Cited by 172Immunotherapy and Immune ResponsesImmune responses and vaccinationsvaccines and immunoinformatics approaches

Novel vaccine technologies for the 21st century

Open access
Mascola, John R., Fauci, Anthony S.·2020·Nature Reviews Immunology

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Registry

Crossref · 10.1038/s41577-019-0243-3

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  • mRNA-based therapy is an effective platform for treatment of infectious diseases and cancer.

    “Messenger RNA (mRNA)-based therapy recently emerged as an effective platform for treatment of infectious diseases and cancer (Jackson et al., 2020; Mascola and Fauci, 2020).”

    From A thermostable mRNA vaccine against COVID-19 (2020) · cites this paper as Mascola and Fauci, 2020

    The Influenza section reports that mRNA vaccines produced robust antibody responses in two phase I trials and describes their potential as a platform against infectious agents. It does not address cancer or establish mRNA-based therapy as an effective treatment for either cancer or infectious disease; its evidence concerns vaccination, and its broader conclusion is prospective. (LLM, conf=0.88)

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Research works printed but not linked: 1

  1. [10]Darrah, P. A. et al. Prevention of tuberculosis in nonhuman primates following intravenous BCG immunization. Nature (in the press). PMC7015856 31894150

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Authors
Mascola, J. R., & Fauci, A. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Fauci, Anthony S.
Venue
Nature Reviews Immunology
Published
2019-11-11
Volume
20
Issue
2
Pages
87-88
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2983736730
Cited by
171
References
10
Citations by year
2026: 13 · 2025: 24 · 2024: 33 · 2023: 24 · 2022: 35 · 2021: 24 · 2020: 17 · 2019: 1
FWCI
7.69
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
vaccine development, gene-based vaccines, tuberculosis vaccine, influenza vaccination, RSV vaccine, adjuvant development
MeSH terms
Drug Development, Adjuvants, Immunologic, BCG Vaccine, Humans, Influenza, Human, Influenza Vaccines, Recombinant Proteins, RNA, Messenger, Vaccines, Vaccines, Synthetic, Viral Fusion Proteins, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus Vaccines, Tuberculosis Vaccines, Latent Tuberculosis

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