Cited by 122MicroRNA in disease regulationDevelopmental Biology and Gene RegulationPlant Molecular Biology Research

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The roles of microRNAs in mouse development

DeVeale, Brian, Swindlehurst-Chan, Jennifer, Blelloch, Robert·2021·Nature Reviews Genetics

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Abstract

Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns during embryonic and postnatal mouse development. The loss of all miRNAs through the deletion of critical miRNA biogenesis factors results in early lethality. The function of each miRNA stems from their cumulative negative regulation of multiple mRNA targets expressed in a particular cell type. During development, miRNAs often coordinate the timing and direction of cell fate transitions. In adults, miRNAs frequently contribute to organismal fitness through homeostatic roles in physiology. Here, we review how the recent dissection of miRNA-knockout phenotypes in mice as well as advances related to their targets, dosage, and interactions have collectively informed our understanding of the roles of miRNAs in mammalian development and adaptive responses.

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Authors: DeVeale, B., Swindlehurst-Chan, J., & Blelloch, R.
Affiliations: University of California, San Francisco (US)
Corresponding author: Blelloch, Robert
ORCID: DeVeale, Brian
Swindlehurst-Chan, Jennifer
Blelloch, Robert
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2021-01-15
Volume: 22
Issue: 5
Pages: 307-323
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/s41576-020-00309-5
OpenAlex: W3123282374
Cited by: 121
References: 130
Citations by year: 2026: 15 · 2025: 21 · 2024: 23 · 2023: 27 · 2022: 23 · 2021: 12
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
National Institute of General Medical Sciences (R01GM122439, R01GM125089)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD093084, P50HD055764)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, mouse development, microRNA biogenesis, miRNA target genes, cell fate transitions, embryonic development, postnatal development, non-coding RNA, homeostasis, adaptive response
MeSH terms: Animals, Cell Differentiation, Growth, Cell Lineage, MicroRNAs, Embryonic Development, Mice

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The roles of microRNAs in mouse development

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