The DOI matches its Crossref record; 206 of the 207 references it cites were found in a registry or an index.
The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
Abstract
The environment, diet, microbiota and body's metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. In this Review, we summarize our current knowledge of AHR and the transcriptional programmes it controls in the immune system. Finally, we discuss the role of AHR in autoimmune and neoplastic diseases of the central nervous system, with a special focus on the gut immune system, the gut-brain axis and the therapeutic potential of targeting AHR in neurological disorders.
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In the citing paper
“AhR, a ligand-dependent transcription factor, can be activated by diverse ligands including indole-based compounds (22, 23).”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [22]
In the citing paper
“The GI microbiome is thought to be a key player in this process as it is essential for the proper maintenance of the intestinal barrier through various mechanisms, e.g., production of SCFA (Bron et al., 2017) as well as tryptophan metabolites (Rothhammer and Quintana, 2019).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Rothhammer and Quintana, 2019
Citations
Cites
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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
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Cited by
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Astrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
Self-citationHuman Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Kapellos, T. S., Bonaguro, L., Gemünd, I. D., Reusch, N., Saglam, A., Hinkley, E. R., & Schultze, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02035 · Cited by 942
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor
Scott, S. A., Fu, J., & Chang, P. V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000047117 · Cited by 696
Metabolic programming and immune suppression in the tumor microenvironment
Arner, E. N., & Rathmell, J. C. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.009 · Cited by 715
Function and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662
Self-citation
Metadata
- Authors
- Rothhammer, V., & Quintana, F. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Quintana, Francisco J.
- Venue
- Nature Reviews Immunology
- Published
- 2019-02-04
- Volume
- 19
- Issue
- 3
- Pages
- 184-197
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2911968308
- Cited by
- 1,197
- References
- 207
- Citations by year
- 2026: 148 · 2025: 189 · 2024: 179 · 2023: 192 · 2022: 173 · 2021: 160 · 2020: 117 · 2019: 37
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- aryl hydrocarbon receptor, environmental sensing, immune regulation, gut immune system, gut-brain axis, autoimmune disease, central nervous system tumors, transcriptional programs, microbiota, neurological disorders
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Diet, Environment, Gene Expression Regulation, Humans, Intestines, Signal Transduction, Receptors, Aryl Hydrocarbon, Autoimmune Diseases of the Nervous System, Adaptive Immunity, Molecular Targeted Therapy, Microbiota
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