Cited by 650Dermatology and Skin DiseasesT-cell and B-cell ImmunologyContact Dermatitis and Allergies

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The immunological anatomy of the skin

Kabashima, Kenji, Honda, Tetsuya, Ginhoux, Florent, Egawa, Gyohei·2019·Nature Reviews Immunology

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Abstract

The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Immunologically important anatomical sites, such as skin appendages (for example, hair follicles and sweat glands) or postcapillary venules, act as special portal sites for immune cells and for establishing tertiary lymphoid structures, including inducible skin-associated lymphoid tissue. Here, we provide an overview of the key findings and concepts of cutaneous immunity in association with skin anatomy and discuss how cutaneous immune cells fine-tune physiological responses in the skin.

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Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The human skin microbiome
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M. C., Florencia, E. F., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,259
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
Gordon, S. R., Maute, R. L., Dulken, B. W., Hutter, G., George, B. M., McCracken, M. N., Gupta, R., Tsai, J. M., Sinha, R., Corey, D., et al. (2017) · Nature · doi:10.1038/nature22396 · Cited by 2,247
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,529
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
Broz, M. L., Binnewies, M., Boldajipour, B., Nelson, A. E., Pollack, J. L., Erle, D. J., Barczak, A., Rosenblum, M. D., Daud, A., Barber, D. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.007 · Cited by 1,207
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157
A diversity profile of the human skin microbiotaPreprint
Grice, E. A., Kong, H. H., Renaud, G., Young, A., Bouffard, G. G., Blakesley, R. W., Wolfsberg, T. G., Turner, M. L. C., & Segre, J. A. (2008) · Genome Research · doi:10.1101/gr.075549.107 · Cited by 1,026
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
Lämmermann, T., Afonso, P. V., Angermann, B., Wang, J. M., Kastenmüller, W., Parent, C. A., & Germain, R. N. (2013) · Nature · doi:10.1038/nature12175 · Cited by 939
Dendritic Cells and Cancer Immunity
Gardner, A., & Ruffell, B. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.006 · Cited by 922
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
SZALLASI, A., Cortright, D. N., Blum, C. A., & Eid, S. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2280 · Cited by 884
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
Guilliams, M., Dutertre, C., Scott, C. L., McGovern, N. N., Sichien, D., Chakarov, S., Gassen, S. V., Chen, J., Poidinger, M., Prijck, S. D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.015 · Cited by 824
Self-citation
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages
Hoeffel, G., Wang, Y., Greter, M., See, P., Teo, P., Malleret, B., Leboeuf, M., Low, D., Oller, G., Almeida, F., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120340 · Cited by 786
Self-citation
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin
Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.004 · Cited by 783
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781
Langerhans cells arise from monocytes in vivo
Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Mérad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 736
Self-citation
Plasmacytoid Dendritic Cells (Natural Interferon- α/β-Producing Cells) Accumulate in Cutaneous Lupus Erythematosus Lesions
Farkas, L., Beiske, K., Lund‐Johansen, F., Brandtzæg, P., & Jahnsen, F. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61689-6 · Cited by 731
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Pitzalis, C., Jones, G. W., Bombardieri, M., & Jones, S. A. (2014) · Nature reviews. Immunology · doi:10.1038/nri3700 · Cited by 715
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
Zaba, L. C., Cardinale, I. R., Gilleaudeau, P., Sullivan-Whalen, M. M., Suárez‐Fariñas, M., Fuentes‐Duculan, J., Novitskaya, I., Khatcherian, A., Bluth, M. J., Lowes, M. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071094 · Cited by 674
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638
Tertiary lymphoid structures in cancer and beyond
