Novel vaccine technologies for the 21st century
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mRNA-based therapy is an effective platform for treatment of infectious diseases and cancer.
“Messenger RNA (mRNA)-based therapy recently emerged as an effective platform for treatment of infectious diseases and cancer (Jackson et al., 2020; Mascola and Fauci, 2020).”
From A thermostable mRNA vaccine against COVID-19 (2020) · cites this paper as Mascola and Fauci, 2020
The Influenza section reports that mRNA vaccines produced robust antibody responses in two phase I trials and describes their potential as a platform against infectious agents. It does not address cancer or establish mRNA-based therapy as an effective treatment for either cancer or infectious disease; its evidence concerns vaccination, and its broader conclusion is prospective. (LLM, conf=0.88)
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- Authors
- Mascola, J. R., & Fauci, A. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fauci, Anthony S.
- Venue
- Nature Reviews Immunology
- Published
- 2019-11-11
- Volume
- 20
- Issue
- 2
- Pages
- 87-88
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC7222935
- OpenAlex
- W2983736730
- Cited by
- 171
- References
- 10
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 33 · 2023: 24 · 2022: 35 · 2021: 24 · 2020: 17 · 2019: 1
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- vaccine development, gene-based vaccines, tuberculosis vaccine, influenza vaccination, RSV vaccine, adjuvant development
- MeSH terms
- Drug Development, Adjuvants, Immunologic, BCG Vaccine, Humans, Influenza, Human, Influenza Vaccines, Recombinant Proteins, RNA, Messenger, Vaccines, Vaccines, Synthetic, Viral Fusion Proteins, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus Vaccines, Tuberculosis Vaccines, Latent Tuberculosis
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