T cells and the skin: from protective immunity to inflammatory skin disorders

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

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Of Mice and Not Men: Differences between Mouse and Human Immunology

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IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

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The skin microbiome

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Psoriasis

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

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Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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Pathogenesis and therapy of psoriasis

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Vitamin effects on the immune system: Vitamins A and D take centre stage

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

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The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

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Human T cell development, localization, and function throughout life

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A Validated Regulatory Network for Th17 Cell Specification

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Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

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Compartmentalized Control of Skin Immunity by Resident Commensals

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Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

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A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

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Normalizing the environment recapitulates adult human immune traits in laboratory mice

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Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

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Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

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Visualizing the generation of memory CD4 T cells in the whole body

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A diversity profile of the human skin microbiotaPreprint

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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

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Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

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A Distinct Function of Regulatory T Cells in Tissue Protection

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Mechanisms regulating skin immunity and inflammation

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Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

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Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial

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Memory T Cell Subsets, Migration Patterns, and Tissue Residence

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Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

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Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

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Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

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Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets

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Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

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Immune surveillance in the skin: mechanisms and clinical consequences

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Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

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A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

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The Vast Majority of CLA+ T Cells Are Resident in Normal Skin

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Alopecia areata

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Resident memory CD8 T cells trigger protective innate and adaptive immune responses

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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

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Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

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Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

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CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

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Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

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The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

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Raising the NKT cell family

Godfrey, D. I., Stankovic, S., & Baxter, A. G. (2010) · Nature Immunology · doi:10.1038/ni.1841 · Cited by 648

Sensing and alarm function of resident memory CD8+ T cells

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Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

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A Role for Skin γδ T Cells in Wound Repair

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DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27

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T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

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CD8+CD103+ Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

Djenidi, F., Adam, J., Goubar, A., Durgeau, A., Meurice, G., de Montpréville, V., Validire, P., Besse, B., & Mami-Chouaib, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402711 · Cited by 622

Alopecia areata

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Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

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Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 Gene

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Spatial map of human T cell compartmentalization and maintenance over decades of life

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A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes

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Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

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CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

Nakanishi, Y., Lu, B., Gerard, C. J., & Iwasaki, A. (2009) · Nature · doi:10.1038/nature08511 · Cited by 567

Investigating International Time Trends in the Incidence and Prevalence of Atopic Eczema 1990–2010: A Systematic Review of Epidemiological Studies

Deckers, I. A. G., McLean, S., Linssen, S., Mommers, M., van Schayck, O. C. P., & Sheikh, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039803 · Cited by 552

Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

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Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

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Alopecia areata

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The emerging role of resident memory T cells in protective immunity and inflammatory disease

Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 537

Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert

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Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis

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Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

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Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α

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Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

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