Skin-resident T cells: the ups and downs of on site immunity
Open accessAbstract
The cutaneous surface of a normal adult individual contains approximately 20 billion T cells, nearly twice the number present in the entire circulation. Recent studies have shown a role for these cells in both normal immunity and in inflammatory skin diseases such as psoriasis. Regulatory T cells protect against autoimmune reactions to self antigens and assist in the resolution of cutaneous inflammation. However, they can also shield tumors from immune detection, allow latent infections to persist and can dysfunction under the conditions present in inflammatory skin diseases. Th17 T cells protect organisms against extracellular pathogens but also have a key role in the pathogenesis of psoriasis. Evidence suggests that effector memory T cells produced during immune reactions survive and persist long term within the skin, providing local and rapid protection against pathogen reexposure. This review summarizes the current understanding of how skin-resident T cells contribute to normal and aberrant immunity in the skin.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.
“All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.26,27,28,29,30,31,32”
From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [26]
In “Skin resident T cells: hiding in plain sight” (page unavailable), the review reports that over 95% of T cells in normal skin are memory T cells and 80% have an effector-memory phenotype; it does not say all are pre-activated. In “Local T cells responses in skin: lessons from psoriasis” (page unavailable), it describes activation of autoreactive T cells after local antigen-presenting cells produce IFNα. That example does not establish that all skin-resident T cells can be activated in an innate fashion by altered local molecular cues. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067 · see citing works
A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860 · see citing works
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 3× · see citing works
“This contention is at odds with clear and elegant experiments in mice showing that TEM do persist long term — not in the blood but within the peripheral tissues (Masopust et al., 2001; Reinhardt et al., 2001).”
BackgroundCD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726 · see citing works
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,698 · see citing works
Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5703 · Cited by 1,696 · see citing works
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659 · see citing works
Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
Nair, R. P., Duffin, K. C., Helms, C. A., Ding, J., Stuart, P. E., Goldgar, D. E., Gudjonsson, J. E., Li, Y., Tejasvi, T., Feng, B., et al. (2009) · Nature Genetics · doi:10.1038/ng.311 · Cited by 1,414 · see citing works
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Nestle, F. O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.-J., & Gilliet, M. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050500 · Cited by 1,126 · see citing works
Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086 · see citing works
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,075 · see citing works
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. S., & von Andrian, U. H. (2003) · Nature · doi:10.1038/nature01726 · Cited by 1,068 · see citing works
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · cited 1× · see citing works
“This contention is at odds with clear and elegant experiments in mice showing that TEM do persist long term — not in the blood but within the peripheral tissues (Masopust et al., 2001; Reinhardt et al., 2001).”
BackgroundLee, E., Trepicchio, W. L., Oestreicher, J. L., Pittman, D. D., Wang, F., Chamian, F. N., Dhodapkar, M. V., & Krueger, J. G. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030451 · Cited by 900 · see citing works
Requirement of Interleukin‐17A for Systemic Anti– <i>Candida albicans</i> Host Defense in Mice
Huang, W., Na, L., Fidel, P. L., & Schwarzenberger, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/422329 · Cited by 859 · see citing works
Grossman, R., Krueger, J. G., Yourish, D., Granelli‐Piperno, A., Murphy, D. P., May, L. T., Kupper, T. S., Sehgal, P. B., & Gottlieb, A. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6367 · Cited by 854 · see citing works
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
Campbell, J. J., Haraldsen, G., Pan, J., Rottman, J. B., Qin, S., Ponath, P. D., Andrew, D. P., Warnke, R. A., Ruffing, N., Kassam, N., et al. (1999) · Nature · doi:10.1038/23495 · Cited by 833 · see citing works
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
Homey, B., Alenius, H. T., Müller, A., Soto, H., Bowman, E. P., Yuan, W., McEvoy, L. M., Lauerma, A., Assmann, T., Bünemann, E., et al. (2002) · Nature Medicine · doi:10.1038/nm0202-157 · Cited by 807 · see citing works
Immune surveillance in the skin: mechanisms and clinical consequences
Kupper, T. S., & Fuhlbrigge, R. C. (2004) · Nature reviews. Immunology · doi:10.1038/nri1310 · Cited by 805 · see citing works
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., Bäckström, B. T., Sobel, R. A., Wucherpfennig, K. W., Strom, T. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1564 · Cited by 803 · see citing works
A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis
Krueger, G. G., Langley, R. G. B., Leonardi, C. L., Yeilding, N. M., Guzzo, C. A., Wang, Y., Dooley, L. T., & Lebwohl, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa062382 · Cited by 803 · see citing works
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796 · see citing works
Self-citationNaive and memory T cells show distinct pathways of lymphocyte recirculation.
Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 791 · see citing works
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
Matusevičius, D., Kivisäkk, P., He, B., Kostulas, N., Özenci, V., Fredrikson, S., & Link, H. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500206 · Cited by 751 · see citing works
Malý, P., Thall, A. D., Petryniak, B., Rogers, C. E., Smith, P. L., Marks, R. M., Kelly, R. J., Gersten, K. M., Cheng, G., Saunders, T. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80137-3 · Cited by 714 · see citing works
Chan, J. R., Blumenschein, W. M., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S. J., Lucian, L. A., Geissler, R. H., Brodie, S. J., Kimball, A. B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060244 · Cited by 679 · see citing works
Long-term Outcome of 525 Patients With Mycosis Fungoides and Sézary Syndrome
Kim, Y. H., Liu, H. L., Mraz‐Gernhard, S., Varghese, A., & Hoppe, R. T. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.7.857 · Cited by 652 · see citing works
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050193 · Cited by 605 · see citing works
Sugiyama, H., Gyulai, R., Toichi, E., Garaczi, E., Shimada, S., Stevens, S. R., McCormick, T. S., & Cooper, K. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.164 · Cited by 571 · see citing works
Berg, E. L., Yoshino, T., Rott, L. S., Robinson, M. K., Warnock, R. A., Kishimoto, T., Picker, L. J., & Butcher, E. C. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.6.1461 · Cited by 548 · see citing works
Boyman, O., Hefti, H. P., Conrad, C., Nickoloff, B. J., Suter, M., & Nestle, F. O. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031482 · Cited by 521 · see citing works
Susan, M. L., Valdez, P. A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I. M., Winer, J., Modrusan, Z. D., Danilenko, D. M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2229 · Cited by 509 · see citing works
Campbell, D., & Butcher, E. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011502 · Cited by 490 · see citing works
Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues
Wakim, L., Waithman, J., van Rooijen, N., Heath, W., & Carbone, F. (2008) · Science · doi:10.1126/science.1151869 · Cited by 473 · see citing works
Kryczek, I., Bruce, A. T., Gudjonsson, J. E., Johnston, A., Aphale, A., Vatan, L., Szeliga, W., Wang, Y., Liu, Y., Welling, T. H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4733 · Cited by 464 · see citing works
Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes
Warnock, R. A., Askari, S., Butcher, E. C., & von Andrian, U. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.205 · Cited by 464 · see citing works
Pişkin, G., Sylva-Steenland, R. M. R., Bos, J. D., & Teunissen, M. B. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1908 · Cited by 455 · see citing works
Understanding the generation and function of memory T cell subsets
Lanzavecchia, A., & Sallusto, F. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.04.010 · Cited by 453 · see citing works
Zaba, L. C., Fuentes‐Duculan, J., Eungdamrong, N. J., Abello, M. V., Novitskaya, I., Pierson, K. C., Gonzalez, J., Krueger, J. G., & Lowes, M. A. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.194 · Cited by 439 · see citing works
IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells
Aarvak, T., Chabaud, M., Miossec, P., & Natvig, J. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1246 · Cited by 410 · see citing works
Hogan, R. J., Usherwood, E. J., Zhong, W., Roberts, A. D., Dutton, R. W., Harmsen, A. G., & Woodland, D. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1813 · Cited by 409 · see citing works
Capon, F., Meglio, P. D., Szaub, J., Prescott, N. J., Dunster, C., Southgate, L., Timms, K. M., Gutin, A., Abkevich, V., Burden, A. D., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0397-0 · Cited by 406 · see citing works
Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.
