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.08.006 · Cited by 60

Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications

Pignanelli, M., Bogiatzi, C., Gloor, G. B., Allen‐Vercoe, E., Reid, G., Urquhart, B. L., Ruetz, K. N., Velenosi, T. J., & Spence, J. D. (2018) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2018.05.007 · Cited by 59

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Menni, C., Louca, P., Berry, S. E., Vijay, A., Astbury, S., Leeming, E. R., Gibson, R., Asnicar, F., Piccinno, G., Wolf, J., et al. (2021) · BMC Medicine · doi:10.1186/s12916-021-01913-w · Cited by 58

The Association between Objectively Measured Physical Activity and the Gut Microbiome among Older Community Dwelling Men

Langsetmo, L., Johnson, A. J., Demmer, R. T., Fino, N. F., ORWOLL, E. S., Ensrud, K. E., Hoffman, A. R., Cauley, J. A., Shmagel, A., Meyer, K. A., et al. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1194-x · Cited by 57

Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults

Fart, F., Rajan, S., Wall, R., Rangel, I., Mall, J. G., Tingö, L., Brummer, R. J., Repsilber, D., Schoultz, I., & Lindqvist, C. M. (2020) · Nutrients · doi:10.3390/nu12092610 · Cited by 55

Enriched taxa were found among the gut microbiota of centenarians in East China

Wang, N., Li, R., Lin, H., Fu, C., Wang, X., Zhang, Y., Su, M., Huang, P., Qian, J., Jiang, F., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222763 · Cited by 55

Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: a cross-sectional study

Awoyemi, A., Trøseid, M., Arnesen, H., Solheim, S., & Seljeflot, I. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0360-3 · Cited by 54

Butyrate Protects Against Salsolinol-Induced Toxicity in SH-SY5Y Cells: Implication for Parkinson’s Disease

Getachew, B., Csoka, A. B., Bhatti, A., Copeland, R., & Tizabi, Y. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00238-5 · Cited by 53

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease

He, W., Luo, Y., Liu, J., Sun, N. L., Guo, D., Cui, L.-L., Zheng, P., Yao, S.-M., Yang, J.-F., & Wang, H. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s270887 · Cited by 52

Fecal Transplantation for Treatment of Clostridium Difficile Infection in Elderly and Debilitated Patients

Friedman-Korn, T., Livovsky, D. M., Maharshak, N., Cohen, N. A., Paz, K., Shitrit, A. B., Goldin, E., & Koslowsky, B. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4833-2 · Cited by 51

Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

Hidalgo‐Liberona, N., González‐Domínguez, R., Vegas, E., Riso, P., Bo’, C. D., Bernardi, S., Peron, G., Guglielmetti, S., Gargari, G., Kroon, P. A., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04976 · Cited by 50

A Randomized Placebo Controlled Clinical Trial to Determine the Impact of Digestion Resistant Starch MSPrebiotic® on Glucose, Insulin, and Insulin Resistance in Elderly and Mid-Age Adults

Alfa, M. J., Strang, D. G., Tappia, P. S., Olson, N. L., DeGagné, P., Bray, D., Murray, B.-L., & Hiebert, B. M. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2017.00260 · Cited by 48

Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial

Ostan, R., Béné, M. C., Spazzafumo, L., Pinto, A., Donini, L. M., Pryen, F., Charrouf, Z., Valentini, L., Lochs, H. H., Bourdel‐Marchasson, I., et al. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.06.010 · Cited by 47

Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects

Ruiz-Saavedra, S., Salazar, N., Suárez, A., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & González, S. (2020) · Nutrients · doi:10.3390/nu12123828 · Cited by 46

The gut microbiome and frailty

Piggott, D. A., & Tuddenham, S. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.012 · Cited by 43

Gut microbiota profile in healthy Indonesians

Rahayu, E. S., Utami, T., Mariyatun, M., Hasan, P. N., Kamil, R. Z., Setyawan, R. H., Pamungkaningtyas, F. H., Harahap, I. A., Wiryohanjoyo, D. V., Pramesi, P. C., et al. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i12.1478 · Cited by 42

Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?

