The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Understanding COVID-19-associated coagulopathy
Open accessAbstract
COVID-19-associated coagulopathy (CAC) is a life-threatening complication of SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving this condition are unclear. Evidence supports the concept that CAC involves complex interactions between the innate immune response, the coagulation and fibrinolytic pathways, and the vascular endothelium, resulting in a procoagulant condition. Understanding of the pathogenesis of this condition at the genomic, molecular and cellular levels is needed in order to mitigate thrombosis formation in at-risk patients. In this Perspective, we categorize our current understanding of CAC into three main pathological mechanisms: first, vascular endothelial cell dysfunction; second, a hyper-inflammatory immune response; and last, hypercoagulability. Furthermore, we pose key questions and identify research gaps that need to be addressed to better understand CAC, facilitate improved diagnostics and aid in therapeutic development. Finally, we consider the suitability of different animal models to study CAC. Here, the authors consider our emerging understanding of COVID-19-associated coagulopathy. They focus on the complex interactions between innate immune, coagulation and fibrinolytic pathways that can lead to potentially life-threatening thrombosis following SARS-CoV-2 infection.
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Altmann, D. M., Whettlock, E. M., Liu, S., Arachchillage, D. J., & Boyton, R. J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00904-7 · Cited by 389
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Ryu, J. K., Yan, Z., Montano, M., Sozmen, E. G., Dixit, K., Suryawanshi, R. K., Matsui, Y., Helmy, E., Kaushal, P., Makanani, S. K., et al. (2024) · Nature · doi:10.1038/s41586-024-07873-4 · Cited by 116
Cell-Specific Mechanisms in the Heart of COVID-19 Patients
Tsai, E. J., Čiháková, D., & Tucker, N. R. (2023) · Circulation Research · doi:10.1161/circresaha.123.321876 · Cited by 37
Metadata
- Authors
- Conway, E. M., Mackman, N., Warren, R. Q., Wolberg, A. S., Mosnier, L. O., Campbell, R. A., Gralinski, L. E., Rondina, M. T., van de Veerdonk, F. L., Hoffmeister, K. M., Griffin, J. H., Nugent, D., Moon, K., & Morrissey, J. H.
- Venue
- Nature Reviews Immunology
- Published
- 2022-08-05
- Volume
- 22
- Issue
- 10
- Pages
- 639-649
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W4289918655
- Cited by
- 359
- References
- 155
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Conway, E. M., Mackman, N., Warren, R. Q., Wolberg, A. S., Mosnier, L. O., Campbell, R. A., Gralinski, L. E., Rondina, M. T., van de Veerdonk, F. L., Hoffmeister, K. M., Griffin, J. H., Nugent, D., Moon, K., & Morrissey, J. H. (2022). Understanding COVID-19-associated coagulopathy. Nature Reviews Immunology. https://doi.org/10.1038/s41577-022-00762-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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