Liang, S., Mozdzanowska, K., Palladino, G., & Gerhard, W. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1653 · Cited by 400 · see citing works
Bækkevold, E. S., Yamanaka, T., Palframan, R. T., Carlsen, H. S., Reinholt, F. P., von Andrian, U. H., Brandtzæg, P., & Haraldsen, G. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1105 · Cited by 378 · see citing works
Bos, J. D., Zonneveld, I. M., Das, P. K., Krieg, S. R., van der Loos, C. M., & Kapsenberg, M. L. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470172 · Cited by 341 · see citing works
Zhu, J., Koelle, D. M., Cao, J., Vazquez, J., Huang, M. L., Hladik, F., Wald, A., & Corey, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061792 · Cited by 340 · see citing works
CCR7 Expression and Memory T Cell Diversity in Humans
Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.877 · Cited by 335 · see citing works
́stergaard, M., Hansen, M. S., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K. E., & Lorenzen, I. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 323 · see citing works
Mora, J. R., Cheng, G., Picarella, D., Briskin, M., Buchanan, N. M., & von Andrian, U. H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041645 · Cited by 309 · see citing works
Hogan, R. J., Zhong, W., Usherwood, E. J., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.981 · Cited by 288 · see citing works
Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis
Nair, R. P., Ruether, A., Stuart, P. E., Jenisch, S., Tejasvi, T., Hiremagalore, R., Schreiber, S., Kabelitz, D., Lim, H. W., Voorhees, J. J., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701255 · Cited by 277 · see citing works
Inhibition of Human CD4+CD25+high Regulatory T Cell Function
Baecher‐Allan, C., Viglietta, V., & Hafler, D. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6210 · Cited by 262 · see citing works
Cellular and Humoral Immunity against Vaccinia Virus Infection of Mice
Xu, R., Johnson, A. J., Liggitt, D., & Bevan, M. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6265 · Cited by 260 · see citing works
Wysocki, C., Jiang, Q., Panoskaltsis‐Mortari, A., Taylor, P. A., McKinnon, K. P., Su, L., Blazar, B. R., & Serody, J. S. (2005) · Blood · doi:10.1182/blood-2005-04-1632 · Cited by 243 · see citing works
Clark, R. A., Huang, S. J., Murphy, G. F., Mollet, I. G., Hijnen, D., Muthukuru, M., SCHANBACHER, C. F., Edwards, V. L., Miller, D. M., Kim, J. E., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071190 · Cited by 242 · see citing works
Self-citationModified Vaccinia Virus Ankara Protects Macaques against Respiratory Challenge with Monkeypox Virus
Stittelaar, K. J., van Amerongen, G., Kondova, I. I., Kuiken, T., van Lavieren, R. F., Pistoor, F. H. M., Niesters, H. G. M., van Doornum, G., van der Zeijst, B. A. M., Mateo, L., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7845-7851.2005 · Cited by 230 · see citing works
Xu, D., Liu, H., Komai‐Koma, M., Campbell, C., McSharry, C. P., Alexander, J. K., & Liew, F. Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.394 · Cited by 226 · see citing works
Yurchenko, E., Tritt, M., Hay, V., Shevach, E. M., Belkaid, Y., & Piccirillo, C. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060956 · Cited by 226 · see citing works
Kleinschek, M. A., Müller, U., Brodie, S. J., Stenzel, W., Köhler, G., Blumenschein, W. M., Straubinger, R. K., McClanahan, T. K., Kastelein, R. A., & Alber, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1098 · Cited by 222 · see citing works
Bos, J. D., Hagenaars, C. E., Das, P. K., Krieg, S. R., Voorn, W. J., & Kapsenberg, M. L. (1989) · Archives of Dermatological Research · doi:10.1007/bf00424268 · Cited by 220 · see citing works
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Schaerli, P., Ebert, L. M., Willimann, K., Blaser, A., Roos, R. S., Loetscher, P., & Moser, B. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032177 · Cited by 218 · see citing works
Kimball, A. B. (2008) · Archives of Dermatology · doi:10.1001/archdermatol.2007.63 · Cited by 213 · see citing works
A Novel Method for the Isolation of Skin Resident T Cells from Normal and Diseased Human Skin
Clark, R. A., Chong, B. F., Mirchandani, N., Yamanaka, K.-I., Murphy, G. F., Dowgiert, R. K., & Kupper, T. S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700199 · Cited by 197 · see citing works
Self-citationStarting at the Beginning: New Perspectives on the Biology of Mucosal T Cells
Cheroutre, H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104522 · Cited by 196 · see citing works
Clark, R. A., & Kupper, T. S. (2006) · Blood · doi:10.1182/blood-2006-02-002873 · Cited by 178 · see citing works
Self-citationAnti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial
Bhushan, M., Bleiker, T. O., Ballsdon, A. E., Allen, M. H., Sopwith, M., Robinson, M. K., Clarke, C., Weller, R., GRAHAM-BROWN, R. A. C., Keefe, M., et al. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04743.x · Cited by 140 · see citing works
Ahmadzadeh, M., Felipe-Silva, A., Heemskerk, B., Powell, D. J., Wunderlich, J. R., Merino, M. J., & Rosenberg, S. A. (2008) · Blood · doi:10.1182/blood-2008-06-163048 · Cited by 139 · see citing works
Human Basal Cell Carcinoma Is Associated with Foxp3+ T cells in a Th2 Dominant Microenvironment
