T cells and the skin: from protective immunity to inflammatory skin disorders

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

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Of Mice and Not Men: Differences between Mouse and Human Immunology

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IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

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The skin microbiome

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Psoriasis

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Cellular and molecular mechanisms of skin wound healing

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Immunology of Acute and Chronic Wound Healing

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The Immune Functions of Keratinocytes in Skin Wound Healing

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The Immunology of Psoriasis-Current Concepts in Pathogenesis

Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

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Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders

Song, Y., Li, J., & Wu, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01952-8 · Cited by 328

Keratinocyte: A trigger or an executor of psoriasis?

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Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

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Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021

Wu, Q., Qian, W., Sun, X., & Jiang, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01362-9 · Cited by 208

Cutaneous T cell lymphoma

Dummer, R., Vermeer, M. H., Scarisbrick, J. J., Kim, Y. H., Stonesifer, C. J., Tensen, C. P., Geskin, L. J., Quaglino, P., & Ramelyte, E. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00296-9 · Cited by 187

An update on Vitiligo pathogenesis

Sénéschal, J., Boniface, K., D’Arino, A., & Picardo, M. (2020) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12949 · Cited by 156

Multifunctional dressings for wound exudate management

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Design principles of microneedles for drug delivery and sampling applications

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Pathophysiology of Skin Resident Memory T Cells

TOKURA, Y., Phadungsaksawasdi, P., Kurihara, K., Fujiyama, T., & Honda, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618897 · Cited by 148

Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

Chen, L., & Shen, Z. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0291-4 · Cited by 142

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

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Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells

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The role of T cells in pemphigus vulgaris and bullous pemphigoid

Fang, H., Li, Q., & Wang, G. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102661 · Cited by 121

Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

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Arsenic-Induced Carcinogenesis and Immune Dysregulation

Huang, H.-W., Lee, C., & Yu, H. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16152746 · Cited by 116

Skin immunity: dissecting the complex biology of our body's outer barrier

Zhang, C., Merana, G. R., Harris-Tryon, T. A., & Scharschmidt, T. C. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00505-y · Cited by 128

The biological basis of disease recurrence in psoriasis: a historical perspective and current models

Puig, L., Costanzo, A., Muñoz‐Elías, E. J., Jazra, M., Wegner, S., Paul, C. F., & Conrad, C. (2021) · British Journal of Dermatology · doi:10.1111/bjd.20963 · Cited by 118

The Skin and Inflamm-Aging

Agrawal, R., Hu, A., & Bollag, W. B. (2023) · Biology · doi:10.3390/biology12111396 · Cited by 123

Local heroes or villains: tissue-resident memory T cells in human health and disease

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Post-inflammatory hyperpigmentation in dark skin: molecular mechanism and skincare implications

Markiewicz, E., Karaman-Jurukovska, N., Mammone, T., & Idowu, O. C. (2022) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s385162 · Cited by 109

Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing

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Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

Wang, R., Gu, S., Kim, Y. H., Lee, A., Lin, H., & Jiang, D. (2025) · MedComm · doi:10.1002/mco2.70406 · Cited by 118

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Stefanov, S., & Andonova, V. (2021) · Pharmaceuticals · doi:10.3390/ph14111083 · Cited by 95

Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli

Lebeer, S., Oerlemans, E. F. M., Claes, I., Henkens, T., Delanghe, L., Wuyts, S., Spacova, I., van den Broek, M. F. L., Tuyaerts, I., Wittouck, S., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100521 · Cited by 95

Chronic urticaria and the pathogenic role of mast cells

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Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

Zwijnenburg, A. J., Pokharel, J., Varnaitė, R., Zheng, W., Hoffer, E., Shryki, I., Comet, N. R., Ehrström, M., Gredmark‐Russ, S., Eidsmo, L., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.025 · Cited by 92

OX40 in the Pathogenesis of Atopic Dermatitis—A New Therapeutic Target

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Vitiligo, From Physiopathology to Emerging Treatments: A Review

Migayron, L., Boniface, K., & Sénéschal, J. (2020) · Dermatology and Therapy · doi:10.1007/s13555-020-00447-y · Cited by 82

Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis

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From Emollients to Biologicals: Targeting Atopic Dermatitis

Salvati, L., Cosmi, L., & Annunziato, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910381 · Cited by 84

Silver crosslinked injectable bFGF-eluting supramolecular hydrogels speed up infected wound healing

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Skin Immunity to Dermatophytes: From Experimental Infection Models to Human Disease

Burstein, V. L., Beccacece, I., Guasconi, L., Mena, C. J., Cervi, L., & Chiapello, L. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.605644 · Cited by 80

Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge

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Dissecting the complexity of γδ T-cell subsets in skin homeostasis, inflammation, and malignancy

Castillo‐González, R., Cibrián, D., & Sánchez‐Madrid, F. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.11.023 · Cited by 72

Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?