Dieu‐Nosjean, M., Goc, J., Giraldo, N. A., Sautès‐Fridman, C., & Fridman, W. H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.006 · Cited by 638
Dynamic T cell migration program provides resident memory within intestinal epithelium
Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
Riol‐Blanco, L., Ordovás-Montañés, J., Perro, M., Naval, E., Thiriot, A., Álvarez, D., Paust, S., Wood, J. N., & von Andrian, U. H. (2014) · Nature · doi:10.1038/nature13199 · Cited by 607
Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence
Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 586
Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia
Egawa, N., Egawa, K., Griffin, H. M., & Doorbar, J. (2015) · Viruses · doi:10.3390/v7072802 · Cited by 585
Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infection
Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A. P., Khanna, K., & Cauley, L. S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313180 · Cited by 537
Early immune events in the induction of allergic contact dermatitis
Kaplan, D. H., Igyártó, B. Z., & Gaspari, A. A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3150 · Cited by 517
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
Kubo, A., Nagao, K., Yokouchi, M., Sasaki, H., & Amagai, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091527 · Cited by 491
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Linehan, J. L., Harrison, O. J., Han, S.-J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.033 · Cited by 456
Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity
Kashem, S. W., Riedl, M. S., Yao, C., Honda, C. N., Vulchanova, L., & Kaplan, D. H. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.016 · Cited by 448
Skin-Associated Lymphoid Tissues (SALT): Origins and Functions
Streilein, J. W. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.4 · Cited by 444
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases
Wolf, K., Müller, R., Borgmann, S., Bröcker, E., & Friedl, P. (2003) · Blood · doi:10.1182/blood-2002-12-3791 · Cited by 442
T cell migration, search strategies and mechanisms
Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423
A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
Iijima, N., & Iwasaki, A. (2014) · Science · doi:10.1126/science.1257530 · Cited by 420
Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema
Wollenberg, A., Kraft, S., Hanau, D., & Bieber, T. R. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343596 · Cited by 414
Antigen-Presenting Cells in the Skin
Kashem, S. W., Haniffa, M. A., & Kaplan, D. H. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052215 · Cited by 392
Tertiary lymphoid organs in infection and autoimmunity
Neyt, K., Perros, F., GeurtsvanKessel, C. H., Hammad, H., & Lambrecht, B. N. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.04.006 · Cited by 389
Dissecting the formation, structure and barrier function of the stratum corneum
Matsui, T., & Amagai, M. (2015) · International Immunology · doi:10.1093/intimm/dxv013 · Cited by 368
Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis
Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 365
Self-citation
Persistence of HIV-1 receptor–positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
Zhu, J., Hladik, F., Davis, A. S. W., Klock, A. M., Peng, T., Johnston, C., Remington, M. L., Magaret, A., Koelle, D. M., Wald, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2006 · Cited by 357
Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells
Engelhardt, J., Boldajipour, B. A., Beemiller, P., Pandurangi, P., Sorensen, C. M., Werb, Z., Egeblad, M., & Krummel, M. F. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.008 · Cited by 347
The influence of skin microorganisms on cutaneous immunity
Belkaid, Y., & Tamoutounour, S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.48 · Cited by 342
Skin-Associated Lymphoid Tissues (SALT): Origins and Functions.
Streilein, J. W. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12536743 · Cited by 339
Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma
Adachi, T., Kobayashi, T., Sugihara, E., Yamada, T., Ikuta, K., Pittaluga, S., Saya, H., Amagai, M., & Nagao, K. (2015) · Nature Medicine · doi:10.1038/nm.3962 · Cited by 336
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
Nagao, K., Kobayashi, T., Moro, K., Ohyama, M., Adachi, T., Kitashima, D. Y., Ueha, S., Horiuchi, K., Tanizaki, H., Kabashima, K., et al. (2012) · Nature Immunology · doi:10.1038/ni.2353 · Cited by 332
