Histone post-translational modifications - cause and consequence of genome function

The hallmarks of cancer

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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

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High-Resolution Profiling of Histone Methylations in the Human Genome

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Metabolic regulation of gene expression by histone lactylation

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Lactate and lactylation in cancer

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Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

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Signaling pathways and targeted therapies for psoriasis

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Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Shi, Y., Zhang, H., Huang, S., Yin, L., Wang, F., Luo, P., & Huang, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01055-2 · Cited by 377

Epigenetics-targeted drugs: current paradigms and future challenges

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Redox regulation: mechanisms, biology and therapeutic targets in diseases

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 322

Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

Liu, R., Ren, X., Park, Y. E., Feng, H., Sheng, X., Song, X., AminiTabrizi, R., Shah, H., Li, L., Zhang, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.005 · Cited by 253

CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer

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Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases

Yao, W., Hu, X., & Wang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01918-w · Cited by 257

Histone lactylation drives CD8+ T cell metabolism and function

Raychaudhuri, D., Singh, P., Chakraborty, B., Hennessey, M., Tannir, A. J., Byregowda, S., Natarajan, S. M., Trujillo‐Ocampo, A., Im, J. S., & Goswami, S. (2024) · Nature Immunology · doi:10.1038/s41590-024-01985-9 · Cited by 234

Rheumatoid arthritis: pathogenesis and therapeutic advances

Gao, Y., Zhang, Y., & Liu, X. (2024) · MedComm · doi:10.1002/mco2.509 · Cited by 217

Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression

Nshanian, M., Gruber, J. J., Geller, B. S., Chleilat, F., Lancaster, S. M., White, S. M., Alexandrova, L. А., Camarillo, J. M., Kelleher, N. L., Zhao, Y., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01191-9 · Cited by 205

The Epigenetic Hallmarks of Cancer

Esteller, M., Dawson, M. A., Kadoch, C., Rassool, F. V., Jones, P. A., & Baylin, S. B. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0296 · Cited by 202

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Merkuri, F., Rothstein, M., & Simões-Costa, M. (2024) · Nature Communications · doi:10.1038/s41467-023-44121-1 · Cited by 173

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Zhou, S., Liu, J., Wan, A., Zhang, Y., & Qi, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01545-6 · Cited by 175

Epigenetic regulation of early human embryo development

Wilkinson, A. L., Zorzan, I., & Rugg‐Gunn, P. J. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.010 · Cited by 169

Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications

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Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Qiao, J., Tan, Y., Liu, H., Yang, B., Zhang, Q., Liu, Q., Sun, W., Li, Z., Wang, Q., Feng, W., et al. (2024) · Advanced Science · doi:10.1002/advs.202307216 · Cited by 141

Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance

Song, J., Yang, P. X., Chen, C., Ding, W., Tillement, O., Bai, H., & Zhang, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02266-z · Cited by 159

Altered glycosylation in cancer: molecular functions and therapeutic potential

Xu, X., Peng, Q., Jiang, X., Tan, S., Yang, W., Han, Y., Oyang, L., Lin, J., Shen, M., Wang, J., et al. (2024) · 癌症：英文版 · doi:10.1002/cac2.12610 · Cited by 131

A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis

Fan, W., Zeng, S., Wang, X., Wang, G., Liao, D., Li, R., He, S., Li, W., Huang, J., Li, X., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03308-5 · Cited by 134

Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics

Marquardt, R. M., Tran, D. N., Lessey, B. A., Rahman, M. S., & Jeong, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad020 · Cited by 137

Environmental exposures influence multigenerational epigenetic transmission

Klibaner-Schiff, E., Simonin, E. M., Akdiş, C. A., Cheong, A. W. Y., Johnson, M. M. D., Karagas, M. R., Kirsh, S., Kline, O., Mazumdar, M., Oken, E., et al. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01762-3 · Cited by 138