Boulanger, N., & Wikel, S. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625993 · Cited by 70

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression

Jonkman, T. H., Dekkers, K. F., Slieker, R. C., Grant, C. D., Ikram, M. A., van Greevenbroek, M. M. J., Franke, L., Veldink, J. H., Boomsma, D. I., Slagboom, P. E., et al. (2022) · Genome biology · doi:10.1186/s13059-021-02585-8 · Cited by 66

Current Concepts of Vitiligo Immunopathogenesis

Hlača, N., Žagar, T., Kaštelan, M., Brajac, I., & Massari, L. P. (2022) · Biomedicines · doi:10.3390/biomedicines10071639 · Cited by 66

Mucosal delivery of fish vaccines: Local and systemic immunity following mucosal immunisations

Somamoto, T., & Nakanishi, T. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.01.005 · Cited by 65

Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis

Park, S., Matte-Martone, C. C., Gonzalez, D. G., Lathrop, E., May, D. P., Pineda, C. M., Moore, J. L., Boucher, J. D., Marsh, E. D., Schmitter-Sánchez, A. D., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00670-5 · Cited by 66

Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation

Mizuguchi, S., Gotoh, K., Nakashima, Y., Setoyama, D., Takata, Y., Ohga, S., & Kang, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714897 · Cited by 83

Microarray patches enable the development of skin-targeted vaccines against COVID-19

Korkmaz, E., Balmert, S. C., Sumpter, T. L., Carey, C. D., Erdös, G., & Falo, L. D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.022 · Cited by 60

A Sponge-Like Double-Layer Wound Dressing with Chitosan and Decellularized Bovine Amniotic Membrane for Promoting Diabetic Wound Healing

Yang, Y., Zhang, Y., Yan, Y., Ji, Q., Dai, Y., Jin, S., Liu, Y., Chen, J., & Teng, L. (2020) · Polymers · doi:10.3390/polym12030535 · Cited by 54

Multifunctional Janus nanofibrous membrane with unidirectional water transport and pH-responsive color-changing for wound dressing

Guo, K., Ou, K., Newton, M. A. A., Zhang, J., Xu, H., Li, J., Xin, B., & Huang, Y. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.10.137 · Cited by 57

Arboviruses: How Saliva Impacts the Journey from Vector to Host

Schneider, C. A., Calvo, E., & Peterson, K. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179173 · Cited by 52

Immunomodulation of wound healing leading to efferocytosis

Zhao, Y., Li, M., Mao, J., Su, Y., Huang, X., Xia, W., Leng, X., & Zan, T. (2024) · Smart Medicine · doi:10.1002/smmd.20230036 · Cited by 52

Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy

Chen, L., Sun, R., Xu, J., Zhai, W., Zhang, D., Yang, M., Yue, C., Chen, Y., Li, S., Turnquist, H. R., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-1024 · Cited by 52

Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis

Balderas-Cordero, D., Canales-Alvarez, O., Sánchez-Sánchez, R., Cabrera-Wrooman, A., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411831 · Cited by 49

Microneedle‐Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia

Younis, N. K., Puigmal, N., Kurdi, A., Badaoui, A. P., Zhang, D., Morales‐Garay, C., Saad, A. J., Cruz, D., Rahy, N. A., Daccache, A., et al. (2024) · Advanced Materials · doi:10.1002/adma.202312088 · Cited by 46

Structure and Immune Function of Afferent Lymphatics and Their Mechanistic Contribution to Dendritic Cell and T Cell Trafficking

Arasa, J., Collado‐Díaz, V., & Halin, C. (2021) · Cells · doi:10.3390/cells10051269 · Cited by 48

CD8+ tissue‐resident memory T cells recruit neutrophils that are essential for flare‐ups in contact dermatitis

Funch, A. B., Mraz, V., Gadsbøll, A.-S. Ø., Jee, M. H., Weber, J. F., Ødum, N., Woetmann, A., Johansen, J. D., Geisler, C., & Bonefeld, C. M. (2021) · Allergy · doi:10.1111/all.14986 · Cited by 44

Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing

Yuan, J., Zhang, D., He, X., Ni, Y., Che, L., Wu, J., Wu, B., Wang, Y., Wang, S., Sha, D., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.09.019 · Cited by 44

3D microextrusion-inkjet hybrid printing of structured human skin equivalents

Lee, H., Park, J. A., Kim, S., Jo, Y., Kang, D., & Jung, S. (2021) · Bioprinting · doi:10.1016/j.bprint.2021.e00143 · Cited by 42

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Li, L., Lu, J., Liu, J., Wu, J., Zhang, X., Meng, Y., Wu, X., Tai, Z., Zhu, Q., & Chen, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1340677 · Cited by 45

