Histone post-translational modifications - cause and consequence of genome function

The hallmarks of cancer

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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

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High-Resolution Profiling of Histone Methylations in the Human Genome

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Metabolic regulation of gene expression by histone lactylation

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

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Coactivator condensation at super-enhancers links phase separation and gene control

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Histone modifications at human enhancers reflect global cell-type-specific gene expression

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CUT&Tag for efficient epigenomic profiling of small samples and single cells

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Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

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Phase separation drives heterochromatin domain formation

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An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

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Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

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Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

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Mechanisms of Polycomb gene silencing: knowns and unknowns

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Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription

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Organizational principles of 3D genome architecture

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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

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Targeted Recruitment of Set1 Histone Methylase by Elongating Pol II Provides a Localized Mark and Memory of Recent Transcriptional Activity

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Regulation of Alternative Splicing by Histone Modifications

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Organization of Chromatin by Intrinsic and Regulated Phase Separation

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

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Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

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Condensin-driven remodelling of X chromosome topology during dosage compensation

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Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation

Fischle, W., Tseng, B. S., Dormann, H. L., Ueberheide, B. M., Garcia, B. A., Shabanowitz, J., Hunt, D. F., Funabiki, H., & Allis, C. D. (2005) · Nature · doi:10.1038/nature04219 · Cited by 996

Lateral Thinking: How Histone Modifications Regulate Gene Expression

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Imaging dynamic and selective low-complexity domain interactions that control gene transcription

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Topologically associating domains are stable units of replication-timing regulation

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Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

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Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4

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A direct link between core histone acetylation and transcriptionally active chromatin.

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50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

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Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

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Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core

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Chromatin Compaction by a Polycomb Group Protein Complex

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Ten principles of heterochromatin formation and function

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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryotePreprint

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Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

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Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

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New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

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Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

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Rapid spontaneous accessibility of nucleosomal DNA

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RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

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Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1016-7 · Cited by 677

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

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Functional annotation of native enhancers with a Cas9–histone demethylase fusion

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Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

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Heterochromatin drives compartmentalization of inverted and conventional nuclei

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Evaluating phase separation in live cells: diagnosis, caveats, and functional consequencesPreprint

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Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery

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Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

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Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

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Histone Methylation

Bannister, A. J., Schneider, R., & Kouzarides, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00798-5 · Cited by 560

H3K4me3 breadth is linked to cell identity and transcriptional consistency

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The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Weinberg, D. N., Papillon-Cavanagh, S., Chen, H., Yue, Y., Chen, X., Rajagopalan, K. N., Horth, C., McGuire, J. T., Xu, X., Nikbakht, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1534-3 · Cited by 524

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

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A Novel Domain in Set2 Mediates RNA Polymerase II Interaction and Couples Histone H3 K36 Methylation with Transcript Elongation

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The evolving metabolic landscape of chromatin biology and epigenetics

Dai, Z., Ramesh, V., & Locasale, J. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0270-8 · Cited by 508

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

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SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

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Understanding nucleosome dynamics and their links to gene expression and DNA replication

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Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

Farrelly, L. A., Thompson, R. E., Zhao, S., Lepack, A. E., Lyu, Y., Bhanu, N. V., Zhang, B., Loh, Y. E., Ramakrishnan, A., Vadodaria, K. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1024-7 · Cited by 494

Maternal H3K27me3 controls DNA methylation-independent imprinting

Inoue, A., Jiang, L., Lu, F., Suzuki, T., & Zhang, Y. (2017) · Nature · doi:10.1038/nature23262 · Cited by 483

Histone modification: cause or cog?

Henikoff, S., & Shilatifard, A. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.06.006 · Cited by 482

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

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Spatial Distribution of Di- and Tri-methyl Lysine 36 of Histone H3 at Active Genes

Bannister, A. J., Schneider, R., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500796200 · Cited by 459

Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice

Schuettengruber, B., & Cavalli, G. (2009) · Development · doi:10.1242/dev.033902 · Cited by 443

Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals

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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Thorslund, T., Ripplinger, A., Hoffmann, S., Wild, T., Uckelmann, M., Villumsen, B. H., Narita, T., Sixma, T. K., Choudhary, C., Bekker‐Jensen, S., et al. (2015) · Nature · doi:10.1038/nature15401 · Cited by 438

Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development

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Profile of Histone Lysine Methylation across Transcribed Mammalian Chromatin

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Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

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Regulated nucleosome mobility and the histone code

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Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

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Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

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Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level

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The roles of histone variants in fine-tuning chromatin organization and function

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