Self-citation
Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
Gao, Y., Lü, C., Su, L., Sharma, A. M., & Lee, R. M. K. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707228 · Cited by 323
Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2769 · Cited by 307
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
Tomura, M., Honda, T., Tanizaki, H., Otsuka, A., Egawa, G., TOKURA, Y., Waldmann, H., Hori, S., Cyster, J. G., Watanabe, T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40926 · Cited by 289
Self-citation
Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor
Ladányi, A., Kiss, J., Somlai, B., Gilde, K., Fejôs, Z., Mohos, A., Gaudi, I., & Tı́már, J. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0286-3 · Cited by 287
Bronchus-Associated Lymphoid Tissue (BALT)
Randall, T. D. (2010) · Advances in immunology · doi:10.1016/b978-0-12-381300-8.00007-1 · Cited by 271
Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march
Egawa, G., & Kabashima, K. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.002 · Cited by 265
Self-citation
The Hair Follicle and Immune Privilege
Paus, R., Ito, N., Takigawa, M., & Ito, T. (2003) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2003.00807.x · Cited by 262
Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?
Colbeck, E. J., Ager, A., Gallimore, A., & Jones, G. W. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01830 · Cited by 252
Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems
Schlitzer, A., McGovern, N. N., & Ginhoux, F. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.011 · Cited by 243
Self-citation
Endometrial Histopathology in Patients with Culture-proved Upper Genital Tract Infection and Laparoscopically Diagnosed Acute Salpingitis
Kiviat, N. B., Wölner‐Hanssen, P., Eschenbach, D. A., Wasserheit, J. N., Paavonen, J. A., Bell, T. A., Critchlow, C. W., Stamm, W. E., Moore, D. E., & Holmes, K. K. (1990) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199002000-00008 · Cited by 242
Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues
Honda, T., Egen, J. G., Lämmermann, T., Kastenmüller, W., Torabi‐Parizi, P., & Germain, R. N. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.017 · Cited by 239
Self-citation
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., et al. (2014) · Nature Immunology · doi:10.1038/ni.2992 · Cited by 232
Self-citation
Kimura’s disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia
Kung, I. T. M., Gibson, J. B., & Bannatyne, P. M. (1984) · Pathology · doi:10.3109/00313028409067909 · Cited by 227
Intravital analysis of vascular permeability in mice using two-photon microscopy
Egawa, G., Nakamizo, S., Natsuaki, Y., Doi, H., Miyachi, Y., & Kabashima, K. (2013) · Scientific Reports · doi:10.1038/srep01932 · Cited by 212
Self-citation
High endothelial venules (HEVs) in human melanoma lesions
Martinet, L., Guellec, S. L., Filleron, T., Lamant, L., Meyer, N., Rochaix, P., Garrido, I., & Girard, J. (2012) · OncoImmunology · doi:10.4161/onci.20492 · Cited by 206
Evaluation of Cutaneous Blood Flow Responses by 133Xenon Washout and a Laser-Doppler Flowmeter
Engelhart, M., & Kristensen, J. K. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12530879 · Cited by 196
Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block
Matheu, M. P., Beeton, C., Garcia, A., Chi, V., Rangaraju, S., Safrina, O., Monaghan, K. P., Uemura, M. I., Li, D., Pal, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.015 · Cited by 196
Crosstalk between perivascular adipose tissue and blood vessels
Rajsheker, S., Manka, D. R., Blomkalns, A. L., Chatterjee, T. K., Stoll, L. L., & Weintraub, N. L. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.11.005 · Cited by 192
Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Collins, N., Jiang, X., Zaid, A., Macleod, B. L., Li, J., Park, C. O., Haque, A., Bedoui, S., Heath, W. R., Mueller, S. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11514 · Cited by 187
CD1a on Langerhans cells controls inflammatory skin disease
Kim, J. H., Hu, Y., Yongqing, T., Kim, J. J., Hughes, V. A., Nours, J. L., Marquez, E. A., Purcell, A. W., Wan, Q., Sugita, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3523 · Cited by 187
Langerin neg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
Wohn, C., Ober-Blöbaum, J. L., Haak, S., Pantelyushin, S., Cheong, C., Zahner, S. P., Onderwater, S., Kant, M., Weighardt, H., Holzmann, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307569110 · Cited by 180