To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host

Alfituri, O. A., Quintana, J. F., MacLeod, A., Garside, P., Benson, R. A., Brewer, J. M., Mabbott, N. A., Morrison, L. J., & Capewell, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01250 · Cited by 41

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Park, J., Overbey, E. G., Narayanan, S. A., Kim, J., Tierney, B. T., Damle, N., Najjar, D., Ryon, K. A., Proszynski, J., Kleinman, A. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48625-2 · Cited by 41

Autoimmune Pemphigus: Latest Advances and Emerging Therapies

Lim, Y. L., Bohelay, G., Hanakawa, S., Musette, P., & Janela, B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.808536 · Cited by 40

Atopic dermatitis: Is innate or adaptive immunity in control? A clinical perspective

Ong, P. Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943640 · Cited by 44

Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy

Silvestrini, A. V. P., Morais, M. F., Debiasi, B. W., Praça, F. S. G., & Bentley, M. V. L. B. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115198 · Cited by 40

CCR4+ Skin-Tropic Phenotype as a Feature of Central Memory CD8+ T Cells in Healthy Subjects and Psoriasis Patients

Casciano, F., Diani, M., Altomare, A., Granucci, F., Secchiero, P., Banfi, G., & Reali, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00529 · Cited by 39

Bioinspired Wearable Thermoelectric Device Constructed with Soft‐Rigid Assembly for Personal Thermal Management

Wu, B. C., Lin, Y., Tian, Y., Wei, W., Xu, Y., Hu, Y., Li, J., Li, K., Hou, C., Zhang, Q., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402319 · Cited by 39

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Chen, Y., Griffiths, C. E. M., & Bulfone‐Paus, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021564 · Cited by 37

Immune mechanisms in human and canine demodicosis: A review

Gazi, U., Özkan, A. T., & Mumcuoğlu, K. Y. (2019) · Parasite Immunology · doi:10.1111/pim.12673 · Cited by 36

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

Espinoza-Monje, M., Campos, J., Alvarez Villamil, E., Jerez, A., Dentice Maidana, S., Elean, M., Salva, S., Kitazawa, H., Villena, J., & García-Cancino, A. (2021) · Microorganisms · doi:10.3390/microorganisms9071486 · Cited by 36

Sulforaphane: A nutraceutical against diabetes-related complications

Mthembu, S. X. H., Mazibuko-Mbeje, S. E., Moetlediwa, M. T., Muvhulawa, N., Silvestri, S., Orlando, P., Nkambule, B. B., Muller, C. J. F., Ndwandwe, D. E., Basson, A. K., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106918 · Cited by 37

CD4+ Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice

Murata, A., & Hayashi, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00775 · Cited by 35

The Potential Roles of T Cells in Periapical Lesions

Wang, L., Yang, F., Qiu, Y., Ye, L., Song, D., & Huang, D. (2021) · Journal of Endodontics · doi:10.1016/j.joen.2021.09.016 · Cited by 35

Targeting T Cell Metabolism in Inflammatory Skin Disease

von Meyenn, L., Bertschi, N., & Schlapbach, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02285 · Cited by 32

Spatiotemporal self-strengthening hydrogels for oral tissue regeneration

Yang, Y., Yuan, J., Ni, Y., Gu, Y., Zhou, J., Yuan, W., Xu, S., Che, L., Zheng, S. Y., Sun, W., et al. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.110119 · Cited by 33

Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes

Arikat, F., Hanna, S. J., Singh, R., Vilela, L., Wong, F. S., Dayan, C. M., Coulman, S. A., & Birchall, J. C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.031 · Cited by 33

Novel potential therapeutic targets of alopecia areata

Xu, W., Wan, S., Xie, B., & Song, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148359 · Cited by 34

Strategies to Develop a Suitable Formulation for Inflammatory Skin Disease Treatment

Guo, J., & Jee, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116078 · Cited by 30

Metabolic Comorbidities in Vitiligo: A Brief Review and Report of New Data from a Single-Center Experience

D’Arino, A., Picardo, M., Truglio, M., Pacifico, A., & Iacovelli, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168820 · Cited by 32

Current knowledge of the implication of lipid mediators in psoriasis

Simard, M., Morin, S., Ridha, Z., & Pouliot, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961107 · Cited by 31

Long-Lived Skin-Resident Memory T Cells Contribute to Concomitant Immunity in Cutaneous LeishmaniasisPreprint

Scott, P. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038059 · Cited by 29

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

Salazar, J., Carmona, T., Zacconi, F. C. M., Venegas-Yazigi, D. A., Cabello‐Verrugio, C., Choi, W. I., & Vilos, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010010 · Cited by 29

Pellino-1 promotes intrinsic activation of skin-resident IL-17A–producing T cells in psoriasis

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Immune cell trafficking: a novel perspective on the gut-skin axis

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