Kaporis, H. G., Guttman‐Yassky, E., Lowes, M. A., Haider, A. S., Fuentes‐Duculan, J., Darabi, K., Whynot, J. A., Khatcherian, A., Cardinale, I. R., Novitskaya, I., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700884 · Cited by 137 · see citing works
Dynamic Programing of CD8+ T Cell Trafficking after Live Viral Immunization
Liu, L., Fuhlbrigge, R. C., Karibian, K., Tian, T., & Kupper, T. S. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.019 · Cited by 132 · see citing works
Vukmanovic-Stejic, M., Agius, E., Booth, N., Dunne, P. J., Lacy, K. E., Reed, J. R., Sobande, T. O., Kissane, S., Salmon, M., Rustin, M. H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35834 · Cited by 131 · see citing works
CCR5-Dependent Regulatory T Cell Migration Mediates Fungal Survival and Severe Immunosuppression
Serezani, A. P. M., Cavassani, K. A., Tristão, F. S. M., Serezani, A. P. M., Martínez, R., Rossi, M. A., & Silva, J. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3049 · Cited by 115 · see citing works
Teraki, Y. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)01624-5 · Cited by 113 · see citing works
Razvi, E. S., Jiang, Z., Woda, B. A., & Welsh, R. M. (1995) · Europe PMC (PubMed Central) · Cited by 112 · see citing works
Gut-Derived Intraepithelial Lymphocytes Induce Long Term Immunity Against Toxoplasma gondii
Lepage, A. C., Buzoni–Gatel, D., Bout, D. T., & Kasper, L. H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4902 · Cited by 111 · see citing works
Edele, F., Molenaar, R., Gütle, D., Dudda, J. C., Jakob, T., Homey, B., Mebius, R. E., Hornef, M. W., & Martin, S. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3745 · Cited by 106 · see citing works
Acquired and natural memory T cells join forces at the mucosal front line
Cheroutre, H., & Madakamutil, L. T. (2004) · Nature reviews. Immunology · doi:10.1038/nri1333 · Cited by 106 · see citing works
Chong, B. F., Murphy, J.-E., Kupper, T. S., & Fuhlbrigge, R. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1575 · Cited by 105 · see citing works
Bui, J. D., Uppaluri, R., Hsieh, C., & Schreiber, R. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0556 · Cited by 101 · see citing works
Teraki, Y., Moriya, N., & Shiohara, T. (1994) · PubMed Central · Cited by 84 · see citing works
Regulatory cells and human cancer
Baecher‐Allan, C., & Anderson, D. E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.11.003 · Cited by 80 · see citing works
Mantoux Test as a model for a secondary immune response in humans
Vukmanovic‐Stejic, M., Reed, J. R., Lacy, K. E., Rustin, M. H. A., & Akbar, A. N. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.08.002 · Cited by 79 · see citing works
van Lint, A. L., Kleinert, L., Clarke, S. R. M., Stock, A. T., Heath, W. R., & Carbone, F. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14843-14851.2005 · Cited by 78 · see citing works
Wakim, L., Gebhardt, T., Heath, W., & Carbone, F. (2008) · Journal of Immunology · doi:10.4049/jimmunol.181.9.5837 · Cited by 69 · see citing works
Mourmouras, V., Fimiani, M., Rubegni, P., Epistolato, M. C., Malagnino, V., Cardone, C., Cosci, E., Nisi, M. C. D., & Miracco, C. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08057.x · Cited by 65 · see citing works
Epidermal T Cells: Their Functional Role and Disease Relevance for Dermatologists
Shiohara, T., & Moriya, N. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12335465 · Cited by 52 · see citing works
T-Cell-Targeted Biologicals for Psoriasis
Griffiths, C. E. M. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010043343912 · Cited by 14 · see citing works
Principles of Cytotoxic T Lymphocyte Induction and Recognition
Whitton, J. L., & Zhang, J. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79657-9_16 · Cited by 10 · see citing works
Flagged first, then by citations
2 of the 97 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Chabaud M Durand JM Buchs N Fossiez F Page G Frappart L Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis and rheumatism 1999 42 963 970 10323452
Cited by
Sorted by citations
Lowes, M. A., Suárez‐Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,710 · see citing works
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257 · see citing works
Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation
Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H., Wang, T., Zheng, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.001 · Cited by 1,021 · see citing works
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897 · see citing works
Skin Acute Wound Healing: A Comprehensive Review
Cañedo‐Dorantes, L., & Cañedo-Ayala, M. (2019) · International Journal of Inflammation · doi:10.1155/2019/3706315 · Cited by 712 · see citing works
Spatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587 · see citing works
Campbell, J. J., Clark, R. A., Watanabe, R., & Kupper, T. S. (2010) · Blood · doi:10.1182/blood-2009-11-251926 · Cited by 519 · see citing works
Self-citationThe emerging role of resident memory T cells in protective immunity and inflammatory disease
Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 514 · see citing works
Sénéschal, J., Clark, R. A., Gehad, A. E., Baecher‐Allan, C., & Kupper, T. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.018 · Cited by 455 · see citing works
Self-citationResident memory T cells in human health and disease
Clark, R. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010641 · Cited by 445 · see citing works