Gutiérrez‐Díaz, I., Fernández-Navarro, T., Salazar, N., Bartolomé, B., Moreno-Arribas, M. V., López, P., Suárez, A., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & González, S. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04102 · Cited by 41

L actobacillus in Jelly Enhances the Effect of Influenza Vaccination in Elderly Individuals

Akatsu, H., Arakawa, K., Yamamoto, T., Kanematsu, T., Matsukawa, N., Ohara, H., & Maruyama, M. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12474 · Cited by 40

Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial

Enani, S. M., Przemska-Kosicka, A., Childs, C. E., Maidens, C. M., Dong, H., Conterno, L., Tuohy, K. M., Todd, S., Gosney, M., & Yaqoob, P. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.01.011 · Cited by 38

Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

Przemska-Kosicka, A., Childs, C. E., Enani, S. M., Maidens, C. M., Dong, H., Bindayel, I. A., Tuohy, K. M., Todd, S., Gosney, M., & Yaqoob, P. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0061-4 · Cited by 37

Gut microbiota in healthy and unhealthy long-living people

Zhang, S., Zeng, B., Chen, Y., Yang, M., Kong, F., Wei, L., Li, F., Zhao, J., & Li, Y. (2021) · Gene · doi:10.1016/j.gene.2021.145510 · Cited by 37

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi0216-062rr · Cited by 36

Gut Microbiota Alteration After Long-Term Consumption of Probiotics in the Elderly

Gao, R., Zhang, X., Huang, L., Shen, R., & Qin, H. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9403-1 · Cited by 32

Combined butyric acid/mesalazine treatment in ulcerative colitis with mild-moderate activity. Results of a multicentre pilot study.

Assisi, R. (2008) · PubMed · Cited by 31

Low anthocyanin plum nectar does not impact cognition, blood pressure and gut microbiota in healthy older adults: A randomized crossover trial

Igwe, E. O., Roodenrys, S. J., Probst, Y., do Rosario, V. A., Netzel, M. E., Hong, H. T., Netzel, G. A., Phan, A. D. T., & Charlton, K. E. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.08.003 · Cited by 24

A period of 10 weeks of increased protein consumption does not alter faecal microbiota or volatile metabolites in healthy older men: a randomised controlled trial

Mitchell, S. M., McKenzie, E. J., Mitchell, C. J., Milan, A. M., Zeng, N., D’Souza, R. F., Ramzan, F., Sharma, P., Rettedal, E. A., Knowles, S. O., et al. (2020) · Journal of Nutritional Science · doi:10.1017/jns.2020.15 · Cited by 23

A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers

Kashtanova, D. A., Klimenko, N. S., Strazhesko, I. D., Starikova, E. V., Glushchenko, O. E., Андреевич, Г. Д., & Ткачева, О. Н. (2020) · Microorganisms · doi:10.3390/microorganisms8081162 · Cited by 22

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., et al. (2023) · Nutrients · doi:10.3390/nu15092211 · Cited by 1,397

Meta-hallmarks of aging and cancer

López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529

Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471

What defines a healthy gut microbiome?

Hul, M. V., Cani, P. D., Petitfils, C., de Vos, W. M., Tilg, H., & El-Omar, E. M. (2024) · Gut · doi:10.1136/gutjnl-2024-333378 · Cited by 448

Gut Microbiota and Ageing: Mechanisms, Age-Related Diseases, and Therapeutic Perspectives

Ferreira, J. M. A., Тукаєв, С., & Giannouli, V. (2026) · Healthcare · doi:10.3390/healthcare14142117 · Cited by 4

Ageing, microbes and health

O’Toole, P. W. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.14477 · Cited by 14

The human gut microbiome and aging

Bradley, E. S., & Haran, J. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359677 · Cited by 197

Gut microbiome and healthy ageing: a systematic review of literature

Almatrafi, R., Alqurainy, N., Hakami, M., Ajina, R., Alrabiah, S., Arafah, A. M., Alotibi, R. S., & Aldriwesh, M. G. (2026) · Microbiology · doi:10.1099/mic.0.001779

Gut microbiome in healthy aging versus those associated with frailty

Lim, M. Y., & Nam, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2278225 · Cited by 72