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The roles of microRNAs in mouse development
Abstract
Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns during embryonic and postnatal mouse development. The loss of all miRNAs through the deletion of critical miRNA biogenesis factors results in early lethality. The function of each miRNA stems from their cumulative negative regulation of multiple mRNA targets expressed in a particular cell type. During development, miRNAs often coordinate the timing and direction of cell fate transitions. In adults, miRNAs frequently contribute to organismal fitness through homeostatic roles in physiology. Here, we review how the recent dissection of miRNA-knockout phenotypes in mice as well as advances related to their targets, dosage, and interactions have collectively informed our understanding of the roles of miRNAs in mammalian development and adaptive responses.
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“Many miRNAs also display tissue-, cell type-, or conditionspecific expression patterns and play key roles in the regulation of developmental programs (DeVeale et al., 2021;Manakov et al., 2009).”
From Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP (2022) · cites this paper as DeVeale et al., 2021
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Metadata
- Authors
- DeVeale, B., Swindlehurst-Chan, J., & Blelloch, R.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Blelloch, Robert
- Venue
- Nature Reviews Genetics
- Published
- 2021-01-15
- Volume
- 22
- Issue
- 5
- Pages
- 307-323
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W3123282374
- Cited by
- 121
- References
- 130
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 23 · 2023: 27 · 2022: 23 · 2021: 12
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute of General Medical Sciences (R01GM122439, R01GM125089)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD093084, P50HD055764)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, mouse development, microRNA biogenesis, miRNA target genes, cell fate transitions, embryonic development, postnatal development, non-coding RNA, homeostasis, adaptive response
- MeSH terms
- Animals, Cell Differentiation, Growth, Cell Lineage, MicroRNAs, Embryonic Development, Mice
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