Self-citationSalminen, A., Kaarniranta, K., & Kauppinen, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01598-8 · Cited by 432 · see citing works
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin
Esaki, H., Brunner, P. M., Renert-Yuval, Y., Czarnowicki, T., Huynh, T., Tran, G., Lyon, S., Rodriguez, G., Immaneni, S., Johnson, D. B., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.013 · Cited by 428 · see citing works
New insights of T cells in the pathogenesis of psoriasis
Cai, Y., Fleming, C., & Yan, J. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.15 · Cited by 384 · see citing works
Villanova, F., Flutter, B. R., Tosi, I., Grys, K., Sreeneebus, H., Perera, G. K., Chapman, A., Smith, C. H., Meglio, P. D., & Nestle, F. O. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.477 · Cited by 385 · see citing works
Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003008 · Cited by 367 · see citing works
Self-citationThe Multitasking Organ: Recent Insights into Skin Immune Function
Meglio, P. D., Perera, G. K., & Nestle, F. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.003 · Cited by 351 · see citing works
The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346 · see citing works
Park, S. L., Zaid, A., Hor, J. L., Christo, S. N., Prier, J. E., Davies, B., Alexandre, Y. O., Gregory, J. L., Russell, T., Gebhardt, T., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0027-5 · Cited by 317 · see citing works
PsoriasisPreprint
Meglio, P. D., Villanova, F., & Nestle, F. O. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015354 · Cited by 315 · see citing works
Recent advances in molecular mechanisms of skin wound healing and its treatments
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395479 · Cited by 298 · see citing works
Current knowledge on psoriasis and autoimmune diseases
McCormick, T. S., Ayala‐Fontanez, N., & Soler, D. C. (2016) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s64950 · Cited by 270 · see citing works
Wikel, S. K. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00337 · Cited by 233 · see citing works
Sun, J., Zhao, Y., & Jin-hong, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067078 · Cited by 237 · see citing works
Psoriasis: what we have learned from mouse models
Wagner, E. F., Schönthaler, H. B., Guinea‐Viniegra, J., & Tschachler, E. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.157 · Cited by 217 · see citing works
Resolved Psoriasis Lesions Retain Expression of a Subset of Disease-Related Genes
Suárez‐Fariñas, M., Fuentes‐Duculan, J., Lowes, M. A., & Krueger, J. G. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.280 · Cited by 215 · see citing works
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
Chi, V., Pennington, M. W., Norton, R. S., Tarcha, E. J., Londono, L. M., Sims-Fahey, B., Upadhyay, S. K., Lakey, J. R. T., Iadonato, S. P., Wulff, H., et al. (2011) · Toxicon · doi:10.1016/j.toxicon.2011.07.016 · Cited by 212 · see citing works
Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., Talasila, S., Berry, A., Gray, J., Becker, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.049 · Cited by 210 · see citing works
The applied anatomy of human skin: A model for regeneration
Abdo, J. M., Sopko, N. A., & Milner, S. M. (2020) · Wound Medicine · doi:10.1016/j.wndm.2020.100179 · Cited by 217 · see citing works
Matejuk, A. (2017) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-017-0477-3 · Cited by 217 · see citing works
Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?
Bal, S. M., Ding, Z., van Riet, E., Jiskoot, W., & Bouwstra, J. A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.09.018 · Cited by 200 · see citing works
Immunology and Skin in Health and DiseasePreprint
Richmond, J. M., & Harris, J. E. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015339 · Cited by 178 · see citing works
Classification of human chronic inflammatory skin disease based on single-cell immune profiling
Liu, Y., Wang, H., Taylor, M. A., Cook, C. P., Martínez‐Berdeja, A., North, J. P., Harirchian, P., Hailer, A., Zhao, Z., Ghadially, R., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl9165 · Cited by 176 · see citing works
Teng, X., Hu, Z., Wei, X., Wang, Z., Guan, T., Liu, N., Liu, X., Ye, N., Deng, G., Luo, C., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300047 · Cited by 170 · see citing works
Skin Immune Landscape: Inside and Outside the Organism
Abdallah, F., Mijouin, L., & Pichon, C. (2017) · Mediators of Inflammation · doi:10.1155/2017/5095293 · Cited by 170 · see citing works
Cutaneous T‐cell lymphoma: 2017 update on diagnosis, risk‐stratification, and management
Wilcox, R. A. (2017) · American Journal of Hematology · doi:10.1002/ajh.24876 · Cited by 148 · see citing works
Fujita, H., Shemer, A., Suárez‐Fariñas, M., Johnson-Huang, L. M., Tintle, S. J., Cardinale, I. R., Fuentes‐Duculan, J., Novitskaya, I., Carucci, J. A., Krueger, J. G., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.016 · Cited by 146 · see citing works
Cutaneous T ‐cell lymphoma: 2016 update on diagnosis, risk‐stratification, and management
Wilcox, R. A. (2015) · American Journal of Hematology · doi:10.1002/ajh.24233 · Cited by 146 · see citing works
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy
Huppert, L., Green, M. D., Kim, L., Chow, C., Leyfman, Y., Daud, A., & Lee, J. C. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00742-4 · Cited by 123 · see citing works