Polyphenols as Potent Epigenetics Agents for Cancer

Rajendran, P., Abdelsalam, S. A., Renu, K., Veeraraghavan, V., Ammar, R. B., & Ahmed, E. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911712 · Cited by 115

The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications

Wang, X., Chen, L., Wei, J., Zheng, H., Zhou, N., Xu, X., Deng, X., Liu, T., & Zou, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02220-z · Cited by 132

Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals

Gest, A. M. M., Sahan, A. Z., Zhong, Y., Lin, W., Mehta, S., & Zhang, J. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00293 · Cited by 112

Epigenetic stress memory: A new approach to study cold and heat stress responses in plants

Ramakrishnan, M., Zhang, Z., Mullasseri, S., Kalendar, R. N., Ahmad, Z., Sharma, A., Liu, G., Zhou, M., & Wei, Q. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1075279 · Cited by 124

Recycling of modified H2A-H2B provides short-term memory of chromatin states

Flury, V., Reverón-Gómez, N., Alcaraz, N., Stewart-Morgan, K. R., Wenger, A., Klose, R. J., & Groth, A. (2023) · Cell · doi:10.1016/j.cell.2023.01.007 · Cited by 100

Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders

Tienda-Vázquez, M. A., Hanel, J. M., Márquez-Arteaga, E. M., Salgado-Álvarez, A. P., Scheckhuber, C. Q., Alanís-Gómez, J. R., Espinoza-Silva, J. I., Ramos-Kuri, M., Hernández-Rosas, F., Melchor-Martínez, E. M., et al. (2023) · Cells · doi:10.3390/cells12121625 · Cited by 108

C/EBPβ: The structure, regulation, and its roles in inflammation-related diseases

Ren, Q., Liu, Z., Wu, L., Yin, G., Xie, X., Kong, W., Zhou, J., & Liu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115938 · Cited by 104

Unlocking the multifaceted molecular functions and diverse disease implications of lactylation

Jing, F., Zhang, J., Zhang, H., & Li, T. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13135 · Cited by 104

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications

To, K. K. W., Xing, E., Larue, R. C., & Li, P. (2023) · Molecules · doi:10.3390/molecules28073043 · Cited by 103

Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity

Hu, Y., Shen, F., Yang, X., Han, T., Long, Z., Wen, J., Huang, J., Shen, J., & Guo, Q. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01574-x · Cited by 101

Unveiling the link between chronic inflammation and cancer

Tripathi, S., Sharma, Y., & Kumar, D. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100347 · Cited by 103

Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity

Raza, A., Salehi, H., Bashir, S., Tabassum, J., Jamla, M., Charagh, S., Barmukh, R., Mir, R. A., Bhat, B. A., Javed, M. A., et al. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03153-7 · Cited by 90

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

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Histone variants and modifications during abiotic stress response

Nunez-Vazquez, R., Desvoyes, B., & Gutiérrez, C. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.984702 · Cited by 82

Emerging epigenetic insights into aging mechanisms and interventions

Wu, Z., Zhang, W., Qu, J. T., & Liu, G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.002 · Cited by 77

Decoding chromatin states by proteomic profiling of nucleosome readers

Lukauskas, S., Tvardovskiy, A., Nguyen, N. V., Stadler, M., Faull, P. A., Ravnsborg, T., Aygenli, B. Ö., Dornauer, S., Flynn, H. R., Lindeboom, R. G. H., et al. (2024) · Nature · doi:10.1038/s41586-024-07141-5 · Cited by 75

The complex role of MEG3: An emerging long non-coding RNA in breast cancer

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Metal Ion Signaling in Biomedicine

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Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Zheng, Q., Weekley, B. H., Vinson, D. A., Zhao, S., Bastle, R. M., Thompson, R. E., Stransky, S., Ramakrishnan, A., Cunningham, A. M., Dutta, S., et al. (2025) · Nature · doi:10.1038/s41586-024-08371-3 · Cited by 66

Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation

Zhang, M., & Tang, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114474 · Cited by 68

Mind the gap: Epigenetic regulation of chromatin accessibility in plants

Candela-Ferre, J., Diego‐Martin, B., Pérez-Alemany, J., & Gallego‐Bartolomé, J. (2024) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiae024 · Cited by 69

Epigenetic control of plant abiotic stress responses

Ma, L., Xing, L., Li, Z., & Jiang, D. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.09.008 · Cited by 73

KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression

Zhang, C., Yu, R., Li, S., Yuan, M., Hu, T., Liu, J., Ke, H., Ye, S., Yun, J., Huang, J., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01533-4 · Cited by 62

Cell-free DNA fragmentomics in cancer

Tsui, W., Jiang, P., & Lo, Y. M. D. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.09.006 · Cited by 72

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Wang, X., Liu, Q., Yu, H., Xie, J., Zhao, J., Fang, Z.-T., Qu, M., Zhang, Y., Yang, Y., & Wang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01812-5 · Cited by 66

Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

Carmona, B., Marinho, H. S., Matos, C. L., Nolasco, S., & Soares, H. (2023) · Biology · doi:10.3390/biology12040561 · Cited by 64

Integrated multi-omics with machine learning to uncover the intricacies of kidney disease

Liu, X., Shi, J., Jiao, Y., An, J., Tian, J., Yang, Y., & Zhuo, L. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae364 · Cited by 58

Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation

Tibben, B. M., & Rothbart, S. B. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168394 · Cited by 61

Epigenetic regulation of cancer stemness

Galassi, C., Manic, G., Esteller, M., Galluzzi, L., & Vitale, I. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02340-6 · Cited by 62

Oxidative Stress, Endothelial Dysfunction, and N -Acetylcysteine in Type 2 Diabetes Mellitus

Li, X., Zou, J., Lin, A., Chi, J., Hao, H., Chen, H., & Liu, Z. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0524 · Cited by 62

APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease

Tian, Q., Li, J., Wu, B., Pang, Y., He, W., Xiao, Q., Wang, J., Yi, L., Tian, N., Shi, X., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184656 · Cited by 53

PROTACs: Novel tools for improving immunotherapy in cancer

Li, S., Chen, T., Liu, J., Zhang, H., Li, J., Wang, Z. P., & Shang, G. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216128 · Cited by 54

Precision epigenetic editing: Technological advances, enduring challenges, and therapeutic applications

Roth, G. V., Gengaro, I. R., & Qi, L. S. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.07.007 · Cited by 59

Epigenetic regulation of hematopoietic stem cell fate

Meng, Y., & Nerlov, C. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.08.005 · Cited by 53

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Zenk, F. L., Fleck, J. S., Jansen, S. M. J., Kashanian, B., Eisinger, B., Santel, M., Dupré, J.-S., Camp, J. G., & Treutlein, B. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01652-0 · Cited by 59

3D genome, on repeat: Higher-order folding principles of the heterochromatinized repetitive genome

Haws, S. A., Simándi, Z., Barnett, R. J., & Phillips‐Cremins, J. E. (2022) · Cell · doi:10.1016/j.cell.2022.06.052 · Cited by 55

Acetylation of histone H3 in cancer progression and prognosis

Miziak, P., Baran, M., Borkiewicz, L., Trombik, T., & Stepulak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010982 · Cited by 49

Cut&tag: a powerful epigenetic tool for chromatin profiling

Fu, Z., Jiang, S., Sun, Y., zheng, S., Zong, L., & Li, P. (2023) · Epigenetics · doi:10.1080/15592294.2023.2293411 · Cited by 55

Natural antisense transcripts as versatile regulators of gene expression

Werner, A., Kanhere, A., Wahlestedt, C., & Mattick, J. S. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00723-z · Cited by 56

Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy

Griñán‐Ferré, C., Bellver‐Sanchís, A., Guerrero, A. T. G., & Pallàs, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107247 · Cited by 55

Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Hu, X., Wu, X., Xu, J., & Xu, X. M. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.010 · Cited by 51

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Wang, Y., Chen, S., Bao, S., Li, Y., Wen, Z., Xu, L., Chen, X., Guo, S., Pang, H., Zhou, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1338922 · Cited by 47

A two-way relationship between histone acetylation and metabolism

Charidemou, E., & Kirmizis, A. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.10.005 · Cited by 49

Epigenetic reprogramming during the maternal‐to‐zygotic transition

Chen, Y., Wang, L., Guo, F., Dai, X., & Zhang, X. (2023) · MedComm · doi:10.1002/mco2.331 · Cited by 51

Metabolite regulation of epigenetics in cancer

Wang, P., Chen, L., Xiong, Y., & Ye, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114815 · Cited by 50

Gut microbiota and epigenetic inheritance: implications for the development of IBD

Guo, X., Li, J., Xu, J., Zhang, L., Huang, C., Nie, Y., & Zhou, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2490207 · Cited by 51

True-to-Scale DNA-Density Maps Correlate With Major Accessibility Differences Between Active and Inactive Chromatin

Gelléri, M., Chen, S., Szczurek, A., Hübner, B., Sterr, M., Neumann, J., Kröger, O., Sadlo, F., Imhoff, J., Markaki, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112567 · Cited by 46

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications

Duan, X., Xing, Z., Qiao, L., Qin, S., Zhao, X., Gong, Y., & Li, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1495221 · Cited by 48

KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions

Van, H. T., Xie, G., Dong, P., Liu, Z. J., & Ge, K. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168453 · Cited by 43

Epigenetic Mechanisms in Latent Epstein-Barr Virus Infection and Associated Cancers

Torne, A. S., & Robertson, E. S. (2024) · Cancers · doi:10.3390/cancers16050991 · Cited by 42

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions

Shao, C., Tang, S., Yu, S., Liu, C., Zhang, Y., Wan, T., He, Z., Yuan, Q., Wu, S., Zhang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55165-2 · Cited by 46

Bacterial chromatin proteins, transcription, and DNA topology: Inseparable partners in the control of gene expression

Hustmyer, C. M., & Landick, R. C. (2024) · Molecular Microbiology · doi:10.1111/mmi.15283 · Cited by 43

Histone Phosphorylation in DNA Damage Response

Gong, P., Guo, Z., Wang, S., Gao, S., & Cao, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062405 · Cited by 44

Epigenetic modulators provide a path to understanding disease and therapeutic opportunityPreprint

Honer, M. A., Ferman, B. I., Gray, Z. H., Bondarenko, E. A., & Whetstine, J. R. (2024) · Genes & Development · doi:10.1101/gad.351444.123 · Cited by 44

Epigenetic rejuvenation by partial reprogramming

Puri, D., & Wagner, W. (2023) · BioEssays · doi:10.1002/bies.202200208 · Cited by 47

Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies

Zhang, Z., & Zhang, Y. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03021-y · Cited by 39

Lactating exposure to microplastics at the dose of infants ingested during artificial feeding induced reproductive toxicity in female mice and their offspring

Dou, Y., Zhang, M., Zhang, H., Zhang, C., Feng, L., Hu, J., Gao, Y., Yuan, X.-Z., Zhao, Y., Zhao, H., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174972 · Cited by 42

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang, X., Xue, X., Pang, M., Yu, L., Qian, J., Li, X., Tian, M., Lü, A., Lu, C. Y., & Liu, Y. (2024) · MedComm · doi:10.1002/mco2.659 · Cited by 45

Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations

Bakulski, K. M., Blostein, F., & London, S. J. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12956 · Cited by 39

Real-time single-molecule imaging of transcriptional regulatory networks in living cells

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Epigenetic Regulation of Aging and its Rejuvenation

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