The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
The immunological anatomy of the skin
Abstract
The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Immunologically important anatomical sites, such as skin appendages (for example, hair follicles and sweat glands) or postcapillary venules, act as special portal sites for immune cells and for establishing tertiary lymphoid structures, including inducible skin-associated lymphoid tissue. Here, we provide an overview of the key findings and concepts of cutaneous immunity in association with skin anatomy and discuss how cutaneous immune cells fine-tune physiological responses in the skin.
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“Epidermal barrier proteins such as filaggrin (FLG) play pivotal roles in maintaining normal skin barrier function (13, 18, 19).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [13]
In the citing paper
“Considering the immune cells are predominantly myeloid‐derived, the observation of CD66b+ cells is consistent with VO differentiation of unique immune cell types that support vascular function.[ 8 , 84 , 85 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [8]
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Cites
Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M. C., Florencia, E. F., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,259
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
Gordon, S. R., Maute, R. L., Dulken, B. W., Hutter, G., George, B. M., McCracken, M. N., Gupta, R., Tsai, J. M., Sinha, R., Corey, D., et al. (2017) · Nature · doi:10.1038/nature22396 · Cited by 2,247
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,529
Broz, M. L., Binnewies, M., Boldajipour, B., Nelson, A. E., Pollack, J. L., Erle, D. J., Barczak, A., Rosenblum, M. D., Daud, A., Barber, D. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.007 · Cited by 1,207
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157
A diversity profile of the human skin microbiotaPreprint
Grice, E. A., Kong, H. H., Renaud, G., Young, A., Bouffard, G. G., Blakesley, R. W., Wolfsberg, T. G., Turner, M. L. C., & Segre, J. A. (2008) · Genome Research · doi:10.1101/gr.075549.107 · Cited by 1,026
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
Lämmermann, T., Afonso, P. V., Angermann, B., Wang, J. M., Kastenmüller, W., Parent, C. A., & Germain, R. N. (2013) · Nature · doi:10.1038/nature12175 · Cited by 939
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Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 594
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Advances in Antimicrobial Microneedle Patches for Combating Infections
Jamaledin, R., Yiu, C. K. Y., Zare, E. N., Niu, L., Vecchione, R., Chen, G., Gu, Z., Tay, F. R., & Makvandi, P. (2020) · Advanced Materials · doi:10.1002/adma.202002129 · Cited by 462
Metadata
- Authors
- Kabashima, K., Honda, T., Ginhoux, F., & Egawa, G.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Kyoto University (JP)
- Corresponding author
- Kabashima, Kenji
- Venue
- Nature Reviews Immunology
- Published
- 2018-11-14
- Volume
- 19
- Issue
- 1
- Pages
- 19-30
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2901552928
- Cited by
- 650
- References
- 105
- Citations by year
- 2026: 73 · 2025: 103 · 2024: 104 · 2023: 103 · 2022: 68 · 2021: 105 · 2020: 66 · 2019: 28
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science (17K19655)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- skin immunity, skin anatomy, skin appendages, hair follicle, sweat glands, postcapillary venules, tertiary lymphoid structures, immune cell recruitment, peripheral nerves, skin microbiome, skin inflammation
- MeSH terms
- Animals, Humans, Immunity, Inflammation, Lymphocytes, Skin
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