Brandum, E. P., Jørgensen, A. S., ROSENKILDE, M. M., & Hjortø, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158340 · Cited by 144 · see citing works
Emerging concepts in tissue-resident T cells: lessons from humans
Thome, J. J. C., & Färber, D. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.05.003 · Cited by 144 · see citing works
Mycosis Fungoides and Sézary Syndrome
Larocca, C. A., & Kupper, T. S. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2018.09.001 · Cited by 146 · see citing works
A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels
Wang, X., McGovern, N. N., Gunawan, M., Richardson, C. D., Windebank, M., Siah, T. W., Lim, H. Y., Fink, K., Li, J. L. Y., Ng, L. G., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.481 · Cited by 140 · see citing works
Chen, L., & Shen, Z. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0291-4 · Cited by 136 · see citing works
Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid Tissues
Egawa, G., & Kabashima, K. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.198 · Cited by 125 · see citing works
The characterization of varicella zoster virus-specific T cells in skin and blood during aging
Vukmanovic-Stejic, M., Sandhu, D., Seidel, J. A., Patel, N., Sobande, T. O., Agius, E., Jackson, S. E., Fuentes-Duculan, J., Suárez-Fariñas, M., Mabbott, N. A., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.63 · Cited by 117 · see citing works
Acute rejection in vascularized composite allotransplantation
Fischer, S., Lian, C. G., Kueckelhaus, M., Strom, T. B., Edelman, E. R., Clark, R. A., Murphy, G. F., Chandraker, A. K., Riella, L. V., Tullius, S. G., et al. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000140 · Cited by 110 · see citing works
Self-citationBrunner, P. M., He, H., Pavel, A. B., Czarnowicki, T., Lefferdink, R., Erickson, T., Canter, T., Puar, N., Rangel, S. M., Malik, K., et al. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.04.036 · Cited by 109 · see citing works
Ueyama, A., Yamamoto, M., Tsujii, K., Furue, Y., Imura, C., Shichijo, M., & Yasui, K. (2014) · The Journal of Dermatology · doi:10.1111/1346-8138.12367 · Cited by 108 · see citing works
Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Bhattacharjee, O., Ayyangar, U., Kurbet, A. S., Ashok, D., & Raghavan, S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00068 · Cited by 106 · see citing works
Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus
Piccinni, M., Lombardelli, L., Logiodice, F., Tesi, D., Kullolli, O., Biagiotti, R., Giudizi, M. G., Romagnani, S., Maggi, E., & Ficarra, G. (2013) · Oral Diseases · doi:10.1111/odi.12094 · Cited by 102 · see citing works
Laborel-Préneron, E., Bianchi, P., Boralévi, F., Lehours, P., Fraysse, F., Morice‐Picard, F., Sugai, M., Sato’o, Y., Badiou, C., Lina, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141067 · Cited by 101 · see citing works
Chen, Y., Yan, Y., Liu, H., Qiu, F., Liang, C.-L., Zhang, Q., Huang, R., Han, L., Lu, C., & Dai, Z. (2020) · Theranostics · doi:10.7150/thno.45211 · Cited by 98 · see citing works
New insights into the role of T cells in pathogenesis of psoriasis and psoriatic arthritis
Karczewski, J., Dobrowolska, A., Rychlewska-Hańczewska, A., & Adamski, Z. (2016) · Autoimmunity · doi:10.3109/08916934.2016.1166214 · Cited by 96 · see citing works
Leech, J. M., Dhariwala, M. O., Lowe, M. M., Chu, K., Merana, G. R., Cornuot, C., Weckel, A., Jessica, M., Leitner, E. G., Gonzalez, J. R., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.10.007 · Cited by 93 · see citing works
Gehad, A. E., Lichtman, M. K., Schmults, C. D., Teague, J. E., Calarese, A. W., Jiang, Y., Watanabe, R., & Clark, R. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.190 · Cited by 93 · see citing works
Self-citationLian, C. G., Bueno, E. M., Granter, S. R., Laga, A. C., Saavedra, A. P., Lin, W. M., Susa, J. S., Zhan, Q., Chandraker, A. K., Tullius, S. G., et al. (2014) · Modern Pathology · doi:10.1038/modpathol.2013.249 · Cited by 93 · see citing works
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin
Smith, S. H., Peredo, C. E., Takeda, Y., Bui, T. T., Neil, J. E., Rickard, D. J., Millerman, E., Therrien, J., Nicodème, E., Brusq, J.-M. G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147979 · Cited by 92 · see citing works
Mitsui, H., Suárez‐Fariñas, M., Belkin, D. A., Levenkova, N., Fuentes‐Duculan, J., Coats, I., Fujita, H., & Krueger, J. G. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.33 · Cited by 92 · see citing works
Peripheral tissue surveillance and residency by memory T cells
Gebhardt, T., Mueller, S. N., Heath, W. R., & Carbone, F. R. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.08.008 · Cited by 91 · see citing works
Revisiting the role of B cells in skin immune surveillance
Egbuniwe, I. U., Karagiannis, S. N., Nestle, F. O., & Lacy, K. E. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.006 · Cited by 89 · see citing works
Pulitzer, M. P. (2017) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.06.006 · Cited by 89 · see citing works
IL-17 in psoriasis: Implications for therapy and cardiovascular co-morbidities
Golden, J. B., McCormick, T. S., & Ward, N. L. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.013 · Cited by 87 · see citing works
Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?
