The DOI matches its Crossref record; 204 of the 207 references it cites were found in a registry or an index.
T cells and the skin: from protective immunity to inflammatory skin disorders
Abstract
Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T RM ) cells, which remain in skin for long periods of time and mediate durable protective immunity. These T RM cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.
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“Additionally, the immune response and inflammatory processes involved in wound healing can vary between mice and humans.”
From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [92]
In the citing paper
“Mice may exhibit a more robust or different immune response compared to humans, meaning that the effects of propolis on immune modulation and inflammation observed in mice may not directly translate to humans [91,92].”
From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [92]
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Items 201–204 of 204
Distinct recirculation potential of CD69+CD103− and CD103+ thymic memory CD8+ T cells
Park, S. L., Mackay, L. K., & Gebhardt, T. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.60 · Cited by 20
Dressel, D., Brütt, C. H., Manfras, B. J., Zollner, T. M., Wunderlich, A., Böhm, B. O., & Boehncke, W. (1997) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1997.tb01571.x · Cited by 20
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis
Timerman, D., Devlin, P. M., Nambudiri, V. E., Wright, N. A., Vleugels, R. A., Clark, R. A., Kupper, T. S., Merola, J. F., & Patel, M. (2016) · Clinical and Experimental Dermatology · doi:10.1111/ced.12803 · Cited by 7
Self-citationPark, C. O., Fu, X., Jiang, X., Pan, Y., Teague, J. E., Collins, N., Tian, T., O’Malley, J. T., Emerson, R., Kim, J. H., et al. (2018) · Journal of Allergy and Clinical Immunology · Cited by 5
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Cellular and molecular mechanisms of skin wound healing
Peña, O. A., & Martin, P. B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00715-1 · Cited by 1,827
Immunology of Acute and Chronic Wound Healing
Raziyeva, K., Kim, Y., Zharkinbekov, Z., Kassymbek, K., Jimi, S., & Saparov, A. (2021) · Biomolecules · doi:10.3390/biom11050700 · Cited by 1,152
The Immune Functions of Keratinocytes in Skin Wound Healing
Piipponen, M., Li, D., & Xu, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228790 · Cited by 550
The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
Milner, J. J., Toma, C., He, Z., Kurd, N. S., Nguyen, Q., McDonald, B., Quezada, L. K., Widjaja, C. E., Witherden, D. A., Crowl, J. T., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.007 · Cited by 278
Metadata
- Authors
- Ho, A. W., & Kupper, T. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Kupper, Thomas S.
- Venue
- Nature Reviews Immunology
- Published
- 2019-04-16
- Volume
- 19
- Issue
- 8
- Pages
- 490-502
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2936645459
- Cited by
- 241
- References
- 207
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 39 · 2023: 41 · 2022: 38 · 2021: 42 · 2020: 28 · 2019: 8
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dermatology Foundation
- National Institutes of Health (5r01ca120372-05)
- National Cancer Institute (R01 CA120372)
- National Institute of Allergy and Infectious Diseases (R01AI127654)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR065807, T32AR007098)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin immunity, tissue-resident memory T cells, memory T cells, effector T cells, skin inflammation, immune-mediated skin disease, innate-like T cells, protective immunity, T cell homing, skin immune response
- MeSH terms
- Animals, Humans, Immunologic Memory, Inflammation, Skin, Skin Diseases, T-Lymphocytes
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