Sensory TRP channels contribute differentially to skin inflammation and persistent itch
Feng, J., Yang, P., Mack, M. R., Dryn, D. O., Luo, J., Gong, X., Liu, S., Oetjen, L. K., Zholos, A. V., Mei, Z., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01056-8 · Cited by 150
Trogocytosis of peptide–MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils
Miyake, K., Shiozawa, N., Nagao, T., Yoshikawa, S., Yamanishi, Y., & Karasuyama, H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615973114 · Cited by 141
Induction and functional characterization of class II MHC (Ia) antigens on murine keratinocytes.
Gaspari, A. A., & Katz, S. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.9.2956 · Cited by 140
The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy
Tong, P. L., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S. S., Jain, R., Shaw, L. E., Grimbaldeston, M. A., & Weninger, W. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.289 · Cited by 122
Functional Redundancy of Langerhans Cells and Langerin+ Dermal Dendritic Cells in Contact Hypersensitivity
Noordegraaf, M., Flacher, V., Stoitzner, P., & Clausen, B. E. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.223 · Cited by 113
Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)
Leinweber, B., Kerl, H., & Cerroni, L. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000176427.99004.d7 · Cited by 108
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses
Sawada, Y., Honda, T., Hanakawa, S., Nakamizo, S., Murata, T., Ueharaguchi-Tanada, Y., Ono, S., Amano, W., Nakajima, S., Egawa, G., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150381 · Cited by 108
Self-citation
CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
Boissonnas, A., Licata, F., Poupel, L., Jacquelin, S., Fetler, L., Krumeich, S., Théry, C., Amigorena, S., & Combadière, C. (2013) · Neoplasia · doi:10.1593/neo.121572 · Cited by 104
Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells
Mattii, M., Lovászi, M., Garzorz, N., Atenhan, A., Quaranta, M., Lauffer, F., Konstantinow, A., Küpper, M., Zouboulis, C. C., Kemény, L. V., et al. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15879 · Cited by 98
Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions
Mitsui, H., Suárez‐Fariñas, M., Belkin, D. A., Levenkova, N., Fuentes‐Duculan, J., Coats, I., Fujita, H., & Krueger, J. G. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.33 · Cited by 92
Dermal Clusters of Mature Dendritic Cells and T Cells Are Associated with the CCL20/CCR6 Chemokine System in Chronic Psoriasis
Kim, T., Jee, H., Fuentes‐Duculan, J., Wu, W. H., Byamba, D., Kim, D., ‍Kim, D. Y., Lew, D., Yang, W.-I., Krueger, J. G., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.534 · Cited by 88
Hair Follicles from Alopecia Areata Patients Exhibit Alterations in Immune Privilege-Associated Gene Expression in Advance of Hair Loss
Kang, H., Wu, W., Lo, B. K. K., Yu, M., Leung, G., Shapiro, J., & McElwee, K. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.180 · Cited by 88
Perivascular Dendritic Macrophages as Immunobiological Constituents of the Human Dermal Microvascular Unit.
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Authors: Kabashima, K., Honda, T., Ginhoux, F., & Egawa, G.
Affiliations: Agency for Science, Technology and Research (SG)
Kyoto University (JP)
Corresponding author: Kabashima, Kenji
ORCID: Kabashima, Kenji
Honda, Tetsuya
Ginhoux, Florent
Egawa, Gyohei
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2018-11-14
Volume: 19
Issue: 1
Pages: 19-30
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-018-0084-5
OpenAlex: W2901552928
Cited by: 650
References: 105
Citations by year: 2026: 73 · 2025: 103 · 2024: 104 · 2023: 103 · 2022: 68 · 2021: 105 · 2020: 66 · 2019: 28
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science (17K19655)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: skin immunity, skin anatomy, skin appendages, hair follicle, sweat glands, postcapillary venules, tertiary lymphoid structures, immune cell recruitment, peripheral nerves, skin microbiome, skin inflammation
MeSH terms: Animals, Humans, Immunity, Inflammation, Lymphocytes, Skin

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The immunological anatomy of the skin

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