Steinbach, K., Vincenti, I., & Merkler, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02827 · Cited by 85 · see citing works
Xia, M., Hu, S., Fu, Y., Jin, W., Yi, Q., Matsui, Y., Yang, J., McDowell, M. A., Sarkar, S., Kalia, V., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.010 · Cited by 85 · see citing works
Eyerich, K., Weisenseel, P., Pinter, A., Schäkel, K., Asadullah, K., Wegner, S., Muñoz‐Elías, E. J., Bartz, H., Taut, F., & Reich, K. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049822 · Cited by 84 · see citing works
Shime, H., Odanaka, M., Tsuiji, M., Matoba, T., Imai, M., Yasumizu, Y., Uraki, R., Minohara, K., Watanabe, M., Bonito, A. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000372117 · Cited by 83 · see citing works
Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage
Presti, E. L., Toia, F., Oieni, S., Buccheri, S., Turdo, A., Mangiapane, L. R., Campisi, G., Caputo, V., Todaro, M., Stassi, G., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0348 · Cited by 83 · see citing works
Auriemma, M., Brzoska, T., Klenner, L., Kupas, V., Goerge, T., Voskort, M., Zhao, Z., Sparwasser, T. D., Luger, T. A., & Loser, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.59 · Cited by 75 · see citing works
Characterization of clinical photosensitivity in cutaneous lupus erythematosus
Foering, K., Chang, A. Y., Piette, E. W., Cucchiara, A. J., Okawa, J., & Werth, V. P. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.03.015 · Cited by 75 · see citing works
Kundu‐Raychaudhuri, S., Chen, Y., Wulff, H., & Raychaudhuri, S. P. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.07.003 · Cited by 74 · see citing works
Memory T cells as an occupying force
Bevan, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041377 · Cited by 73 · see citing works
Cutaneous T‐cell lymphoma: 2014 Update on diagnosis, risk‐stratification, and management
Wilcox, R. A. (2014) · American Journal of Hematology · doi:10.1002/ajh.23756 · Cited by 71 · see citing works
Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management
Wilcox, R. A. (2011) · American Journal of Hematology · doi:10.1002/ajh.22139 · Cited by 71 · see citing works
Allie, S. R., & Randall, T. D. (2020) · Viral Immunology · doi:10.1089/vim.2019.0141 · Cited by 70 · see citing works
The panoply of αβT cells in the skin
Nomura, T., Kabashima, K., & Miyachi, Y. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.07.010 · Cited by 68 · see citing works
The role of the histamine H 4 receptor in atopic dermatitis and psoriasis
Schaper‐Gerhardt, K., Roßbach, K., Nikolouli, E., Werfel, T., Gutzmer, R., & Mommert, S. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14550 · Cited by 68 · see citing works
Guttman‐Yassky, E., Zhou, L., & Krueger, J. G. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.03.021 · Cited by 69 · see citing works
Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype
Gaudenzio, N., Laurent, C., Valitutti, S., & Espinosa, É. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.029 · Cited by 66 · see citing works
Composite tissue allotransplantation: opportunities and challenges
Iske, J., Nian, Y., Maenosono, R., Maurer, M. M., Sauer, I. M., & Tullius, S. G. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0215-3 · Cited by 66 · see citing works
Brunner, P. M., Israel, A., Leonard, A., Pavel, A. B., Kim, H. J., Zhang, N., Czarnowicki, T., Patel, K. R., Murphrey, M. B., Ramsey, K., et al. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.11.025 · Cited by 63 · see citing works
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma
Clark, R. A., Shackelton, J. B., Watanabe, R., Calarese, A. W., Yamanaka, K.-I., Campbell, J. J., Teague, J. E., Kuo, H. P., Hijnen, D., & Kupper, T. S. (2010) · Blood · doi:10.1182/blood-2010-05-287664 · Cited by 62 · see citing works
Self-citationMicroarray patches enable the development of skin-targeted vaccines against COVID-19
Korkmaz, E., Balmert, S. C., Sumpter, T. L., Carey, C. D., Erdös, G., & Falo, L. D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.022 · Cited by 59 · see citing works
Clinical perspectives on the age-related increase of immunosuppressive activity
Salminen, A. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02193-4 · Cited by 57 · see citing works
Use of Probiotics for Dermal Applications
Cinque, B., Torre, C. L., Melchiorre, E., Marchesani, G., Zoccali, G., Palumbo, P., Marzio, L. D., Masci, A., Mosca, L. N., Mastromarino, P., et al. (2011) · Microbiology monographs · doi:10.1007/978-3-642-20838-6_9 · Cited by 55 · see citing works
Tissue‐resident T cells, in situ immunity and transplantation
Turner, D., Gordon, C. L., & Färber, D. L. (2014) · Immunological Reviews · doi:10.1111/imr.12149 · Cited by 56 · see citing works
Role of developmental immunotoxicity and immune dysfunction in chronic disease and cancer
Dietert, R. R. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.09.006 · Cited by 54 · see citing works
Bobrowicz, M., Fassnacht, C., Ignatova, D., Chang, Y., Dimitriou, F., & Guenova, E. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000509281 · Cited by 53 · see citing works
Gone but Not Forgotten: Lesional Memory in Psoriatic Skin
Clark, R. A. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.374 · Cited by 54 · see citing works
Self-citationCohen, A. J., Nikbakht, N., & Uitto, J. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041245 · Cited by 54 · see citing works
Adaptation in the innate immune system and heterologous innate immunity
Martin, S. F. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1676-2 · Cited by 51 · see citing works
Phenotypic Characterization of Leukocytes in Prenatal Human Dermis
Schuster, C., Vaculik, C., Prior, M., Fiala, C., Mildner, M., Eppel, W., Stingl, G., & Elbe‐Bürger, A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.187 · Cited by 50 · see citing works
Litvinov, I. V., Shtreis, A., Kobayashi, K., Glassman, S. J., Tsang, M., Woetmann, A., Sasseville, D., Ødum, N., & Duvic, M. A. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1175799 · Cited by 50 · see citing works
Transcutaneous delivery of CpG-adjuvanted allergen via laser-generated micropores
Hessenberger, M., Weiss, R., Weinberger, E. E., Boehler, C., Thalhamer, J., & Scheiblhofer, S. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.09.086 · Cited by 50 · see citing works
Treg‐enriched CD 4+ T cells attenuate collagen synthesis in keloid fibroblasts
Murao, N., Seino, K., Hayashi, T., Ikeda, M., Funayama, E., Furukawa, H., Yamamoto, Y., & Oyama, A. (2014) · Experimental Dermatology · doi:10.1111/exd.12368 · Cited by 49 · see citing works
Iżykowska, K., Przybylski, G. K., Gand, C., Braun, F., Grabarczyk, P., Kuss, A. W., Olek‐Hrab, K., Torres, A. N. B., Vermeer, M. H., Zoutman, W. H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17383 · Cited by 49 · see citing works
More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function
Sil, P., Wong, S., & Martinez, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01376 · Cited by 48 · see citing works
Psoriasis and Related Disorders
Burden, A. D., & Kirby, B. (2016) · doi:10.1002/9781118441213.rtd0036 · Cited by 48 · see citing works
Regulatory T cells and their role in allergic disease
Conrad, M. L., Barrientos, G., Cai, X., Mukherjee, S., Das, M., Victor, E. S., & Harb, H. (2024) · Allergy · doi:10.1111/all.16326 · Cited by 47 · see citing works
Wang, F., Smith, N., Maier, L. E., Xia, W., Hammerberg, C., Chubb, H. A., Chen, C., Riblett, M., Johnston, A., Gudjonsson, J. E., et al. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10961.x · Cited by 47 · see citing works
Hautz, T., Zelger, B. G., Brandacher, G., Mueller, H., Grahammer, J., Zelger, B., Lee, W. A., Cavadas, P. C., Margreiter, R., Pratschke, J., et al. (2011) · Transplant International · doi:10.1111/j.1432-2277.2011.01369.x · Cited by 47 · see citing works
- Authors
- Clark, R. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Clark, Rachael A.
- ORCID
- Clark, Rachael A.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 130
- Issue
- 2
- Pages
- 362-370
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC2922675
- OpenAlex
- W2074644098
- Cited by
- 298
- References
- 97
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 16 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 21 · 2019: 20 · 2018: 15 · 2017: 20 · 2016: 18 · 2015: 24 · 2014: 35 · 2013: 21 · 2012: 28
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Scleroderma Foundation
- Leukemia and Lymphoma Society
- National Institutes of Health (1K08AI060890-01A1, 1R01AR056720-01A1, 1R01CA122569-01A)
- Damon Runyon Cancer Research Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin-resident T cells, skin immunity, regulatory T cells, Th17 cells, effector memory T cells, psoriasis, skin inflammation, autoimmune tolerance, tumor immune evasion, viral latency, T cell dysfunction
- MeSH terms
- Animals, Endocytosis, Humans, Immune System, Immunologic Memory, Inflammation, Models, Biological, Psoriasis, Skin, Skin Physiological Phenomena, T-Lymphocytes, Autoimmunity, T-Lymphocyte Subsets, Interleukin-17, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
